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Author : Zhenzhen Quan
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (89 download)
Download or read book Regulation of Starvation-induced Gene Expression in Saccharomyces Cerevisiae written by Zhenzhen Quan and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Maryam Binti Mohamed Rehan
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (86 download)
Download or read book Multiple Mechanisms Mediating the Starvation Induced Activation of Recombination at HIS4 in Saccharomyces Cerevisiae written by Maryam Binti Mohamed Rehan and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Meiotic recombination occurs at relatively high levels at specific regions in the genome called hotspots. The transcription factor-dependent hotspots ([alpha]-hotspots) have been widely studied in yeast, and are beginning to be elucidated in mammals. The HIS4 hotspot activity in Saccharomyces cerevisiae requires binding of Bas1p, Bas2p, Rap1p and Gcn4p. Bas1p acts in conjunction with Bas2p to regulate basal level of transcription of their target genes, and can be stimulated under conditions of adenine starvation and accumulation of metabolites AICAR and SAICAR from the purine biosynthesis pathway. Gcn4p activates transcription of yeast genes in response to starvation for amino acids and purines. This study focused on the influence of nutritional starvation on HIS4 hotspot activity, and different mechanisms mediating this effect. Our data suggests that deletion of genes known to accumulate AICAR/SAICAR can stimulate recombination at HIS4 in a Bas1p-dependent manner. Furthermore, intracellular and extracellular starvation for adenine and amino acids also activates recombination at HIS4. In addition, moderate levels of starvation only affect recombination when chromatin is already hyperacetylated, by the inactivation of the Set2p methyltransferase. Bas1p plays an essential role in mediating the effect of starvation and the set2 mutation on recombination. We showed that Gcn4p is not required for HIS4 hotspot activity, but plays a modest role in the effect of starvation in an adenine auxotrophic strain. Additionally, the starvation effect is also mediated by an as yet unknown factor independent from Bas1p/Bas2p and Gcn4p. This work provides additional information regarding the regulation of a transcription factor-dependent hotspot activity, and factors influencing its activation. Furthermore, data in this study indicate that BAS1, and not BAS2 exhibit haploinsufficiency with respect to its function in activating meiotic recombination. This implies that Bas1p is rate-limiting for HIS4 hotspot activity.
Author : Dhananjay M. Nawandar
Publisher :
ISBN 13 :
Total Pages : 82 pages
Book Rating : 4.:/5 (762 download)
Download or read book CCR4-NOT Complex in Gen4 Regulated Gene Expression After Transcription and Determination of Appropriate Conditions to Study Amino Acid Starvation in Yeast Saccharomyces Cerevisiae written by Dhananjay M. Nawandar and published by . This book was released on 2011 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael Springer
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.:/5 (82 download)
Download or read book Computational and Experimental Dissection of the Response of Saccharomyces Cerevisiae to Inorganic Phosphate Starvation written by Michael Springer and published by . This book was released on 2003 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Norberto Villa
Publisher :
ISBN 13 :
Total Pages : 140 pages
Book Rating : 4.:/5 (18 download)
Download or read book The Saccharomyces Cerevisiae (budding Yeast) Ccr4-Not Complex Affects Gene Expression Post-transcriptionally Under Amino Acid Starvation Conditions written by Norberto Villa and published by . This book was released on 2018 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nicholas Santoro
Publisher :
ISBN 13 :
Total Pages : 478 pages
Book Rating : 4.3/5 (91 download)
Download or read book Distinct Binding Sites and Signaling Pathways Regulate the Saccharomyces Cerevisiae Heat Shock Transcription Factor written by Nicholas Santoro and published by . This book was released on 2000 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shane Patrick Kelly
Publisher :
ISBN 13 :
Total Pages : 125 pages
Book Rating : 4.:/5 (911 download)
Download or read book Changes in Gene Expression During Nitrogen Starvation are Mediated by Targeted Degradation of Translation and MRNA Decay Factors in Saccharomyces Cerevisiae written by Shane Patrick Kelly and published by . This book was released on 2015 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy is the cellular mechanism of recruitment and decay of cytoplasmic molecules, proteins, and organelles that are obsolete for a particular growth condition. Autophagic degradation is distinct from proteasomal degradation by the formation of a de-novo double membrane which engulfs its cargo to be delivered for degradation to the yeast vacuole. Once thought to be only a general phenomenon of bulk decay, several autophagic pathways have demonstrated selectivity. In the following work we show that during nitrogen starvation (a potent inducer of autophagy) in the yeast Saccharomyces cerevisiae, a subset of translation factors are degraded selectively and rapidly. We go on to show that their efficient decay is dependent on a ubiquitin deubiquitinase, Ubp3p. Furthermore, we show that the proteasomal pathway is activated during nitrogen starvation and through which the selective degradation of the mRNA decay factors Dcp2p and Pop2p occurs. Interestingly, the decay of these latter factors are also dependent on Ubp3p. Ubp3p is also degraded during nitrogen starvation; we postulate as an auto-regulatory mechanism to inhibit the complete destruction of the selected proteins. Previous work in the autophagy field indicated that the mRNA of ATG8 was rapidly increased during nitrogen starvation. Since Atg8p is important for autophagosome biogenesis and expansion we sought a link between ATG8 increase and Dcp2p's decay. Our findings indicate that the 5'->3' mRNA decay pathway regulates autophagy during log growth by selectively degrading ATG8 mRNA. Furthermore, the proteasomal decay of Dcp2p coincides with an increase in ATG8 mRNA half-life during nitrogen starvation. This work has uncovered a novel mechanism of autophagic regulation that may be used to modulate autophagy to influence therapeutic outcomes.
Author : Jeffrey N. Strathern
Publisher :
ISBN 13 :
Total Pages : 700 pages
Book Rating : 4.3/5 (555 download)
Download or read book The Molecular Biology of the Yeast Saccharomyces: Metabolism and gene expression written by Jeffrey N. Strathern and published by . This book was released on 1981 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Channing Der
Publisher : Springer
ISBN 13 : 9781402043284
Total Pages : 0 pages
Book Rating : 4.0/5 (432 download)
Download or read book RAS Family GTPases written by Channing Der and published by Springer. This book was released on 2006-09-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. This book features chapters contributed by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.
Author : Vince Harjono
Publisher :
ISBN 13 :
Total Pages : 111 pages
Book Rating : 4.:/5 (13 download)
Download or read book Mechanisms of Post-Transcriptional Regulation in S. Cerevisiae written by Vince Harjono and published by . This book was released on 2022 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-transcriptional regulation represents a powerful and versatile mechanism to fine-tune gene expression to meet cellular and environmental demands. One important aspect of post-transcriptional regulation involves regulation of protein translation, the process of building proteins from a messenger RNA. In this dissertation, I use biochemical and molecular biology techniques to study how translation is mechanistically regulated by both mRNA and protein factors. In chapter 2, I discuss the development of a quantitative method in eukaryotes to measure ribosomal stalls of cis-mRNA factors on protein elongation. We find that different distributions of nonoptimal codons trigger different surveillance and rescue pathways despite similar levels of elongation delay. In chapter 3, I explore the relationship between translatability and mRNA localization during glucose starvation and investigate potential factors that influence this relationship. We find that a complex made from Rvb1 and Rvb2 is involved in promoter-directed cytoplasmic fate in a subset of stress response genes in glucose starvation. Furthermore, we use carefully designed reporters to interrogate how translatability determines cytoplasmic localization and find that active translation is linked to exclusion from stress-induced cytoplasmic granules. Finally in chapter 4, I discuss improvements on the method we have developed, possible future directions for the work described in this dissertation, and my concluding remarks.
Author : Michael Sassen
Publisher : GRIN Verlag
ISBN 13 : 3638400573
Total Pages : 85 pages
Book Rating : 4.6/5 (384 download)
Download or read book Global Transcriptional Responses of Fission Yeast to Glucose Starvation Stress written by Michael Sassen and published by GRIN Verlag. This book was released on 2005-07-20 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diploma Thesis from the year 2005 in the subject Biology - Genetics / Gene Technology, grade: 1,1, TU Bergakademie Freiberg, language: English, abstract: 1. Introduction 1.1 Schizosaccharomyces pombe as a Model System S. pombe functions as a suitable model system since it is easy and inexpensive to rear, has a convenient size, a short life cycle, and is genetically manipulable. As a unicellular eukaryote, the fission yeast S. pombe can exist either in a haploid or diploid state and possesses two different mating types (h+ and h-). The wild type, however, is h90, which means it can switch mating type. Figure 1.01: Left, picture of S. pombe cells At top are two dividing cells in late mitotic phase, showing the fission yeast typical septum at the point of cytoplasmic division. The lower cell is in early M phase, having its chromosomes already segregated. Figure 1.02: Right, fission yeast cell cycle Diagrammatic representation of the S. pombe cell cycles with the interchange between the two occurring in G1 phase (Figure obtained and used with permission from Trevor Pemberton, University of Sussex). [...] S. pombe can undergo two different life cycles, either the vegetative (mitotic) cycle or the sporulation (meiotic) cycle, depending on the environment it is living in. These two cycles are shown in figure 2 with the change between the two occurring in cells at the G1 stage of the mitotic cycle. Under laboratory conditions, given all nutrients required, S. pombe prefers the haploid state. This makes it a favorable organism for genetic research since it ensures that introduced mutations are not masked by another wild type allele. [...]
Author : Sally E. Smith
Publisher : Academic Press
ISBN 13 : 0080559344
Total Pages : 815 pages
Book Rating : 4.0/5 (85 download)
Download or read book Mycorrhizal Symbiosis written by Sally E. Smith and published by Academic Press. This book was released on 2010-07-26 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The roots of most plants are colonized by symbiotic fungi to form mycorrhiza, which play a critical role in the capture of nutrients from the soil and therefore in plant nutrition. Mycorrhizal Symbiosis is recognized as the definitive work in this area. Since the last edition was published there have been major advances in the field, particularly in the area of molecular biology, and the new edition has been fully revised and updated to incorporate these exciting new developments. Over 50% new material Includes expanded color plate section Covers all aspects of mycorrhiza Presents new taxonomy Discusses the impact of proteomics and genomics on research in this area
Author : Marilyn H. Meinke
Publisher :
ISBN 13 :
Total Pages : 184 pages
Book Rating : 4.:/5 (319 download)
Download or read book Regulation of Expression of a Gene for Glycogen Synthases in Saccharomyces Cerevisiae written by Marilyn H. Meinke and published by . This book was released on 1993 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Torsten Hothorn
Publisher : CRC Press
ISBN 13 : 1482204584
Total Pages : 454 pages
Book Rating : 4.4/5 (822 download)
Download or read book A Handbook of Statistical Analyses using R, Third Edition written by Torsten Hothorn and published by CRC Press. This book was released on 2014-06-25 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Like the best-selling first two editions, A Handbook of Statistical Analyses using R, Third Edition provides an up-to-date guide to data analysis using the R system for statistical computing. The book explains how to conduct a range of statistical analyses, from simple inference to recursive partitioning to cluster analysis. New to the Third Edition Three new chapters on quantile regression, missing values, and Bayesian inference Extra material in the logistic regression chapter that describes a regression model for ordered categorical response variables Additional exercises More detailed explanations of R code New section in each chapter summarizing the results of the analyses Updated version of the HSAUR package (HSAUR3), which includes some slides that can be used in introductory statistics courses Whether you’re a data analyst, scientist, or student, this handbook shows you how to easily use R to effectively evaluate your data. With numerous real-world examples, it emphasizes the practical application and interpretation of results.
Author : Malte Kleinschmidt
Publisher :
ISBN 13 :
Total Pages : 130 pages
Book Rating : 4.:/5 (255 download)
Download or read book Regulation of Gene Expression and Adhesion in Saccharomyces Cerevisiae written by Malte Kleinschmidt and published by . This book was released on 2005 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : João Carlos Serafim Varela
Publisher :
ISBN 13 :
Total Pages : 134 pages
Book Rating : 4.:/5 (689 download)
Download or read book Regulation of Gene Expression and Signaling in Saccharomyces Cerevisiae Under Osmotic and Salt Stress written by João Carlos Serafim Varela and published by . This book was released on 1995 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chang Seo Park
Publisher :
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.:/5 (54 download)
Download or read book Coordinate Regulation of Glycolytic Gene Expression in Saccharomyces Cerevisiae written by Chang Seo Park and published by . This book was released on 1994 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
