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Author : Arezu Jahani-Asl
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (694 download)
Download or read book Regulation of Mitochondrial Fission and Fusion in Neuronal Injury written by Arezu Jahani-Asl and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bingwei Lu
Publisher : Springer Science & Business Media
ISBN 13 : 940071291X
Total Pages : 271 pages
Book Rating : 4.4/5 (7 download)
Download or read book Mitochondrial Dynamics and Neurodegeneration written by Bingwei Lu and published by Springer Science & Business Media. This book was released on 2011-05-16 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.
Author : Andrew Michael Slupe
Publisher :
ISBN 13 :
Total Pages : 206 pages
Book Rating : 4.:/5 (889 download)
Download or read book Regulation of Dynamin-related Protein 1-mediated Mitochondrial Fission by Reversible Phosphorylation and Its Contribution to Neuronal Survival Following Injury written by Andrew Michael Slupe and published by . This book was released on 2014 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: While these results suggest that the CaN:Drp1 signaling axis may be a potential target for neuroprotective therapeutic exploitation, the mechanism by which disruption of the CaN:Drp1 signaling axis specifically and mitochondrial elongation generally results in resistance to ischemic injury remains unknown. Additional studies reported here demonstrate that mitochondrial fragmentation remains a prominent feature of injured neurons regardless of the fidelity of the CaN:Drp1 signaling axis. Mitochondrial fragmentation at the time of injury was found to occur in a Drp1-independent manner. Chronic mitochondrial elongation was also found to leave unaltered the ability of neurons to detoxify reactive oxygen species, buffer intracellular calcium and supply ATP for homeostatic function.
Author : Bingwei Lu
Publisher : Springer
ISBN 13 : 9789400712928
Total Pages : 260 pages
Book Rating : 4.7/5 (129 download)
Download or read book Mitochondrial Dynamics and Neurodegeneration written by Bingwei Lu and published by Springer. This book was released on 2013-01-02 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.
Author : James D. Adams
Publisher : Royal Society of Chemistry
ISBN 13 : 1849731608
Total Pages : 319 pages
Book Rating : 4.8/5 (497 download)
Download or read book Extracellular and Intracellular Signaling written by James D. Adams and published by Royal Society of Chemistry. This book was released on 2011 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)
Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Author :
Publisher : Academic Press
ISBN 13 : 0080962823
Total Pages : 423 pages
Book Rating : 4.0/5 (89 download)
Download or read book Primary Cilia written by and published by Academic Press. This book was released on 2009-11-30 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. - Covers protocols for primary cilia across several systems and species - Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time - Relevant to clinicians and scientists working in a wide range of fields
Author : Sergej M. Ostojic
Publisher : Academic Press
ISBN 13 : 0128227729
Total Pages : 720 pages
Book Rating : 4.1/5 (282 download)
Download or read book Clinical Bioenergetics written by Sergej M. Ostojic and published by Academic Press. This book was released on 2020-11-12 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth. Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others. - Provides a thorough discussion of foundational aspects of bioenergetics and disease, modes of analysis, and treatments for impaired bioenergetics - Discusses the role of bioenergetics and treatment pathways in brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among other diseases and disorders - Features chapter contributions from international leaders in translational bioenergetics research and clinical practice
Author : Mark Jacob Barsoum
Publisher :
ISBN 13 :
Total Pages : 306 pages
Book Rating : 4.:/5 (318 download)
Download or read book Mitochondrial Dynamics in Neurodegeneration written by Mark Jacob Barsoum and published by . This book was released on 2004 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Noel Challamel
Publisher : John Wiley & Sons
ISBN 13 : 1786307189
Total Pages : 306 pages
Book Rating : 4.7/5 (863 download)
Download or read book Modern Trends in Structural and Solid Mechanics 3 written by Noel Challamel and published by John Wiley & Sons. This book was released on 2021-06-29 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book – comprised of three separate volumes – presents the recent developments and research discoveries in structural and solid mechanics; it is dedicated to Professor Isaac Elishakoff. This third volume is devoted to non-deterministic mechanics. Modern Trends in Structural and Solid Mechanics 3 has broad scope, covering topics such: design optimization under uncertainty, interval field approaches, convex analysis, quantum inspired topology optimization and stochastic dynamics. The book is illustrated by many applications in the field of aerospace engineering, mechanical engineering, civil engineering, biomedical engineering and automotive engineering. This book is intended for graduate students and researchers in the field of theoretical and applied mechanics.
Author : Mitsuo Tagaya
Publisher : Springer
ISBN 13 : 9811045674
Total Pages : 254 pages
Book Rating : 4.8/5 (11 download)
Download or read book Organelle Contact Sites written by Mitsuo Tagaya and published by Springer. This book was released on 2017-08-16 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.
Author : J.J. Lemasters
Publisher : Springer Science & Business Media
ISBN 13 : 1489925511
Total Pages : 647 pages
Book Rating : 4.4/5 (899 download)
Download or read book Integration of Mitochondrial Function written by J.J. Lemasters and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: In aerobic tissues such as heart, brain, kidney, liver and brown fat, mitochon dria account for more than 20% of cell protein and play an essential role in res piration, ATP formation, ketogenesis, gluconeogenesis, amino acid metabolism, ureagenesis, thermogenesis and a variety of other metabolic activities. The mecha nisms by which these activities are integrated and regulated within the overall context of cellular physiology is of much current research interest. In order to bring together scientists examining the various diverse aspects of this overall pro blem, an International Conference on INTEGRATION OF MITOCHONDRIAL FUNC TION was held June 4-7, 1987 at the Hanes Art Center on the campus of the Uni versity of North Carolina at Chapel Hill. The chapters of this volume derive from presentations made at this conference. The focus of INTEGRATION OF MITOCHONDRIAL FUNCTION is on signifi cant new experimental and theoretical advances concerning integration of mito chondrial function at the organelle, cell, tissue and whole organism levels of organization.
Author : Andras Nagy
Publisher : Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press
ISBN 13 :
Total Pages : 784 pages
Book Rating : 4.3/5 (91 download)
Download or read book Manipulating the Mouse Embryo written by Andras Nagy and published by Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press. This book was released on 2003 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides background information and detailed protocols for developing a mouse colony and using the animals in transgenic and gene-targeting experiments. The protocols list the animals, equipment, and reagents required and step-by-step procedures. Topics include in vitro culture of preimplantation embryos, surgical procedures, the production of chimeras, and the analysis of genome alterations. The third edition adds protocols for cloning mice, modifying embryonic stem cells, intracytoplasmic sperm injection, and cryopreservation of embryos.
Author : Heide Schatten
Publisher : Cambridge University Press
ISBN 13 : 0521195993
Total Pages : 275 pages
Book Rating : 4.5/5 (211 download)
Download or read book Scanning Electron Microscopy for the Life Sciences written by Heide Schatten and published by Cambridge University Press. This book was released on 2013 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to modern scanning electron microscopy instrumentation, methodology and techniques, highlighting novel applications to cell and molecular biology.
Author : Merri Lynn Casem
Publisher : Academic Press
ISBN 13 : 0128016841
Total Pages : 408 pages
Book Rating : 4.1/5 (28 download)
Download or read book Case Studies in Cell Biology written by Merri Lynn Casem and published by Academic Press. This book was released on 2016-03-15 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Case Studies in Cell Biology presents real world scenarios to help readers use science process and reasoning skills. The case studies require application and analyzation of concepts beyond rote memory of biological concepts. The book is based on the student learning outcomes from the American Society for Cell Biology, offering practical application for both the classroom and research laboratory. - Guides the reader in applying knowledge directly to real world scenarios - Includes case studies to bridge foundational cell biological concepts to translational science - Aids students in synthesizing information and applying science processes
Author :
Publisher : Academic Press
ISBN 13 : 0128201347
Total Pages : 254 pages
Book Rating : 4.1/5 (282 download)
Download or read book Cell Death Regulation in Health and Disease - Part A written by and published by Academic Press. This book was released on 2020-04-02 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Death Regulation in Health and Disease - Part A, Volume 351, the latest release in the International Review of Cell and Molecular Biology reviews current advances in cell and molecular biology. The series publishes timely topics authored by prominent cell and molecular biologists. This release is part of a 3-part series which comprises a comprehensive view of cell death regulation in a variety of biological contexts. Chapters cover Membrane dynamics in cell death regulation, The role of necroptosis in intestinal dysfunction, Regulation of cell death in the cardiovascular system, Cell death in bacterial and viral infection, and much more. - Provides a comprehensive collection of front-of-the line research in the field of cell death regulation - Authored by established and active cell and molecular biologists and drawn from international sources - Includes invited review articles that cover selected topics in multiple organisms and disease settings
Author : Stephen Bondy
Publisher : Springer Science & Business Media
ISBN 13 : 1607616025
Total Pages : 468 pages
Book Rating : 4.6/5 (76 download)
Download or read book Aging and Age-Related Disorders written by Stephen Bondy and published by Springer Science & Business Media. This book was released on 2010-09-02 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.
