Protein Crystallography In Drug Discovery Volume 20

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Protein Crystallography in Drug Discovery, Volume 20

Author : Robert E. Babine
Publisher : John Wiley & Sons
ISBN 13 : 9783527306787
Total Pages : 284 pages
Book Rating : 4.3/5 (67 download)

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Book Synopsis Protein Crystallography in Drug Discovery, Volume 20 by : Robert E. Babine

Download or read book Protein Crystallography in Drug Discovery, Volume 20 written by Robert E. Babine and published by John Wiley & Sons. This book was released on 2004-02-13 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.

Protein Crystallography in Drug Discovery

Author : Robert E. Babine
Publisher : John Wiley & Sons
ISBN 13 : 3527606351
Total Pages : 278 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Protein Crystallography in Drug Discovery by : Robert E. Babine

Download or read book Protein Crystallography in Drug Discovery written by Robert E. Babine and published by John Wiley & Sons. This book was released on 2008-07-15 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1437 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1437 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Fragment Based Drug Design

Author : Lawrence C. Kuo
Publisher : Academic Press
ISBN 13 : 0123812747
Total Pages : 662 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Fragment Based Drug Design by : Lawrence C. Kuo

Download or read book Fragment Based Drug Design written by Lawrence C. Kuo and published by Academic Press. This book was released on 2011-03-09 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. Also elaborated by experienced researchers in FBDD are sample preparations of fragments, proteins, and GPCR as well as examples of how to generate leads from hits. Offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD

Chemogenomics in Drug Discovery

Author : Hugo Kubinyi
Publisher : John Wiley & Sons
ISBN 13 : 3527604022
Total Pages : 487 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Chemogenomics in Drug Discovery by : Hugo Kubinyi

Download or read book Chemogenomics in Drug Discovery written by Hugo Kubinyi and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.

Chemoinformatics in Drug Discovery

Author : Tudor I. Oprea
Publisher : John Wiley & Sons
ISBN 13 : 3527604200
Total Pages : 515 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Chemoinformatics in Drug Discovery by : Tudor I. Oprea

Download or read book Chemoinformatics in Drug Discovery written by Tudor I. Oprea and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides the first-ever inside view of today's integrated approach to rational drug design. Chemoinformatics experts from large pharmaceutical companies, as well as from chemoinformatics service providers and from academia demonstrate what can be achieved today by harnessing the power of computational methods for the drug discovery process. With the user rather than the developer of chemoinformatics software in mind, this book describes the successful application of computational tools to real-life problems and presents solution strategies to commonly encountered problems. It shows how almost every step of the drug discovery pipeline can be optimized and accelerated by using chemoinformatics tools -- from the management of compound databases to targeted combinatorial synthesis, virtual screening and efficient hit-to-lead transition. An invaluable resource for drug developers and medicinal chemists in academia and industry.

G Protein-Coupled Receptors as Drug Targets

Author : Roland Seifert
Publisher : John Wiley & Sons
ISBN 13 : 3527606955
Total Pages : 304 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis G Protein-Coupled Receptors as Drug Targets by : Roland Seifert

Download or read book G Protein-Coupled Receptors as Drug Targets written by Roland Seifert and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book comprehensively discusses an important biological process that has not yet been covered in such depth in any other existing books on GPCRs. The international team of highly distinguished authors addresses in detail current models and concepts, to introduce medicinal chemists, physiologists, pharmacologists, and medical researchers into the advances in the understanding of GPCR activation and constitutive activity. In addition, the book provides an overview on methods of investigating constitutive GPCR activity. The text is well illustrated by selected experimental data and schemes._The chaptes are all cross-referenced with each other and cover general mechnisms, methodological approaches and cover selected important GPCR sysstems, the consequences for drug action, including, side effects, and rational drug design for GPCR targets. A highly recommended reference for researchers in academia and industry. authors addresses in detail current models and concepts, so as to introduce pharmaceutical chemists, physiologists and medical researchers to the advances in the understanding of GPCR activation and constitutive activity, and provides an overview of the methods of investigating GPCR activity. The text is backed by abundant case studies and methodological advice for analyzing GPCRs, covering selected pharmacologically relevant GPCR systems, the consequences for drug action, including unwanted side effects, and rational drug design for GPCR targets. A highly practical reference for researchers in academia and industry.

Molecular Interaction Fields

Author : Gabriele Cruciani
Publisher : John Wiley & Sons
ISBN 13 : 3527607137
Total Pages : 328 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Molecular Interaction Fields by : Gabriele Cruciani

Download or read book Molecular Interaction Fields written by Gabriele Cruciani and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique reference source, edited by the world's most respected expert on molecular interaction field software, covers all relevant principles of the GRID force field and its applications in medicinal chemistry. Entire chapters on 3D-QSAR, pharmacophore searches, docking studies, metabolism predictions and protein selectivity studies, among others, offer a concise overview of this emerging field. As an added bonus, this handbook includes a CD-ROM with the latest commercial versions of the GRID program and related software.

Voltage-Gated Ion Channels as Drug Targets

Author : David J. Triggle
Publisher : John Wiley & Sons
ISBN 13 : 3527607749
Total Pages : 492 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Voltage-Gated Ion Channels as Drug Targets by : David J. Triggle

Download or read book Voltage-Gated Ion Channels as Drug Targets written by David J. Triggle and published by John Wiley & Sons. This book was released on 2006-08-21 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.

Combinatorial Chemistry

Author : Willi Bannwarth
Publisher : John Wiley & Sons
ISBN 13 : 9783527306930
Total Pages : 706 pages
Book Rating : 4.3/5 (69 download)

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Book Synopsis Combinatorial Chemistry by : Willi Bannwarth

Download or read book Combinatorial Chemistry written by Willi Bannwarth and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. "Experimental details and complete reaction data [...] are a constant theme running through this work" (Angewandte Chemie) "Recommended to newcomers in the field of combinatorial chemical synthesis because of its broad scope" (Journal of the American Chemical Society)

Structure-based Drug Discovery

Author : Harren Jhoti
Publisher : Springer
ISBN 13 : 9789048171231
Total Pages : 0 pages
Book Rating : 4.1/5 (712 download)

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Book Synopsis Structure-based Drug Discovery by : Harren Jhoti

Download or read book Structure-based Drug Discovery written by Harren Jhoti and published by Springer. This book was released on 2010-10-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.

Computer Applications in Pharmaceutical Research and Development

Author : Sean Ekins
Publisher : John Wiley & Sons
ISBN 13 : 0470037229
Total Pages : 840 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Computer Applications in Pharmaceutical Research and Development by : Sean Ekins

Download or read book Computer Applications in Pharmaceutical Research and Development written by Sean Ekins and published by John Wiley & Sons. This book was released on 2006-07-11 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. Chapters are organized into the following sections: * Computers in pharmaceutical research and development: a general overview * Understanding diseases: mining complex systems for knowledge * Scientific information handling and enhancing productivity * Computers in drug discovery * Computers in preclinical development * Computers in development decision making, economics, and market analysis * Computers in clinical development * Future applications and future development Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth. Finally, tables of software resources are provided in many of the chapters. This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET, drug discovery, and technology development. The book's cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.

Microwaves in Organic and Medicinal Chemistry

Author : C. Oliver Kappe
Publisher : John Wiley & Sons
ISBN 13 : 3527606831
Total Pages : 422 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Microwaves in Organic and Medicinal Chemistry by : C. Oliver Kappe

Download or read book Microwaves in Organic and Medicinal Chemistry written by C. Oliver Kappe and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and the IUPAC. In this handy source of information for any practicing synthetic chemist they focus on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. They consider the underlying theory, latest developments in microwave applications and include a variety of examples from recent literature, as well as less common applications that are equally relevant for organic and medicinal chemists. An indispensable reference for researchers with an affinity to modern methods.

Molecular Biology in Medicinal Chemistry

Author : Theodor Dingermann
Publisher : John Wiley & Sons
ISBN 13 : 3527605185
Total Pages : 435 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Molecular Biology in Medicinal Chemistry by : Theodor Dingermann

Download or read book Molecular Biology in Medicinal Chemistry written by Theodor Dingermann and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods. With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.

Biophysical Techniques in Drug Discovery

Author : Angeles Canales
Publisher : Royal Society of Chemistry
ISBN 13 : 1788012860
Total Pages : 336 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Biophysical Techniques in Drug Discovery by : Angeles Canales

Download or read book Biophysical Techniques in Drug Discovery written by Angeles Canales and published by Royal Society of Chemistry. This book was released on 2017-11-14 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery. This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.

Protein Crystallization

Author : Terese M. Bergfors
Publisher : Internat'l University Line
ISBN 13 : 0972077448
Total Pages : 505 pages
Book Rating : 4.9/5 (72 download)

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Book Synopsis Protein Crystallization by : Terese M. Bergfors

Download or read book Protein Crystallization written by Terese M. Bergfors and published by Internat'l University Line. This book was released on 2009 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Macromolecular Crystallography

Author : Mark R. Sanderson
Publisher : OUP Oxford
ISBN 13 : 0191523429
Total Pages : 293 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Macromolecular Crystallography by : Mark R. Sanderson

Download or read book Macromolecular Crystallography written by Mark R. Sanderson and published by OUP Oxford. This book was released on 2007-08-23 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macromolecular Crystallography is the study of macromolecules (proteins and nucleic acids) using X-ray crystallographic techniques in order to determine their molecular structure. The knowledge of accurate molecular structures is a pre-requisite for rational drug design, and for structure-based function studies to aid the development of effective therapeutic agents and drugs. The successful determination of the complete genome (genetic sequence) of several species (including humans) has recently directed scientific attention towards identifying the structure and function of the complete complement of proteins that make up that species; a new and rapidly growing field of study called 'structural genomics'. There are now several important and well-funded global initiatives in operation to identify all of the proteins of key model species. One of the main requirements for these initiatives is a high-throughput crystallization facility to speed-up the protein identification process. The extent to which these technologies have advanced, calls for an updated review of current crystallographic theory and practice. This practical reference book features the latest conventional and high-throughput methods, and includes contributions from a team of internationally recognized leaders and experts. It will be of relevance and use to graduate students, research scientists and professionals currently working in the field of conventional and high-throughput macromolecular crystallography.