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Author : A. W. Hayes
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (636 download)
Download or read book Principles and Methods of Toxicology (student Edition) written by A. W. Hayes and published by . This book was released on 1986 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Frank A Barile
Publisher : CRC Press
ISBN 13 : 1842145282
Total Pages : 368 pages
Book Rating : 4.8/5 (421 download)
Download or read book Principles of Toxicology Testing, Second Edition written by Frank A Barile and published by CRC Press. This book was released on 2013-04-02 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.
Author : A. Wallace Hayes
Publisher : CRC Press
ISBN 13 : 9780849337789
Total Pages : 2304 pages
Book Rating : 4.3/5 (377 download)
Download or read book Principles and Methods of Toxicology, Fifth Edition written by A. Wallace Hayes and published by CRC Press. This book was released on 2007-09-25 with total page 2304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.
Author : A. Wallace Hayes
Publisher : CRC Press
ISBN 13 : 1842145363
Total Pages : 2186 pages
Book Rating : 4.8/5 (421 download)
Download or read book Hayes' Principles and Methods of Toxicology, Sixth Edition written by A. Wallace Hayes and published by CRC Press. This book was released on 2014-10-10 with total page 2186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.
Author : Barry Levine
Publisher : Amer. Assoc. for Clinical Chemistry
ISBN 13 : 9781890883874
Total Pages : 406 pages
Book Rating : 4.8/5 (838 download)
Download or read book Principles of Forensic Toxicology written by Barry Levine and published by Amer. Assoc. for Clinical Chemistry. This book was released on 2003 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nicholas T. Lappas
Publisher : Academic Press
ISBN 13 : 0128192879
Total Pages : 545 pages
Book Rating : 4.1/5 (281 download)
Download or read book Forensic Toxicology written by Nicholas T. Lappas and published by Academic Press. This book was released on 2021-10-22 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Forensic Toxicology: Principles and Concepts takes the reader back to the origins of forensic toxicology providing an overview of the largely unchanging principles of the discipline. The text focuses on the major tenets in forensic toxicology, including an introduction to the discipline, principles of forensic toxicology including pharmacokinetics, pharmacodynamics, drug interactions and toxicogenomics, fundamentals of forensic toxicology analysis, types of interpretations based on analytical forensic toxicology results, and reporting from the laboratory to the courtroom. Also included in the second edition is a Unit focused on the forensic toxicology of individual drugs of abuse. Includes significant emphasis on the fundamental principles and concepts of forensic toxicology Provides students with an introduction to the core tenets of the discipline, focusing on the concepts, strategies, and methodologies utilized by professionals in the field Coauthored by a forensic toxicologist with over 40 years of experience as a professor who has taught graduate courses in forensic and analytical toxicology and who has served as a consultant and expert witness in civil and criminal cases
Author : Robert Chilcott
Publisher : John Wiley & Sons
ISBN 13 : 0470773081
Total Pages : 392 pages
Book Rating : 4.4/5 (77 download)
Download or read book Principles and Practice of Skin Toxicology written by Robert Chilcott and published by John Wiley & Sons. This book was released on 2008-07-31 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.
Author : A Wallace Hayes
Publisher : CRC Press
ISBN 13 : 9781135465650
Total Pages : 1912 pages
Book Rating : 4.4/5 (656 download)
Download or read book Principles and Methods of Toxicology written by A Wallace Hayes and published by CRC Press. This book was released on 2001-01-11 with total page 1912 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its fourth edition, this core text and standard reference in toxicology has once again been updated to incorporate the latest testing procedures and address new challenges faced by toxicologists. The author brings together more than 70 distinguished investigators to detail current testing procedures, offer guidelines on data interpretation and highlight major areas of controversy. The book deals with the methods of toxicology, as well as principles and agents. New chapters on exposure assessment and epidemiology for toxicologists have been added. The reader will find an in-depth look at the principles underlying toxicology, such as absorption, distribution, metabolism and excretion, as well as topics dealing with pharmacokinetics. Principles and Methods of Toxicology, Fourth Edition allows the working toxicologist, whether a senior professional or graduate student, to understand and use basic experiments in toxicology.
Author : Tõnu Püssa
Publisher : CRC Press
ISBN 13 : 1466504110
Total Pages : 408 pages
Book Rating : 4.4/5 (665 download)
Download or read book Principles of Food Toxicology written by Tõnu Püssa and published by CRC Press. This book was released on 2013-08-20 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following in the tradition of the popular first edition, Principles of Food Toxicology, Second Edition integrates the general principles of toxicology with a systematic characterization of the most important food-borne toxicants. Ideal as a textbook in a food toxicology course, and also as a monograph dealing with principles of food toxicology as t
Author : James M. Parry
Publisher : Humana Press
ISBN 13 : 9781617794209
Total Pages : 433 pages
Book Rating : 4.7/5 (942 download)
Download or read book Genetic Toxicology written by James M. Parry and published by Humana Press. This book was released on 2011-12-07 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study. The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of the industries working with both natural and synthetic chemicals. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Intuitive and cutting-edge, Genetic Toxicology: Principles and Methods provides crucial support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design in this vital field.
Author : Robert F. Phalen
Publisher : CRC Press
ISBN 13 : 9780849333439
Total Pages : 174 pages
Book Rating : 4.3/5 (334 download)
Download or read book Methods in Inhalation Toxicology written by Robert F. Phalen and published by CRC Press. This book was released on 1996-11-06 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conducting studies of natural and man-made air contaminants is a specialized research activity that draws upon skills from a variety of disciplines including toxicology, pharmacology, industrial hygiene, and environmental health. Methods in Inhalation Toxicology describes how knowledge from these disciplines is integrated into the design and conduct of inhalation studies. Each of the vital aspects of conducting these studies is discussed in detail, including the use of animal subjects and the related quality control and ethical considerations, air purification methodology, exposure atmosphere generation and characterization, inhalation exposure systems, and real-time and post-exposure biological assessments. These methods will enable you to conduct inhalation studies, easily adding any specific measures of particular interest to your research. The book covers techniques needed to: provide suitable clean air for experiments correctly generate the particles and gases being studied select the proper exposure system monitor the exposure prepare tissues for study ensure that animals do not have confounding lung disease The helpful descriptions and detailed lists of suppliers of preferred equipment and materials will help you to perform valid, reproducible inhalation toxicology studies. Methods in Inhalation Toxicology is a perfect textbook for students in toxicology programs, as well as for scientists who conduct inhalation studies in both academic and industrial environments.
Author : John Timbrell
Publisher : CRC Press
ISBN 13 : 9780748407378
Total Pages : 408 pages
Book Rating : 4.4/5 (73 download)
Download or read book Principles of Biochemical Toxicology, Third Edition written by John Timbrell and published by CRC Press. This book was released on 1999-10-21 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research into the biochemical basis of toxicology has expanded rapidly over recent years, amidst concerns over the adverse effects of drugs, environmental pollution and occupational hazards. Following on from the acclaimed first two editions of Principles of Biochemical Toxicology, John Timbrell has expanded the text to include: summary sections questions and model answers thoroughly revised artwork These features, plus the new easy-to-read format will make biochemical toxicology more accessible to undergraduates and postgraduates coming across the subject for the first time, particularly when undertaking self-directed study. This comprehensive textbook provides a thorough explanation of dose-response relationships; disposition and metabolism; toxic responses to foreign compounds, and detailed examples to illustrate mechanisms of toxicity. There is also an expanded and updated bibliography, directing the reader to further reading if required. Students and lecturers will find the clear and concise approach, which established this book as the leading textbook in its field, an essential aid to learning and teaching.
Author : A. Wallace Hayes
Publisher : Academic Press
ISBN 13 : 9780128159217
Total Pages : 0 pages
Book Rating : 4.1/5 (592 download)
Download or read book Loomis's Essentials of Toxicology written by A. Wallace Hayes and published by Academic Press. This book was released on 2019-10-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Loomis's Essentials of Toxicology, Fifth Edition, provides the information on the harmful biologic effects associated with exposures to chemicals of all types. The scope of this book includes a discussion of the major types of chemicals involved, their general properties and detrimental biologic effects, the methods used to demonstrate these effects, the basis for clinical diagnosis, and therapy for the harmful effects of chemicals on humans. Individual examples are used to demonstrate the principle discussed. This reference volume will be an invaluable resource for both toxicologists and graduate and advanced undergraduate students in toxicology and public health.
Author : Stine Karen
Publisher : CRC Press
ISBN 13 : 084932856X
Total Pages : 392 pages
Book Rating : 4.8/5 (493 download)
Download or read book Principles of Toxicology, Second Edition written by Stine Karen and published by CRC Press. This book was released on 2006-01-24 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by two experienced toxicology lecturers, Principles of Toxicology provides a broad-based yet in-depth introduction to this diverse subject. Comprehensive and easy-to-read, the book covers this broad and interdisciplinary field from the viewpoint of three different functional levels: molecular and cellular; physiological; and ecological and environmental. This revised second edition expands the coverage of the book while keeping the organizational format that made the first edition a bestseller. It also includes a series of brief case studies illustrating the application of toxicological principles to current issues of interest. Each and every chapter has been revised, several have been significantly rewritten, and three are entirely new. This new edition retains the extensive cross-referencing system that links all sections and enhances the integration of material. It also includes an appendix of selected toxicants that describes chemical structure and category of use. These features combine to make finding specific information quick and easy. The highly readable format and uniform, consistent presentation of information will make this the most used reference on your shelf. See what's new in the second edition:
Author : A. Wallace Hayes
Publisher : CRC Press
ISBN 13 : 1000875776
Total Pages : 2143 pages
Book Rating : 4.0/5 (8 download)
Download or read book Hayes' Principles and Methods of Toxicology written by A. Wallace Hayes and published by CRC Press. This book was released on 2023-07-03 with total page 2143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.
Author : John Joseph Fenton
Publisher : CRC Press
ISBN 13 : 1420042068
Total Pages : 600 pages
Book Rating : 4.4/5 (2 download)
Download or read book Toxicology written by John Joseph Fenton and published by CRC Press. This book was released on 2001-10-10 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: REAL-LIFE CASES, TUTORIAL QUESTIONS, NARRATIVE HISTORY Intriguing anecdotal pedagogy, like the alleged arsenical poisonings of Napoleon and President Taylor and the probable mercury overdose of Isaac Newton, is one of the things that set Toxicology: A Case-Oriented Approach apart from other toxicology texts. Based on an undergraduate-graduate combined toxicology course at West Chester University, this innovative text captures readers' interest by combining modern case studies, historical cases, and hundreds of illustrations and tables. Each chapter presents several case scenarios that involve the reader with questions about diagnosis, testing methods, treatment, and other pertinent information. TOXICOLOGY FOR THE LABORATORY AND THE EMERGENCY ROOM In an easy-to-read style, this book covers the major organ systems and reviews the effects of toxins in each system. Most contemporary books are almost entirely clinical or entirely analytical. Toxicology: A Case-Oriented Approach treats each area extensively to benefit students and professionals who need to know aspects of both. It describes diagnosis and treatment of each specific poisonous exposure and discusses chemical basis and the laboratory testing of toxins. This dual perspective, coupled with the book's interesting narrative approach, lets readers quickly absorb the information they need to understand toxicology in the laboratory and in the Emergency Department.
Author : A. Wallace Hayes
Publisher :
ISBN 13 : 9780881674392
Total Pages : 445 pages
Book Rating : 4.6/5 (743 download)
Download or read book Principles and Methods of Toxicology written by A. Wallace Hayes and published by . This book was released on 1995 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt:
