Post Transcriptional Gene Regulation In Human Disease

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Post-transcriptional Gene Regulation in Human Disease

Author : Buddhi Prakash Jain
Publisher : Academic Press
ISBN 13 : 0323914241
Total Pages : 396 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Post-transcriptional Gene Regulation in Human Disease by : Buddhi Prakash Jain

Download or read book Post-transcriptional Gene Regulation in Human Disease written by Buddhi Prakash Jain and published by Academic Press. This book was released on 2022-08-12 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail. Includes full-color imagery illustrating key concepts and post-transcriptional disease processes, as well as descriptions of methods for studying post-transcriptional gene regulation Presents fundamental knowledge, molecular and biochemical mechanisms, and recent findings in concise and easily understandable formats Features a summary and conclusion at the end of each chapter

Post-Transcriptional Gene Regulation

Author : Jeffrey Wilusz
Publisher : Springer Science & Business Media
ISBN 13 : 1588297837
Total Pages : 330 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Post-Transcriptional Gene Regulation by : Jeffrey Wilusz

Download or read book Post-Transcriptional Gene Regulation written by Jeffrey Wilusz and published by Springer Science & Business Media. This book was released on 2008 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Step-by-step instructions that ensure successful results.

Transcriptional and Post-transcriptional Regulation

Author : Ghedira Kais
Publisher : BoD – Books on Demand
ISBN 13 : 1789237912
Total Pages : 136 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Transcriptional and Post-transcriptional Regulation by : Ghedira Kais

Download or read book Transcriptional and Post-transcriptional Regulation written by Ghedira Kais and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes are regulated at the cellular level. The editor embarked upon this writing project entitled "Transcriptional and Post-transcriptional Regulation" to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will enjoy reading and benefit from the chapters of this book.

Gene Regulation

Author : David S. Latchman
Publisher : Psychology Press
ISBN 13 : 9780415365109
Total Pages : 374 pages
Book Rating : 4.3/5 (651 download)

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Book Synopsis Gene Regulation by : David S. Latchman

Download or read book Gene Regulation written by David S. Latchman and published by Psychology Press. This book was released on 2005 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the student with a clear, up-to-date description of gene regulation in eukaryotes, distilling the vast and complex primary literature into a concise overview. For this fifth edition, in addition to extensive updating of existing material, sections on large-scale methodologies have been expanded, and a new section included on regulation by small interfering RNAs. More detail has been added on the role of multi-protein complexes in transcriptional activation and the discussion of the regulation of transcription factor activity by specific modifications to include acetylation and ubiquitination as well as phosphorylation. The final chapter on gene regulation and human disease now includes additional novel examples, such as RNA edition in motor neurone disease, role of the transcriptional co-activator CBP in Alzheimer's disease and PML-RAR involvement in acute promyelocytic leukemia.

Advances in Animal Genomics

Author : Sukanta Mondal
Publisher : Academic Press
ISBN 13 : 0128206128
Total Pages : 340 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Advances in Animal Genomics by : Sukanta Mondal

Download or read book Advances in Animal Genomics written by Sukanta Mondal and published by Academic Press. This book was released on 2020-11-25 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Animal Genomics provides an outstanding collection of integrated strategies involving traditional and modern - omics (structural, functional, comparative and epigenomics) approaches and genomics-assisted breeding methods which animal biotechnologists can utilize to dissect and decode the molecular and gene regulatory networks involved in the complex quantitative yield and stress tolerance traits in livestock. Written by international experts on animal genomics, this book explores the recent advances in high-throughput, next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches which have enabled to produce huge genomic and transcriptomic resources globally on a genome-wide scale. This book is an important resource for researchers, students, educators and professionals in agriculture, veterinary and biotechnology sciences that enables them to solve problems regarding sustainable development with the help of current innovative biotechnologies. Integrates basic and advanced concepts of animal biotechnology and presents future developments Describes current high-throughput next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches for sustainable livestock production Illustrates integrated strategies to dissect and decode the molecular and gene regulatory networks involved in complex quantitative yield and stress tolerance traits in livestock Ensures readers will gain a strong grasp of biotechnology for sustainable livestock production with its well-illustrated discussion

Transcriptional Gene Regulation in Health and Disease

Author :
Publisher : Academic Press
ISBN 13 : 0128123400
Total Pages : 256 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Transcriptional Gene Regulation in Health and Disease by :

Download or read book Transcriptional Gene Regulation in Health and Disease written by and published by Academic Press. This book was released on 2018-01-02 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcriptional Gene Regulation in Health and Disease, Volume 335, the latest release in the International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists drawn from international sources Offers a wide range of perspectives on specific subjects

RNA-Based Regulation in Human Health and Disease

Author :
Publisher : Academic Press
ISBN 13 : 0128171944
Total Pages : 444 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis RNA-Based Regulation in Human Health and Disease by :

Download or read book RNA-Based Regulation in Human Health and Disease written by and published by Academic Press. This book was released on 2020-08-19 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

Non-coding RNA Mediated Post-Transcriptional Regulation in Human Diseases

Author : Shaveta Kanoria
Publisher : Frontiers Media SA
ISBN 13 : 2889762483
Total Pages : 133 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Non-coding RNA Mediated Post-Transcriptional Regulation in Human Diseases by : Shaveta Kanoria

Download or read book Non-coding RNA Mediated Post-Transcriptional Regulation in Human Diseases written by Shaveta Kanoria and published by Frontiers Media SA. This book was released on 2022-05-27 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Post-transcriptional Gene Expression Regulation in Developmental Disorders

Author : Alexander Kitaygorodsky
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (126 download)

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Book Synopsis Post-transcriptional Gene Expression Regulation in Developmental Disorders by : Alexander Kitaygorodsky

Download or read book Post-transcriptional Gene Expression Regulation in Developmental Disorders written by Alexander Kitaygorodsky and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis dissertation, I describe three related projects. First, we used a combinatorial multi-testing framework to find excess burden of noncoding de novo mutations in congenital heart disease (impacting both transcriptional and post-transcriptional regulatory stages). This finding was central to the rest of my work, motivating the development of new computational approaches to predict genetic effect of noncoding variants through the lens of post-transcriptional regulation. Second, we used convolutional neural networks to model and understand sequence specific RBP binding processes. Finally, we designed a graphical neural network model capable of integrating cause and consequence to predict genetic effect of rare noncoding variants. In summary, we developed new machine learning methods to analyze multimodal human genome sequencing data, uncover deeper insights into post-transcriptional gene regulatory processes, and advance genomic medicine.

Transcription Factors and Human Disease

Author : Gregg L. Semenza
Publisher : Oxford Monographs on Medical G
ISBN 13 : 9780195112399
Total Pages : 396 pages
Book Rating : 4.1/5 (123 download)

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Book Synopsis Transcription Factors and Human Disease by : Gregg L. Semenza

Download or read book Transcription Factors and Human Disease written by Gregg L. Semenza and published by Oxford Monographs on Medical G. This book was released on 1998 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that participate in specific physiologic responses. Transcription Factors and Human Disease presents the basic science of transcriptional regulation and then describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites. The involvement of transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is briefly discussed. The effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis are also explored. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.

Gene Control

Author : David Latchman
Publisher : Garland Science
ISBN 13 : 113684421X
Total Pages : 449 pages
Book Rating : 4.1/5 (368 download)

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Book Synopsis Gene Control by : David Latchman

Download or read book Gene Control written by David Latchman and published by Garland Science. This book was released on 2010-01-21 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene Control offers a current description of how gene expression is controlled in eukaryotes, reviewing and summarizing the extensive primary literature into an easily accessible format. Gene Control is a comprehensively restructured and expanded edition of Latchmans Gene Regulation: A Eukaryotic Perspective, Fifth Edition. The first part of the book deals with the fundamental processes of gene control at the levels of chromatin structure, transcription, and post-transcriptional processes. Three pairs of chapters deal with each of these aspects, first describing the basic process itself, followed by the manner in which it is involved in controlling gene expression. The second part of the book deals with the role of gene control in specific biological processes. Certain chapters deal with the importance of gene control in cellular signaling processes and for normal development of the embryo. Another chapter discusses the key roles played by gene-regulatory processes in the specification of differentiated cell types such as muscle cells and neurons. The final chapters discuss the consequences of errors in gene control; the relationship between gene misregulation and human diseases, especially cancer; and potential therapies designed specifically to target particular levels of gene control. Gene Control will be of value to students in biological sciences, as well as to scientists and clinicians interested in how genes are regulated in health and disease.

Encyclopedia of Bioinformatics and Computational Biology

Author :
Publisher : Elsevier
ISBN 13 : 0128114320
Total Pages : 3421 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Bioinformatics and Computational Biology by :

Download or read book Encyclopedia of Bioinformatics and Computational Biology written by and published by Elsevier. This book was released on 2018-08-21 with total page 3421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases

Post-transcriptional Mechanisms in Endocrine Regulation

Author : K.M.J. Menon, PhD
Publisher : Springer
ISBN 13 : 3319251244
Total Pages : 347 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Post-transcriptional Mechanisms in Endocrine Regulation by : K.M.J. Menon, PhD

Download or read book Post-transcriptional Mechanisms in Endocrine Regulation written by K.M.J. Menon, PhD and published by Springer. This book was released on 2015-12-30 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.

Gene Regulation

Author : David Latchman
Publisher : Garland Science
ISBN 13 : 0203016335
Total Pages : 405 pages
Book Rating : 4.2/5 (3 download)

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Book Synopsis Gene Regulation by : David Latchman

Download or read book Gene Regulation written by David Latchman and published by Garland Science. This book was released on 2007-01-25 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene regulation is an essential process in the development and maintenance of a healthy body, and as such, is a central focus in both basic science and medical research. Gene Regulation, Fifth Edition provides the student and researcher with a clear, up-to-date description of gene regulation in eukaryotes, distilling the vast and complex primary literature into a concise overview.

Post-transcriptional Regulation through Long Non-coding RNAs (lncRNAs)

Author : Michael Ladomery
Publisher : MDPI
ISBN 13 : 3036512179
Total Pages : 156 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Post-transcriptional Regulation through Long Non-coding RNAs (lncRNAs) by : Michael Ladomery

Download or read book Post-transcriptional Regulation through Long Non-coding RNAs (lncRNAs) written by Michael Ladomery and published by MDPI. This book was released on 2021-08-18 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of eight articles, of which seven are reviews and one is a research paper, that together form a Special Issue that describes the roles that long noncoding RNAs (lncRNA) play in gene regulation at a post-transcriptional level.

Post-transcriptional Control of Gene Expression

Author : Laura Ghisolfi
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (14 download)

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Book Synopsis Post-transcriptional Control of Gene Expression by : Laura Ghisolfi

Download or read book Post-transcriptional Control of Gene Expression written by Laura Ghisolfi and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Epigenetic Mechanisms of Gene Regulation

Author : Vincenzo E. A. Russo
Publisher :
ISBN 13 :
Total Pages : 716 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Epigenetic Mechanisms of Gene Regulation by : Vincenzo E. A. Russo

Download or read book Epigenetic Mechanisms of Gene Regulation written by Vincenzo E. A. Russo and published by . This book was released on 1996 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.