Phosphodiesterase Inhibitors

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Phosphodiesterase Inhibitors

Author :
Publisher : Elsevier
ISBN 13 : 0080538819
Total Pages : 228 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Phosphodiesterase Inhibitors by :

Download or read book Phosphodiesterase Inhibitors written by and published by Elsevier. This book was released on 1996-08-16 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Utilizes actual testing and research of new PDE inhibitors Valuable for researchers and students alike

Hepatotoxicity

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781719520
Total Pages : 848 pages
Book Rating : 4.7/5 (195 download)

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Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Phosphodiesterases and Their Inhibitors

Author : Spiros Liras
Publisher : John Wiley & Sons
ISBN 13 : 3527682368
Total Pages : 240 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Phosphodiesterases and Their Inhibitors by : Spiros Liras

Download or read book Phosphodiesterases and Their Inhibitors written by Spiros Liras and published by John Wiley & Sons. This book was released on 2014-03-03 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.

Cyclic Nucleotide Phosphodiesterases in Health and Disease

Author : Joseph A. Beavo
Publisher : CRC Press
ISBN 13 : 1420020846
Total Pages : 728 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Cyclic Nucleotide Phosphodiesterases in Health and Disease by : Joseph A. Beavo

Download or read book Cyclic Nucleotide Phosphodiesterases in Health and Disease written by Joseph A. Beavo and published by CRC Press. This book was released on 2006-12-05 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph

Phosphodiesterases: CNS Functions and Diseases

Author : Han-Ting Zhang
Publisher : Springer
ISBN 13 : 3319588117
Total Pages : 471 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Phosphodiesterases: CNS Functions and Diseases by : Han-Ting Zhang

Download or read book Phosphodiesterases: CNS Functions and Diseases written by Han-Ting Zhang and published by Springer. This book was released on 2017-09-26 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.

Heart Failure: A Companion to Braunwald's Heart Disease E-Book

Author : G. Michael Felker
Publisher : Elsevier Health Sciences
ISBN 13 : 0323609880
Total Pages : 784 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Heart Failure: A Companion to Braunwald's Heart Disease E-Book by : G. Michael Felker

Download or read book Heart Failure: A Companion to Braunwald's Heart Disease E-Book written by G. Michael Felker and published by Elsevier Health Sciences. This book was released on 2019-02-06 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald’s Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. Covers the pathophysiological basis for the development and progression of heart failure. Serves as a definitive resource to prepare for the ABIM’s Heart Failure board exam. 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).

Caffeine for the Sustainment of Mental Task Performance

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309082587
Total Pages : 172 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Caffeine for the Sustainment of Mental Task Performance by : Institute of Medicine

Download or read book Caffeine for the Sustainment of Mental Task Performance written by Institute of Medicine and published by National Academies Press. This book was released on 2002-01-07 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.

Methylxanthines and Phosphodiesterase Inhibitors in the Treatment of Airways Disease

Author : J.F. Costello
Publisher : CRC Press
ISBN 13 : 9781850705970
Total Pages : 208 pages
Book Rating : 4.7/5 (59 download)

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Book Synopsis Methylxanthines and Phosphodiesterase Inhibitors in the Treatment of Airways Disease by : J.F. Costello

Download or read book Methylxanthines and Phosphodiesterase Inhibitors in the Treatment of Airways Disease written by J.F. Costello and published by CRC Press. This book was released on 1994-10-15 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a technically detailed state-of-the-art text on phosphodiesterase inhibition and the practical applications of theophylline and other phosphodiesterase inhibitors in asthma and chronic obstructive airways disease. It contains important new information on the mechanisms of drug action and on the inhibition of individual isoenzymes of the phosphodiesterase enzyme family as a potentially useful, safe, and non-toxic approach to asthma therapy.

Biologic and Systemic Agents in Dermatology

Author : Paul S. Yamauchi
Publisher : Springer
ISBN 13 : 3319668846
Total Pages : 574 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Biologic and Systemic Agents in Dermatology by : Paul S. Yamauchi

Download or read book Biologic and Systemic Agents in Dermatology written by Paul S. Yamauchi and published by Springer. This book was released on 2018-01-02 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading experts in the field and designed for dermatologists and residents, this book includes evidence-based medicine that underscores the clinical data, as well as practical tips on how to use both biologic and systemic agents in the field of dermatology. In the past decade, there have been several groundbreaking advances in medical dermatology. Novel biologic and systemic agents have been developed to treat inflammatory disorders, including psoriasis and atopic dermatitis, as well as skin malignancies such as melanoma. Biologic and Systemic Agents in Dermatology encompasses these developments by describing the mechanism of action of these various agents and the clinical efficacy and safety to treating these respective disorders. The utilization of biologic and systemic agents in other dermatologic conditions, pharmacoeconomics, pharmacovigilance, and clinical trials outcomes are discussed as well as topics including tumor necrosis, conventional systemic agents for psoriatic disease, and oral agents for atopic dermatitis.

Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia

Author : Giuseppe Morgia
Publisher : Academic Press
ISBN 13 : 0128113987
Total Pages : 328 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia by : Giuseppe Morgia

Download or read book Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia written by Giuseppe Morgia and published by Academic Press. This book was released on 2018-01-05 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia: From Research to Bedside offers full acknowledgment of the basic research of lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH), also connecting the clinical and practice management of the disease. It provides a full comprehension of LUTS and BPH from several aspects, allowing for a schematic interpretation of the disease and subsequent medical management. Going beyond the guidelines in the field, this title enhances the knowledge of BPH onset, allowing for the advancement of research, beneficial clinical implication and treatment. Perfect for researchers, urologists, pathologists and endocrinologists, this must-have reference provides what is needed to understand LUTS and BPH in one easy to reference place. Provides a clear understanding of the pathological mechanisms that are present in lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) Incorporates research with the clinical aspects of LUTS and BPH, including surgical techniques Presents an overview of LUTS and BPH in one easy to reference place

Phosphodiesterases as Drug Targets

Author : Sharron H. Francis
Publisher : Springer Science & Business Media
ISBN 13 : 364217969X
Total Pages : 522 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Phosphodiesterases as Drug Targets by : Sharron H. Francis

Download or read book Phosphodiesterases as Drug Targets written by Sharron H. Francis and published by Springer Science & Business Media. This book was released on 2011-06-21 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.

Introduction to Basics of Pharmacology and Toxicology

Author : Abialbon Paul
Publisher : Springer Nature
ISBN 13 : 9813360097
Total Pages : 1156 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Introduction to Basics of Pharmacology and Toxicology by : Abialbon Paul

Download or read book Introduction to Basics of Pharmacology and Toxicology written by Abialbon Paul and published by Springer Nature. This book was released on 2021-03-13 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

Heart Failure in the Child and Young Adult

Author : John L Jefferies
Publisher : Academic Press
ISBN 13 : 0128026138
Total Pages : 824 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Heart Failure in the Child and Young Adult by : John L Jefferies

Download or read book Heart Failure in the Child and Young Adult written by John L Jefferies and published by Academic Press. This book was released on 2017-12-05 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart Failure in the Child and Young Adult: From Bench to Bedside combines multiple etiologies for pediatric heart failure, including congenital heart disease, cardiomyopathies, infectious diseases and metabolic abnormalities. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure, then progresses through diagnosis, management, treatment and surgery, finally concluding with advanced special topics, including genetics, self-management and nanomedicine. Provides coverage of the basic science of heart failure, its epidemiology and economic aspects, outpatient and inpatient management, and advanced therapies, including mechanical circulatory support and heart transplantation Combines cutting-edge research with current guidelines from the field

Bipyridine Phosphodiesterase Inhibitors in Clinical Practice

Author : Martin Goenen
Publisher :
ISBN 13 : 9780904052060
Total Pages : 24 pages
Book Rating : 4.0/5 (52 download)

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Book Synopsis Bipyridine Phosphodiesterase Inhibitors in Clinical Practice by : Martin Goenen

Download or read book Bipyridine Phosphodiesterase Inhibitors in Clinical Practice written by Martin Goenen and published by . This book was released on 1990-01-01 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Sildenafil

Author : Udo Dunzendorfer
Publisher : Springer Science & Business Media
ISBN 13 : 9783764362553
Total Pages : 216 pages
Book Rating : 4.3/5 (625 download)

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Book Synopsis Sildenafil by : Udo Dunzendorfer

Download or read book Sildenafil written by Udo Dunzendorfer and published by Springer Science & Business Media. This book was released on 2004-10-25 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This drug is a landmark discovery, which consequently has become the definitive therapy for the treatment of erectile dysfunction (ED). Following the major breakthrough in the field of nitric oxide (NO)-physiology and pharmacology leading to sildenafil being marketed, the most current information is presented in this reference book, including ongoing research from several disparate groups about NO as endothelium-derived relaxing factor (EDRF) and also as a neurotransmitter for nerves innervating erectile tissue in mammals. The development of sildenafil as an oral phosphodiesterase-5 (PDE5) inhibitor drug for the treatment of ED resulted in one of the first products, which made its way successfully from basic NO research to routine clinical therapy. This volume addresses all fields of sildenafil application in both men and women. In a highly competitive research environment with a critical medical need for drug improvements the reader will learn more about clinical resistance to sildenafil treatment and the modalities to overcome the failure rates. The individual chapters cover clinical use, pharmacokinetics, pharmacodynamics, biochemistry, and cultural aspects. They are written by leading experts in their respective fields. Therefore, readers a?? whether professionals in the pharmaceutical industry, physicians treating ED, biochemists, chemists or pharmacologists a?? will find a detailed and up-to-date knowledge base about current research activities and an excellent overview for further research on this compound class and its cultural impact.

Davis's Drug Guide for Rehabilitation Professionals

Author : Charles D. Ciccone
Publisher : F.A. Davis
ISBN 13 : 0803640048
Total Pages : 1217 pages
Book Rating : 4.8/5 (36 download)

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Book Synopsis Davis's Drug Guide for Rehabilitation Professionals by : Charles D. Ciccone

Download or read book Davis's Drug Guide for Rehabilitation Professionals written by Charles D. Ciccone and published by F.A. Davis. This book was released on 2013-03-21 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-of-a-kind guide specifically for rehabilitation specialists! A leader in pharmacology and rehabilitation, Charles Ciccone, PT, PhD offers a concise, easy-to-access resource that delivers the drug information rehabilitation specialists need to know. Organized alphabetically by generic name, over 800 drug monographs offer the most up-to-date information on drug indications, therapeutic effects, potential adverse reactions, and much more! A list of implications for physical therapy at the end of each monograph helps you provide the best possible care for your patients. It’s the perfect companion to Pharmacology in Rehabilitation, 4th Edition!

Advances in Clinical Audiology

Author : Stavros Hatzopoulos
Publisher : BoD – Books on Demand
ISBN 13 : 9535130439
Total Pages : 261 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Advances in Clinical Audiology by : Stavros Hatzopoulos

Download or read book Advances in Clinical Audiology written by Stavros Hatzopoulos and published by BoD – Books on Demand. This book was released on 2017-03-29 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Clinical Audiology is an excursus on the latest findings in clinical audiology with a strong emphasis in new emerging technologies which facilitate and optimize a better assessment of the human patient. The book has been edited with a strong educational perspective (all chapters include an extensive introduction to their corresponding topic and an extensive glossary of terms). The book contains material suitable for graduate students in audiology, ENT, hearing science, and neuroscience.