Phosphodiesterases Cns Functions And Diseases

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Phosphodiesterases: CNS Functions and Diseases

Author : Han-Ting Zhang
Publisher : Springer
ISBN 13 : 3319588117
Total Pages : 471 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Phosphodiesterases: CNS Functions and Diseases by : Han-Ting Zhang

Download or read book Phosphodiesterases: CNS Functions and Diseases written by Han-Ting Zhang and published by Springer. This book was released on 2017-09-26 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.

Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System

Author : Nicholas J. Brandon
Publisher : John Wiley & Sons
ISBN 13 : 1118836308
Total Pages : 400 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System by : Nicholas J. Brandon

Download or read book Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System written by Nicholas J. Brandon and published by John Wiley & Sons. This book was released on 2014-03-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews advances in understanding phosphodiesteraseswithin the central nervous system and their therapeuticapplications. A range of expert authors from both academia andindustry describe these, then focus on the areas of greatestscientific and medical interest to provide more detailed coverage.Therapeutic and drug discovery applications are covered fordiseases including Alzheimer's, Parkinson's, schizophrenia,erectile dysfunction, and spinal cord injuries. There is also achapter on drug discovery tools such as in vitro assays and X-raystructures for medicinal chemistry studies.

Phosphodiesterases

Author :
Publisher :
ISBN 13 : 9783319588100
Total Pages : pages
Book Rating : 4.5/5 (881 download)

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Book Synopsis Phosphodiesterases by :

Download or read book Phosphodiesterases written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.

cGMP: Generators, Effectors and Therapeutic Implications

Author : Harald H. H. W. Schmidt
Publisher : Springer Science & Business Media
ISBN 13 : 3540689648
Total Pages : 581 pages
Book Rating : 4.5/5 (46 download)

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Book Synopsis cGMP: Generators, Effectors and Therapeutic Implications by : Harald H. H. W. Schmidt

Download or read book cGMP: Generators, Effectors and Therapeutic Implications written by Harald H. H. W. Schmidt and published by Springer Science & Business Media. This book was released on 2008-12-17 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.

Cyclic Nucleotide Phosphodiesterases in Health and Disease

Author : Joseph A. Beavo
Publisher : CRC Press
ISBN 13 : 1420020846
Total Pages : 728 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Cyclic Nucleotide Phosphodiesterases in Health and Disease by : Joseph A. Beavo

Download or read book Cyclic Nucleotide Phosphodiesterases in Health and Disease written by Joseph A. Beavo and published by CRC Press. This book was released on 2006-12-05 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph

Cyclic Nucleotide Signaling

Author : Xiaodong C. Cheng
Publisher : CRC Press
ISBN 13 :
Total Pages : 264 pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Cyclic Nucleotide Signaling by : Xiaodong C. Cheng

Download or read book Cyclic Nucleotide Signaling written by Xiaodong C. Cheng and published by CRC Press. This book was released on 2015 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mechanisms of Neuroinflammation

Author : Gonzalo Emiliano Aranda Abreu
Publisher : BoD – Books on Demand
ISBN 13 : 9535134515
Total Pages : 320 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Mechanisms of Neuroinflammation by : Gonzalo Emiliano Aranda Abreu

Download or read book Mechanisms of Neuroinflammation written by Gonzalo Emiliano Aranda Abreu and published by BoD – Books on Demand. This book was released on 2017-08-23 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Frontal-subcortical Circuits in Psychiatric and Neurological Disorders

Author : David G. Lichter
Publisher : Guilford Press
ISBN 13 : 9781572306233
Total Pages : 474 pages
Book Rating : 4.3/5 (62 download)

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Book Synopsis Frontal-subcortical Circuits in Psychiatric and Neurological Disorders by : David G. Lichter

Download or read book Frontal-subcortical Circuits in Psychiatric and Neurological Disorders written by David G. Lichter and published by Guilford Press. This book was released on 2001-01-01 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors review knowledge on the anatomy of the frontal-subcortical circuits, their connections to other brain regions, and their influences on motor, cognitive, affective, and behavioral functioning. Specific clinical problems are addressed, including Parkinson's disease, obsessive/compulsive disorder, ADHD, and more. of full-color illustrations.

Basic Neurochemistry

Author : Scott Brady
Publisher : Academic Press
ISBN 13 : 0080959016
Total Pages : 1120 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Basic Neurochemistry by : Scott Brady

Download or read book Basic Neurochemistry written by Scott Brady and published by Academic Press. This book was released on 2011-11-02 with total page 1120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475

Case Studies in Movement Disorders

Author : Roberto Erro
Publisher : Cambridge University Press
ISBN 13 : 1107472423
Total Pages : 183 pages
Book Rating : 4.1/5 (74 download)

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Book Synopsis Case Studies in Movement Disorders by : Roberto Erro

Download or read book Case Studies in Movement Disorders written by Roberto Erro and published by Cambridge University Press. This book was released on 2017-04-27 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thorough collection of movement disorders cases, each discussed by international experts and accompanied by illustrative video content.

Neurobiology of Depression

Author : Francisco Lopez-Munoz
Publisher : CRC Press
ISBN 13 : 143983850X
Total Pages : 526 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Neurobiology of Depression by : Francisco Lopez-Munoz

Download or read book Neurobiology of Depression written by Francisco Lopez-Munoz and published by CRC Press. This book was released on 2011-09-09 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.

Caffeine for the Sustainment of Mental Task Performance

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309082587
Total Pages : 172 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Caffeine for the Sustainment of Mental Task Performance by : Institute of Medicine

Download or read book Caffeine for the Sustainment of Mental Task Performance written by Institute of Medicine and published by National Academies Press. This book was released on 2002-01-07 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.

Parkinson's Disease and Other Movement Disorders

Author : Mark Edwards
Publisher : Oxford University Press, USA
ISBN 13 : 019856984X
Total Pages : 336 pages
Book Rating : 4.1/5 (985 download)

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Book Synopsis Parkinson's Disease and Other Movement Disorders by : Mark Edwards

Download or read book Parkinson's Disease and Other Movement Disorders written by Mark Edwards and published by Oxford University Press, USA. This book was released on 2008 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reference on the management of Parkinson's disease and other movement disorders, this book offers practical advice on the classification and diagnosis of patients, and available treatment options.

Pelvic Organ Dysfunction in Neurological Disease

Author : Clare J. Fowler
Publisher : Cambridge University Press
ISBN 13 : 9780521198318
Total Pages : 358 pages
Book Rating : 4.1/5 (983 download)

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Book Synopsis Pelvic Organ Dysfunction in Neurological Disease by : Clare J. Fowler

Download or read book Pelvic Organ Dysfunction in Neurological Disease written by Clare J. Fowler and published by Cambridge University Press. This book was released on 2010-11-04 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pelvic Organ Dysfunction in Neurological Disease describes the neurological control of human bladder, bowel and sexual function and then details the dysfunctions which may arise as a consequence of various neurological diseases. Easy to read, the book will be of value to any healthcare professional managing patients in whom pelvic organ functions have been compromised by neurological disease. The book provides a structured approach to present day understanding of the neurological control of pelvic organs and the investigation and management of each type of organ dysfunction. A unique feature of this book is that it addresses the impact of specific neurological disorders on all three functions. The authors have all been associated with the Department of Uro-Neurology at the National Hospital for Neurology and Neurosurgery, London since it was established 20 years ago. This book is a timely review of their accumulated knowledge and the latest literature.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders: Volume 7

Author : Zareen Amtul
Publisher : Bentham Science Publishers
ISBN 13 : 9811447500
Total Pages : 166 pages
Book Rating : 4.8/5 (114 download)

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Book Synopsis Frontiers in Clinical Drug Research - CNS and Neurological Disorders: Volume 7 by : Zareen Amtul

Download or read book Frontiers in Clinical Drug Research - CNS and Neurological Disorders: Volume 7 written by Zareen Amtul and published by Bentham Science Publishers. This book was released on 2020-08-07 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The seventh volume of this series features reviews that cover the following topics related to the treatment of neurodegenerative diseases, epilepsy and stroke: -Fatty Acid Amides as a New Potential Therapeutic Agent in Multiple Sclerosis -Epileptic Seizures Detection Based on Non-Linear Characteristics Coupled with Machine Learning Techniques -Hampering Essential Tremor Neurodegeneration in Essential Tremor: Present and Future Directions -The Potential Therapeutic Role of the Melatoninergic System in Treatment of Epilepsy and Comorbid Depression -Modeling Neurodegenerative Diseases Using Transgenic Model of Drosophila -Genetic Basis in Stroke Treatment: Targets of Potent Inhibitors

The Neurology of Olfaction

Author : Christopher H. Hawkes
Publisher : Cambridge University Press
ISBN 13 : 0521682169
Total Pages : 265 pages
Book Rating : 4.5/5 (216 download)

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Book Synopsis The Neurology of Olfaction by : Christopher H. Hawkes

Download or read book The Neurology of Olfaction written by Christopher H. Hawkes and published by Cambridge University Press. This book was released on 2009-02-12 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Written by two experts in the field, this book provides information useful to physicians for assessing and managing chemosensory disorders - with appropriate case-histories - and summarizes the current scientific knowledge of human olfaction. It will be of particular interest to neurologists, otolaryngologists, psychologists, psychiatrists, and neuroscientists."--BOOK JACKET.

Marsden's Book of Movement Disorders

Author : Ivan Donaldson
Publisher : Oxford University Press
ISBN 13 : 0191502243
Total Pages : 1512 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Marsden's Book of Movement Disorders by : Ivan Donaldson

Download or read book Marsden's Book of Movement Disorders written by Ivan Donaldson and published by Oxford University Press. This book was released on 2012-03-29 with total page 1512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the final work of the late Professor C. David Marsden, who was the most influential figure in the field of movement disorders, in terms of his contributions to both research and clinical practice, in the modern era. It was conceived and written by David Marsden and his colleague at the Institute of Neurology, Prof. Ivan Donaldson. It was their intention that this would be the most comprehensive book on movement disorders and also that it would serve as the 'clinical Bible' for the management of these conditions. It provides a masterly survey of the entire topic, which has been made possible only by vast laboratory and bedside experience. Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to rare, and very rare conditions such as Niemann-Pick disease. Chapters follow a structured format with historical overviews, definitions, clinical features, differential diagnosis, investigations and treatment covered in a structured way. It is extensively illustrated with many original photographs and diagrams of historical significance. Among these illustrations are still images of some original film clips of some of Dr. Marsden's patients published here for the first time. Comprehensively referenced and updated by experts from the Institute of Neurology at Queen Square, this book is a valuable reference for, not just movement disorder specialists and researchers, but also for clinicians who care for patients with movement disorders.