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Parkinsons Disease Cell Vulnerability And Disease Progression
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Book Synopsis Parkinson's Disease: Cell Vulnerability and Disease Progression by : Javier Blesa
Download or read book Parkinson's Disease: Cell Vulnerability and Disease Progression written by Javier Blesa and published by Frontiers Media SA. This book was released on 2016-01-04 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Download PDF Download EPUB Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinson's Disease. This e-Book discusses the etiopathogenesis of Parkinson's Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinson's Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinson's Disease.
Book Synopsis Parkinson's Disease Cell Vulnerability and Disease Progression by :
Download or read book Parkinson's Disease Cell Vulnerability and Disease Progression written by and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinson's Disease. This e-Book discusses the etiopathogenesis of Parkinson's Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinson's Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinson's Disease.
Book Synopsis Etiology of Parkinson's Disease by : Jonas H. Ellenberg
Download or read book Etiology of Parkinson's Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Book Synopsis Recent Advances in Parkinson's Disease by :
Download or read book Recent Advances in Parkinson's Disease written by and published by Elsevier. This book was released on 2020-04-16 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more. Covers all key aspects of current research on Parkinson ́s disease Includes topics that range from basic studies on disease models and pathogenic pathways (e.g., protein misfolding, immune and glial mechanisms) to clinical studies on disease features, microbiome, pathophysiology and therapeutic approaches Presents articles authored by world leaders in their respective fields
Book Synopsis Selective Cellular Vulnerability and Pathology Progression Patterns in Two Mouse Models of Parkinson's Disease by : Fanni Fruzsina Geibl
Download or read book Selective Cellular Vulnerability and Pathology Progression Patterns in Two Mouse Models of Parkinson's Disease written by Fanni Fruzsina Geibl and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash
Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Download or read book Parkinson's Disease written by and published by . This book was released on 2004 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Leucine-Rich Repeat Kinase 2 (LRRK2) by : Hardy J. Rideout
Download or read book Leucine-Rich Repeat Kinase 2 (LRRK2) written by Hardy J. Rideout and published by Springer. This book was released on 2017-03-28 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
Book Synopsis Selective Cellular Vulnerability and Pathology Progression Patterns in Two Mouse Models of Parkinson's Disease by : Fanni Fruzsina Geibl
Download or read book Selective Cellular Vulnerability and Pathology Progression Patterns in Two Mouse Models of Parkinson's Disease written by Fanni Fruzsina Geibl and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Parkinson's Disease and Related Disorders by : Peter Riederer
Download or read book Parkinson's Disease and Related Disorders written by Peter Riederer and published by Springer Science & Business Media. This book was released on 2006-11-23 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a comprehensive overview on current clinical and basic research issues related to Parkinson’s disease and its related disorders. The book is the result of the 16th International Congress of Parkinson’s Disease and Related disorders congress 2005. Its contents are suitable for neurologists, psychiatrists, neurosurgeons, basic researchers, geneticians and patients as well as their relatives.
Book Synopsis Disease-Modifying Targets in Neurodegenerative Disorders by : Veerle Baekelandt
Download or read book Disease-Modifying Targets in Neurodegenerative Disorders written by Veerle Baekelandt and published by Academic Press. This book was released on 2017-03-31 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress Summarizes how patients are treated today, providing a glance at future disease management Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists Written and peer reviewed by outstanding scientists in their respective fields
Book Synopsis An Essay on the Shaking Palsy by : James Parkinson
Download or read book An Essay on the Shaking Palsy written by James Parkinson and published by . This book was released on 1817 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Systems Biology of Parkinson's Disease by : Peter Wellstead
Download or read book Systems Biology of Parkinson's Disease written by Peter Wellstead and published by Springer Science & Business Media. This book was released on 2012-05-08 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Systems Biology of Parkinson’s Disease will be underpinned by new measurement techniques. This is particularly true of the pathology of Parkinson's Disease, where recent developments in brain imaging have offered new insights into the morphology of dopaminergic neurons that have profound implications for the special vulnerability and role of this class of neurons.
Book Synopsis Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson’s Disease by :
Download or read book Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson’s Disease written by and published by Academic Press. This book was released on 2021-11-10 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson’s Disease explores the results of numerous studies surrounding in vitro and animal model evidence that looks at the impact of a-synucleinopathy on neuronal dysfunction and behavioral impairments, (ii) how research in animal models supports the development of therapeutic strategies, and (iii) how findings in animal models might relate to the disease process in humans. In this book, the author's shed light upon the complex scenario of the mechanisms of cell death and approaches to neuroprotection/disease modification in PD, both in vitro to in vivo. Along with degeneration, the pathological hallmark of PD is the presence of intraneuronal proteinaceous cytoplasmic inclusions, named Lewy Bodies (LB) that invade the whole nervous system as the disease progresses. Several fundamental discoveries have shed light upon the implication of the a-syn protein in the pathogenesis of familial and sporadic forms of PD. Other proteins also accumulate in LB, but a-syn is a major protein component of the pathological landmarks. Updates on the latest research surrounding Mechanisms of Cell Death in Parkinson’s Disease Includes In vitro and In vivo models of synucleinopathy Presents therapeutic strategies in Parkinson’s Disease
Book Synopsis Navigating Life with Parkinson's Disease by : Sotirios A. Parashos
Download or read book Navigating Life with Parkinson's Disease written by Sotirios A. Parashos and published by Brain and Life Books. This book was released on 2020 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: "It is hard to believe it has been only 7 years since the publication of our first edition. In this short time, so much has changed in what we know about Parkinson's disease and how to treat it. As I read through the first edition, I found much information was already out of date within 4 years from publication. New knowledge about the role of protein misfolding and how it leads to nerve cell damage in Parkinson's, about when and where the disease may be starting, about how it may progress and spread through the brain, about how it affects almost all aspects of body functions, about how all this new knowledge is shaping the quest for a cure, about how important exercise is, and about how the multidisciplinary approach to disease management changes the quality of life of people with Parkinson's has been accumulating at a dizzying pace. More than 200 years after the publication of Parkinson's An Essay on the Shaking Palsy and just over 50 years after the implementation of levodopa in Parkinson's treatment, it looks as though scientists are poised to make a breakthrough toward effective treatments of the disease itself, not just the symptoms, and paths that may eventually lead to a cure are now visible. Such progress would be impossible without the hard work of many researchers; the financial support of the corresponding government agencies; the advocacy of national and international Parkinson's organizations and the philanthropy of their donors; and the tireless efforts and open minds of the doctors, nurses, therapists, and social workers caring for people with Parkinson's and their families. Above all, none of this progress would be possible without the active participation of people with Parkinson's and their families through advocacy, community engagement, and participation in clinical trials. To them we would like to extend a great "thank you"."--
Book Synopsis Recent Advances in Parkinsons Disease by :
Download or read book Recent Advances in Parkinsons Disease written by and published by Elsevier. This book was released on 2010-08-20 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist
Book Synopsis Parkinson’s Disease and Movement Disorders by : Charles H. Adler
Download or read book Parkinson’s Disease and Movement Disorders written by Charles H. Adler and published by Springer Science & Business Media. This book was released on 2000-04-07 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of movement disorders is relatively broad, encompassing disorders of increased movement, such as tremors, dystonia, and tics, to disorders characterized by a paucity of movement, such as Parkinson's disease. Our understanding of the pathogenic mechanisms and our treatment options are expanding at a rapid pace. This expansion ranges from the medical and surgical advances in treating Parkinson's disease to the flood of genetic abnormalities that have now been found to cause various movement disorders. Although many patients are seen by the movement disorders specialist in neurology clinics around the country, most of these patients receive their followup care from a primary care physician or "general" neurologist who must be versed in the character istics and treatment plans of this diverse group of disorders. The major goal of Parkinson's Disease and Movement Disorders: Diagnosis and Treatment Guidelines for the Practicing Physician is to distill this immense amount of information and to educate the practitioner about the many facets of the movement disorders field. We believe that this book fills a large void, since most texts on movement disorders are more detailed and geared toward the specialist. We have asked the chapter authors to emphasize the clinical characteristics of each disorder, discuss the differential diagnosis and the diagnostic testing, and then outline the various treatment options, as if they were teaching during a preceptorship in their clinic.
