Organic Synthesis Using Biocatalysis

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Organic Synthesis Using Biocatalysis

Author : Animesh Goswami
Publisher : Academic Press
ISBN 13 : 012411542X
Total Pages : 438 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Organic Synthesis Using Biocatalysis by : Animesh Goswami

Download or read book Organic Synthesis Using Biocatalysis written by Animesh Goswami and published by Academic Press. This book was released on 2015-09-06 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. Provides a concise background of the application of biocatalysis for the synthesis of organic compounds Expert contributors present recipes for carrying out biocatalytic reactions, including subject worthy discussions on biocatalysis in organic synthesis, biocatalysis for selective organic transformation, enzymes as catalysis for organic synthesis, biocatalysis in Industry, including pharmaceuticals, and more Contains detailed, separate chapters that describe the application of biocatalysis

Biocatalysis in Organic Synthesis

Author : Nicholas J. Turner
Publisher : Royal Society of Chemistry
ISBN 13 : 1782625305
Total Pages : 416 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Biocatalysis in Organic Synthesis by : Nicholas J. Turner

Download or read book Biocatalysis in Organic Synthesis written by Nicholas J. Turner and published by Royal Society of Chemistry. This book was released on 2018-02-08 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of biocatalysis in organic synthesis is rapidly gaining popularity amongst chemists. Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials. Together these advantages can contribute to more sustainable manufacturing processes across a wide range of industries ranging from pharmaceuticals to biofuels. The biocatalytic toolbox has expanded significantly in the past five years and given the current rate of development of new engineered biocatalysts it is likely that the number of available biocatalysts will double in the next few years. This textbook gives a comprehensive overview of the current biocatalytic toolbox and also establishes new guidelines or rules for “biocatalytic retrosynthesis”. Retrosynthesis is a well known and commonly used technique whereby organic chemists start with the structure of their target molecule and generate potential starting materials and intermediates through a series of retrosynthetic disconnections. These disconnections are then used to devise a forward synthesis, in this case using biocatalytic transformations in some of the key steps. Target molecules are disconnected with consideration for applying biocatalysts, as well as chemical reagents and chemocatalysts, in the forward synthesis direction. Using this textbook, students will be able to place biocatalysis within the context of other synthetic transformations that they have learned earlier in their studies. This additional awareness of biocatalysis will equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. In addition to guidelines for identifying where biocatalysts can be applied in organic synthesis, this textbook also provides examples of current applications of biocatalysis using worked examples and case studies. Tutorials enable the reader to practice disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. The book contains a complete description of the current biocatalyst classes that are available for use and also suggests areas where new enzymes are likely to be developed in the next few years. This textbook is an essential resource for lecturers and students studying synthetic organic chemistry. It also serves as a handy reference for practicing chemists who wish to embed biocatalysis into their synthetic toolbox.

Modern Biocatalysis

Author : Gavin Williams
Publisher : Royal Society of Chemistry
ISBN 13 : 1788014537
Total Pages : 594 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Modern Biocatalysis by : Gavin Williams

Download or read book Modern Biocatalysis written by Gavin Williams and published by Royal Society of Chemistry. This book was released on 2018-05-31 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current ‘hot’ topics in biocatalysis, where recent advances in research are defining new grounds in enzyme-catalyzed processes. With contributions from leading academics around the world, this book makes a ground-breaking contribution to this progressive field and is essential reading for graduates and researchers investigating (bio)catalysis, enzyme engineering, chemical biology, and synthetic biology.

Enzyme-Based Organic Synthesis

Author : Cheanyeh Cheng
Publisher : John Wiley & Sons
ISBN 13 : 1118995155
Total Pages : 719 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Enzyme-Based Organic Synthesis by : Cheanyeh Cheng

Download or read book Enzyme-Based Organic Synthesis written by Cheanyeh Cheng and published by John Wiley & Sons. This book was released on 2022-02-03 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzyme-Based Organic Synthesis An insightful exploration of an increasingly popular technique in organic chemistry In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice. The distinguished author provides a single point of access for enzymatic methods applicable to organic synthesis and focuses on enzyme catalyzed organic synthesis with six different classes of enzyme. This book serves as a link between enzymology and biocatalysis and serves as an invaluable reference for the growing number of organic chemists using biocatalysis. Enzyme-Based Organic Synthesis provides readers with multiple examples of practical applications of the main enzyme classes relevant to the pharmaceutical, medical, food, cosmetics, fragrance, and health care industries. Readers will also find: A thorough introduction to foundational topics, including the discovery and nature of enzymes, enzyme structure, catalytic function, molecular recognition, enzyme specificity, and enzyme classes Practical discussions of organic synthesis with oxidoreductases, including oxidation reactions and reduction reactions Comprehensive explorations of organic synthesis with transferases, including transamination with aminotransferases and phosphorylation with kinases In-depth examinations of organic synthesis with hydrolases, including the hydrolysis of the ester bond Perfect for organic synthetic chemists, chemical and biochemical engineers, biotechnologists, process chemists, and enzymologists, Enzyme-Based Organic Synthesis is also an indispensable resource for practitioners in the pharmaceutical, food, cosmetics, and fragrance industries that regularly apply this type of synthesis.

Future Directions in Biocatalysis

Author : Tomoko Matsuda
Publisher : Elsevier
ISBN 13 : 0444637508
Total Pages : 460 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Future Directions in Biocatalysis by : Tomoko Matsuda

Download or read book Future Directions in Biocatalysis written by Tomoko Matsuda and published by Elsevier. This book was released on 2017-08-11 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Future Directions in Biocatalysis, Second Edition, presents the future direction and latest research on how to utilize enzymes, i.e., natural catalysts, to make medicines and other necessities for humans. It emphasizes the most important and unique research on biocatalysis instead of simply detailing the ABC’s on the topic. This book is an indispensable tool for new researchers in the field to help identify specific needs, start new projects that address current environmental concerns, and develop techniques based on green technology. It provides invaluable hints and clues for conducting new research on enzymes, with final sections outlining future directions in biocatalysis further expanding the science into new applications. Gives future directions in the area of biocatalysis research Presents research topics based on their uniqueness, originality, and novelty Includes many explanatory figures to demonstrate concepts to both organic chemists and biochemists Shows that there is no boundary between organic chemistry and biochemistry

Biocatalysis in Organic Synthesis

Author : Nicholas J Turner
Publisher : Royal Society of Chemistry
ISBN 13 : 1788013425
Total Pages : 416 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Biocatalysis in Organic Synthesis by : Nicholas J Turner

Download or read book Biocatalysis in Organic Synthesis written by Nicholas J Turner and published by Royal Society of Chemistry. This book was released on 2018-02-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of biocatalysis in organic synthesis is rapidly gaining popularity amongst chemists. Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials. Together these advantages can contribute to more sustainable manufacturing processes across a wide range of industries ranging from pharmaceuticals to biofuels. The biocatalytic toolbox has expanded significantly in the past five years and given the current rate of development of new engineered biocatalysts it is likely that the number of available biocatalysts will double in the next few years. This textbook gives a comprehensive overview of the current biocatalytic toolbox and also establishes new guidelines or rules for “biocatalytic retrosynthesis”. Retrosynthesis is a well known and commonly used technique whereby organic chemists start with the structure of their target molecule and generate potential starting materials and intermediates through a series of retrosynthetic disconnections. These disconnections are then used to devise a forward synthesis, in this case using biocatalytic transformations in some of the key steps. Target molecules are disconnected with consideration for applying biocatalysts, as well as chemical reagents and chemocatalysts, in the forward synthesis direction. Using this textbook, students will be able to place biocatalysis within the context of other synthetic transformations that they have learned earlier in their studies. This additional awareness of biocatalysis will equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. In addition to guidelines for identifying where biocatalysts can be applied in organic synthesis, this textbook also provides examples of current applications of biocatalysis using worked examples and case studies. Tutorials enable the reader to practice disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. The book contains a complete description of the current biocatalyst classes that are available for use and also suggests areas where new enzymes are likely to be developed in the next few years. This textbook is an essential resource for lecturers and students studying synthetic organic chemistry. It also serves as a handy reference for practicing chemists who wish to embed biocatalysis into their synthetic toolbox.

Organic Synthesis with Enzymes in Non-Aqueous Media

Author : Giacomo Carrea
Publisher : John Wiley & Sons
ISBN 13 : 3527621733
Total Pages : 328 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Organic Synthesis with Enzymes in Non-Aqueous Media by : Giacomo Carrea

Download or read book Organic Synthesis with Enzymes in Non-Aqueous Media written by Giacomo Carrea and published by John Wiley & Sons. This book was released on 2008-04-09 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals. Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes. The one-stop reference for everyone working in this hot field.

Biotransformations in Organic Chemistry

Author : Kurt Faber
Publisher : Springer Science & Business Media
ISBN 13 : 3642974236
Total Pages : 329 pages
Book Rating : 4.6/5 (429 download)

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Book Synopsis Biotransformations in Organic Chemistry by : Kurt Faber

Download or read book Biotransformations in Organic Chemistry written by Kurt Faber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of natural catalysts - enzymes - for the transformation of non-natural is not at all new: they have been used for more man-made organic compounds than one hundred years, employed either as whole cells, cell organelles or isolated enzymes [1]. Certainly, the object of most of the early research was totally different from that of the present day. Thus the elucidation of biochemical pathways and enzyme mechanisms was in the foreground of the reasearch some decades ago. It was mainly during the 1980s that the enormous potential of applying natural catalysts to transform non-natural organic compounds was recognized. What started as a trend in the late 1970s could almost be called a fashion in synthetic organic chemistry in the 1990s. Although the early euphoria during the 'gold rush' in this field seems to have eased somewhat, there is still no limit to be seen for the future development of such methods. As a result of this extensive, recent research, there have been an estimated 5000 papers published on the subject [2]. To collate these data as a kind of 'super-review' would clearly be an impossible task and, furthermore, such a hypothetical book would be unpalatable for the non-expert.

Biocatalysis for Green Chemistry and Chemical Process Development

Author : Junhua (Alex) Tao
Publisher : John Wiley & Sons
ISBN 13 : 1118028295
Total Pages : 494 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Biocatalysis for Green Chemistry and Chemical Process Development by : Junhua (Alex) Tao

Download or read book Biocatalysis for Green Chemistry and Chemical Process Development written by Junhua (Alex) Tao and published by John Wiley & Sons. This book was released on 2011-06-09 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials. The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.

Enzyme Biocatalysis

Author : Andrés Illanes
Publisher : Springer Science & Business Media
ISBN 13 : 1402083610
Total Pages : 398 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Enzyme Biocatalysis by : Andrés Illanes

Download or read book Enzyme Biocatalysis written by Andrés Illanes and published by Springer Science & Business Media. This book was released on 2008-06-19 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds. We sincerely hope that this book will represent an element in the toolbox of gr- uate students in applied biology and chemical and biochemical engineering and also of undergraduate students with formal training in organic chemistry, biochemistry, thermodynamics and chemical reaction kinetics. Beyond that, the book pretends also to illustrate the potential of biocatalytic processes with case studies in the ?eld of organic synthesis, which we hope will be of interest for the academia and prof- sionals involved in R&D&I. If some of our young readers are encouraged to engage or persevere in their work in biocatalysis this will certainly be our more precious reward.

Biocatalysis for Practitioners

Author : Gonzalo de Gonzalo
Publisher : John Wiley & Sons
ISBN 13 : 352734683X
Total Pages : 54 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Biocatalysis for Practitioners by : Gonzalo de Gonzalo

Download or read book Biocatalysis for Practitioners written by Gonzalo de Gonzalo and published by John Wiley & Sons. This book was released on 2021-07-19 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.

Biotransformations in Organic Chemistry — A Textbook

Author : Kurt Faber
Publisher : Springer Science & Business Media
ISBN 13 : 3642976077
Total Pages : 368 pages
Book Rating : 4.6/5 (429 download)

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Book Synopsis Biotransformations in Organic Chemistry — A Textbook by : Kurt Faber

Download or read book Biotransformations in Organic Chemistry — A Textbook written by Kurt Faber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of natural catalysts - enzymes - for the transformation of non-natural man-made organic compounds is not at all new: they have been used for more than one hundred years, employed either as whole cells, cell organelles or isolated enzymes [1]. Certainly, the object of most of the early research was totally different from that of the present day. Thus the elucidation of biochemical pathways and enzyme mechanisms was the main reason for research some decades ago. It was mainly during the 1980s that the enormous potential of applying natural catalysts to transform non-natural organic compounds was recognized. What started as a trend in the late 1970s could almost be called a fashion in synthetic organic chemistry in the 1990s. Although the early euphoria during the 'gold rush' in this field seems to have eased somewhat, there is still no limit to be seen for the future development of such methods. As a result of this extensive, recent research, there have been all estimated 8000 papers published on the subject [2-14]. To collate these data as a kind of 'super-review' would clearly be an impossible task and, furthermore, such a hypothetical book would be unpalatable for the non-expert.

Modification of Polymers

Author : Charles E. Carraher
Publisher : Springer Science & Business Media
ISBN 13 : 1461337488
Total Pages : 414 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Modification of Polymers by : Charles E. Carraher

Download or read book Modification of Polymers written by Charles E. Carraher and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sheer volume of topics which could have been included under our general title prompted us to make some rather arbitrary decisions about content. Modification by irradiation is not included because the activity in this area is being treated elsewhere. We have chosen to emphasize chemical routes to modification and have striven to pre sent as balanced a representation of current activity as time and page count permit. Industrial applications, both real and potential, are included. Where appropriate, we have encouraged the contributors to include review material to help provide the reader with adequate context. The initial chapter is a review from a historical perspective of polymer modification and contains an extensive bibliography. The remainder of the book is divided into four general areas: Reactions and Preparation of Copolymers Reactions and Preparation of Block and Graft Copolymers Modification Through Condensation Reactions Applications The chemical modification of homopolymers such as polyvinylchlo ride, polyethylene, poly(chloroalkylene sulfides), polysulfones, poly chloromethylstyrene, polyisobutylene, polysodium acrylate, polyvinyl alcohol, polyvinyl chloroformate, sulfonated polystyrene; block and graft copolymers such as poly(styrene-block-ethylene-co-butylene block-styrene), poly(I,4-polybutadiene-block ethylene oxide), star chlorine-telechelic polyisobutylene, poly(isobutylene-co-2,3-dimethyl- 1,3-butadiene), poly(styrene-co-N-butylmethacrylate); cellulose, dex tran and inulin, is described.

Enzymes in Organic Synthesis

Author : Ruth Porter
Publisher : John Wiley & Sons
ISBN 13 : 0470718625
Total Pages : 192 pages
Book Rating : 4.4/5 (77 download)

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Book Synopsis Enzymes in Organic Synthesis by : Ruth Porter

Download or read book Enzymes in Organic Synthesis written by Ruth Porter and published by John Wiley & Sons. This book was released on 2009-09-14 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Biocatalysis

Author : Gonzalo de Gonzalo
Publisher : Royal Society of Chemistry
ISBN 13 : 1782626190
Total Pages : 532 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Biocatalysis by : Gonzalo de Gonzalo

Download or read book Biocatalysis written by Gonzalo de Gonzalo and published by Royal Society of Chemistry. This book was released on 2017-11-02 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implementing biocatalytic strategies in an industrial setting is a challenging task, especially when commercial scale necessitates a balance between industrial need and economic viability. With invited contributions from a wide range of chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and the key aspects needed for economic success. Focussing on industry related issues, this book will be a useful tool for future research by both practitioners and academics.

Biocatalysts and Enzyme Technology

Author : Klaus Buchholz
Publisher : John Wiley & Sons
ISBN 13 : 3527672001
Total Pages : 609 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Biocatalysts and Enzyme Technology by : Klaus Buchholz

Download or read book Biocatalysts and Enzyme Technology written by Klaus Buchholz and published by John Wiley & Sons. This book was released on 2012-12-21 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of a bestselling textbook offers an instructive and comprehensive overview of our current knowledge of biocatalysis and enzyme technology. The book now contains about 40% more printed content. Three chapters are completely new, while the others have been thoroughly updated, and a section with problems and solutions as well as new case studies have been added. Following an introduction to the history of enzyme applications, the text goes on to cover in depth enzyme mechanisms and kinetics, production, recovery, characterization and design by protein engineering. The authors treat a broad range of applications of soluble and immobilized biocatalysts, including wholecell systems, the use of non-aqueous reaction systems, applications in organic synthesis, bioreactor design and reaction engineering. Methods to estimate the sustainability, important internet resources and their evaluation, and legislation concerning the use of biocatalysts are also covered.

Industrial Biocatalysis

Author : Peter Grunwald
Publisher : CRC Press
ISBN 13 : 9814463892
Total Pages : 1232 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Industrial Biocatalysis by : Peter Grunwald

Download or read book Industrial Biocatalysis written by Peter Grunwald and published by CRC Press. This book was released on 2014-12-11 with total page 1232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts—with their environmentally friendly properties—are currently employed. Drivers are the big societal challenges resulting from concerns about the global climate change and the need for an assured energy supply. Modern biocatalysis relies to a large extent on the tremendous advances in the so-called omics techniques and the structural elucidation of biomolecules, which have led to synthetic biology and metabolic engineering as new research fields with high application potential for the rational design of enzymes and microbial production strains. In this book, renowned scientists discuss the actual developments in these research fields together with a variety of application-oriented topics.