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Optimization In Medicine
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Book Synopsis Optimization in Medicine by : Carlos J. S. Alves
Download or read book Optimization in Medicine written by Carlos J. S. Alves and published by Springer Science & Business Media. This book was released on 2007-12-20 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a wide range of medical applications that can utilize mathematical computing. This work grew out of a workshop on optimization which was held during the 2005 CIM Thematic Term on Optimization in Coimbra, Portugal. It provides an overview of the state-of-the-art in optimization in medicine and will serve as an excellent reference for researchers in the medical computing community and for those working in applied mathematics and optimization.
Book Synopsis Optimization in Medicine and Biology by : Gino J. Lim
Download or read book Optimization in Medicine and Biology written by Gino J. Lim and published by CRC Press. This book was released on 2008-01-08 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thanks to recent advancements, optimization is now recognized as a crucial component in research and decision-making across a number of fields. Through optimization, scientists have made tremendous advances in cancer treatment planning, disease control, and drug development, as well as in sequencing DNA, and identifying protein structures. Op
Book Synopsis Clinical Trial Optimization Using R by : Alex Dmitrienko
Download or read book Clinical Trial Optimization Using R written by Alex Dmitrienko and published by CRC Press. This book was released on 2019-03-22 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Trial Optimization Using R explores a unified and broadly applicable framework for optimizing decision making and strategy selection in clinical development, through a series of examples and case studies. It provides the clinical researcher with a powerful evaluation paradigm, as well as supportive R tools, to evaluate and select among simultaneous competing designs or analysis options. It is applicable broadly to statisticians and other quantitative clinical trialists, who have an interest in optimizing clinical trials, clinical trial programs, or associated analytics and decision making. This book presents in depth the Clinical Scenario Evaluation (CSE) framework, and discusses optimization strategies, including the quantitative assessment of tradeoffs. A variety of common development challenges are evaluated as case studies, and used to show how this framework both simplifies and optimizes strategy selection. Specific settings include optimizing adaptive designs, multiplicity and subgroup analysis strategies, and overall development decision-making criteria around Go/No-Go. After this book, the reader will be equipped to extend the CSE framework to their particular development challenges as well.
Book Synopsis Handbook of Healthcare Operations Management by : Brian T. Denton
Download or read book Handbook of Healthcare Operations Management written by Brian T. Denton and published by Springer Science & Business Media. This book was released on 2013-02-28 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the Preface: Collectively, the chapters in this book address application domains including inpatient and outpatient services, public health networks, supply chain management, and resource constrained settings in developing countries. Many of the chapters provide specific examples or case studies illustrating the applications of operations research methods across the globe, including Africa, Australia, Belgium, Canada, the United Kingdom, and the United States. Chapters 1-4 review operations research methods that are most commonly applied to health care operations management including: queuing, simulation, and mathematical programming. Chapters 5-7 address challenges related to inpatient services in hospitals such as surgery, intensive care units, and hospital wards. Chapters 8-10 cover outpatient services, the fastest growing part of many health systems, and describe operations research models for primary and specialty care services, and how to plan for patient no-shows. Chapters 12 – 16 cover topics related to the broader integration of health services in the context of public health, including optimizing the location of emergency vehicles, planning for mass vaccination events, and the coordination among different parts of a health system. Chapters 17-18 address supply chain management within hospitals, with a focus on pharmaceutical supply management, and the challenges of managing inventory for nursing units. Finally, Chapters 19-20 provide examples of important and emerging research in the realm of humanitarian logistics.
Book Synopsis Dynamic Capacity Management for Healthcare by : Pierce Story
Download or read book Dynamic Capacity Management for Healthcare written by Pierce Story and published by CRC Press. This book was released on 2016-04-19 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: While hospitals can learn from other industries, they cannot be improved or run like factories. With work that is more individualized than standardized, and limited control over volume and arrivals, even the leanest-minded hospital must recognize that healthcare systems are more dynamic than nearly any work environment. Written with the creativity needed to navigate the rapidly changing landscape of healthcare, Dynamic Capacity Management for Healthcare: Advanced Methods and Tools for Optimization presents the unique new tools, methodologies, and thinking required of healthcare systems that want to survive and thrive in a reduced reimbursement, higher-cost world. Demonstrating his approaches and recommendations through case studies specific to the complex issues of healthcare delivery, Pierce Story, a long-time and passionate healthcare operations expert, shows how hospitals and health systems can make leaps in performance in an environment in which both financial and human resources are shrinking as expectations for clinical perfection continue to rise. Through its unique approach to the dynamic management of complex care systems, this volume raises the bar for what is possible. This text presents an excellent opportunity for healthcare’s change agents to meet the challenges and responsibilities of our day.
Book Synopsis Handbook of Optimization in Medicine by : Panos M. Pardalos
Download or read book Handbook of Optimization in Medicine written by Panos M. Pardalos and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Optimization in Medicine is devoted to examining the dramatic increase in the application of effective optimization techniques to the delivery of health care. The articles, written by experts, focus on models and algorithms that have led to more efficient and sophisticated treatments of patients. Topics covered include: optimization in medical imaging, classification and data mining with medical applications, treatment of epilepsy and other brain disorders, treatment of head-and-neck, prostate, and other cancers using conventional conformal and intensity-modulated radiation therapy as well as proton therapy, treatment selection for breast cancer based on new classification schemes, optimization for the genome project, optimal timing of organ transplants.
Book Synopsis Antibiotic Optimization by : Robert C. Owens
Download or read book Antibiotic Optimization written by Robert C. Owens and published by CRC Press. This book was released on 2004-11-04 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on topics ranging from the economics of drug-resistant infections and the management of antimicrobial use to new information on methods to optimize the selection, route of administration, dosing, and duration of antimicrobial therapies for common infections. In addition to offering ideas on studied programmatic approaches for judi
Book Synopsis Motion Planning in Medicine: Optimization and Simulation Algorithms for Image-Guided Procedures by : Ron Alterovitz
Download or read book Motion Planning in Medicine: Optimization and Simulation Algorithms for Image-Guided Procedures written by Ron Alterovitz and published by Springer. This book was released on 2008-09-20 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by Ron Alterovitz and Ken Goldberg, this monograph combines ideas from robotics, physically-based modeling, and operations research to develop new motion planning and optimization algorithms for image-guided medical procedures.
Book Synopsis Essays and Surveys in Global Optimization by : Charles Audet
Download or read book Essays and Surveys in Global Optimization written by Charles Audet and published by Springer Science & Business Media. This book was released on 2005-12-05 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global optimization aims at solving the most general problems of deterministic mathematical programming: to find the global optimum of a nonlinear, nonconvex, multivariate function of continuous and/or integer variables subject to constraints which may be themselves nonlinear and nonconvex. In addition, once the solutions are found, proof of its optimality is also expected from this methodology. Therefore, with these difficulties in mind, global optimization is becoming an increasingly powerful and important methodology. Essays and Surveys in Global Optimization is the most recent examination of its mathematical capability, power, and wide ranging solutions to many fields in the applied sciences.
Book Synopsis Dose Optimization in Drug Development by : Rajesh Krishna
Download or read book Dose Optimization in Drug Development written by Rajesh Krishna and published by CRC Press. This book was released on 2006-05 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference provides a concise overview of the key principles in dose selection and optimization and demonstrates applicability to recent successful new drug applications. Compiling key issues and current research on safety, efficacy, and clinical pharmacology, and PK-PD, this volume critically highlights the multidisciplinary nature of drug development and spans the fields of pharmacokinetics, clinical pharmacology, biostatistics, and experimental medicine.
Book Synopsis Optimization of Behavioral, Biobehavioral, and Biomedical Interventions by : Linda M. Collins
Download or read book Optimization of Behavioral, Biobehavioral, and Biomedical Interventions written by Linda M. Collins and published by Springer. This book was released on 2018-02-08 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a framework for development, optimization, and evaluation of behavioral, biobehavioral, and biomedical interventions. Behavioral, biobehavioral, and biomedical interventions are programs with the objective of improving and maintaining human health and well-being, broadly defined, in individuals, families, schools, organizations, or communities. These interventions may be aimed at, for example, preventing or treating disease, promoting physical and mental health, preventing violence, or improving academic achievement. This volume introduces the multiphase optimization strategy (MOST), pioneered at The Methodology Center at the Pennsylvania State University, as an alternative to the classical approach of relying solely on the randomized controlled trial (RCT). MOST borrows heavily from perspectives taken and approaches used in engineering, and also integrates concepts from statistics and behavioral science, including the RCT. As described in detail in this book, MOST consists of three phases: preparation, in which the conceptual model underlying the intervention is articulated; optimization, in which experimentation is used to gather the information necessary to identify the optimized intervention; and evaluation, in which the optimized intervention is evaluated in a standard RCT. Through numerous examples, the book demonstrates that MOST can be used to develop interventions that are more effective, efficient, economical, and scalable. Optimization of Behavioral, Biobehavioral, and Biomedical Interventions: The Multiphase Optimization Strategy is the first book to present a comprehensive introduction to MOST. It will be an essential resource for behavioral, biobehavioral, and biomedical scientists; statisticians, biostatisticians, and analysts working in epidemiology and public health; and graduate-level courses in development and evaluation of interventions.
Book Synopsis Advances and Trends in Optimization with Engineering Applications by : Tamas Terlaky
Download or read book Advances and Trends in Optimization with Engineering Applications written by Tamas Terlaky and published by SIAM. This book was released on 2017-04-26 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimization is of critical importance in engineering. Engineers constantly strive for the best possible solutions, the most economical use of limited resources, and the greatest efficiency. As system complexity increases, these goals mandate the use of state-of-the-art optimization techniques. In recent years, the theory and methodology of optimization have seen revolutionary improvements. Moreover, the exponential growth in computational power, along with the availability of multicore computing with virtually unlimited memory and storage capacity, has fundamentally changed what engineers can do to optimize their designs. This is a two-way process: engineers benefit from developments in optimization methodology, and challenging new classes of optimization problems arise from novel engineering applications. Advances and Trends in Optimization with Engineering Applications reviews 10 major areas of optimization and related engineering applications, providing a broad summary of state-of-the-art optimization techniques most important to engineering practice. Each part provides a clear overview of a specific area and discusses a range of real-world problems. The book provides a solid foundation for engineers and mathematical optimizers alike who want to understand the importance of optimization methods to engineering and the capabilities of these methods.
Book Synopsis Optimization in Drug Discovery by : Gary W. Caldwell
Download or read book Optimization in Drug Discovery written by Gary W. Caldwell and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates. Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.
Book Synopsis Optimization of Pharmaceutical R&D Programs and Portfolios by : Zoran Antonijevic
Download or read book Optimization of Pharmaceutical R&D Programs and Portfolios written by Zoran Antonijevic and published by Springer. This book was released on 2014-10-10 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Very little has been published on optimization of pharmaceutical portfolios. Moreover, most of published literature is coming from the commercial side, where probability of technical success (PoS) is treated as fixed, and not as a consequence of development strategy or design. In this book there is a strong focus on impact of study design on PoS and ultimately on the value of portfolio. Design options that are discussed in different chapters are dose-selection strategies, adaptive design and enrichment. Some development strategies that are discussed are indication sequencing, optimal number of programs and optimal decision criteria. This book includes chapters written by authors with very broad backgrounds including financial, clinical, statistical, decision sciences, commercial and regulatory. Many authors have long held executive positions and have been involved with decision making at a product or at a portfolio level. As such, it is expected that this book will attract a very broad audience, including decision makers in pharmaceutical R&D, commercial and financial departments. The intended audience also includes portfolio planners and managers, statisticians, decision scientists and clinicians. Early chapters describe approaches to portfolio optimization from big Pharma and Venture Capital standpoints. They have stronger focus on finances and processes. Later chapters present selected statistical and decision analysis methods for optimizing drug development programs and portfolios. Some methodological chapters are technical; however, with a few exceptions they require a relatively basic knowledge of statistics by a reader.
Book Synopsis Optimizing Patient Flow by : Eugene Litvak
Download or read book Optimizing Patient Flow written by Eugene Litvak and published by . This book was released on 2018 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimizing patient flow : advanced strategies for managing variability to enhance access, quality, and safety offers readers innovate techniques for maximizing patient flow and improving operations management while providing clear examples of successful impementation. This all-new book can help health care organizations to reduce and manage variability, thereby increasing the reliablity of systems and processes and improving health care quality and safety.
Book Synopsis Enhanced Recovery After Surgery by : Olle Ljungqvist
Download or read book Enhanced Recovery After Surgery written by Olle Ljungqvist and published by Springer Nature. This book was released on 2020-03-30 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first comprehensive, authoritative reference that provides a broad and comprehensive overview of Enhanced Recovery After Surgery (ERAS). Written by experts in the field, chapters analyze elements of care that are both generic and specific to various surgeries. It covers the patient journey through such a program, commencing with optimization of the patient’s condition, patient education, and conditioning of their expectations. Organized into nine parts, this book discusses metabolic responses to surgery, anaesthetic contributions, and optimal fluid management after surgery. Chapters are supplemented with examples of ERAS pathways and practical tips on post-operative pain control, feeding, mobilization, and criteria for discharge. Enhanced Recovery After Surgery: A Complete Guide to Optimizing Outcomes is an indispensable manual that thoroughly explores common post-operative barriers and challenges.
Book Synopsis Handbook of Clinical Automation, Robotics, and Optimization by : Judith Welsh (R.N.)
Download or read book Handbook of Clinical Automation, Robotics, and Optimization written by Judith Welsh (R.N.) and published by Wiley-Interscience. This book was released on 1996 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive landmark book describes the technology of the future in diagnostic medicine, how to integrate it into the modern hospital and how to work with people to adapt, change and plan for a smooth transition to a fully robotic laboratory. Features an extensive section on point-of-care testing along with a modern perspective of how this will transform medicine. Global experts in their fields have authored all chapters which include a unique one on machine vision and another (with several plates) that discusses the automation of a clinical laboratory in Japan.
