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ON CONSTRUCTION & IDENTIFICATI

Author : Xiaoqing Cheng
Publisher : Open Dissertation Press
ISBN 13 : 9781361040621
Total Pages : 132 pages
Book Rating : 4.0/5 (46 download)

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Book Synopsis ON CONSTRUCTION & IDENTIFICATI by : Xiaoqing Cheng

Download or read book ON CONSTRUCTION & IDENTIFICATI written by Xiaoqing Cheng and published by Open Dissertation Press. This book was released on 2017-01-26 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "On Construction and Identification Problems in Probabilistic Boolean Networks" by Xiaoqing, Cheng, 程晓青, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: In recent decades, rapidly evolving genomic technologies provide a platform for exploring the massive amount of genomic data. At the same time, it also triggers dramatic development in systems biology. A number of mathematical models have been proposed to understand the dynamical behavior of the biological systems. Among them, Boolean Network (BN) and its stochastic extension Probabilistic Boolean Network (PBN) have attracted much attention. Identification and construction problems are two kinds of vital problems in studying the behavior of a PBN. A novel problem of observability of singleton attractors was firstly proposed, which was defined as identifying the minimum number of consecutive nodes to discriminate different singleton attractors. It may help in finding biomarkers for different disease types, thus it plays a vital role in the study of signaling networks. The observability of singleton attractor problem can be solved in O(n) time, where n is the number of genes in a BN. Later, the problem was extended to discriminating periodical attractors. For the periodical case, one has to consider multiple time steps and a new algorithm was proposed. Moreover, one may also curious about identifying the minimum set of nodes that can determine uniquely the attractor cycles from the others in the network, this problem was also addressed. In order to study realistic PBNs, inference on the structure of PBNs from gene expression time series data was investigated. The number of samples required to uniquely determine the structure of a PBN was studied. Two models were proposed to study different classes of PBNs. Using theoretical analysis and computational experiments the structure of a PBN can be exactly identified with high probability from a relatively small number of samples for some classes of PBNs having bounded indegree. Furthermore, it is shown that there exist classes of PBNs for which it is impossible to uniquely determine their structure from samples under these two models. Constructing the structure of a PBN from a given probability transition matrix is another key problem. A projection-based gradient descent method was proposed for solving huge size constrained least square problems. It is a matrixfree iterative scheme for solving the minimizer of the captured problem. A convergence analysis of the scheme is given, and the algorithm is then applied to the construction of a PBN given its probability transition matrix. Efficiency and effectiveness of the proposed method are verified through numerical experiments. Semi-tensor product approach is another powerful tool in constructing of BNs. However, to our best knowledge, there is no result on the relationship of the structure matrix and transition matrix of a BN. It is shown that the probability structure matrix and probability transition matrix are similar matrices. Three main problems in PBN were discussed afterward: dynamics, steady-state distribution and the inverse problem. Numerical examples are provided to show the validity of our proposed theory. Subjects: Algebra, Boolean Genetic regulation - Mathematical models

On Construction and Identification Problems in Probabilistic Boolean Networks

Author : Xiaoqing Cheng
Publisher :
ISBN 13 : 9781361040645
Total Pages : pages
Book Rating : 4.0/5 (46 download)

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Book Synopsis On Construction and Identification Problems in Probabilistic Boolean Networks by : Xiaoqing Cheng

Download or read book On Construction and Identification Problems in Probabilistic Boolean Networks written by Xiaoqing Cheng and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "On Construction and Identification Problems in Probabilistic Boolean Networks" by Xiaoqing, Cheng, 程晓青, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: In recent decades, rapidly evolving genomic technologies provide a platform for exploring the massive amount of genomic data. At the same time, it also triggers dramatic development in systems biology. A number of mathematical models have been proposed to understand the dynamical behavior of the biological systems. Among them, Boolean Network (BN) and its stochastic extension Probabilistic Boolean Network (PBN) have attracted much attention. Identification and construction problems are two kinds of vital problems in studying the behavior of a PBN. A novel problem of observability of singleton attractors was firstly proposed, which was defined as identifying the minimum number of consecutive nodes to discriminate different singleton attractors. It may help in finding biomarkers for different disease types, thus it plays a vital role in the study of signaling networks. The observability of singleton attractor problem can be solved in O(n) time, where n is the number of genes in a BN. Later, the problem was extended to discriminating periodical attractors. For the periodical case, one has to consider multiple time steps and a new algorithm was proposed. Moreover, one may also curious about identifying the minimum set of nodes that can determine uniquely the attractor cycles from the others in the network, this problem was also addressed. In order to study realistic PBNs, inference on the structure of PBNs from gene expression time series data was investigated. The number of samples required to uniquely determine the structure of a PBN was studied. Two models were proposed to study different classes of PBNs. Using theoretical analysis and computational experiments the structure of a PBN can be exactly identified with high probability from a relatively small number of samples for some classes of PBNs having bounded indegree. Furthermore, it is shown that there exist classes of PBNs for which it is impossible to uniquely determine their structure from samples under these two models. Constructing the structure of a PBN from a given probability transition matrix is another key problem. A projection-based gradient descent method was proposed for solving huge size constrained least square problems. It is a matrixfree iterative scheme for solving the minimizer of the captured problem. A convergence analysis of the scheme is given, and the algorithm is then applied to the construction of a PBN given its probability transition matrix. Efficiency and effectiveness of the proposed method are verified through numerical experiments. Semi-tensor product approach is another powerful tool in constructing of BNs. However, to our best knowledge, there is no result on the relationship of the structure matrix and transition matrix of a BN. It is shown that the probability structure matrix and probability transition matrix are similar matrices. Three main problems in PBN were discussed afterward: dynamics, steady-state distribution and the inverse problem. Numerical examples are provided to show the validity of our proposed theory. Subjects: Algebra, Boolean Genetic regulation - Mathematical models

Computational Systems Bioinformatics

Author : Xiaobo Zhou
Publisher : World Scientific
ISBN 13 : 9812707042
Total Pages : 398 pages
Book Rating : 4.8/5 (127 download)

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Book Synopsis Computational Systems Bioinformatics by : Xiaobo Zhou

Download or read book Computational Systems Bioinformatics written by Xiaobo Zhou and published by World Scientific. This book was released on 2008 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational systems biology is a new and rapidly developing field of research, concerned with understanding the structure and processes of biological systems at the molecular, cellular, tissue, and organ levels through computational modeling as well as novel information theoretic data and image analysis methods. By focusing on either information processing of biological data or on modeling physical and chemical processes of biosystems, and in combination with the recent breakthrough in deciphering the human genome, computational systems biology is guaranteed to play a central role in disease prediction and preventive medicine, gene technology and pharmaceuticals, and other biotechnology fields. This book begins by introducing the basic mathematical, statistical, and data mining principles of computational systems biology, and then presents bioinformatics technology in microarray and sequence analysis step-by-step. Offering an insightful look into the effectiveness of the systems approach in computational biology, it focuses on recurrent themes in bioinformatics, biomedical applications, and future directions for research.

Probabilistic Boolean Networks

Author : Ilya Shmulevich
Publisher : SIAM
ISBN 13 : 0898716926
Total Pages : 276 pages
Book Rating : 4.8/5 (987 download)

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Book Synopsis Probabilistic Boolean Networks by : Ilya Shmulevich

Download or read book Probabilistic Boolean Networks written by Ilya Shmulevich and published by SIAM. This book was released on 2010-01-21 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive treatment of probabilistic Boolean networks, unifying different strands of current research and addressing emerging issues.

Positive Systems

Author : James Lam
Publisher : Springer
ISBN 13 : 3030043274
Total Pages : 333 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Positive Systems by : James Lam

Download or read book Positive Systems written by James Lam and published by Springer. This book was released on 2019-01-12 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents high-quality original contributions on positive systems, including those with positivity in compartmental switched systems, Markovian jump systems, Boolean networks, interval observer design, fault detection, and delay systems. It comprises a selection of the best papers from POSTA 2018, the 6th International Conference on Positive Systems, which was held in Hangzhou, China, in August 2018. The POSTA conference series represents a targeted response to the growing need for research that reports on and critically discusses a wide range of topics concerning the theory and applications of positive systems. The book offers valuable insights for researchers in applied mathematics, control theory and their applications.

Applied Statistics for Network Biology

Author : Matthias Dehmer
Publisher : John Wiley & Sons
ISBN 13 : 3527638083
Total Pages : 441 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Applied Statistics for Network Biology by : Matthias Dehmer

Download or read book Applied Statistics for Network Biology written by Matthias Dehmer and published by John Wiley & Sons. This book was released on 2011-04-08 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book introduces to the reader a number of cutting edge statistical methods which can e used for the analysis of genomic, proteomic and metabolomic data sets. In particular in the field of systems biology, researchers are trying to analyze as many data as possible in a given biological system (such as a cell or an organ). The appropriate statistical evaluation of these large scale data is critical for the correct interpretation and different experimental approaches require different approaches for the statistical analysis of these data. This book is written by biostatisticians and mathematicians but aimed as a valuable guide for the experimental researcher as well computational biologists who often lack an appropriate background in statistical analysis.

Probabilistic Boolean Networks

Author : Ilya Shmulevich
Publisher : SIAM
ISBN 13 : 0898717639
Total Pages : 277 pages
Book Rating : 4.8/5 (987 download)

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Book Synopsis Probabilistic Boolean Networks by : Ilya Shmulevich

Download or read book Probabilistic Boolean Networks written by Ilya Shmulevich and published by SIAM. This book was released on 2010-01-01 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive treatment of probabilistic Boolean networks (PBNs), an important model class for studying genetic regulatory networks. This book covers basic model properties, including the relationships between network structure and dynamics, steady-state analysis, and relationships to other model classes." "Researchers in mathematics, computer science, and engineering are exposed to important applications in systems biology and presented with ample opportunities for developing new approaches and methods. The book is also appropriate for advanced undergraduates, graduate students, and scientists working in the fields of computational biology, genomic signal processing, control and systems theory, and computer science.

ECAI 2002

Author : Frank Van Harmelen
Publisher : IOS Press
ISBN 13 : 9781586032579
Total Pages : 774 pages
Book Rating : 4.0/5 (325 download)

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Book Synopsis ECAI 2002 by : Frank Van Harmelen

Download or read book ECAI 2002 written by Frank Van Harmelen and published by IOS Press. This book was released on 2002 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the 137 papers accepted for presentation at the 15th European Conference on Artificial Intelligence (ECAI '02), which is organized by the European Co-ordination Committee on Artificial Intelligence.

Bayesian Networks and Influence Diagrams: A Guide to Construction and Analysis

Author : Uffe B. Kjærulff
Publisher : Springer Science & Business Media
ISBN 13 : 1461451043
Total Pages : 388 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Bayesian Networks and Influence Diagrams: A Guide to Construction and Analysis by : Uffe B. Kjærulff

Download or read book Bayesian Networks and Influence Diagrams: A Guide to Construction and Analysis written by Uffe B. Kjærulff and published by Springer Science & Business Media. This book was released on 2012-11-30 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bayesian Networks and Influence Diagrams: A Guide to Construction and Analysis, Second Edition, provides a comprehensive guide for practitioners who wish to understand, construct, and analyze intelligent systems for decision support based on probabilistic networks. This new edition contains six new sections, in addition to fully-updated examples, tables, figures, and a revised appendix. Intended primarily for practitioners, this book does not require sophisticated mathematical skills or deep understanding of the underlying theory and methods nor does it discuss alternative technologies for reasoning under uncertainty. The theory and methods presented are illustrated through more than 140 examples, and exercises are included for the reader to check his or her level of understanding. The techniques and methods presented for knowledge elicitation, model construction and verification, modeling techniques and tricks, learning models from data, and analyses of models have all been developed and refined on the basis of numerous courses that the authors have held for practitioners worldwide.

The Probabilistic Method

Author : Noga Alon
Publisher : John Wiley & Sons
ISBN 13 : 1119062071
Total Pages : 400 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis The Probabilistic Method by : Noga Alon

Download or read book The Probabilistic Method written by Noga Alon and published by John Wiley & Sons. This book was released on 2015-11-02 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the Third Edition “Researchers of any kind of extremal combinatorics or theoretical computer science will welcome the new edition of this book.” - MAA Reviews Maintaining a standard of excellence that establishes The Probabilistic Method as the leading reference on probabilistic methods in combinatorics, the Fourth Edition continues to feature a clear writing style, illustrative examples, and illuminating exercises. The new edition includes numerous updates to reflect the most recent developments and advances in discrete mathematics and the connections to other areas in mathematics, theoretical computer science, and statistical physics. Emphasizing the methodology and techniques that enable problem-solving, The Probabilistic Method, Fourth Edition begins with a description of tools applied to probabilistic arguments, including basic techniques that use expectation and variance as well as the more advanced applications of martingales and correlation inequalities. The authors explore where probabilistic techniques have been applied successfully and also examine topical coverage such as discrepancy and random graphs, circuit complexity, computational geometry, and derandomization of randomized algorithms. Written by two well-known authorities in the field, the Fourth Edition features: Additional exercises throughout with hints and solutions to select problems in an appendix to help readers obtain a deeper understanding of the best methods and techniques New coverage on topics such as the Local Lemma, Six Standard Deviations result in Discrepancy Theory, Property B, and graph limits Updated sections to reflect major developments on the newest topics, discussions of the hypergraph container method, and many new references and improved results The Probabilistic Method, Fourth Edition is an ideal textbook for upper-undergraduate and graduate-level students majoring in mathematics, computer science, operations research, and statistics. The Fourth Edition is also an excellent reference for researchers and combinatorists who use probabilistic methods, discrete mathematics, and number theory. Noga Alon, PhD, is Baumritter Professor of Mathematics and Computer Science at Tel Aviv University. He is a member of the Israel National Academy of Sciences and Academia Europaea. A coeditor of the journal Random Structures and Algorithms, Dr. Alon is the recipient of the Polya Prize, The Gödel Prize, The Israel Prize, and the EMET Prize. Joel H. Spencer, PhD, is Professor of Mathematics and Computer Science at the Courant Institute of New York University. He is the cofounder and coeditor of the journal Random Structures and Algorithms and is a Sloane Foundation Fellow. Dr. Spencer has written more than 200 published articles and is the coauthor of Ramsey Theory, Second Edition, also published by Wiley.

High-Dimensional Probability

Author : Roman Vershynin
Publisher : Cambridge University Press
ISBN 13 : 1108415199
Total Pages : 299 pages
Book Rating : 4.1/5 (84 download)

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Book Synopsis High-Dimensional Probability by : Roman Vershynin

Download or read book High-Dimensional Probability written by Roman Vershynin and published by Cambridge University Press. This book was released on 2018-09-27 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated package of powerful probabilistic tools and key applications in modern mathematical data science.

Foundations of Probabilistic Programming

Author : Gilles Barthe
Publisher : Cambridge University Press
ISBN 13 : 110848851X
Total Pages : 583 pages
Book Rating : 4.1/5 (84 download)

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Book Synopsis Foundations of Probabilistic Programming by : Gilles Barthe

Download or read book Foundations of Probabilistic Programming written by Gilles Barthe and published by Cambridge University Press. This book was released on 2020-12-03 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the theoretical underpinnings of modern probabilistic programming and presents applications in e.g., machine learning, security, and approximate computing. Comprehensive survey chapters make the material accessible to graduate students and non-experts. This title is also available as Open Access on Cambridge Core.

Analysis and Control of Boolean Networks

Author : Daizhan Cheng
Publisher : Springer Science & Business Media
ISBN 13 : 0857290975
Total Pages : 472 pages
Book Rating : 4.8/5 (572 download)

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Book Synopsis Analysis and Control of Boolean Networks by : Daizhan Cheng

Download or read book Analysis and Control of Boolean Networks written by Daizhan Cheng and published by Springer Science & Business Media. This book was released on 2010-11-23 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analysis and Control of Boolean Networks presents a systematic new approach to the investigation of Boolean control networks. The fundamental tool in this approach is a novel matrix product called the semi-tensor product (STP). Using the STP, a logical function can be expressed as a conventional discrete-time linear system. In the light of this linear expression, certain major issues concerning Boolean network topology – fixed points, cycles, transient times and basins of attractors – can be easily revealed by a set of formulae. This framework renders the state-space approach to dynamic control systems applicable to Boolean control networks. The bilinear-systemic representation of a Boolean control network makes it possible to investigate basic control problems including controllability, observability, stabilization, disturbance decoupling etc.

Bayesian Networks

Author : Olivier Pourret
Publisher : John Wiley & Sons
ISBN 13 : 9780470994542
Total Pages : 446 pages
Book Rating : 4.9/5 (945 download)

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Book Synopsis Bayesian Networks by : Olivier Pourret

Download or read book Bayesian Networks written by Olivier Pourret and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bayesian Networks, the result of the convergence of artificial intelligence with statistics, are growing in popularity. Their versatility and modelling power is now employed across a variety of fields for the purposes of analysis, simulation, prediction and diagnosis. This book provides a general introduction to Bayesian networks, defining and illustrating the basic concepts with pedagogical examples and twenty real-life case studies drawn from a range of fields including medicine, computing, natural sciences and engineering. Designed to help analysts, engineers, scientists and professionals taking part in complex decision processes to successfully implement Bayesian networks, this book equips readers with proven methods to generate, calibrate, evaluate and validate Bayesian networks. The book: Provides the tools to overcome common practical challenges such as the treatment of missing input data, interaction with experts and decision makers, determination of the optimal granularity and size of the model. Highlights the strengths of Bayesian networks whilst also presenting a discussion of their limitations. Compares Bayesian networks with other modelling techniques such as neural networks, fuzzy logic and fault trees. Describes, for ease of comparison, the main features of the major Bayesian network software packages: Netica, Hugin, Elvira and Discoverer, from the point of view of the user. Offers a historical perspective on the subject and analyses future directions for research. Written by leading experts with practical experience of applying Bayesian networks in finance, banking, medicine, robotics, civil engineering, geology, geography, genetics, forensic science, ecology, and industry, the book has much to offer both practitioners and researchers involved in statistical analysis or modelling in any of these fields.

A First Course in Systems Biology

Author : Eberhard Voit
Publisher : Garland Science
ISBN 13 : 1351332945
Total Pages : 480 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis A First Course in Systems Biology by : Eberhard Voit

Download or read book A First Course in Systems Biology written by Eberhard Voit and published by Garland Science. This book was released on 2017-09-05 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: A First Course in Systems Biology is an introduction for advanced undergraduate and graduate students to the growing field of systems biology. Its main focus is the development of computational models and their applications to diverse biological systems. The book begins with the fundamentals of modeling, then reviews features of the molecular inventories that bring biological systems to life and discusses case studies that represent some of the frontiers in systems biology and synthetic biology. In this way, it provides the reader with a comprehensive background and access to methods for executing standard systems biology tasks, understanding the modern literature, and launching into specialized courses or projects that address biological questions using theoretical and computational means. New topics in this edition include: default modules for model design, limit cycles and chaos, parameter estimation in Excel, model representations of gene regulation through transcription factors, derivation of the Michaelis-Menten rate law from the original conceptual model, different types of inhibition, hysteresis, a model of differentiation, system adaptation to persistent signals, nonlinear nullclines, PBPK models, and elementary modes. The format is a combination of instructional text and references to primary literature, complemented by sets of small-scale exercises that enable hands-on experience, and large-scale, often open-ended questions for further reflection.

Algebraic Identification of Smart Systems

Author : Natalia A. Serdyukova
Publisher : Springer Nature
ISBN 13 : 3030544702
Total Pages : 186 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Algebraic Identification of Smart Systems by : Natalia A. Serdyukova

Download or read book Algebraic Identification of Smart Systems written by Natalia A. Serdyukova and published by Springer Nature. This book was released on 2020-08-20 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a continuation of our recently published book “Algebraic formalization of smart systems. Theory and practice.” It incorporates a new concept of quasi-fractal algebraic systems, based on A.I. Maltsev’s theory of algebraic systems and the theory of fractals developed by Benoit Mandelbrot, to investigate smart systems in more detail. The main tool used in the book, quasi-fractal algebraic systems, helps us to see smart systems in more detail by adding new factors, which e.g. make it possible to describe the previously indivisible elements of the initial model of factors. The techniques presented include fixed-point theorem, theorems of group theory, theory of Boolean algebras, and Erdös-Renyi algorithms. Given its focus, the book is intended for anyone interested in smart system theory.

Introduction to Information Retrieval

Author : Christopher D. Manning
Publisher : Cambridge University Press
ISBN 13 : 1139472100
Total Pages : pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Introduction to Information Retrieval by : Christopher D. Manning

Download or read book Introduction to Information Retrieval written by Christopher D. Manning and published by Cambridge University Press. This book was released on 2008-07-07 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Class-tested and coherent, this textbook teaches classical and web information retrieval, including web search and the related areas of text classification and text clustering from basic concepts. It gives an up-to-date treatment of all aspects of the design and implementation of systems for gathering, indexing, and searching documents; methods for evaluating systems; and an introduction to the use of machine learning methods on text collections. All the important ideas are explained using examples and figures, making it perfect for introductory courses in information retrieval for advanced undergraduates and graduate students in computer science. Based on feedback from extensive classroom experience, the book has been carefully structured in order to make teaching more natural and effective. Slides and additional exercises (with solutions for lecturers) are also available through the book's supporting website to help course instructors prepare their lectures.