Nuclear Organization In Development And Disease

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Nuclear Organization in Development and Disease

Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470093749
Total Pages : 300 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Nuclear Organization in Development and Disease by : Derek J. Chadwick

Download or read book Nuclear Organization in Development and Disease written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2006-02-08 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book draws together contributions from cell and developmental biologists, structural biologists, geneticists and clinical scientists aimed at a better understanding of the cellular and molecular basis of these diseases. Topics include: How nuclear structure and location within a nucleus affect gene expression Chromatin organization and cell differentiation The nature of the interactions between the nuclear envelope and the cytoskeleton The extent to which the cytoskeleton mediates communication between the cell membrane and nucleus in regulating gene expression and whether disruption of such communication might underlie the disease processes It is hoped that a better understanding of the mechanisms leading to disease pathogenesis may ultimately lead to more rational and appropriate treatments.

Epigenetics: Development and Disease

Author : Tapas Kumar Kundu
Publisher : Springer Science & Business Media
ISBN 13 : 9400745257
Total Pages : 698 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Epigenetics: Development and Disease by : Tapas Kumar Kundu

Download or read book Epigenetics: Development and Disease written by Tapas Kumar Kundu and published by Springer Science & Business Media. This book was released on 2012-11-13 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.

Nuclear Organization and Function

Author : Terri Grodzicker
Publisher :
ISBN 13 : 9781936113071
Total Pages : 0 pages
Book Rating : 4.1/5 (13 download)

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Book Synopsis Nuclear Organization and Function by : Terri Grodzicker

Download or read book Nuclear Organization and Function written by Terri Grodzicker and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on presentations by the world-renowned investigators who gathered at the 75th annual Cold Spring Harbor Symposium on Quantitative Biology to discuss the organization and function of the cell nucleus. It reviews the latest advances in research into nuclear structure, the organization of the genome within the nucleus, and spatiotemporal coordination of nuclear processes. The topics examined include nuclear domains, chromatin organization, transcription and RNA processing, DNA replication, nuclear reprogramming, and epigenetics. Cancer, premature aging syndromes, and other diseases that may be associated with altered nuclear organization are also covered.

Nuclear Mechanics and Genome Regulation

Author :
Publisher : Academic Press
ISBN 13 : 0123810108
Total Pages : 393 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Nuclear Mechanics and Genome Regulation by :

Download or read book Nuclear Mechanics and Genome Regulation written by and published by Academic Press. This book was released on 2010-10-12 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years new discoveries have made this an exciting and important field of research. This exhaustive volume presents comprehensive chapters and detailed background information for researchers working with in the field of nuclear mechanics and genome regulation. Both classic and state-of-the-art methods readily adaptable and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields

Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine

Author : Malgorzata Kloc
Publisher : Springer Nature
ISBN 13 : 3031065735
Total Pages : 657 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine by : Malgorzata Kloc

Download or read book Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine written by Malgorzata Kloc and published by Springer Nature. This book was released on 2022-11-08 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.

Knowledge Management for Nuclear Research and Development Organizations

Author : International Atomic Energy Agency
Publisher : Technical Reports (Internation
ISBN 13 : 9789201255105
Total Pages : 59 pages
Book Rating : 4.2/5 (551 download)

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Book Synopsis Knowledge Management for Nuclear Research and Development Organizations by : International Atomic Energy Agency

Download or read book Knowledge Management for Nuclear Research and Development Organizations written by International Atomic Energy Agency and published by Technical Reports (Internation. This book was released on 2012 with total page 59 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication elaborates on the role of nuclear knowledge management in a research and development (R&D) context, and on the importance of facilitating innovation and future development of nuclear technologies for nuclear power, its associated fuel cycles, and nuclear applications in medicine, industry and agriculture. It highlights aspects including transferring and preserving knowledge, exchanging information, establishing and supporting cooperative networks, and training the next generation of nuclear experts. It concludes with basic concepts, trends and key drivers for nuclear knowledge management to R&D project managers and other workers from nuclear R&D organizations.

Epigenetic Gene Expression and Regulation

Author : Suming Huang
Publisher : Academic Press
ISBN 13 : 0128004711
Total Pages : 482 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Epigenetic Gene Expression and Regulation by : Suming Huang

Download or read book Epigenetic Gene Expression and Regulation written by Suming Huang and published by Academic Press. This book was released on 2015-10-19 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Proteogenomics

Author : Ákos Végvári
Publisher : Springer
ISBN 13 : 3319423169
Total Pages : 184 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Proteogenomics by : Ákos Végvári

Download or read book Proteogenomics written by Ákos Végvári and published by Springer. This book was released on 2016-09-29 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights key technologies and identifies areas for further development in proteogenomics. The utility and usefulness of very large Omics data sets (Next Gen Sequencing of DNA, RNA-seq, ribosome profiling, mass spectrometry- and antibody-based proteomics) is discussed and opportunities and challenges of related bioinformatics applications are outlined. The reader will be able to appreciate the interdisciplinary nature of the continuously evolving area of proteogenomics, which has already grown beyond its original concept of verifying gene annotations by proteomics. The chapters presented in this book are arranged to offer a general overview, rather than to provide detailed descriptions of technologies. The selected applications will provide useful insight into the level of detail that can be obtained in relation to certain diseases areas, including cancer biology and personalized medicine. The readers will find that each chapter delivers a comprehensive approach to proteogenomics, each from the point of view of a specific application. Research scientists interested in innovative processes that can offer a unique and at the same time a more complete access to technological developments and concepts that in turn can contribute to a better understand biological functions should read this book.

Cytogenomics

Author : Thomas Liehr
Publisher : Academic Press
ISBN 13 : 0128235802
Total Pages : 430 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Cytogenomics by : Thomas Liehr

Download or read book Cytogenomics written by Thomas Liehr and published by Academic Press. This book was released on 2021-05-25 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The book’s second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists. Offers applied approaches empowering a new generation of cytogenomic research using a balanced combination of classical and advanced technologies Provides a framework for interpreting chromosome structure and how this affects the functioning of the genome in health and disease Features chapter contributions from international leaders in the field

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Health Effects of Exposure to Low Levels of Ionizing Radiation

Author : National Research Council
Publisher : National Academies
ISBN 13 : 0309039959
Total Pages : 436 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Health Effects of Exposure to Low Levels of Ionizing Radiation by : National Research Council

Download or read book Health Effects of Exposure to Low Levels of Ionizing Radiation written by National Research Council and published by National Academies. This book was released on 1990-02-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.

Nuclear and Radiological Emergencies in Animal Production Systems, Preparedness, Response and Recovery

Author : Ivancho Naletoski
Publisher : Springer Nature
ISBN 13 : 3662630214
Total Pages : 195 pages
Book Rating : 4.6/5 (626 download)

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Book Synopsis Nuclear and Radiological Emergencies in Animal Production Systems, Preparedness, Response and Recovery by : Ivancho Naletoski

Download or read book Nuclear and Radiological Emergencies in Animal Production Systems, Preparedness, Response and Recovery written by Ivancho Naletoski and published by Springer Nature. This book was released on 2021-05-31 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access volume explains how major nuclear and radiological emergencies (NREs) can have implications at local, national and international level. The response to NREs requires a competent decision-making structure, clear communication and effective information exchange. National veterinary services have the responsibility to plan, design and manage animal production system in their countries. These activities cover animal health, animal movement control, production control and improvement, and control of the products of animal origin before their placement on the market. Release of radionuclides after NREs can cause substantial contamination in the animal production systems. Critical responsibility of veterinary authorities is therefore to prevent such contamination, establish early response mechanisms to mitigate the consequences and prevent placement of contaminated products of animal origin on the market for human consumption. This work summarizes the critical technical points for effective management of NREs for national veterinary services.

The Nuclear Envelope: Methods and Protocols

Author : Sue Shackleton
Publisher : Methods in Molecular Biology
ISBN 13 : 9781493980680
Total Pages : 540 pages
Book Rating : 4.9/5 (86 download)

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Book Synopsis The Nuclear Envelope: Methods and Protocols by : Sue Shackleton

Download or read book The Nuclear Envelope: Methods and Protocols written by Sue Shackleton and published by Methods in Molecular Biology. This book was released on 2018-05-19 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a wide range of protocols used in studying the nuclear envelope, with special attention to the experimental adjustments that may be required to successfully investigate this complex organelle in cells from various organisms. The Nuclear Envelope: Methods and Protocols is divided into five sections: Part I - Nuclear Envelope Isolation; Part II - Nuclear Envelope Protein Interactions, Localization, and Dynamics; Part III - Nuclear Envelope Interactions with the Cytoskeleton; Part IV - Nuclear Envelope-Chromatin Interactions; and Part V - Nucleo-Cytoplasmic Transport. Many of the modifications discussed in this book have only been circulated within laboratories that have conducted research in this field for many years. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, The Nuclear Envelope: Methods and Protocols is a timely resource for researchers who have joined this dynamic and rapidly growing field.

Heritable Human Genome Editing

Author : The Royal Society
Publisher : National Academies Press
ISBN 13 : 0309671132
Total Pages : 239 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Heritable Human Genome Editing by : The Royal Society

Download or read book Heritable Human Genome Editing written by The Royal Society and published by National Academies Press. This book was released on 2021-01-16 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Epigenetics in Cardiac Disease

Author : Johannes Backs
Publisher : Springer
ISBN 13 : 3319414577
Total Pages : 322 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Epigenetics in Cardiac Disease by : Johannes Backs

Download or read book Epigenetics in Cardiac Disease written by Johannes Backs and published by Springer. This book was released on 2016-11-21 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.

The Medical Implications of Nuclear War

Author : Fred Solomon
Publisher : National Academies Press
ISBN 13 : 9780309078665
Total Pages : 609 pages
Book Rating : 4.0/5 (786 download)

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Book Synopsis The Medical Implications of Nuclear War by : Fred Solomon

Download or read book The Medical Implications of Nuclear War written by Fred Solomon and published by National Academies Press. This book was released on 1986-01-15 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned scientists, this volume portrays the possible direct and indirect devastation of human health from a nuclear attack. The most comprehensive work yet produced on this subject, The Medical Implications of Nuclear War includes an overview of the potential environmental and physical effects of nuclear bombardment, describes the problems of choosing who among the injured would get the scarce medical care available, addresses the nuclear arms race from a psychosocial perspective, and reviews the medical needs--in contrast to the medical resources likely to be available--after a nuclear attack. "It should serve as the definitive statement on the consequences of nuclear war."--Arms Control Today

Model Rules of Professional Conduct

Author : American Bar Association. House of Delegates
Publisher : American Bar Association
ISBN 13 : 9781590318737
Total Pages : 216 pages
Book Rating : 4.3/5 (187 download)

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Book Synopsis Model Rules of Professional Conduct by : American Bar Association. House of Delegates

Download or read book Model Rules of Professional Conduct written by American Bar Association. House of Delegates and published by American Bar Association. This book was released on 2007 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts.