New Approaches in Eukaryotic DNA Replication

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Publisher : Springer Science & Business Media
ISBN 13 : 1468443976
Total Pages : 361 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis New Approaches in Eukaryotic DNA Replication by : A. De Recondo

Download or read book New Approaches in Eukaryotic DNA Replication written by A. De Recondo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA replication in eukaryotes is an important field, particular ly because of its direct impact on the study of cancer. The under standing of molecular mechanisms of replication and their regulation should allow a better comprehension of the alterations that lead to the proliferation of tumor cells and to error-prone repair in cells exposed to radiation or chemical carcinogens. During the last several years, many enzymes and proteins which participate in replication of DNA in eukaryotic cells have been identified, isolated and characterized. New concepts in chromatin structure have refocused attention on the study of replication of DNA complexed with his tones and non-histone chromosomal proteins. However, progress has been noticeably slower than for prokaryotes, essentially because of the difficulty in genetic analysis of eukaryo tic DNA replication. In June 1980, a workshop was organized in Cargese, Corsica (France) to facilitate exchanges of information between workers spe cializing in prokaryotes and those specializing in eukaryotes, and to allow discussion of new experimental approaches. With this in mind, special interest has been taken in the origin and termination of chromosome cycles and how they are controlled.

DNA Replication

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Publisher : Springer
ISBN 13 : 9811069557
Total Pages : 581 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis DNA Replication by : Hisao Masai

Download or read book DNA Replication written by Hisao Masai and published by Springer. This book was released on 2018-01-22 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.

Eukaryotic DNA Replication

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Author :
Publisher : OUP Oxford
ISBN 13 : 0191565768
Total Pages : 304 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Eukaryotic DNA Replication by : Sue Cotterill

Download or read book Eukaryotic DNA Replication written by Sue Cotterill and published by OUP Oxford. This book was released on 1999-02-18 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eukaryotic DNA Replication: A Practical Approach is a comprehensive practical manual, with each of its eleven chapters describing an aspect of the methods currently used to investigate DNA replication in eukaryotes. The sequence of the chapters corresponds roughly to the order of events during DNA replication. The first chapters are concerned with initiation, looking at methods to characterize origins of replication and the proteins that interact with them. There then follow chapters describing protocols for the study of the elongation phase and the synthesis of the telomeres. The final chapters provide a more general overview of the study of DNA replication - including its investigation in model systems such as yeast, xenopus and viruses, and looks into methods used to study DNA:protein interactions that could be applied to the study of replication proteins. This exciting new volume provides over 120 tried and tested protocols for the analysis of eukaryotic DNA replication and will be of major interest to a wide variety of molecular and cell biologists, biochemists and medical researchers.

Molecular Biology of The Cell

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Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The DNA Replication-Repair Interface

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Publisher : Academic Press
ISBN 13 : 0323907342
Total Pages : 454 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis The DNA Replication-Repair Interface by :

Download or read book The DNA Replication-Repair Interface written by and published by Academic Press. This book was released on 2021-11-12 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Replication-Coupled Repair, Volume 661 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including the Repair of replication-born DNA breaks by sister chromatid recombination, High resolution and high throughput DNA cyclization measurements to interrogate DNA bendability, A programmable detection method for genomic signatures: from disease diagnosis to genome editing, Characterization of the telomerase modulating activities of yeast DNA helicases, Eukaryotic DNA replication with purified budding yeast proteins, Single molecule studies of yeast Rad51 paralogs, Light activation and deactivation of Cas9 for DNA repair studies, and more. Other chapters explore MIDAS: Direct sequencing to map mitotic DNA synthesis and common fragile sites at high precision, Studying the DNA damage response in embryonic systems, GLASS-ChIP to map Mre11 cleavage sites in the human genome, New chemical biology approaches to trap reaction intermediates in living cells, Single-molecule imaging approaches for monitoring replication fork conflicts at genomic DNA G4 structures and R-loops in human cells, Monitoring the replication of structured DNA through heritable epigenetic change, Visualizing replication fork encounters with DNA interstrand crosslinks, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology series Includes the latest information on replication-coupled repair

DNA Replication

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Publisher :
ISBN 13 : 9789811069567
Total Pages : 581 pages
Book Rating : 4.0/5 (695 download)

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Book Synopsis DNA Replication by : Hisao Masai

Download or read book DNA Replication written by Hisao Masai and published by . This book was released on 2017 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Concepts in Eukaryotic DNA Replication

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Publisher :
ISBN 13 : 9780879695576
Total Pages : 0 pages
Book Rating : 4.6/5 (955 download)

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Book Synopsis Concepts in Eukaryotic DNA Replication by : Melvin L. DePamphilis

Download or read book Concepts in Eukaryotic DNA Replication written by Melvin L. DePamphilis and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: National Institutes of Health, Bethesda, MD. Abridged version of the first fourteen chapters of the monograph: DNA Replication in Eukaryotic Cells, c1996, by DePamphilis. Recent advances are summarized in a new chapter: DNA Replication in Eukaryotic Cells: 1996 to 1998. For students and researchers. Softcover.

Eukaryotic DNA Replication

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Publisher : Oxford University Press
ISBN 13 : 9780199635856
Total Pages : 232 pages
Book Rating : 4.6/5 (358 download)

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Book Synopsis Eukaryotic DNA Replication by : J. Julian Blow

Download or read book Eukaryotic DNA Replication written by J. Julian Blow and published by Oxford University Press. This book was released on 1996 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA replication is an area of intense research effort which has recently yielded fascinating new insights into the phenomenon. In this book, leading researchers review this rapidly advancing field. The book begins with reviews of the molecular and genetic components of the replication machinery, and builds into a detailed picture of how the replication process is regulated within the cell cycle. Topics include the initiation of replication, origin recognition, the enzymology of the replication fork, the use of SV40 to identify key components of the replication machinery, and how replication is co-ordinated with other cell cycle events in Xenopus cell-free extracts and in budding and fission yeasts. Eukaryotic DNA Replication is a unique and very timely description of the latest research findings in this key subject area. It is essential reading for all researchers and advanced undergraduates interested in the topic.

Eukaryotic Nucleus

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Publisher : CRC Press
ISBN 13 : 9780936923390
Total Pages : 446 pages
Book Rating : 4.9/5 (233 download)

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Book Synopsis Eukaryotic Nucleus by : Samuel H. Wilson

Download or read book Eukaryotic Nucleus written by Samuel H. Wilson and published by CRC Press. This book was released on 1990-08-31 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Eukaryotic Nucleus

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Publisher : CRC Press
ISBN 13 : 9780936923321
Total Pages : 446 pages
Book Rating : 4.9/5 (233 download)

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Book Synopsis The Eukaryotic Nucleus by : Samuel H. Wilson

Download or read book The Eukaryotic Nucleus written by Samuel H. Wilson and published by CRC Press. This book was released on 1990-08-09 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series provides, in two volumes, a complete and exhaustive review of the subject of the eukaryotic nucleus, the site of the DNA. The focus of the book is how the information in the DNA is transcribed, accessed and maintained.

Concepts of Biology

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Publisher :
ISBN 13 : 9789888407453
Total Pages : 618 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Concepts of Biology by : Samantha Fowler

Download or read book Concepts of Biology written by Samantha Fowler and published by . This book was released on 2018-01-07 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.

The Initiation of DNA Replication in Eukaryotes

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Publisher :
ISBN 13 : 9783319246956
Total Pages : pages
Book Rating : 4.2/5 (469 download)

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Book Synopsis The Initiation of DNA Replication in Eukaryotes by : Daniel L. Kaplan

Download or read book The Initiation of DNA Replication in Eukaryotes written by Daniel L. Kaplan and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

Microbiology

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Publisher :
ISBN 13 : 9781938168147
Total Pages : 1301 pages
Book Rating : 4.1/5 (681 download)

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Book Synopsis Microbiology by : Nina Parker

Download or read book Microbiology written by Nina Parker and published by . This book was released on 2016-05-30 with total page 1301 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology's art program enhances students' understanding of concepts through clear and effective illustrations, diagrams, and photographs. Microbiology is produced through a collaborative publishing agreement between OpenStax and the American Society for Microbiology Press. The book aligns with the curriculum guidelines of the American Society for Microbiology."--BC Campus website.

National Library of Medicine Current Catalog

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Publisher :
ISBN 13 :
Total Pages : 1456 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1983 with total page 1456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Systems Biology of Cancer

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Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.5/5 (214 download)

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Book Synopsis Systems Biology of Cancer by : Sam Thiagalingam

Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Biodata Mining And Visualization: Novel Approaches

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Publisher : World Scientific Publishing Company
ISBN 13 : 9813107081
Total Pages : 324 pages
Book Rating : 4.8/5 (131 download)

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Book Synopsis Biodata Mining And Visualization: Novel Approaches by : Havukkala Ilkka

Download or read book Biodata Mining And Visualization: Novel Approaches written by Havukkala Ilkka and published by World Scientific Publishing Company. This book was released on 2010-06-23 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a lack of an exposition on interdisciplinary and innovative methods of data mining and visualization for biodata. This book fills the gap by introducing an interdisciplinary set of the most recent methods and references on novel techniques from artificial intelligence, data mining, engineering, pattern recognition, and ontological data mining fields that are applicable to bioinformatics. The latest novel approaches are explained in detail, their advantages and disadvantages are summarized, and pointers to the future development of new applications are given. By widening the pool from which biologists and bioinformaticians can adopt methods for biodata mining and visualization, computational data mining experts in nonbiological fields are also encouraged to utilize their expertise in order to contribute to the progress of computational biology, thus enhancing the collaboration between these two disciplines.

Enzymes of Nucleic Acid Synthesis and Modification

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Publisher : CRC Press
ISBN 13 : 1351088750
Total Pages : 441 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Enzymes of Nucleic Acid Synthesis and Modification by : Samson T. Jacob

Download or read book Enzymes of Nucleic Acid Synthesis and Modification written by Samson T. Jacob and published by CRC Press. This book was released on 2018-01-18 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: The First volume gives an overview of the enzymes involved in DNA synthesis and modification; the second volume deals with the RNA-enzymes. Although the major emphasis of the book is on eukaryotic enzymes, a separate chapter dealing with prokaryotic DNA repair enzymes has been included to discuss the major advances in this field in recent years. There are two separate chapters on RNA polymerases to provide a comprehensive coverage of the enzymes from lower eukaryotes, plants and higher eukaryotes.