Molecular And Cellular Biology Of Diabetes Mellitus Insulin Secretion

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Molecular Biology of Diabetes

Author : Boris Draznin
Publisher : Springer Science & Business Media
ISBN 13 : 1461202418
Total Pages : 411 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Molecular Biology of Diabetes by : Boris Draznin

Download or read book Molecular Biology of Diabetes written by Boris Draznin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a rapidly evolving and extremely important area of medical science, it is often difficult for the student, teacher, and researcher to keep abreast of all the important advances. The purpose of Molecular Biology ofDiabetes, Parts I and II is to bring to these individuals the latest knowledge of diabetes-related research in a comprehensive, yet concise manner. To this end, we have assembled chapters, written by most of the world's experts in the field, that we believe compre hensively survey and synthesize a coherent understanding of the subject. Studies of the etiology of type I and type II diabetes are extremely exciting and essential, since we hope to one day prevent the disease using gene therapy. These aspects are covered in Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion. In type II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. This abnor mality of insulin secretion is believed to be related to a defect(s) in glucose sensing. Uncoupling of glucose sensing from insulin secre tion may be the crucial step in the pathogenesis of noninsulin-depen dent diabetes. In this volume, we have invited authors to describe their studies on all known factors affecting ~-cell function, including autoimmunity and genetics of diabetes, as well as molecular mecha nisms of insulin synthesis and secretion. In the last few years, the most rapidly advancing area of research in diabetes has been, in fact, related to insulin action.

Diabetes Mellitus in Children

Author : Mark A. Sperling
Publisher :
ISBN 13 : 9781416027539
Total Pages : 0 pages
Book Rating : 4.0/5 (275 download)

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Book Synopsis Diabetes Mellitus in Children by : Mark A. Sperling

Download or read book Diabetes Mellitus in Children written by Mark A. Sperling and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pancreatic Beta Cell in Health and Disease

Author : Susumu Seino
Publisher : Springer Science & Business Media
ISBN 13 : 4431754520
Total Pages : 475 pages
Book Rating : 4.4/5 (317 download)

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Book Synopsis Pancreatic Beta Cell in Health and Disease by : Susumu Seino

Download or read book Pancreatic Beta Cell in Health and Disease written by Susumu Seino and published by Springer Science & Business Media. This book was released on 2008-04-08 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.

The Pancreatic Beta Cell

Author :
Publisher : Academic Press
ISBN 13 : 0128004401
Total Pages : 517 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Pancreatic Beta Cell by :

Download or read book The Pancreatic Beta Cell written by and published by Academic Press. This book was released on 2014-02-20 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on the pancreatic beta cell. - Expertise of the contributors - Coverage of a vast array of subjects - In depth current information at the molecular to the clinical levels - Three-dimensional structures in color - Elaborate signaling pathways

International Textbook of Diabetes Mellitus

Author : R. A. DeFronzo
Publisher : John Wiley & Sons
ISBN 13 : 1118387678
Total Pages : 1200 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis International Textbook of Diabetes Mellitus by : R. A. DeFronzo

Download or read book International Textbook of Diabetes Mellitus written by R. A. DeFronzo and published by John Wiley & Sons. This book was released on 2015-03-11 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.

Molecular and Cellular Biology of Diabetes Mellitus: Insulin secretion

Author : Boris Draznin
Publisher :
ISBN 13 : 9780845142578
Total Pages : 198 pages
Book Rating : 4.1/5 (425 download)

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Book Synopsis Molecular and Cellular Biology of Diabetes Mellitus: Insulin secretion by : Boris Draznin

Download or read book Molecular and Cellular Biology of Diabetes Mellitus: Insulin secretion written by Boris Draznin and published by . This book was released on 1989 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology of Diabetes, Part II

Author : Boris Draznin
Publisher : Humana
ISBN 13 : 9780896032873
Total Pages : 556 pages
Book Rating : 4.0/5 (328 download)

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Book Synopsis Molecular Biology of Diabetes, Part II by : Boris Draznin

Download or read book Molecular Biology of Diabetes, Part II written by Boris Draznin and published by Humana. This book was released on 1994-11-16 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: These comprehensive yet concise collections of articles by world experts survey the latest findings on the molecular biology of diabetes and insulin action and synthesize a coherent understanding of the subject. Topics include the etiology of type I and type II diabetes, molecular and cellular aspects of insulin action, and the mechanism of the insulin-stimulated glucose uptake.

The Genetic Landscape of Diabetes

Author : Laura Dean
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (55 download)

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Book Synopsis The Genetic Landscape of Diabetes by : Laura Dean

Download or read book The Genetic Landscape of Diabetes written by Laura Dean and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Insulin-like Growth Factors

Author : Derek LeRoith
Publisher : CRC Press
ISBN 13 : 9780849357121
Total Pages : 328 pages
Book Rating : 4.3/5 (571 download)

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Book Synopsis Insulin-like Growth Factors by : Derek LeRoith

Download or read book Insulin-like Growth Factors written by Derek LeRoith and published by CRC Press. This book was released on 1991-05-28 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.

The Heterogeneity of Cancer Metabolism

Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Handbook of Diabetes

Author : Rudy Bilous
Publisher : John Wiley & Sons
ISBN 13 : 1118975979
Total Pages : 322 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Handbook of Diabetes by : Rudy Bilous

Download or read book Handbook of Diabetes written by Rudy Bilous and published by John Wiley & Sons. This book was released on 2021-04-29 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: HANDBOOK OF DIABETES The Handbook of Diabetes provides concise and efficient coverage of the diagnosis, epidemiology, and management of diabetes and its complications. Containing hundreds of attractive colour diagrams, illustrations, and clinical photographs, this popular quick-reference guide focuses on the management and measurement of diabetes mellitus with highly visual references. Now in its fifth edition, this market-leading book aligns with the most recent guidelines from the American Diabetes Association (ADA), the European Association for the Study of Diabetes (EASD), Diabetes UK, and the National Institute for Health and Care Excellence (NICE), presenting authoritative clinical coverage of diabetes in an accessible format with rich pedagogical features. Five new chapters provide detailed coverage of liver disease, diabetes education, bariatric surgery, diabetes and cancer, and the use of incretin-based therapies and SGLT2 Inhibitors in the management of Type II diabetes Updated and expanded topics include the relation between hypoglycaemia and dementia, anxiety and depression, the NICE Quality and Outcomes Framework (QOF), and the impacts of diabetes to self-care, mental health, and decision-making Provides a wealth of pedagogical features such as vignettes and case histories, important learning points, summaries of key clinical trials, and links to further readings Handbook of Diabetes, remains the essential practical companion for all health professionals involved in managing patients with diabetes, and an up-to-date reference for diabetes and endocrinology researchers, scientists, and academics.

Mechanisms of Insulin Action

Author : Alan R. Saltiel
Publisher : Springer Science & Business Media
ISBN 13 : 0387722041
Total Pages : 223 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Mechanisms of Insulin Action by : Alan R. Saltiel

Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Cellular Transplantation

Author : Craig Halberstadt
Publisher : Elsevier
ISBN 13 : 0080469043
Total Pages : 699 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Cellular Transplantation by : Craig Halberstadt

Download or read book Cellular Transplantation written by Craig Halberstadt and published by Elsevier. This book was released on 2011-10-10 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. - Provides detailed description of clinical trials in cell transplantation - Review of current therapeutic approaches - Coverage of the broad range of diseases addressed by cell therapeutics - Discussion of stem cell biology and its role in transplantation

Glucose Sensing

Author : Chris D. Geddes
Publisher : Springer Science & Business Media
ISBN 13 : 0387330151
Total Pages : 460 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Glucose Sensing by : Chris D. Geddes

Download or read book Glucose Sensing written by Chris D. Geddes and published by Springer Science & Business Media. This book was released on 2007-12-29 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential reference for any laboratory working in the analytical fluorescence glucose sensing field. The increasing importance of these techniques is typified in one emerging area by developing non-invasive and continuous approaches for physiological glucose monitoring. This volume incorporates analytical fluorescence-based glucose sensing reviews, specialized enough to be attractive to professional researchers, yet appealing to a wider audience of scientists in related disciplines of fluorescence.

Ultimate Guide to Insulin

Author : Gaffar Zaman
Publisher :
ISBN 13 : 1789849217
Total Pages : 132 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Ultimate Guide to Insulin by : Gaffar Zaman

Download or read book Ultimate Guide to Insulin written by Gaffar Zaman and published by . This book was released on 2019-02-06 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents a qualitative and quantitative approach to understand, manage and enforce the integration of insulin into diabetes mellitus. Utilizing a sound theoretical and practical foundation and illustrating procedural techniques through scientific examples, the book bridges the gap between insulin and diabetes mellitus management. Detailed procedures have been omitted because of the variety of equipment and commercial kits used in today's clinical laboratories.

Molecular Basis of Pancreas Development and Function

Author : Joel F. Habener
Publisher : Springer Science & Business Media
ISBN 13 : 1461516692
Total Pages : 413 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Molecular Basis of Pancreas Development and Function by : Joel F. Habener

Download or read book Molecular Basis of Pancreas Development and Function written by Joel F. Habener and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes mellitus is rapidly increasing in prevalence throughout both developed and developing countries. The social and economic burden of this disease is estimated to cost 14 billion dollars worldwide. In the USA alone, 15 million individuals are diabetic, nearly half of them unaware of their condition. Complications of diabetes mellitus are the leading causes for blindness, limb amputation and chronic renal failure and kidney transplantation in industrialized countries. Further, diabetes mellitus per se and the metabolic derangement associated with diabetes are important risk factors for cardiovascular disease. Diabetes, as defined by an elevated fasting blood glucose level is presently subdivided in etiologically distinct groups. The most prevalent being type 2 (adult onset) diabetes characterized by insulin resistance and failure of the ~-cell to supply insulin in amounts sufficient to meet the body's needs. Type 1 (juvenile) diabetes, most commonly with an onset during childhood and adolescence, is caused by an auto-immune destruction of the pancreatic ~-cells. The causations of both type 1 and type 2 diabetes involve a combination of complex genetic traits and environmental influences. A third category are the mature onset diabetes of the young (MODY). This comparatively small group of patients (-10% of diabetes) presents relative early in life «30 years of age) compared to the more common late onset type 2 diabetes.