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Author : Steven A. Cryer
Publisher :
ISBN 13 :
Total Pages : 40 pages
Book Rating : 4.:/5 (415 download)
Download or read book Modeling Agglomeration Processes in Fluid Bed Granulation written by Steven A. Cryer and published by . This book was released on 1998 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lennart Fries
Publisher : Cuvillier Verlag
ISBN 13 : 3736942451
Total Pages : 222 pages
Book Rating : 4.7/5 (369 download)
Download or read book Discrete particle modeling of a fluidized bed granulator written by Lennart Fries and published by Cuvillier Verlag. This book was released on 2012-10-29 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Size-enlargement and structuration processes in fluidized beds such as granulation and agglomeration play an important role in the pharmaceutical and fine chemical industries as well as in food technology to improve the flowability and the instant properties of solid products. Dustfree and free-flowing particles can be produced in a process with favourable heat- and mass transfer conditions. Furthermore, this technology allows the formulation of particles with novel functionalities by applying coating layers or via the encapsulation of active ingredients. Several interdependent micro mechanisms including particle collisions, wetting, drying and phase transitions govern the process dynamics and complicate predictions on the effect of variable operating conditions on product properties such as structure, strength and re-dissolution behaviour. Profound knowledge on these mechanisms is needed to understand the influence of individual process parameters on the final product properties. A suitable approach to model the particle interactions in fluidized beds is the Discrete Element Method (DEM) coupled with Computational Fluid Dynamics (CFD). Information on gas and particle velocities, particle rotation and collision dynamics, which are very complicated to measure in fluidized beds, can be studied in detail with this technique. This thesis presents DEM-CFD simulation results for three different granulator configurations (top-spray, Wurster-coater, spouted bed) in comparison to experimental results, regarding the agglomeration of amorphous maltodextrin (DE 21). In simulation and experiment the identical geometry of the equipment was used. Mechanical material properties, such as the coefficient of restitution and the Young’s modulus, which are required for the DEM model and which are frequently used as fitting parameters, were measured via static and dynamic deformation tests using maltodextrin agglomerates, beads and bars. The strength of the experimentally produced agglomerates was characterized with a compression tester. Their flow behaviour was assessed with the help of a shear cell. Very promising results were obtained showing that the homogeneity of particle wetting can well be approximated with the residence time distribution of the particles inside the spray zone.Homogeneous wetting allows achieving a narrow product size distribution (Fries et al., 2011a).Furthermore, the growth rate of the agglomerates can well be correlated with the simulated wetting intensity, the collision frequency and the collision velocity distribution inside the spray zone. The agglomerate strength shows a strong correlation with the particle-wall collision frequency and velocity distribution found in the simulations. Good agreement was found between the simulation results for the maximum particle deformation and for the energy dissipation during collisions and the measured deformation at the breakage point and the breakage energy. Due to the high numerical effort, DEM is only suitable for small scale applications. However, the obtained information on the kinetics of particle-particle interactions can be applied as input for macroscopic process models in the framework of a multi scale modeling scheme (Fries et al., 2011b; Werther et al., 2011). It can be concluded that DEM is a powerful tool for the detailed characterization of fluidized bed granulators. Highly relevant practical answers can be obtained from the model such as the choice of the optimal equipment geometry depending on material properties and product requirements. The model can point out where to position the spray nozzles in order to achieve homogeneous particle wetting and if a draft tube is helpful to maintain stable particle circulation. Based on such findings the model shows potential to increase the throughput of a fluidized bed granulator, while avoiding a bed collapse.
Author : Agba D. Salman
Publisher : Elsevier
ISBN 13 : 0080467881
Total Pages : 1403 pages
Book Rating : 4.0/5 (84 download)
Download or read book Granulation written by Agba D. Salman and published by Elsevier. This book was released on 2006-11-24 with total page 1403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Granulation provides a complete and comprehensive introduction on the state-of-the-art of granulation and how it can be applied both in an academic context and from an industrial perspective. Coupling science and engineering practices it covers differing length scales from the sub-granule level through behaviour through single granules, to bulk granule behaviour and equipment design. With special focus on a wide range of industrially relevant areas from fertilizer production, through to pharmaceuticals. Experimental data is complemented by mathematical modelling in this emerging field, allowing for a greater understanding of the basis of particle products and this important industry sector.Four themes run through the book: 1. The Macro Scale processing for Granulation – including up to date descriptions of the methods used for granulation and how they come about and how to monitor – on-line these changes.2. The Applications of granulation from an industrial perspective, with current descriptive roles and how they are undertaken with relevance to industry, and effective properties.3. Mechanistic descriptions of granulation and the different rate processes occurring within the granulator. This includes methods of modelling the process using Population – Balance Equations, and Multi-level Computational Fluid Dynamics Models.4. The Micro Scale: Granules and Smaller, looking at single granules and there interactions and modelling, while also considering the structure of granules and their constituent liquid bridges.* Covers a wide range of subjects and industrial applications* Provides an understanding of current issues for industrial and academic environments* Allows the reader an understanding of the science behind engineered granulation processes
Author : Dilip M. Parikh
Publisher : CRC Press
ISBN 13 : 1000366383
Total Pages : 905 pages
Book Rating : 4.0/5 (3 download)
Download or read book Handbook of Pharmaceutical Granulation Technology written by Dilip M. Parikh and published by CRC Press. This book was released on 2021-05-11 with total page 905 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theoretical discussions covering granulation and engineering perspectives. Covers new advances in expert systems, process modelling and bioavailability Chapters on emerging technologies in particle engineering Updated Current research and developments in granulation technologies
Author : César de Prada
Publisher : MDPI
ISBN 13 : 3039214551
Total Pages : 298 pages
Book Rating : 4.0/5 (392 download)
Download or read book Process Modelling and Simulation written by César de Prada and published by MDPI. This book was released on 2019-09-23 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since process models are nowadays ubiquitous in many applications, the challenges and alternatives related to their development, validation, and efficient use have become more apparent. In addition, the massive amounts of both offline and online data available today open the door for new applications and solutions. However, transforming data into useful models and information in the context of the process industry or of bio-systems requires specific approaches and considerations such as new modelling methodologies incorporating the complex, stochastic, hybrid and distributed nature of many processes in particular. The same can be said about the tools and software environments used to describe, code, and solve such models for their further exploitation. Going well beyond mere simulation tools, these advanced tools offer a software suite built around the models, facilitating tasks such as experiment design, parameter estimation, model initialization, validation, analysis, size reduction, discretization, optimization, distributed computation, co-simulation, etc. This Special Issue collects novel developments in these topics in order to address the challenges brought by the use of models in their different facets, and to reflect state of the art developments in methods, tools and industrial applications.
Author : Ravendra Singh
Publisher : Elsevier
ISBN 13 : 0444639667
Total Pages : 700 pages
Book Rating : 4.4/5 (446 download)
Download or read book Process Systems Engineering for Pharmaceutical Manufacturing written by Ravendra Singh and published by Elsevier. This book was released on 2018-03-16 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: Process Systems Engineering for Pharmaceutical Manufacturing: From Product Design to Enterprise-Wide Decisions, Volume 41, covers the following process systems engineering methods and tools for the modernization of the pharmaceutical industry: computer-aided pharmaceutical product design and pharmaceutical production processes design/synthesis; modeling and simulation of the pharmaceutical processing unit operation, integrated flowsheets and applications for design, analysis, risk assessment, sensitivity analysis, optimization, design space identification and control system design; optimal operation, control and monitoring of pharmaceutical production processes; enterprise-wide optimization and supply chain management for pharmaceutical manufacturing processes. Currently, pharmaceutical companies are going through a paradigm shift, from traditional manufacturing mode to modernized mode, built on cutting edge technology and computer-aided methods and tools. Such shifts can benefit tremendously from the application of methods and tools of process systems engineering. - Introduces Process System Engineering (PSE) methods and tools for discovering, developing and deploying greener, safer, cost-effective and efficient pharmaceutical production processes - Includes a wide spectrum of case studies where different PSE tools and methods are used to improve various pharmaceutical production processes with distinct final products - Examines the future benefits and challenges for applying PSE methods and tools to pharmaceutical manufacturing
Author : Jim Litster
Publisher : Springer Science & Business Media
ISBN 13 : 9401705461
Total Pages : 258 pages
Book Rating : 4.4/5 (17 download)
Download or read book The Science and Engineering of Granulation Processes written by Jim Litster and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book had its origins in a meeting between two (relatively) young particle technology researchers on Rehobeth Beach in Delaware in 1992 near the holiday house of Reg Davies (then Director of the Particle Science and Technology Research Center in Dupont). As we played in the sand, we shared an excitement for developments in particle technology, especially particle characterization, that would lead operations such as granulation to be placed on a sound scientific and engineering footing. The immediate outcome from this interaction was the development of new industry short courses in granulation and related topics which we taught together both in Australia and North America. This book follows closely the structure and approaches developed in these courses, particularly the emphasis on particle design in granulation, where the impact of both formulation properties and process variables on product attributes needs to be understood and quantified. The book has been a long time in the making. We have been actively preparing the book for at least five years. Although the chapters have relatively good bibliographies, this book is not a review of the field. Rather it is an attempt by the authors to present a comprehensive engineering approach to granulator design, scale up and operation. It is exciting for us to see the explosion of research interest around the world in this area in the last five to seven years. Some of the most recent work will have to find its way into the second edition.
Author : Renata Koerfer
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (955 download)
Download or read book Mathematical Modeling and Fuzzy Control of a Fluidized Bed Agglomeration Process written by Renata Koerfer and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : P. J. Cullen
Publisher : John Wiley & Sons
ISBN 13 : 0470710551
Total Pages : 508 pages
Book Rating : 4.4/5 (77 download)
Download or read book Pharmaceutical Blending and Mixing written by P. J. Cullen and published by John Wiley & Sons. This book was released on 2015-07-20 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in four parts, this book provides a dedicated and in-depth reference for blending within the pharmaceutical manufacturing industry. It links the science of blending with regulatory requirements associated with pharmaceutical manufacture. The contributors are a combination of leading academic and industrial experts, who provide an informed and industrially relevant perspective of the topic. This is an essential book for the pharmaceutical manufacturing industry, and related academic researchers in pharmaceutical science and chemical and mechanical engineering.
Author :
Publisher : Bookboon
ISBN 13 : 8776811808
Total Pages : 58 pages
Book Rating : 4.7/5 (768 download)
Download or read book Modelling Batch Systems Using Population Balances written by and published by Bookboon. This book was released on with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A. Rehmat
Publisher :
ISBN 13 :
Total Pages : 12 pages
Book Rating : 4.:/5 (183 download)
Download or read book Modeling of Agglomeration in a Fluidized Bed written by A. Rehmat and published by . This book was released on 1988 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : George Kyzas
Publisher : BoD – Books on Demand
ISBN 13 : 1789843073
Total Pages : 96 pages
Book Rating : 4.7/5 (898 download)
Download or read book Granularity in Materials Science written by George Kyzas and published by BoD – Books on Demand. This book was released on 2018-10-24 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Granular materials are a special topic of recent research and are a milestone of science and technology. These materials are very simple: they are large conglomerations of discrete macroscopic particles. Granular materials have a broad area of development, which is growing rapidly day by day. Their impact on commercial applications and academia and education is huge. The basic points of this book are the important applications and properties of granular materials. For example, special mention is made of rheological points, shapes, and civil engineering aspects.
Author : John G. Yates
Publisher : Springer
ISBN 13 : 3319395939
Total Pages : 214 pages
Book Rating : 4.3/5 (193 download)
Download or read book Fluidized-Bed Reactors: Processes and Operating Conditions written by John G. Yates and published by Springer. This book was released on 2016-09-27 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fluidized-bed reactor is the centerpiece of industrial fluidization processes. This book focuses on the design and operation of fluidized beds in many different industrial processes, emphasizing the rationale for choosing fluidized beds for each particular process. The book starts with a brief history of fluidization from its inception in the 1940’s. The authors present both the fluid dynamics of gas-solid fluidized beds and the extensive experimental studies of operating systems and they set them in the context of operating processes that use fluid-bed reactors. Chemical engineering students and postdocs as well as practicing engineers will find great interest in this book.
Author : Herold G. Dehling
Publisher : Elsevier
ISBN 13 : 0080548970
Total Pages : 291 pages
Book Rating : 4.0/5 (85 download)
Download or read book Stochastic Modelling in Process Technology written by Herold G. Dehling and published by Elsevier. This book was released on 2007-07-03 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an ever increasing need for modelling complex processes reliably. Computational modelling techniques, such as CFD and MD may be used as tools to study specific systems, but their emergence has not decreased the need for generic, analytical process models. Multiphase and multicomponent systems, and high-intensity processes displaying a highly complex behaviour are becoming omnipresent in the processing industry. This book discusses an elegant, but little-known technique for formulating process models in process technology: stochastic process modelling. The technique is based on computing the probability distribution for a single particle's position in the process vessel, and/or the particle's properties, as a function of time, rather than - as is traditionally done - basing the model on the formulation and solution of differential conservation equations. Using this technique can greatly simplify the formulation of a model, and even make modelling possible for processes so complex that the traditional method is impracticable. Stochastic modelling has sporadically been used in various branches of process technology under various names and guises. This book gives, as the first, an overview of this work, and shows how these techniques are similar in nature, and make use of the same basic mathematical tools and techniques. The book also demonstrates how stochastic modelling may be implemented by describing example cases, and shows how a stochastic model may be formulated for a case, which cannot be described by formulating and solving differential balance equations. - Introduction to stochastic process modelling as an alternative modelling technique - Shows how stochastic modelling may be succesful where the traditional technique fails - Overview of stochastic modelling in process technology in the research literature - Illustration of the principle by a wide range of practical examples - In-depth and self-contained discussions - Points the way to both mathematical and technological research in a new, rewarding field
Author : Jim Litster
Publisher : Cambridge University Press
ISBN 13 : 1107007372
Total Pages : 343 pages
Book Rating : 4.1/5 (7 download)
Download or read book Design and Processing of Particulate Products written by Jim Litster and published by Cambridge University Press. This book was released on 2016-10-20 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique text providing comprehensive coverage of fundamental particle science, processing and technology. Including quantitative tools, real-world case studies and end-of-chapter problems, it is ideal for students in engineering and applied sciences, as well as for practitioners in a range of industries manufacturing particulate products.
Author : Wen-Ching Yang
Publisher : CRC Press
ISBN 13 : 0824748360
Total Pages : 873 pages
Book Rating : 4.8/5 (247 download)
Download or read book Handbook of Fluidization and Fluid-Particle Systems written by Wen-Ching Yang and published by CRC Press. This book was released on 2003-03-19 with total page 873 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference details particle characterization, dynamics, manufacturing, handling, and processing for the employment of multiphase reactors, as well as procedures in reactor scale-up and design for applications in the chemical, mineral, petroleum, power, cement and pharmaceuticals industries. The authors discuss flow through fixed beds, elutriation and entrainment, gas distributor and plenum design in fluidized beds, effect of internal tubes and baffles, general approaches to reactor design, applications for gasifiers and combustors, dilute phase pneumatic conveying, and applications for chemical production and processing. This is a valuable guide for chemists and engineers to use in their day-to-day work.
Author : Peter G. Smith
Publisher : John Wiley & Sons
ISBN 13 : 0470995416
Total Pages : 264 pages
Book Rating : 4.4/5 (79 download)
Download or read book Applications of Fluidization to Food Processing written by Peter G. Smith and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluidization is a technique that enables solid particles to take on some of the properties of a fluid. Despite being very widely used within the food processing industry, understanding of this important technique is often limited. Applications of Fluidization to Food Processing sets out the established theory of fluidization and relates this to food processing applications, particularly in: • Drying • Freezing • Mixing • Granulation • Fermentation This important and thorough book, written by Peter Smith, who has many years’ experience teaching and researching in food processing, is an essential tool and reference for food scientists and technologists, and engineers working within the food industry. Libraries, and research and development groups within all universities and research establishments where food science, food studies, food technology, physics and engineering are studied and taught should have copies of this useful book.
