Mitochondria As Targets For Phytochemicals In Cancer Prevention And Therapy

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Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy

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Author : Dhyan Chandra
Publisher : Springer Science & Business Media
ISBN 13 : 1461493269
Total Pages : 260 pages
Book Rating : 4.4/5 (614 download)

Book Synopsis Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy by : Dhyan Chandra

Download or read book Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy written by Dhyan Chandra and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the importance of phytochemicals and mitochondria in cancer prevention and therapy. Recent scientific discoveries have identified that naturally occurring biologically active compounds (i.e. phytochemicals) target multiple steps of tumorigenesis leading to the inhibition or delay in cancer progression. Mitochondria, organelles within a cell, are a critical target for phytochemicals in regulating the initiation, promotion, and progression of cancer. The book is divided into three parts to better communicate the important findings related to phytochemicals and mitochondria in cancer research. The first part describes updates on environmental and genetic factors causing cancer initiation and progression, the role of mitochondria function in regulating the process of tumorigenesis, and the role of mitochondria in regulating cell death such as apoptosis, autophagy, and necroptosis. The second part focuses on the elucidation of key target proteins that could be exploited for cancer prevention, an the role of phytochemicals in cancer prevention, updates on basic research related to phytochemicals action critical for cancer prevention, and updates on translational knowledge on cancer prevention by phytochemicals. The third part provides updates on phytochemicals targeting mitochondria for cancer therapy, an overview of action of phytochemicals on cancer stem cells, updates on the role of microRNA in phytochemicals-based therapy of cancer, and updates on phytochemicals-based translation research on therapy for metastatic cancer.

Mitochondria: The Anti- cancer Target for the Third Millennium

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Author : Jiri Neuzil
Publisher : Springer
ISBN 13 : 9401789843
Total Pages : 382 pages
Book Rating : 4.4/5 (17 download)

Book Synopsis Mitochondria: The Anti- cancer Target for the Third Millennium by : Jiri Neuzil

Download or read book Mitochondria: The Anti- cancer Target for the Third Millennium written by Jiri Neuzil and published by Springer. This book was released on 2014-05-26 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will be focused on mitochondria as very promising targets for anti-cancer drugs, yet to be fully exploited. It will contain chapters focused on aspects of basic research as well as on clinical relevance, which will be written by specialists in the field. That the role of mitochondria in human pathologies goes beyond the neoplastic diseases will be documented by a chapter of the role of mitochondria in Friedreich's ataxia.

Phytochemicals

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Author : Venketeshwer Rao
Publisher : BoD – Books on Demand
ISBN 13 : 9535121707
Total Pages : 351 pages
Book Rating : 4.5/5 (351 download)

Book Synopsis Phytochemicals by : Venketeshwer Rao

Download or read book Phytochemicals written by Venketeshwer Rao and published by BoD – Books on Demand. This book was released on 2015-09-30 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global dietary recommendations emphasize the consumption of plant-based foods for the prevention and management of chronic diseases. Plants contain many biologically active compounds referred to as phytochemicals or functional ingredients. These compounds play an important role in human health. Prior to establishing the safety and health benefits of these compounds, they must first be isolated, purified, and their physico-chemical properties established. Once identified, their mechanisms of actions are studied. The chapters are arranged in the order from isolation, purification and identification to in vivo and clinical studies, there by covering not only the analytical procedures used but also their nutraceutical and therapeutic properties.

Dietary Phytochemicals in Cancer Prevention and Treatment

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Author : American Institute for Cancer Research
Publisher : Springer Science & Business Media
ISBN 13 : 1461303990
Total Pages : 349 pages
Book Rating : 4.4/5 (613 download)

Book Synopsis Dietary Phytochemicals in Cancer Prevention and Treatment by : American Institute for Cancer Research

Download or read book Dietary Phytochemicals in Cancer Prevention and Treatment written by American Institute for Cancer Research and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sixth annual research conference of the American Institute for Cancer Research was held August 31 and September 1, 1995, at the Loews L'Enfant Plaza Hotel in Washing ton, DC. In view of the promising leads in the diet/nutrition and cancer research field, the conference was devoted to "Dietary Phytochemicals in Cancer Prevention and Treatment. " The number of sessions was increased over that in previous conferences in order to accommodate the topics of interest. The conference overview, entitled "Plants and Cancer: Food, Fiber, and Phytochemicals," provided a framework for the following sessions. In addition, the attendees were reminded that for several decades epidemiologists have noted a lower risk of lung, esophageal, stomach, and colon cancer in populations consuming diets high in fruits and vegetables. However, isolation and ingestion of individual protective factors are not the preferred action since the complexity of the food and the matrix in which nutritional factors are embedded are important. The individual sessions then provided more insight as to why eating fruits and vegetables is associated with a lower risk of cancer. The first of these sessions was on "Isothiocyanates" that induce both the Phase I and Phase II enzymes that increase detoxification and conjugation reactions, thus causing more rapid removal of any xenobiotic or carcinogen. Thus, less carcinogen is available for interaction with DNA or other critical cellular macromolecules.

Chemoprevention of Cancer

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Author : Daniel W. Nixon
Publisher : CRC Press
ISBN 13 : 9780849368509
Total Pages : 160 pages
Book Rating : 4.3/5 (685 download)

Book Synopsis Chemoprevention of Cancer by : Daniel W. Nixon

Download or read book Chemoprevention of Cancer written by Daniel W. Nixon and published by CRC Press. This book was released on 1994-11-08 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemoprevention of Cancer guides you through the exciting new field of cancer chemoprevention. It covers epidemiology, known chemopreventive compounds, development of new chemopreventive agents, specific examples of preventive agents and their mechanisms of action, and current prevention clinical trials.

Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Author : Sajal Chakraborti
Publisher : Springer Nature
ISBN 13 : 9811654220
Total Pages : 4078 pages
Book Rating : 4.8/5 (116 download)

Book Synopsis Handbook of Oxidative Stress in Cancer: Therapeutic Aspects by : Sajal Chakraborti

Download or read book Handbook of Oxidative Stress in Cancer: Therapeutic Aspects written by Sajal Chakraborti and published by Springer Nature. This book was released on 2022-09-28 with total page 4078 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.

Life Over Cancer

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Author : Keith Block
Publisher : Bantam
ISBN 13 : 0553801147
Total Pages : 610 pages
Book Rating : 4.5/5 (538 download)

Book Synopsis Life Over Cancer by : Keith Block

Download or read book Life Over Cancer written by Keith Block and published by Bantam. This book was released on 2009-04-21 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Keith Block is at the global vanguard of innovative cancer care. As medical director of the Block Center for Integrative Cancer Treatment in Evanston, Illinois, he has treated thousands of patients who have lived long, full lives beyond their original prognoses. Now he has distilled almost thirty years of experience into the first book that gives patients a systematic, research-based plan for developing the physical and emotional vitality they need to meet the demands of treatment and recovery. Based on a profound understanding of how body and mind can work together to defeat disease, this groundbreaking book offers: • Innovative approaches to conventional treatments, such as “chronotherapy”–chemotherapy timed to patients’ unique circadian rhythms for enhanced effectiveness and reduced toxicity • Dietary choices that make the biochemical environment hostile to cancer growth and recurrence, and strengthen the immune system’s ability to attack remaining cancer cells • Precise supplement protocols to tame treatment side effects, relieve disease-related symptoms, and modify processes like inflammation and glycemia that can fuel cancer if left untreated • A new paradigm for exercise and stress reduction that restores your strength, reduces anxiety and depression, and supports the body’s own ability to heal • A complete program for remission maintenance–a proactive plan to make sure the cancer never returns Also included are “quick-start” maps to help you find the information you need right now and many case histories that will support and inspire you. Encouraging, compassionate, and authoritative, Life over Cancer is the guide patients everywhere have been waiting for.

Nutraceuticals and Cancer

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Author : Fazlul H. Sarkar
Publisher : Springer Science & Business Media
ISBN 13 : 9789400726307
Total Pages : 383 pages
Book Rating : 4.7/5 (263 download)

Book Synopsis Nutraceuticals and Cancer by : Fazlul H. Sarkar

Download or read book Nutraceuticals and Cancer written by Fazlul H. Sarkar and published by Springer Science & Business Media. This book was released on 2011-11-22 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.

Cancer Chemoprevention

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Author : Raymond C. Bergan
Publisher : Springer
ISBN 13 : 9781461356639
Total Pages : 0 pages
Book Rating : 4.3/5 (566 download)

Book Synopsis Cancer Chemoprevention by : Raymond C. Bergan

Download or read book Cancer Chemoprevention written by Raymond C. Bergan and published by Springer. This book was released on 2012-10-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a broad overview of topics related to cancer chemoprevention. It provides a review of topics ranging from basic research arenas to clinical trial design, implementation, and interpretation. It covers all key areas necessary for understanding the field of cancer chemoprevention for the interested reader, for individuals wishing to enter this area of investigation, and for individuals seeking guidance in particular areas of research, relating to agent identification, basic science investigations and clinical trials. The genesis of this book is based on the fact that cancer chemoprevention is a relatively new and rapidly evolving field spanning a wide array of disciplines, and forces researchers to address difficult and complex questions whose answers are not readily available. Cancer Chemoprevention provides a ready resource whose importance and intent lie in its ability to gather and solidify disparate data to explicitly outline areas of difficulty and to highlight future areas of important development. It provides broad outlines for current, ongoing and future directions in this area with various target organ sites, written by experts in their respective fields, whose primary research focuses upon that individual field.

Mitochondrial Dysfunction and Nanotherapeutics

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Author : Marcos Roberto de Oliveira
Publisher : Academic Press
ISBN 13 : 0323886183
Total Pages : 602 pages
Book Rating : 4.3/5 (238 download)

Book Synopsis Mitochondrial Dysfunction and Nanotherapeutics by : Marcos Roberto de Oliveira

Download or read book Mitochondrial Dysfunction and Nanotherapeutics written by Marcos Roberto de Oliveira and published by Academic Press. This book was released on 2021-07-15 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span. This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described. Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies. Contains detailed information on mitochondrial dysfunction Reviews our current understanding of the role of mitochondria in aging Includes coverage of specific conditions, including sports and affective disorders, among others Discusses mitochondria targeted delivery of therapeutic compounds

Phytochemicals from Medicinal Plants

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Author : Hafiz Ansar Rasul Suleria
Publisher : CRC Press
ISBN 13 : 0429511809
Total Pages : 30 pages
Book Rating : 4.4/5 (295 download)

Book Synopsis Phytochemicals from Medicinal Plants by : Hafiz Ansar Rasul Suleria

Download or read book Phytochemicals from Medicinal Plants written by Hafiz Ansar Rasul Suleria and published by CRC Press. This book was released on 2019-11-15 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemicals from Medicinal Plants: Scope, Applications and Potential Health Claims explores the importance of medicinal plants and their potential benefits for human health. This book looks at bioactive compounds from medicinal plants, the health benefits of bioactive compounds, the applications of plant-based products in the food and pharmaceutical industries. The first section discusses available sources of bioactive compounds from medicinal plants, biochemistry, structural composition, potential biological activities, and how bioactive molecules are isolated from medicinal plants. The authors examine the applications of bioactive molecules from a health perspective, looking at the pharmacological aspects of medicinal plants, the phytochemical and biological activities of different natural products, and ethnobotany/and medicinal properties, and also present a novel dietary approach for disease management. The book goes on to examine the plant-based products are used and can be used in various sectors of the food and pharmaceutical industries.

Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I

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Author : Rajesh Kumar Singh
Publisher : Bentham Science Publishers
ISBN 13 : 9815040081
Total Pages : 285 pages
Book Rating : 4.8/5 (15 download)

Book Synopsis Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I by : Rajesh Kumar Singh

Download or read book Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I written by Rajesh Kumar Singh and published by Bentham Science Publishers. This book was released on 2022-07-05 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 1 of the book set covers these topics: - Heterocyclic anticancer compounds derived from natural sources with their mechanism of action - The role of terpenoids as anticancer compounds: an insight into prevention and treatment - Recent advances in synthesis and anticancer activity of benzothiazole hybrids as anticancer agents - Structure-activity relationship studies of novel hybrid quinoline and quinolone derivatives as anticancer agents - Tetrazoles: structure and activity relationship as anticancer agents - Progress in nitrogen and oxygen-based heterocyclic compounds for their anticancer activity: an update (2017-2020)

Dietary Phytochemicals

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Author : Chukwuebuka Egbuna
Publisher : Springer Nature
ISBN 13 : 3030729990
Total Pages : 262 pages
Book Rating : 4.0/5 (37 download)

Book Synopsis Dietary Phytochemicals by : Chukwuebuka Egbuna

Download or read book Dietary Phytochemicals written by Chukwuebuka Egbuna and published by Springer Nature. This book was released on 2021-08-20 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents comprehensive coverage on the importance of good nutrition in the treatment and management of obesity, cancer and diabetes. Naturally occurring bioactive compounds are ubiquitous in most dietary plants available to humans and provide opportunities for the management of diseases. The text provides information about the major causes of these diseases and their association with nutrition. The text also covers the role of dietary phytochemicals in drug development and their pathways. Later chapters emphasize novel bioactive compounds as anti-diabetic, anti-cancer and anti-obesity agents and describe their mechanisms to regulate cell metabolism. Written by global team of experts, Dietary Phytochemicals: A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes describes the potentials of novel phytochemicals, their sources, and underlying mechanism of action. The chapters were drawn systematically and incorporated sequentially to facilitate proper understanding. This book is intended for nutritionists, physicians, medicinal chemists, drug developers in research and development, postgraduate students and scientists in area of nutrition and life sciences.

Cancer Genetics and Therapeutics

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Author : Madhumita Roy
Publisher : Springer Nature
ISBN 13 : 9811394717
Total Pages : 227 pages
Book Rating : 4.8/5 (113 download)

Book Synopsis Cancer Genetics and Therapeutics by : Madhumita Roy

Download or read book Cancer Genetics and Therapeutics written by Madhumita Roy and published by Springer Nature. This book was released on 2019-09-16 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book discusses cancer and the potential use of phytochemicals as cancer therapeutics. It begins with the basics of cancer, including the definition, types, etiology and molecular mechanisms involved, before discussing the fundamentals of diagnosis, treatment and associated problems as well as remedial measures. Since cancer is not a single disease, and the mechanisms of carcinogenesis are different for different cancers, it examines the genes and proteins involved in carcinogenesis, and signal transduction pathways for each individual cancer type. Further, the book reviews the latest research on phytochemicals for cancer treatment, highlighting their anti-cancer properties, sources, structure, active biomolecules and probable mechanisms of action, and describing their biochemical properties in the context of cancer prevention and treatment.

Oncological Functional Nutrition

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Author : Maira Rubi Segura Campos
Publisher : Academic Press
ISBN 13 : 012819829X
Total Pages : 210 pages
Book Rating : 4.1/5 (281 download)

Book Synopsis Oncological Functional Nutrition by : Maira Rubi Segura Campos

Download or read book Oncological Functional Nutrition written by Maira Rubi Segura Campos and published by Academic Press. This book was released on 2021-08-20 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncological Functional Nutrition: Phytochemicals and Medicinal Plants presents the anticancer activities, metabolism, mechanism of action, doses, and sources of various phytochemicals and medicinal plants. Broken into five parts, this book addresses cancer epidemiology, molecular and therapeutic bases of cancer, macro and micronutrients in cancer prevention and treatment, phytochemicals in the cancer treatment, and medical plants as potential functional foods or resources for the obtention of metabolites with anticancer activity. Written for nutritionists, food scientists, health professionals, oncologists, endocrinologists, natural product chemists, ethnobotanists, chemists, pharmacists, biochemists, and students studying relating fields, Oncological Functional Nutrition: Phytochemicals and Medicinal Plants will be a useful reference for those interested in learning more about functional nutrition and cancer. Discusses functional nutrition as alternative therapy Provides recommendations and intervention strategies related to the consumption of phytochemicals, food, and medicinal plants Addresses cancer epidemiology, the molecular and therapeutic bases of cancer, phytochemicals in the cancer treatment, and medical plants

Gene Expression and Control

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Author : Fumiaki Uchiumi
Publisher : BoD – Books on Demand
ISBN 13 : 1789855179
Total Pages : 202 pages
Book Rating : 4.7/5 (898 download)

Book Synopsis Gene Expression and Control by : Fumiaki Uchiumi

Download or read book Gene Expression and Control written by Fumiaki Uchiumi and published by BoD – Books on Demand. This book was released on 2019-04-17 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription is the most fundamental nuclear event, by which the information of nucleotide sequences on DNA is transcribed into RNA by multiple proteins, including RNA polymerases. Transcription determines the functions of proteins and the behaviour of cells, appropriately responding to environmental changes.This book is intended for scientists, especially those who are interested in the future prospect of gene expression and control in medicine and industry. This book consists of 9 chapters, divided into four parts. Each chapter is written by experts both in the basic and applied scientific field. A collection of articles presented by active and laboratory-based investigators provides evidence from the research, giving us a rigid platform to discuss "Gene Expression and Control."

Natural Products for Cancer Prevention and Therapy

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Author : Anupam Bishayee
Publisher : MDPI
ISBN 13 : 3038973106
Total Pages : 285 pages
Book Rating : 4.0/5 (389 download)

Book Synopsis Natural Products for Cancer Prevention and Therapy by : Anupam Bishayee

Download or read book Natural Products for Cancer Prevention and Therapy written by Anupam Bishayee and published by MDPI. This book was released on 2018-11-07 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients