Microenvironment in Disease and Aging

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Publisher : Frontiers Media SA
ISBN 13 : 2889634167
Total Pages : 201 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Microenvironment in Disease and Aging by : Mark A. LaBarge

Download or read book Microenvironment in Disease and Aging written by Mark A. LaBarge and published by Frontiers Media SA. This book was released on 2020-01-24 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Exosomes, Stem Cells and MicroRNA

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Author :
Publisher : Springer
ISBN 13 : 3319744704
Total Pages : 154 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Exosomes, Stem Cells and MicroRNA by : Karl L. Mettinger

Download or read book Exosomes, Stem Cells and MicroRNA written by Karl L. Mettinger and published by Springer. This book was released on 2018-05-12 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.

Stem Cells and Aging

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Publisher : Academic Press
ISBN 13 : 0128204133
Total Pages : 322 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Stem Cells and Aging by : Surajit Pathak

Download or read book Stem Cells and Aging written by Surajit Pathak and published by Academic Press. This book was released on 2021-03-17 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Environmental Factors in Skin Diseases

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805583133
Total Pages : 205 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Environmental Factors in Skin Diseases by : Ethel Tur

Download or read book Environmental Factors in Skin Diseases written by Ethel Tur and published by Karger Medical and Scientific Publishers. This book was released on 2007-01-01 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the increasing exposure of the skin to damaging environmental influences such as ultraviolet radiation, climatic determinants, chemicals or infections, research in this field is rapidly progressing. The interaction between the skin and the environment presents a fascinating and challenging research subject. For instance, skin aging and skin carcinogenesis are caused by both genetic and environmental factors. And also in diseases like psoriasis, atopic dermatitis and collagen diseases, genetic, immunologic and environmental factors interact. In recent years, new technologies to investigate skin response have allowed researchers to explore the interplay of environmental and genomic elements in skin cell biology, decipher the biochemical steps undertaken in the process, and study the genetics underlying variations in skin response to the environment. In this volume the state-of-the-art findings, ranging from molecular biology to epidemiology, are discussed thoroughly. The publication thus provides new insights for dermatologists, allergologists and immunologists who seek a better understanding of disease processes and new therapeutic strategies.

Angiogenesis in Adipose Tissue

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Publisher : Springer Science & Business Media
ISBN 13 : 1461480698
Total Pages : 378 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Angiogenesis in Adipose Tissue by : Yihai Cao

Download or read book Angiogenesis in Adipose Tissue written by Yihai Cao and published by Springer Science & Business Media. This book was released on 2013-09-05 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis has recently played a critical role in regulation of adipose tissue expansion and regression. Like most other tissues in the body, adipose expansion and regression is accompanied by alteration of blood vessel density and structures. The vascular alteration plays an active role in regulation of adipose tissue size and functions. Targeting blood vessels in the adipose tissue have demonstrated to be a novel approach for possibly treatment of cancer, obesity and other metabolic diseases. This book provides the most updated information on this type research and discusses future opportunities for therapy..

Myeloma Bone Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 1607615541
Total Pages : 257 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis Myeloma Bone Disease by : G. David Roodman

Download or read book Myeloma Bone Disease written by G. David Roodman and published by Springer Science & Business Media. This book was released on 2010-04-28 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies.

Photodamage

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Publisher : Wiley-Blackwell
ISBN 13 : 9780865423435
Total Pages : 312 pages
Book Rating : 4.4/5 (234 download)

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Book Synopsis Photodamage by : Barbara Gilchrest

Download or read book Photodamage written by Barbara Gilchrest and published by Wiley-Blackwell. This book was released on 1995-09-06 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The adverse effects of sunlight on the skin are well known, but only now is the scientific basis and rationale for treatment being evaluated. With the current level of interest from the general public and dermatologists in suntanning, sunburn and skin cancer, there is a great need for an authoritative, comprehensive review of the mechanisms, prevention and treatment of photodamage. There are only a handful of reputable clinical investigators who could put together an important volume and of this group, Dr. Gilchrest is probably the leading worker. She has collected all the latest information on photobiology, the effect of light on skin structure and function, clinical problems, prevention in adults and children, and medical and surgical treatment

The Neuronal Microenvironment

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Author :
Publisher : Neuromethods
ISBN 13 :
Total Pages : 768 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Neuronal Microenvironment by : Alan A. Boulton

Download or read book The Neuronal Microenvironment written by Alan A. Boulton and published by Neuromethods. This book was released on 1988-05-09 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: Techniques in the neurosciences are evolving rapidly. There are currently very few volumes dedicated to the methodology - ployed by neuroscientists, and those that are available often seem either out of date or limited in scope. This series is about the methods most widely used by modern-day neuroscientists and is written by their colleagues who are practicing experts. Volume 1 will be useful to all neuroscientists since it concerns those procedures used routmely across the widest range of s- disciplines. Collecting these general techniques together in a single volume strikes us not only as a service, but will no doubt prove of exceptional utilitarian value as well. Volumes 2 and 3 describe all current procedures for the analyses of amines and theirmetabolites and of amino acids, respectively. These collections will clearly be of value to all neurosclentists working m or contemplating research in these fields. Similar reasons exist for Volume 4 on receptor binding techniques, since experimental details are provided for all types of ligand-receptor binding, including chapters on general principles, drug discovery and development, and a most useful appendix on computer programs for Scatchard, nonlinear, and competitive d- placement analyses. Volume 5 provides procedures for the asse- ment of enzymes involved in biogenic amine synthesis and catabolism. Volumes in the NEUROMETHODS series will be useful to neurochemists, -pharmacologists, -physiologists, -anatomlsts, psychopharmacologists, psychiatrists, neurologists, and chemists (organic, analytical, pharmaceutical, medicinal); in fact, everyone involved in the neurosciences, both basic and clinical.

Is Cancer Inevitable?

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Author :
Publisher : JHU Press
ISBN 13 : 1421442752
Total Pages : 155 pages
Book Rating : 4.4/5 (214 download)

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Book Synopsis Is Cancer Inevitable? by : Ashani T. Weeraratna

Download or read book Is Cancer Inevitable? written by Ashani T. Weeraratna and published by JHU Press. This book was released on 2021-12-07 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: How can new understandings about cancer cell interactions help doctors better control, and eventually cure, cancer? Cancer is a formidable enemy. In fact, people born in America since 1960 face a one in two chance of being diagnosed with cancer in their lifetimes. However, there's growing evidence that fewer cancers will be death sentences for patients. New approaches and understandings are transforming the medical world, increasing success rates for remissions, disease management, and cures. Dr. Ashani Weeraratna is at the forefront of this new level of care. In Is Cancer Inevitable?, Weeraratna—a pioneering melanoma researcher whose work explores the role aging plays in cancer cells' spread and drug resistance—gives readers an inside look at several of the latest cancer advances. Detailing the actions that are reducing the disease's impact and exploring what the future may hold, she explains how the molecular mechanisms involved in metastasis and the cells' microenvironments influence cancer's development and progression. Over the years, she writes, our understanding of how cancer cells move throughout the body, change as they plant themselves in the body's microenvironments, and even communicate with one another have led to major insights about how cancer works. With compelling detail, she takes us inside her lab, revealing how new insights are leading to major breakthroughs, even among patients with Stage IV cancer. She also explains how age-related changes in the microenvironment contribute to multiple aspects of melanoma formation and development. Such scholarship, she argues, is moving us toward a day when more patients will be declared cancer-free. An inspiring and deeply personal book, Is Cancer Inevitable? offers readers newfound hope. Features • Explores key insights and studies developed in recent years that have greatly influenced the world of cancer research, including how aging microenvironments within our bodies encourage metastasis and therapy resistance • Guides readers through Dr. Ashani Weeraratna's personal story of coming to the United States from Lesotho at the age of 17 and rising to become one of the pioneers in her field • Brings readers inside Weeraratna's lab, describing both the processes and the missions of her work • Raises awareness about how cancer works within the body and what any patient or family encountering the disease needs to understand—while also offering them hope based on new and forthcoming diagnostic and treatment methods • Outlines why we will never control—let alone cure—cancer if we don't find a common purpose and come together in collaboration, inviting the greatest minds from around the world to participate in finding and implementing solutions Johns Hopkins Wavelengths In classrooms, field stations, and laboratories in Baltimore and around the world, the Bloomberg Distinguished Professors of Johns Hopkins University are opening the boundaries of our understanding of many of the world's most complex challenges. The Johns Hopkins Wavelengths book series brings readers inside their stories, illustrating how their pioneering discoveries benefit people in their neighborhoods and across the globe in artificial intelligence, cancer research, food systems' environmental impacts, health equity, science diplomacy, and other critical arenas of study. Through these compelling narratives, their insights will spark conversations from dorm rooms to dining rooms to boardrooms.

Brain Aging

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Publisher : CRC Press
ISBN 13 : 9781420005523
Total Pages : 408 pages
Book Rating : 4.0/5 (55 download)

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Book Synopsis Brain Aging by : David R. Riddle

Download or read book Brain Aging written by David R. Riddle and published by CRC Press. This book was released on 2007-04-19 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

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Author :
Publisher : Academic Press
ISBN 13 : 0128121475
Total Pages : 622 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by : M. A. Hayat

Download or read book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2017-09-07 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating ‘toxic assets’ and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. As the latest release in the Autophagy book series, users will find a detailed explanation of the role of molecular mechanisms. Presents the most advanced information regarding the role of the autophagic system in life and death States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities Summarizes the most up-to-date findings on how autophagy is executed and regulated at the molecular level and how its disruption can lead to disease Authored by global leaders in the field, bringing the broadest, most expert coverage available

Encyclopedia of Bone Biology

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Author :
Publisher : Academic Press
ISBN 13 : 0128140828
Total Pages : 2390 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Bone Biology by :

Download or read book Encyclopedia of Bone Biology written by and published by Academic Press. This book was released on 2020-06-26 with total page 2390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Bone Biology, Three Volume Set covers hot topics from within the rapidly expanding field of bone biology and skeletal research, enabling a complete understanding of both bone physiology and its relation to other organs and pathophysiology. This encyclopedia will serve as a vital resource for those involved in bone research, research in other fields that cross link with bone, such as metabolism and immunology, and physicians who treat bone diseases. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from advanced undergraduate students to research professionals. Chapters also explore the latest advances and hot topics that have emerged in recent years, including the Hematopoietic Niche and Nuclear Receptors. In the electronic edition, each chapter will include hyperlinked references and further readings as well as cross-references to related articles. Incorporates perspectives from experts working within the domains of biomedicine, including physiology, pathobiology, pharmacology, immunology, endocrinology, orthopedics and metabolism Provides an authoritative introduction for non-specialists and readers from undergraduate level upwards, as well as up-to-date foundational content for those familiar with the field Includes multimedia features, cross-references and color images/videos

Aging

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318026530
Total Pages : 224 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Aging by : L. Robert

Download or read book Aging written by L. Robert and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-16 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging inspired a large number of theories trying to rationalize the aging process common to all living beings. In this publication the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are reviewed. Furthermore theoretical and experimental evidence of the most important theoretical elements based on Darwinian evolution, cellular aging, role of cell membranes, free radicals and oxidative processes, receptor-mediated reactions, the extracellular matrix and immune functions as well as the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are discussed. These presentations of theories and related experimental facts give a global overview of up to date concepts of the biology of the aging process and are of essential reading not only for specialists in this field but also for practitioners of scientific, medical, social and experimental sciences.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

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Author :
Publisher : Academic Press
ISBN 13 : 0128094273
Total Pages : 430 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by : M. A. Hayat

Download or read book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2016-12-28 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Cooperation of Liver Cells in Health and Disease

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Cooperation of Liver Cells in Health and Disease by : Z. Kmiec

Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

The Aging Mind

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Publisher : National Academies Press
ISBN 13 : 9780309172196
Total Pages : 288 pages
Book Rating : 4.1/5 (721 download)

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Book Synopsis The Aging Mind by : National Research Council

Download or read book The Aging Mind written by National Research Council and published by National Academies Press. This book was released on 2000-04-18 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Possible new breakthroughs in understanding the aging mind that can be used to benefit older people are now emerging from research. This volume identifies the key scientific advances and the opportunities they bring. For example, science has learned that among older adults who do not suffer from Alzheimer’s disease or other dementias, cognitive decline may depend less on loss of brain cells than on changes in the health of neurons and neural networks. Research on the processes that maintain neural health shows promise of revealing new ways to promote cognitive functioning in older people. Research is also showing how cognitive functioning depends on the conjunction of biology and culture. The ways older people adapt to changes in their nervous systems, and perhaps the changes themselves, are shaped by past life experiences, present living situations, changing motives, cultural expectations, and emerging technology, as well as by their physical health status and sensory-motor capabilities. Improved understanding of how physical and contextual factors interact can help explain why some cognitive functions are impaired in aging while others are spared and why cognitive capability is impaired in some older adults and spared in others. On the basis of these exciting findings, the report makes specific recommends that the U.S. government support three major new initiatives as the next steps for research.

Biochemistry and Cell Biology of Ageing: Part I Biomedical Science

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Author :
Publisher : Springer
ISBN 13 : 9811328358
Total Pages : 526 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Biochemistry and Cell Biology of Ageing: Part I Biomedical Science by : J. Robin Harris

Download or read book Biochemistry and Cell Biology of Ageing: Part I Biomedical Science written by J. Robin Harris and published by Springer. This book was released on 2019-02-18 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.