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Mhc Gene Regulation
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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Book Synopsis MHC Gene Regulation by : Kathleen E. Sullivan
Download or read book MHC Gene Regulation written by Kathleen E. Sullivan and published by . This book was released on 1987 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modulation of MHC Antigen Expression and Disease by : G. Eric Blair
Download or read book Modulation of MHC Antigen Expression and Disease written by G. Eric Blair and published by Cambridge University Press. This book was released on 1995-11-09 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression--explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression--both in the etiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumor rejection. This book will be valuable to researchers and clinicians in molecular biology, immunology, oncology, and virology.
Book Synopsis The Effects of Chromatin on MHC Class II Gene Regulation by : Jorge A. Gomez
Download or read book The Effects of Chromatin on MHC Class II Gene Regulation written by Jorge A. Gomez and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis MHC Molecules: Expression, Assembly and Function by : Robert G. Urban
Download or read book MHC Molecules: Expression, Assembly and Function written by Robert G. Urban and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3 nant expression systems have been used to make MHC molecules con taining a single peptide of interest. To date, fifteen single peptide class I structures (incorporating three different HLA and two different H-2 allotypes/isotypes) and four additional class II structures (two single peptide complexes and two superantigen complexes) have been reported. These advances have enabled us to study the atomic detail of antigen presentation and the general mechanisms behind peptide binding, and begin to construct models of T cell recognition. Another area of research which has exploded over the past five years has been the identification of MHC-associated peptides. There are several methods one can use to determine the sequence identity of MHC restricted peptides. Historically, the most successful technique, albeit crude and encumbered with serious limitations, has been the use of overlapping synthetic peptides and T cell clones. Unfortunately, this method absolutely requires: (i) knowledge of the target antigen; (ii) availability of T cell clones; and (iii) a relatively short overall length for the target source protein, such that a set of overlapping pep tides can be affordably synthesized. Briefly, the entire sequence of the tar get protein is chemically synthesized using overlapping peptides which are then screened for biological activity using standard T cell presen tation assays. Despite its limitations, this method was used to identify the first immunodominant epitopes reported in the literature and con tinues to be used successfully today.
Book Synopsis Major Histocompatibility Complex (MHC) in Health and Disease by : Jerzy K. Kulski
Download or read book Major Histocompatibility Complex (MHC) in Health and Disease written by Jerzy K. Kulski and published by MDPI. This book was released on 2020-01-15 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.
Book Synopsis Regulation of MHC Class II and IL-8 Gene Expression by RB by : Hongquan Zhang
Download or read book Regulation of MHC Class II and IL-8 Gene Expression by RB written by Hongquan Zhang and published by . This book was released on 2000 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Antigen Processing and Presentation by : Robert Edward Humphreys
Download or read book Antigen Processing and Presentation written by Robert Edward Humphreys and published by . This book was released on 1994 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the few volumes dedicated to antigen processing, this unique text is not only especially current but also valuable for its description of petentially "hot" areas with its "Future Directions" sections. * Current, important topics covered by this text include: Processing and presentation of foreign and self protein antigens to T lymphocytes Intracellular assembley and transport of MHC proteins Regulation of the assembley and expression of processed antigen-MHC complexes
Book Synopsis Molecular Regulation of the MHC Class II-associated Invariant Chain Gene (Ii) Expression by : Li Zhu
Download or read book Molecular Regulation of the MHC Class II-associated Invariant Chain Gene (Ii) Expression written by Li Zhu and published by . This book was released on 1990 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transcriptional Regulation of Class II MHC Gene Expression in Astrocytes by : Wolfgang Michael Rohn
Download or read book Transcriptional Regulation of Class II MHC Gene Expression in Astrocytes written by Wolfgang Michael Rohn and published by . This book was released on 1998 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis MHC Ligands and Peptide Motifs by : Hans-Georg Rammensee
Download or read book MHC Ligands and Peptide Motifs written by Hans-Georg Rammensee and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is centered on a comprehensive list of MHC peptide motifs and ligands as known to date, together with selected T cell epitopes, arranged in an easy-to-read fashion. This information is put into context by chapters on MHC gene organization, MHC structure, T cell epitope prediction, antigen processing and T cell responses. In addition, the book provides a great deal of complementary information: amino acid sequences of MHC class I alpha1 and alpha2 domains and of class II alpha1 and beta1 domains, the established or predicted composition and specificity of MHC pockets, notes on MHC nomenclature including old assignments and reference to useful internet addresses. A handy reference manual that should be helpful for all those dealing with MHC-associated peptides.
Book Synopsis Regulation of MHC Class II Gene Expression at the Fetal-maternal Interface by : Ann C. Morris
Download or read book Regulation of MHC Class II Gene Expression at the Fetal-maternal Interface written by Ann C. Morris and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transgenic Mice and Mutants in MHC Research by : Igor K. Egorov
Download or read book Transgenic Mice and Mutants in MHC Research written by Igor K. Egorov and published by Springer. This book was released on 1990-04-30 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains papers presented at the international conference on "Transgenic Mice and Mutants in MHC Research", held in Bar Harbor, Maine, in June, 1989. The meeting brought together eighty researchers working in the field. While mouse H-2 mutants have been known for many years their studies continue to contribute a great deal to our understanding of structure/function relationships and evolution of MHC molecules. Recently a new direction of research has emerged on regulation, expression and function of MHC genes using transgenic animals carrying exogenous MHC genes from the same or other species or engineered MHC genes. With the introduction of transgenic mice more specific questions about the various functions of MHC genes can be answered as, for example, the role of soluble and membrane-bound MHC molecules in self tolerance and elimination of specific T cell clones, recognition of human MHC antigens by the mouse immune system, the role of individual human MHC genes in disease susceptibility. New approaches for evaluation of the role of MHC linked and unlinked genes in susceptibility of mice to malignant tumors and their metastases have been also reported. Our purpose has been to provide a forum for discussion of these new developments. Many questions remain to be answered but the necessary tools have become available. We thank the contributors and hope that the readers will benefit from this Pro ceedings. We wish to acknowledge the financial sponsorship for the meeting by The Pew Charitable Trust and Howard Hughes Medical Institute.
Book Synopsis Regulation of the Class II MHC Gene Expression by Macrophages from BCGr and BCGs Mice and the Regulation of Surface Expression of Class II Molecules by PGE2 by : Jyotsna Nath
Download or read book Regulation of the Class II MHC Gene Expression by Macrophages from BCGr and BCGs Mice and the Regulation of Surface Expression of Class II Molecules by PGE2 written by Jyotsna Nath and published by . This book was released on 1988 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of MHC Class I Gene Expression by Cytokines by : Jedd D. Wolchok
Download or read book Regulation of MHC Class I Gene Expression by Cytokines written by Jedd D. Wolchok and published by . This book was released on 1993 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis HLA and MHC by : Michael J. Browning
Download or read book HLA and MHC written by Michael J. Browning and published by Taylor & Francis. This book was released on 1996 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a review of the major histocompatibility complex (MHC), and the role it plays in the immune response and in disease. The emphasis throughout is on the human MHC, but relevant animal studies are inclded to give a comprehensive review of the subject.
