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Massachusetts 2015 Als
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Book Synopsis The Ice Bucket Challenge by : Casey Sherman
Download or read book The Ice Bucket Challenge written by Casey Sherman and published by University Press of New England. This book was released on 2017-09-05 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: While everyone knows of the Ice Bucket Challenge, the viral craze that swept the nation in summer 2014, too few know the truly inspirational story behind it. Pete Frates was a man at war with his own body. A man whose love for others was unshakable. A man who refused to fight alone, and in so doing mobilized a global army to combat one of the most devastating diseases on earth: ALS, or Lou Gehrig's disease. When disease crippled Frates, the former Boston College baseball star turned tragedy into inspiration. Pete's story is a testament to the power of love, the steadfastness of family, the generosity of strangers, and the compassion of crowds. Half of the authors' proceeds will go to the Frates family.
Book Synopsis Palliative Care in Amyotrophic Lateral Sclerosis by : David Oliver
Download or read book Palliative Care in Amyotrophic Lateral Sclerosis written by David Oliver and published by OUP Oxford. This book was released on 2014-03-20 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amytrophic Lateral Sclerosis (ALS or motor neurone disease) is a progressive neurodegenerative disease that can cause profound suffering for both the patient and their family. Whilst new treatments for ALS are being developed, these are not curative and offer only the potential to slow its progression. Palliative care must therefore be integral to the clinical approach to the disease. Palliative Care in Amyotrophic Lateral Sclerosis: From diagnosis to bereavement reflects the wide scope of this care; it must cover not just the terminal phase, but support the patient and their family from the onset of the disease. Both the multidisciplinary palliative care team and the neurology team are essential in providing a high standard of care and allowing quality of life (both patient and carer) to be maintained. Clear guidelines are provided to address care throughout the disease process. Control of symptoms is covered alongside the psychosocial care of patients and their families. Case studies are used to emphasise the complexity of the care needs and involvement of the patient and family, culminating in discussion of bereavement. Different models of care are explored, and this new edition utilizes the increase in both the evidence-base and available literature on the subject. New topics discussed include complementary therapies, personal and family experiences of ALS, new genetics research, and updated guidelines for patient care, to ensure this new edition remains the essential guide to palliative care in ALS.
Book Synopsis Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia by : Henry Houlden
Download or read book Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia written by Henry Houlden and published by Frontiers Media SA. This book was released on 2021-06-28 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Retinal Degeneration and Therapy Approaches by : Nicolás Cuenca
Download or read book Retinal Degeneration and Therapy Approaches written by Nicolás Cuenca and published by Frontiers Media SA. This book was released on 2022-04-18 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Atlas of Forecasts written by Katy Borner and published by MIT Press. This book was released on 2021-08-31 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forecasting the future with advanced data models and visualizations. To envision and create the futures we want, society needs an appropriate understanding of the likely impact of alternative actions. Data models and visualizations offer a way to understand and intelligently manage complex, interlinked systems in science and technology, education, and policymaking. Atlas of Forecasts, from the creator of Atlas of Science and Atlas of Knowledge, shows how we can use data to predict, communicate, and ultimately attain desirable futures. Using advanced data visualizations to introduce different types of computational models, Atlas of Forecasts demonstrates how models can inform effective decision-making in education, science, technology, and policymaking. The models and maps presented aim to help anyone understand key processes and outcomes of complex systems dynamics, including which human skills are needed in an artificial intelligence-empowered economy; what progress in science and technology is likely to be made; and how policymakers can future-proof regions or nations. This Atlas offers a driver's seat-perspective for a test-drive of the future.
Book Synopsis Stem Cells in Neurodegeneration: Disease Modeling and Therapeutics by : Kim A. Staats
Download or read book Stem Cells in Neurodegeneration: Disease Modeling and Therapeutics written by Kim A. Staats and published by Frontiers Media SA. This book was released on 2021-08-17 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Research on Human Social Interaction in the Age of Mobile Devices by : Xu, Xiaoge
Download or read book Handbook of Research on Human Social Interaction in the Age of Mobile Devices written by Xu, Xiaoge and published by IGI Global. This book was released on 2016-06-16 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Digital innovations, such as mobile technologies, have had a significant impact on the way people relate to one another, as well as the way they obtain and distribute information. As mobile devices continue to evolve, it has become easier to socialize; however, these mobile advancements have also made certain aspects of interaction more complex. The Handbook of Research on Human Social Interaction in the Age of Mobile Devices features an interdisciplinary perspective on mobile innovations and the use of this technology in daily life. Investigating the successes, issues, and challenges of the utilization of mobile technology, this handbook of research is a comprehensive reference source for professionals, educators, policymakers, and students interested in the impact these devices have on digital interaction, media, and communication.
Book Synopsis The Human Hypothalamus by : Dick F. Swaab
Download or read book The Human Hypothalamus written by Dick F. Swaab and published by Elsevier. This book was released on 2021-07-01 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the middle and posterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson's, Alzheimer's and other neurological disorders relate to the hypothalamus. - Reviews the anatomy and physiology of the middle and posterior hypothalmus - Provides cytoarchitecture and chemoarchitecture from rodents - Discusses hypothalamic related disorders of eating, sleeping, anxiety, and mood - Covers how Parkinson's, Alzheimer's and other neurological disorders relate to the hypothalamus - Explores the role of the hypothalamus in sexual behavior and gender identity
Book Synopsis Techno-Societal 2016 by : Prashant M. Pawar
Download or read book Techno-Societal 2016 written by Prashant M. Pawar and published by Springer. This book was released on 2017-06-16 with total page 1088 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume originates from the proceedings of a multidisciplinary conference, Techno-Societal 2016 in Maharashtra, India, that brings together faculty members of various engineering colleges to solve Indian regional relevant problems under the guidance of eminent researchers from various reputed organizations. The focus is on technologies that help develop and improve society, in particular on issues such as the betterment of differently abled people, environment impact, livelihood, rural employment, agriculture, healthcare, energy, transport, sanitation, water, education. This conference aims to help innovators to share their best practices or products developed to solve specific local problems which in turn may help the other researchers to take inspiration to solve problems in their region. On the other hand, technologies proposed by expert researchers may find applications in different regions. This back and forth process for local-global interaction will help in solving local problems by global approach and help in solving global problems by improving local conditions.
Book Synopsis Honores inauditi by : Rebecca J. Henzel
Download or read book Honores inauditi written by Rebecca J. Henzel and published by BRILL. This book was released on 2022-03-16 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: Das vorliegende Buch bietet erstmals eine holistische und diachrone Untersuchung aller Ehrenstatuen der römischen Provinz Sizilien. Auf Grundlage eines umfangreichen Katalogs von meist unpubliziertem archäologischen und epigraphischen Material werden Fragen zu deren Entwicklung und zum räumlichen sowie sozialen Kontext beantwortet. This book presents the first comprehensive survey of honorary statues in Sicily. A wealth of previously unpublished material reconstructs the spatial and social contexts of honorary statues, offering a unique window on urbanism and society of the first Roman province.
Book Synopsis The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments by : Manoj Kumar Jaiswal
Download or read book The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments written by Manoj Kumar Jaiswal and published by Frontiers Media SA. This book was released on 2017-04-17 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, devastating and fatal disease characterized by selective loss of upper and lower motor neurons of the cerebral cortex, brainstem, spinal cord and muscle atrophy. In spite of many years of research, the pathogenesis of ALS is still not well understood. ALS is a multifaceted genetic disease, in which genetic susceptibility to motor neuron death interacts with environmental factors and there is still no cure for this deleterious disease. At present, there is only one FDA approved drug, Riluzole which according to past studies only modestly slows the progression of the disease, and improves survival by up to three months. The suffering of the ALS patients, and their families is enormous and the economic burden is colossal. There is therefore a pressing need for new therapies. Different molecular pathways and pathological mechanisms have been implicated in ALS. According to past studies, altered calcium homeostasis, abnormal mitochondrial function, protein misfolding, axonal transport defects, excessive production of extracellular superoxide radicals, glutamate-mediated excitotoxicity, inflammatory events, and activation of oxidative stress pathways within the mitochondria and endoplasmic reticulum can act as major contributor that eventually leads to loss of connection between muscle and nerve ultimately resulting to ALS. However, the detailed molecular and cellular pathophysiological mechanisms and origin and temporal progression of the disease still remained elusive. Ongoing research and future advances will likely advance our improve understanding about various involved pathological mechanism ultimately leading to discoveries of new therapeutic cures. Importantly, clinical biomarkers of disease onset and progression are thus also urgently needed to support the development of the new therapeutic agents and novel preventive and curative strategies. Effective translation from pre-clinical to clinical studies will further require extensive knowledge regarding drug activity, bioavailability and efficacy in both the pre-clinical and clinical setting, and proof of biological activity in the target tissue. During the last decades, the development of new therapeutic molecules, advance neuroimaging tools, patient derived induced stem cells and new precision medicine approaches to study ALS has significantly improved our understanding of disease. In particular, new genetic tools, neuroimaging methods, cellular probes, biomarker study and molecular techniques that achieve high spatiotemporal resolution have revealed new details about the disease onset and its progression. In our effort to provide the interested reader, clinician and researchers a comprehensive summaries and new findings in this field of ALS research, hereby we have created this electronic book which comprises of twenty seven chapters having various reviews, perspective and original research articles. All these chapters and articles in this book not only summarize the cutting-edge techniques, approaches, cell and animal models to study ALS but also provide unprecedented coverage of the current developments and new hypothesis emerging in ALS research. Some examples are novel genetic and cell culture based models, mitochondria-mediated therapy, oxidative stress and ROS mechanism, development of stem cells and mechanism-based therapies as well as novel biomarkers for designing and testing effective therapeutic strategies that can benefit ALS patients who are at the earlier stages in the disease. I am extremely grateful to all the contributors to this book and want to thank them for their phenomenal efforts. Manoj Kumar Jaiswal, Ph.D. February 5, 2017 New York, NY
Book Synopsis Neuropathology of Neurodegenerative Diseases by : Gabor G. Kovacs
Download or read book Neuropathology of Neurodegenerative Diseases written by Gabor G. Kovacs and published by Cambridge University Press. This book was released on 2017-12-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.
Book Synopsis Amyotrophic Lateral Sclerosis by : Francesco Pagnini
Download or read book Amyotrophic Lateral Sclerosis written by Francesco Pagnini and published by Oxford University Press. This book was released on 2018-02-16 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder with a progressive and fatal course, with no known medical therapies that can reverse the disease or halt its progression. Palliative care is the mainstay of disease management, aimed at maximizing Quality Of Life (QOL) for the patient and caregiver. Clinicians caring for patients with ALS need to understand complex psychological issues in the patient and caregiver, including depression, anxiety, hopelessness, and wish for hastened death (physician-assisted suicide). They also need to confront the psychological implications of rapidly advancing genetic research, the impact of cognitive and behavioural dysfunction in a sizable minority of ALS patients, and caregiver burnout. Healthcare providers can optimize care by better understanding not only these factors, but by learning how to facilitate their management with problem-solving, coping techniques, and with psychologically-based approaches such as mindfulness and other non-pharmacological approaches aimed at maximizing QOL. Amyotrophic Lateral Sclerosis: Understanding and Optimizing Quality of Life and Psychological Well-Being provides a detailed review and evaluation of ALS, presented in a comprehensive and integrated fashion. The book achieves this through detailed and up-to-date information about the current state of knowledge in this field. It also offers new insights regarding future directions for research. This book will provide clinicians with a comprehensive description of the psychological aspects of ALS and their management, and incorporates chapters written by recognized scholars in their respective fields.
Book Synopsis Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis: Genetics, Clinical and Pathological Features, and Disease Mechanisms by : Annakaisa Haapasalo
Download or read book Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis: Genetics, Clinical and Pathological Features, and Disease Mechanisms written by Annakaisa Haapasalo and published by Frontiers Media SA. This book was released on 2021-12-03 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Gene Therapy for the Central and Peripheral Nervous System by : Andrew P. Tosolini
Download or read book Gene Therapy for the Central and Peripheral Nervous System written by Andrew P. Tosolini and published by Frontiers Media SA. This book was released on 2018-05-10 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene therapy is at the forefront of current techniques that aim to re-establish functional connectivity, after an insult to the brain, spinal cord or peripheral nerves. Gene therapy makes the most of the existing cellular machinery and anatomical networks to facilitate molecular changes in DNA, RNA and proteins aiming to repair these disrupted connections. For instance, gene therapy is currently being used to target genes in conditions including spinal cord injury, amyotrophic lateral sclerosis, spinal muscular atrophy, stroke and multiple sclerosis, amongst others. The various delivery routes include viral-vectors, genetically modified cellular implants, naked DNA/RNA, liposomes, Cre-Lox recombination, optogenetics and nanoparticles. In particular, gene therapy aims to restore function by augmenting the expression of neuroprotective/axonal growth-promoting neurotrophic factors (e.g., BDNF, CNTF, NGF and GDNF, etc.). Furthermore, the downstream intracellular signalling pathways after receptor activation can also be targeted (e.g., mTor, MAPK, etc.). On the other hand, gene therapy can also be used to downregulate and/or remove faulty mutated genes, such as those contributing to disease progression or that inhibit axonal regeneration (e.g., SOD-1, TDP-43, Nogo-A, MAG, OmGP, etc.). Depending on the methodology, these genes, for instance, can be silenced, removed or replaced to alleviate the underlying pathology. As such, gene therapy can transform a largely toxic and inhibitory milieu surrounding a neuronal/axonal insult into a growth-permissive environment that will ultimately aid neuronal survival and functional regeneration. Moreover, gene therapy has the capacity to target non-neuronal cells and can be even used for neuroanatomical tract tracing. Ultimately, the principal outcome of gene therapy is to functionally restore damaged neuronal and/or axonal connections irrespective of the system it is being introduced in to. This Research Topic is devoted to work using gene therapy for the both the central and/or peripheral nervous system.
Book Synopsis Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches by : Claudia Duran-Aniotz
Download or read book Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches written by Claudia Duran-Aniotz and published by Frontiers Media SA. This book was released on 2022-10-05 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Social Media written by Kelli S. Burns and published by Bloomsbury Publishing USA. This book was released on 2017-03-20 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Social media is arguably one of the most powerful technology-enabled innovations since the Internet itself. This single-volume book provides a broad and easily understandable discussion of the evolution of social media; related problems and controversies, especially for youth; key people and organizations; and useful social media data. Social media is an integral part of people's lives. More than half of the world's 2.4 billion Internet users sign in to a social network regularly—a figure that continues to grow. More than half of online adults now use two or more social media sites; 71 percent of Internet users are on Facebook. This book surveys the history of social media, addresses the power of social media for positive change, describes the problems and controversies social media have caused, and suggests potential solutions to these issues. Geared toward students and general readers, this accessibly written book covers such topics as the link between social media and body image, the psychological affects of social media use, online conversations about sexual assault, corporate use of social media data, political campaigning through social media, fan tweeting during television shows, and crisis communication through social media. Readers will also gain insights into the range of serious problems related to social media, including privacy concerns, social media addiction, social media hoaxes and scams, the pressure to project an ideal self, the curation of content presented on social media, cyberbullying, sexting, Facebook depression and envy, online shaming, and the impact of social media use on communication skills.
