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Author : Nicolás Cuenca
Publisher : Frontiers Media SA
ISBN 13 : 2889749541
Total Pages : 292 pages
Book Rating : 4.8/5 (897 download)
Download or read book Retinal Degeneration and Therapy Approaches written by Nicolás Cuenca and published by Frontiers Media SA. This book was released on 2022-04-18 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Catherine Bowes Rickman
Publisher : Springer
ISBN 13 : 3319171216
Total Pages : 824 pages
Book Rating : 4.3/5 (191 download)
Download or read book Retinal Degenerative Diseases written by Catherine Bowes Rickman and published by Springer. This book was released on 2015-10-01 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains the proceedings of the XVI International Symposium on Retinal Degeneration (RD2014), to be held July 13-18, 2014 at the Asilomar Conference Center in Pacific Grove, California. A majority of those who will speak and present posters at the meeting will contribute to this volume. The Symposium addresses the blinding diseases of inherited retinal degenerations, which have no effective treatments and age-related macular degeneration, which has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 75. The RD2014 Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy; and several sight restoration approaches, including optogenetics. While advances in these areas of retinal degenerations will be included, several new topics either were in their infancy or did not exist at the time of the last RD Symposium, RD2012. These include many new developments in sight restoration using optogenetics, retinal or RPE cell transplantation, stem cell approaches and visual prosthetic devices. In addition, major advances will be presented in other basic mechanisms in age-related macular degeneration, several new aspects of gene and antioxidant therapy and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2014 meeting and included.
Author : Bernhard H. F. Weber
Publisher : Humana Press
ISBN 13 : 9781493986682
Total Pages : 417 pages
Book Rating : 4.9/5 (866 download)
Download or read book Retinal Degeneration written by Bernhard H. F. Weber and published by Humana Press. This book was released on 2018-11-17 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides key updates on several methods from the first edition as well as including new novel techniques to address the most recent technological developments and their applications in retinal research Chapters guide readers through gene identification approaches, detailed protocols to generate functional retinal pigment epithelium cells, mouse retina and other animal models, fundus imaging and angiography, and cell-based treatment approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Retinal Degeneration: Methods and Protocols, Second Edition aims to ensure successful scientific work in the further study of this vital field.
Author : Steven D. Schwartz
Publisher : Springer
ISBN 13 : 3319494791
Total Pages : 143 pages
Book Rating : 4.3/5 (194 download)
Download or read book Cellular Therapies for Retinal Disease written by Steven D. Schwartz and published by Springer. This book was released on 2017-06-20 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book familiarizes the reader with the current landscape of cell-based therapies for the treatment of retinal disease, including diseases that affect the choriocapillaris, retinal pigment epithelium, photoreceptors, and retinal ganglion cells. Instead of utilizing a disease-centric approach to the topic, this book—edited by two world-renowned stem cell scientists—focuses on strategies for developing and transplanting the cells. This includes the creation of replacement cells, cell-based neuroprotection, and in vitro disease modeling and testing. The final chapters briefly review parallel approaches that do not directly utilize cellular transplantation. The use of cellular transplantation to treat retinal disease has recently become a viable and exciting therapeutic approach. The visibility of the retina and its laminar cellular architecture render it an ideal organ for the development of surgically delivered cellular therapies. Having an in-depth understanding of the current state of cell therapy for the eye is an essential first step toward utilizing similar approaches in other organs. Ophthalmologists, translational clinician-scientists, stem cell scientists, and researchers interested in eye disease will find Cellular Therapies for Retinal Disease: A Strategic Approach essential reading and it is also suitable for workshops or courses at the undergraduate or Ph.D. level.
Author : R.P. Casaroli-Marano
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318025852
Total Pages : 220 pages
Book Rating : 4.3/5 (18 download)
Download or read book Cell-Based Therapy for Retinal Degenerative Disease written by R.P. Casaroli-Marano and published by Karger Medical and Scientific Publishers. This book was released on 2014-04-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, some of the leading authorities present their exploration of applications of stem cell therapy to the treatment of major causes of blindness, including degenerative diseases and glaucoma. The diagnostic approach to patients, general concepts of cell-based therapy, immunological considerations, approaches to cell delivery (including engineered scaffolds), combined cell and gene therapy, nanomedicine applications to cell therapy and regulatory issues pertaining to manufacture and production are all considered in detail. The book serves as an excellent introduction to a field that is now entering early-stage clinical trials and promises to operate at the leading edge of regenerative medicine. Retina specialists, general ophthalmologists as well as researchers will find here a wealth of information on the translational aspects of cell-based therapies. Further, business executives and students interested in understanding the potential applications of stem cell therapy to retinal degenerative disease and glaucoma will also find this book informative reading.
Author : Marco A. Zarbin
Publisher : Springer
ISBN 13 : 3030052222
Total Pages : 280 pages
Book Rating : 4.0/5 (3 download)
Download or read book Cell-Based Therapy for Degenerative Retinal Disease written by Marco A. Zarbin and published by Springer. This book was released on 2019-03-01 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of “de-risking” that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology.
Author : de la Rosa (Enrique J.)
Publisher : Royal Society of Chemistry
ISBN 13 : 1782629491
Total Pages : 276 pages
Book Rating : 4.7/5 (826 download)
Download or read book Therapies for Retinal Degeneration written by de la Rosa (Enrique J.) and published by Royal Society of Chemistry. This book was released on 2018 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses approaches to the treatment of retinal diseases, targeting common processes and components.
Author : Matthew M. LaVail
Publisher : Springer Science & Business Media
ISBN 13 : 1461500672
Total Pages : 458 pages
Book Rating : 4.4/5 (615 download)
Download or read book Retinal Degenerations written by Matthew M. LaVail and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: The topics in this volume explore the etiology, cellular mechanisms, epidemiology, genetics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration. Special focus is highlighted in the areas of Mechanisms of Photoreceptor Degeneration and Cell Death (extremely important because very little is known how or why photoreceptors die in these diseases, despite an abundance of genetic information), Age-Related Macular Degeneration (with several novel approaches to its analysis), Usher Syndrome (the most severe form of retinitis pigmentosa, which includes an early or congenital loss of hearing along with blindness), and Gene Therapy. In addition, the section on Basic Science Related to Retinal Degeneration is particularly strong with several laboratories reporting on new discoveries in the area of outer segment phagocytosis, a key component of photoreceptor-retinal pigment epithelial cell interactions in normal and degenerating retinas.
Author : Christopher L. Cioffi
Publisher : Springer Nature
ISBN 13 : 3030566196
Total Pages : 278 pages
Book Rating : 4.0/5 (35 download)
Download or read book Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases written by Christopher L. Cioffi and published by Springer Nature. This book was released on 2020-09-23 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current state of ocular drug therapy and future therapeutic opportunities for a wide variety of conditions, including Age-related Macular Degeneration, Diabetic Retinopathy and Macular Edema, Glaucoma, and Inherited Retinal Diseases. Retinal diseases are major contributors to moderate or severe vision impairment in adults aged 50 years and older. The respective patient populations for many of these indications is expected to significantly increase as the world population continues to grow older. An improved understanding of the etiological underpinnings of ocular degenerative diseases over the past decade has significantly bolstered ophthalmic drug discovery. In this volume, contributions from leading experts explore the unique challenges faced for ocular drug discovery and delivery providing the reader with detailed information on ocular pharmacokinetics, in vitro, ex vivo and in vivo models for retinal disease pathology and emerging gene therapy treatments. The book is intended for all researchers and clinicians who wish to increase their knowledge on the latest findings in ocular drug therapy.
Author : Frank G. Holz
Publisher : Springer Science & Business Media
ISBN 13 : 3642221076
Total Pages : 324 pages
Book Rating : 4.6/5 (422 download)
Download or read book Age-related Macular Degeneration written by Frank G. Holz and published by Springer Science & Business Media. This book was released on 2012-08-31 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Age-related macular degeneration is the most common cause for the loss of central vision beyond the age of 50 in industrial nations. Triplication of the number of affected patients is expected over the next 25 years. Especially over the last years the standard of knowledge regarding etiology, risk factors, diagnostics and therapy of this retina illness has substantially grown – this will be covered in this up-to-date multi-authored work. Apart from epidemiologically and genetically identified risk factors both the various pathophysiological aspects including the role of the complement system and clinical manifestations including OCT and angiographic characteristics are clearly represented. Furthermore, the different therapeutic approaches are presented and discussed, including proven procedures such as intravitreal anti-VEGF therapy and seeing-aid systems, in addition to the latest and upcoming methods in the area of pharmacology. The volume is well-illustrated and tables and summaries complete the presentation.
Author : Gregory R. Bock
Publisher : John Wiley & Sons
ISBN 13 : 0470092637
Total Pages : 226 pages
Book Rating : 4.4/5 (7 download)
Download or read book Retinal Dystrophies written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2004-04-02 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retinal dystrophies are the major causes of incurable blindness in the Western world. Our insight into their aetiology has improved remarkably over the past decade and a number of key genes have been identified. Together with a more detailed understanding of disease processes, this knowledge is stimulating new approaches to therapeutic strategies involving gene therapy, growth factors and retinal cell transplantation. Molecular genetic studies have provided detailed information on the pathogenesis of retinal dystrophies. An important proof of principle that gene therapy holds great promise for the treatment of these conditions was demonstrated in the rds mouse: introduction of a functional copy of the peripherin gene subretinally resulted in complete rescue of rod outer segment structure. Novel approaches are being developed based on the manipulation of biochemical pathways that previously were not considered relevant to these diseases. For example, renewed interest in retinal dystrophy pathogenesis led to the successful use of high dose vitamin A treatment in Sorsby fundus dystrophy. This important new book covers all aspects of retinal dystrophies from the molecular and developmental biology of these disorders to possible therapeutic approaches, with special reference to gene therapy. Specific chapters deal with the molecular genetics of gene therapies, clinical genetic studies, molecular and cellular mechanisms of the development of the disease, functional genomics of retinal diseases, animal models of retinal dystrophies, and finally with studies on gene therapeutic approaches to correcting the disorder. With contributions by many of the leading researchers worldwide, this book is likely to be an important milestone in this rapidly developing field.
Author : Elias Reichel
Publisher : JP Medical Ltd
ISBN 13 : 1907816925
Total Pages : 348 pages
Book Rating : 4.9/5 (78 download)
Download or read book Handbook of Retinal Disease: a Case-based Approach written by Elias Reichel and published by JP Medical Ltd. This book was released on 2015-02-15 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Retinal Disease offers the benefit of a case discussion by describing retinal disorders through real-life examples.The book features over 75 cases with high quality images and a highly structured, deductive approach.This book is the most clinically relevant guide possible to the latest imaging techniques used in the diagnosis of retinal diseases.
Author : Peter Wiedemann
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805565534
Total Pages : 108 pages
Book Rating : 4.8/5 (55 download)
Download or read book Macular and Retinal Diseases written by Peter Wiedemann and published by Karger Medical and Scientific Publishers. This book was released on 1997-01-01 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the number of patients with macular diseases continues to increase, new diagnostic and therapeutic tools are simultaneously being introduced. This book presents new clinical approaches in the diagnosis and treatment of macular diseases. Internationally recognized surgeons present their latest results regarding their experiences in the macular area. Macular hole surgery is discussed in detail, as well as different therapeutic approaches for age related macular degeneration. A description on the latest advances in laser scanning ophthalmoscopy and in multi-focal ERG is also included. Other papers examine complications in the removal of the posterior vitreous cortex, the use of intraocular implants for drug delivery, and a review of current experimental therapies for AMD. This book will appeal to retinologists, ophthalmologists, and in particular retinal surgeons, with an interest in future developments in this field.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481601245
Total Pages : 138 pages
Book Rating : 4.4/5 (816 download)
Download or read book Advances in Retinal Degeneration Research and Treatment: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Retinal Degeneration Research and Treatment / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Retinal Degeneration. The editors have built Advances in Retinal Degeneration Research and Treatment / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Retinal Degeneration in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Retinal Degeneration Research and Treatment / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Kyriaki Thermos
Publisher : Frontiers Media SA
ISBN 13 : 2889766284
Total Pages : 180 pages
Book Rating : 4.8/5 (897 download)
Download or read book Novel Therapeutic Approaches for the Treatment of Ocular Disease, Volume I written by Kyriaki Thermos and published by Frontiers Media SA. This book was released on 2022-07-27 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert E. Anderson
Publisher : Springer Science & Business Media
ISBN 13 : 1441913998
Total Pages : 715 pages
Book Rating : 4.4/5 (419 download)
Download or read book Retinal Degenerative Diseases written by Robert E. Anderson and published by Springer Science & Business Media. This book was released on 2010-03-17 with total page 715 pages. Available in PDF, EPUB and Kindle. Book excerpt: none
Author : Weiye Li
Publisher : Elsevier Health Sciences
ISBN 13 : 0128220635
Total Pages : 298 pages
Book Rating : 4.1/5 (282 download)
Download or read book Age-Related Macular Degeneration written by Weiye Li and published by Elsevier Health Sciences. This book was released on 2021-03-23 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: A consolidated view of a complex disorder, Age-Related Macular Degeneration, summarizes the latest evidence-based studies and translates these advancements into practical, actionable knowledge. This concise resource covers the fundamentals of age-related macular degeneration (AMD) diagnosis and treatment along with a modern definition of the disorder that acknowledges the range of presentations that ophthalmologists see in real practice. Offering practical, clinical guidance in addition to capturing new therapeutic approaches in the pipeline, this book is an essential reference for ophthalmologists, optometrists, and researchers. Takes a concise, yet comprehensive, approach to AMD, covering both basic science and clinical guidance. Features clinical guidelines on the diagnosis and treatment of AMD, including classification, signs/symptoms, imaging, and differential diagnosis in the pre-optical coherence tomography (OCT) and modern OCT eras. Presents up-to-date information on AMD therapies currently in the development pipeline and offers insights for the future of translational research. Explains molecular genetics and pathogenic events of AMD from both basic and clinical perspectives, which may help readers seek promising new therapeutic targets Contains more than 250 images, with multimodal imaging techniques that clearly demonstrate AMD pathophysiology and clinical pathology.
