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Luminescent Lanthanide Chelates And Methods Of Use
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Book Synopsis Luminescent Lanthanide Chelates and Methods of Use by :
Download or read book Luminescent Lanthanide Chelates and Methods of Use written by and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The invention provides lanthanide chelates capable of intense luminescence. The celates comprise a lanthanide chelator covalently joined to a coumarin-like or quinolone-like sensitizer. Exemplary sensitzers include 2- or 4-quinolones, 2- or 4-coumarins, or derivatives thereof e.g. carbostyril 124 (7-amino-4-methyl-2-quinolone), coumarin 120 (7-amino-4-methyl-2-coumarin), coumarin 124 (7-amino-4-(trifluoromethyl)-2-coumarin), aminomethyltrimethylpsoralen, etc. The chelates form high affinity complexes with lanthanides, such as terbium or europium, through chelator groups, such as DTPA. The chelates may be coupled to a wide variety of compounds to create specific labels, probes, diagnostic and/or therapeutic reagents, etc. The chelates find particular use in resonance energy transfer between chelate-lanthanide complexes and another luminescent agent, often a fluorescent non-metal based resonance energy acceptor. The methods provide useful information about the structure, conformation, relative location and/or interactions of macromolecules.
Book Synopsis Lanthanide Luminescence by : Pekka Hänninen
Download or read book Lanthanide Luminescence written by Pekka Hänninen and published by Springer Science & Business Media. This book was released on 2011-06-21 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lanthanides have fascinated scientists for more than two centuries now, and since efficient separation techniques were established roughly 50 years ago, they have increasingly found their way into industrial exploitation and our everyday lives. Numerous applications are based on their unique luminescent properties, which are highlighted in this volume. It presents established knowledge about the photophysical basics, relevant lanthanide probes or materials, and describes instrumentation-related aspects including chemical and physical sensors. The uses of lanthanides in bioanalysis and medicine are outlined, such as assays for in vitro diagnostics and research. All chapters were compiled by renowned scientists with a broad audience in mind, providing both beginners in the field and advanced researchers with comprehensive information on on the given subject.
Book Synopsis The Development of Luminescent Lanthanide Chelates for Cellular Based Assays by : Jason Patrick Cross
Download or read book The Development of Luminescent Lanthanide Chelates for Cellular Based Assays written by Jason Patrick Cross and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Phthalamide Lanthanide Complexes for Use as Luminescent Markers by :
Download or read book Phthalamide Lanthanide Complexes for Use as Luminescent Markers written by and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
Book Synopsis Luminescence of Lanthanide Ions in Coordination Compounds and Nanomaterials by : Ana de Bettencourt-Dias
Download or read book Luminescence of Lanthanide Ions in Coordination Compounds and Nanomaterials written by Ana de Bettencourt-Dias and published by John Wiley & Sons. This book was released on 2014-09-08 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book presents the theoretical principles, current applications and latest research developments in the field of luminescent lanthanide complexes; a rapidly developing area of research which is attracting increasing interest amongst the scientific community. Luminescence of Lanthanide Ions in Coordination Compounds and Nanomaterials begins with an introduction to the basic theoretical and practical aspects of lanthanide ion luminescence, and the spectroscopic techniques used to evaluate the efficiency of luminescence. Subsequent chapters introduce a variety of different applications including: • Circularly polarized luminescence • Luminescence bioimaging with lanthanide complexes • Two-photon absorption of lanthanide complexes • Chemosensors • Upconversion luminescence • Excitation spectroscopy • Heterometallic complexes containing lanthanides Each chapter presents a detailed introduction to the application, followed by a description of experimental techniques specific to the area and an extensive review of recent literature. This book is a valuable introduction to the literature for scientists new to the field, as well as providing the more experienced researcher with a comprehensive resource covering the most relevant information in the field; a ‘one stop shop’ for all key references.
Book Synopsis Lanthanide Probes in Life, Chemical, and Earth Sciences by : J.-C. G. Bünzli
Download or read book Lanthanide Probes in Life, Chemical, and Earth Sciences written by J.-C. G. Bünzli and published by . This book was released on 1989 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lanthanide elements were first used some thirty years ago in the optical glass industry, followed shortly by their use as NMR shift reagents in organic chemistry. Since then, the application of lanthanides in studies of organic and biochemical systems by use of their NMR and spectroscopic properties has created a rapidly growing interest in the physics and chemistry of these elements. Their use in industrial catalysts, electronic and optical components, high-temperature superconductors, in medicine as X-ray intensifying materials, relaxation agents for imaging techniques or radioisotopes for pharmaceutical applications, have combined with their utilisation in science as probes of a wide variety of phenomena giving them a prominent place in modern science. In this book, leading experts describe the various facets of the application of lanthanides as probes in life, chemical and earth sciences. The aim is to provide guidance to scientists who may wish to use the unique advantages of lanthanide probes in their own fields.To supplement the chapters on the basic concepts of the application of lanthanides, chapters are provided on the basic chemistry of these elements and on the synthetic and analytical aspects of lanthanides and their compounds. The book thus provides a great deal of useful information which will no doubt assist scientists in using these fascinating and valuable elements in their research.
Book Synopsis Salicylamide-lanthanide Complexes for Use as Luminescent Markers by :
Download or read book Salicylamide-lanthanide Complexes for Use as Luminescent Markers written by and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
Book Synopsis Handbook of Detection of Enzymes on Electrophoretic Gels by : Gennady P. Manchenko
Download or read book Handbook of Detection of Enzymes on Electrophoretic Gels written by Gennady P. Manchenko and published by CRC Press. This book was released on 2002-12-26 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Still widely used as gene markers, isozymes detected by zymogram techniques have proven valuable in a range of other biological applications over the last few years. Along with these new applications, many new techniques have also emerged. Yet more than eight years since the Handbook of Detection of Enzymes on Electrophoretic Gels was first publish
Book Synopsis Highly Luminescent Lanthanide Complexes with Specific Coordination Structures by : Kohei Miyata
Download or read book Highly Luminescent Lanthanide Complexes with Specific Coordination Structures written by Kohei Miyata and published by Springer Science & Business Media. This book was released on 2014-04-08 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis deals with strongly luminescent lanthanide complexes having novel coordination structures. Luminescent lanthanide complexes are promising candidates as active materials for EL devices, lasers, and bio-sensing applications. The organic ligands in lanthanide complexes control geometrical and vibrational frequency structures that are closely related to the luminescent properties. In most of the previous work, however, lanthanide complexes have high-vibrational frequency C–H units close to the metal center for radiationless transition. In this thesis, the luminescent properties of lanthanide complexes with low-vibrational frequency C–F and P=O units are elucidated in terms of geometrical, vibrational, and chemical structures. The author also describes lanthanide coordination polymers with both high thermal stability (decomposition point > 300°C) and strong-luminescent properties (emission quantum yield > 80%). The author believes that novel studies on the characteristic structures and photophysical properties of lanthanide complexes may open up a frontier field in photophysical, coordination and material chemistry.
Book Synopsis Luminescent 1-hydroxy-2-pyridinone Chelates of Lanthanides by :
Download or read book Luminescent 1-hydroxy-2-pyridinone Chelates of Lanthanides written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous solutions and are useful as molecular probes, for example in medical diagnostics and bioanalytical assay systems. The invention also provides methods of using the complexes of the invention.
Book Synopsis Official Gazette of the United States Patent and Trademark Office by :
Download or read book Official Gazette of the United States Patent and Trademark Office written by and published by . This book was released on 1997 with total page 942 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lanthanide Single Molecule Magnets by : Jinkui Tang
Download or read book Lanthanide Single Molecule Magnets written by Jinkui Tang and published by Springer. This book was released on 2015-04-24 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book begins by providing basic information on single-molecule magnets (SMMs), covering the magnetism of lanthanide, the characterization and relaxation dynamics of SMMs and advanced means of studying lanthanide SMMs. It then systematically introduces lanthanide SMMs ranging from mononuclear and dinuclear to polynuclear complexes, classifying them and highlighting those SMMs with high barrier and blocking temperatures – an approach that provides some very valuable indicators for the structural features needed to optimize the contribution of an Ising type spin to a molecular magnet. The final chapter presents some of the newest developments in the lanthanide SMM field, such as the design of multifunctional and stimuli-responsive magnetic materials as well as the anchoring and organization of the SMMs on surfaces. In addition, the crystal structure and magnetic data are clearly presented with a wealth of illustrations in each chapter, helping newcomers and experts alike to better grasp ongoing trends and explore new directions. Jinkui Tang is a professor at Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. Peng Zhang is currently pursuing his PhD at Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, with a specific focus on the molecular magnetism of lanthanide compounds under the supervision of Prof. Jinkui Tang.
Download or read book From Antenna to Assay written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Ligand-sensitized luminescent lanthanide(III) complexes are of considerable current interest due to their unique photophysical properties (micro- to millisecond lifetimes, characteristic and narrow emission bands, and large Stokes shifts), which make them well suited to serve as labels in fluorescence-based bioassays. The long-lived Ln(III) emission can be temporally resolved from scattered light and background fluorescence, resulting in vastly enhanced measurement sensitivity. One of the challenges in this field is the design of sensitizing ligands that provide highly emissive Ln(III) complexes that also possess sufficient stability and aqueous solubility required for practical applications. In this account we give an overview of some of the general properties of the trivalent lanthanides and follow with a summary of advances made in our laboratory in the development of highly luminescent Tb(III) and Eu(III) complexes for applications in biotechnology. A focus of our research has been the optimization of these compounds as potential commercial agents for use in Homogeneous Time Resolved Fluorescence (HTRF) technology, the requirements and current use of which will be briefly discussed. Our approach involves developing high-stability octadentate Tb(III) and Eu(III) complexes that rely on all-oxygen donor atoms as well as using multi-chromophore chelates to increase molar absorptivity compared to earlier examples that utilize a single pendant antenna chromophore. We have found that ligands based on 2-hydroxyisophthalamide (IAM) provide exceptionally emissive Tb(III) complexes with quantum yield values up to ca. 60%. Solution thermodynamic studies have indicated that these complexes are stable at the nanomolar concentrations required for commercial assays. Through synthetic modification of the IAM-chromophore, in conjunction with time-dependent density functional theory (TD-DFT) calculations, we have developed a method to predict absorption and emission properties of these chromophores as a tool to guide ligand design. Additionally we have investigated chiral IAM ligands that yield Tb(III) complexes possessing both high quantum yield values and strong circularly polarized luminescence (CPL) activity. To efficiently sensitize Eu(III) emission, we have utilized ligands based on the 1-hydroxypyridin-2-one (1,2-HOPO) chelate, which are remarkable since they combine both excellent photophysical properties in addition to exceptional aqueous stabilities. A more compete understanding of this chromophore has been achieved by combining low temperature phosphorescence measurements with the same TD-DFT approach used with the IAM system. Also, Eu(III) complexes with strong CPL activity have been obtained through preparation of chiral 1,2-HOPO ligands. Using the unique spectroscopic properties of Eu(III), we have also undertaken the kinetic analysis of radiative and non-radiative decay pathways for a series of complexes, which has highlighted the importance of the metal ion symmetry on the ensuing photophysical properties. Lastly, the commercial development of a Tb-IAM compound that offers improved performance in the common HTRF platform and has the potential to vastly improve the sensitivity of measurements carried out using this technique is presented.
Book Synopsis Handbook on the Physics and Chemistry of Rare Earths by : Pecharsky Vitalij
Download or read book Handbook on the Physics and Chemistry of Rare Earths written by Pecharsky Vitalij and published by Elsevier. This book was released on 2020-08-27 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook on the Physics and Chemistry of Rare Earths: Including Actinides, Volume 57, is a continuous series of books covering all aspects of rare earth science, including chemistry, life sciences, materials science and physics. The book's main emphasis is on rare earth elements [Sc, Y, and the lanthanides (La through Lu], but whenever relevant, information is also included on the closely related actinide elements. Presents up-to-date overviews and new developments in the field of rare earths, covering both their physics and chemistry Contains Individual chapters that are comprehensive and broad, along with critical reviews Provides contributions from highly experienced, invited experts
Book Synopsis Handbook on the Physics and Chemistry of Rare Earths by :
Download or read book Handbook on the Physics and Chemistry of Rare Earths written by and published by Elsevier. This book was released on 2011-09-22 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical spectroscopy has been instrumental in the discovery of many lanthanide elements. In return, these elements have always played a prominent role in lighting devices and light conversion technologies (Auer mantles, incandescent lamps, lasers, cathode-ray and plasma displays). They are also presently used in highly sensitive luminescent bio-analyses and cell imaging. This volume of the Handbook on the Physics and Chemistry of Rare Earths is entirely devoted to the photophysical properties of these elements. It is dedicated to the late Professor William T (Bill) Carnall who has pioneered the understanding of lanthanide spectra in the 1960’s and starts with a Dedication to this scientist. The following five chapters describe various aspects of lanthanide spectroscopy and its applications. Chapters 231 presents state-of-the-art theoretical calculations of lanthanide energy levels and transition intensities. It is followed by a review (Chapter 232) on both theoretical and experimental aspects of f-d transitions, a less well known field of lanthanide spectroscopy, yet very important for the design of new optical materials. Chapter 233 describes how confinement effects act on the photophysical properties of lanthanides when they are inserted into nanomaterials, including nanoparticles, nanosheets, nanowires, nanotubes, insulating and semiconductor nanocrystals. The use of lanthanide chelates for biomedical analyses is presented in Chapter 234; long lifetimes of the excited states of lanthanide ions allow the use of time-resolved spectroscopy, which leads to highly sensitive analyses devoid of background effect from the autofluorescence of the samples. The last review (Chapter 235) provides a comprehensive survey of near-infrared (NIR) emitting molecular probes and devices, spanning an all range of compounds, from simple chelates to macrocyclic complexes, heterometallic functional edifices, coordination polymers and other extended structures. Applications ranging from telecommunications to light-emitting diodes and biomedical analyses are assessed. - Provides a comprehensive look at optical spectroscopy and its applications- A volume in the continuing authoritative series which deals with the chemistry, materials science, physics and technology of the rare earth elements
Book Synopsis Lanthanide Metal-Organic Frameworks by : Peng Cheng
Download or read book Lanthanide Metal-Organic Frameworks written by Peng Cheng and published by Springer. This book was released on 2015-01-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Structure and Bonding publishes critical reviews on topics of research concerned with chemical structure and bonding. The scope of the series spans the entire Periodic Table and addresses structure and bonding issues associated with all of the elements. It also focuses attention on new and developing areas of modern structural and theoretical chemistry such as nanostructures, molecular electronics, designed molecular solids, surfaces, metal clusters and supramolecular structures. Physical and spectroscopic techniques used to determine, examine and model structures fall within the purview of Structure and Bonding to the extent that the focus is on the scientific results obtained and not on specialist information concerning the techniques themselves. Issues associated with the development of bonding models and generalizations that illuminate the reactivity pathways and rates of chemical processes are also relevant. The individual volumes in the series are thematic. The goal of each volume is to give the reader, whether at a university or in industry, a comprehensive overview of an area where new insights are emerging that are of interest to a larger scientific audience. Thus each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years should be presented using selected examples to illustrate the principles discussed. A description of the physical basis of the experimental techniques that have been used to provide the primary data may also be appropriate, if it has not been covered in detail elsewhere. The coverage need not be exhaustive in data, but should rather be conceptual, concentrating on the new principles being developed that will allow the reader, who is not a specialist in the area covered, to understand the data presented. Discussion of possible future research directions in the area is welcomed. Review articles for the individual volumes are invited by the volume editors. Readership: research scientists at universities or in industry, graduate students.
Book Synopsis Bioconjugate Techniques by : Greg T. Hermanson
Download or read book Bioconjugate Techniques written by Greg T. Hermanson and published by Academic Press. This book was released on 2010-07-26 with total page 1233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates Includes entirely new chapters on the latest areas in the field of bioconjugation as follows: Microparticles and nanoparticlesSilane coupling agentsDendrimers and dendronsChemoselective ligationQuantum dotsLanthanide chelatesCyanine dyesDiscrete PEG compoundsBuckyballs,fullerenes, and carbon nanotubesMass tags and isotope tagsBioconjugation in the study of protein interactions
