Bioconjugate Techniques

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Bioconjugate Techniques

Author : Greg T. Hermanson
Publisher : Academic Press
ISBN 13 : 0080568726
Total Pages : 1233 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Bioconjugate Techniques by : Greg T. Hermanson

Download or read book Bioconjugate Techniques written by Greg T. Hermanson and published by Academic Press. This book was released on 2010-07-26 with total page 1233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates Includes entirely new chapters on the latest areas in the field of bioconjugation as follows: Microparticles and nanoparticlesSilane coupling agentsDendrimers and dendronsChemoselective ligationQuantum dotsLanthanide chelatesCyanine dyesDiscrete PEG compoundsBuckyballs,fullerenes, and carbon nanotubesMass tags and isotope tagsBioconjugation in the study of protein interactions

Bioconjugate Techniques

Author : Greg T. Hermanson
Publisher : Academic Press
ISBN 13 : 008057212X
Total Pages : 785 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Bioconjugate Techniques by : Greg T. Hermanson

Download or read book Bioconjugate Techniques written by Greg T. Hermanson and published by Academic Press. This book was released on 1996-01-15 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioconjugate Techniques is the essential guide to the modification and crosslinking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. Armed with this information and the abundant protocols provided, readers will form unique complexes that can be used for detecting, quantifying, and targeting important analytes. This book helps readers make: high activity antibody-enzymes conjugates, immunotoxins, immunogen complexes, liposome conjugates; as well as biotinylated molecules, avidin or streptavidin conjugates, colloidal gold labeled proteins, PEG or dextran complexes, labeled oligonucleotide probes, and fluorescently tagged or radiolabeled molecules. This book is the first to thoroughly capture the entire field of bioconjugate chemistry in a single volume Serves as a practical guide to modification and cross-linking technology for research, diagnostics, and therapeutics Provides useful, detailed, easy-to-follow, step-by-step protocols Contains easy-to-read, and easy-to-understand key concepts for making bioconjugates of all types Efficiently covers the chemistry of bioconjugation, the major reagents available for modification and cross-linking, and the application of these reagents to the synthesis of highly active conjugates Cites over more than references keyed to concepts covered in the book Uses more than 600 figures to illustrate bioconjugate reagents, their reactions, and applications Suggests sources for all key reagents

Bioconjugate Techniques

Author : Greg T. Hermanson
Publisher : Elsevier
ISBN 13 : 0080527906
Total Pages : 813 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Bioconjugate Techniques by : Greg T. Hermanson

Download or read book Bioconjugate Techniques written by Greg T. Hermanson and published by Elsevier. This book was released on 1996-01-15 with total page 813 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioconjugate Techniques is the essential guide to the modification and crosslinking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. Armed with this information and the abundant protocols provided, readers will form unique complexes that can be used for detecting, quantifying, and targeting important analytes. This book helps readers make: high activity antibody-enzymes conjugates, immunotoxins, immunogen complexes, liposome conjugates; as well as biotinylated molecules, avidin or streptavidin conjugates, colloidal gold labeled proteins, PEG or dextran complexes, labeled oligonucleotide probes, and fluorescently tagged or radiolabeled molecules. This book is the first to thoroughly capture the entire field of bioconjugate chemistry in a single volume Serves as a practical guide to modification and cross-linking technology for research, diagnostics, and therapeutics Provides useful, detailed, easy-to-follow, step-by-step protocols Contains easy-to-read, and easy-to-understand key concepts for making bioconjugates of all types Efficiently covers the chemistry of bioconjugation, the major reagents available for modification and cross-linking, and the application of these reagents to the synthesis of highly active conjugates Cites over more than references keyed to concepts covered in the book Uses more than 600 figures to illustrate bioconjugate reagents, their reactions, and applications Suggests sources for all key reagents

Bioconjugate Techniques

Author : Greg T. Hermanson
Publisher : Academic Press
ISBN 13 : 0123822408
Total Pages : 1166 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Bioconjugate Techniques by : Greg T. Hermanson

Download or read book Bioconjugate Techniques written by Greg T. Hermanson and published by Academic Press. This book was released on 2013-07-25 with total page 1166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioconjugate Techniques, Third Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions, with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. Offers a one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Provides step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates Features full color illustrations Includes a more extensive introduction into the vast field of bioconjugation and one of the most thorough overviews of immobilization chemistry ever presented

Chemistry of Bioconjugates

Author : Ravin Narain
Publisher : John Wiley & Sons
ISBN 13 : 1118776372
Total Pages : 496 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Chemistry of Bioconjugates by : Ravin Narain

Download or read book Chemistry of Bioconjugates written by Ravin Narain and published by John Wiley & Sons. This book was released on 2013-12-02 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores bioconjugate properties and applications ofpolymers, dendrimers, lipids, nanoparticles, and nanotubes Bioconjugation has enabled breakthroughs across many areas ofindustry and biomedicine. With its emphasis on synthesis,properties and applications, this book enables readers tounderstand the connection between chemistry and the biologicalapplication of bioconjugated materials. Its detailed descriptionsof methods make it possible for researchers to fabricate and takefull advantage of bioconjugates for a broad range of applications.Moreover, the book sets the foundation for the development of newapplications, including assays, imaging, biosensors, drug delivery,and diagnostics. Chemistry of Bioconjugates features contributions from aninternational team of leading experts and pioneers in the field.These contributions reflect the authors’ firsthand laboratoryexperience as well as a thorough review of the current literature.The book’s six sections examine: General methods of bioconjugation Polymer bioconjugates Organic nanoparticle-based bioconjugates Inorganic nanomaterial bioconjugates, including metals andmetal oxides Cell-based, hydrogel/microgel, and glyco-bioconjugates Characterization, physico-(bio)chemical properties, andapplications of bioconjugates This comprehensive exploration of bioconjugates includesdiscussions of polymers, dendrimers, lipids, nanoparticles, andnanotubes. References at the end of each chapter serve as a gatewayto the most important original research findings and reviews in thefield. By drawing together and analyzing all the latest chemicalmethods and research findings on the physico-chemical andbiochemical properties of bioconjugates, Chemistry ofBioconjugates sheds new light on the significance and potentialof bioconjugation. The book is recommended for organic and polymerchemists, biochemists, biomaterial scientists, carbohydratechemists, biophysicists, bioengineers, and drug and gene deliveryscientists.

Chemical Linkers in Antibody-Drug Conjugates (ADCs)

Author : Floris van Delft
Publisher : Royal Society of Chemistry
ISBN 13 : 1839162635
Total Pages : 477 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Chemical Linkers in Antibody-Drug Conjugates (ADCs) by : Floris van Delft

Download or read book Chemical Linkers in Antibody-Drug Conjugates (ADCs) written by Floris van Delft and published by Royal Society of Chemistry. This book was released on 2021-12-22 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Linkers in Antibody-Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety.

Enzyme Immunoassays

Author : S.S. Deshpande
Publisher : Springer Science & Business Media
ISBN 13 : 1461311691
Total Pages : 473 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Enzyme Immunoassays by : S.S. Deshpande

Download or read book Enzyme Immunoassays written by S.S. Deshpande and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique reference provides a pragmatic approach to the development of successful commercial immunodiagnostic products based on enzyme immunoessay technology. Presenting both the basic and applied principles, Enzyme Immunoassays gathers information on all aspects of this process, from the initial conceptualization to the introduction of the product to the market.

Click Triazoles

Author : Janez Košmrlj
Publisher : Springer
ISBN 13 : 3642294294
Total Pages : 236 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Click Triazoles by : Janez Košmrlj

Download or read book Click Triazoles written by Janez Košmrlj and published by Springer. This book was released on 2012-05-30 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: B. R. Buckley and H. Heaney: Mechanistic Investigations of Copper(I)- Catalyzed Alkyne–Azide Cycloaddition Reactions.- J. D. Crowley and D. A. McMorran: “Click-Triazole” Coordination Chemistry: Exploiting 1,4-Disubstituted-1,2,3-Triazoles as Ligands.- S. Lee and A. H. Flood: Binding Anions in Rigid and Reconfigurable Triazole Receptors.- M. Watkinson: Click Triazoles as Chemosensors.- H.-F. Chow, C.-M. Lo and Y. Chen: Triazole-Based Polymer Gels.- T. Zheng, S. H. Rouhanifard, A. S. Jalloh, P. Wu: Click Triazoles for Bioconjugation.- S. Mignani, Y. Zhou, T. Lecourt and L. Micouin: Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles.

Bioconjugation Protocols

Author : Christof M. Niemeyer
Publisher : Springer Science & Business Media
ISBN 13 : 1592598137
Total Pages : 329 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Bioconjugation Protocols by : Christof M. Niemeyer

Download or read book Bioconjugation Protocols written by Christof M. Niemeyer and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are a number of outstanding volumes that provide a comprehensive overview of bioconjugation techniques. However, many of the conventional approaches to the synthesis of chemically modified protein conjugates lack efficient means to control the stoichiometry of conjugation, as well as the s- cific site of attachment of the conjugated moiety. Moreover, the recent dev- opments in microarray technologies as well as in nanobiotechnology—a novel field of research rapidly evolving at the crossroads of physics, chemistry, b- technology, and materials science—call for a summary of modern bioconjugation strategies to overcome the limitations of the classical approaches. Bioconjugation Protocols: Methods and Strategies is intended to provide an update of many of the classic techniques and also to introduce and summarize newer approaches that go beyond the pure biomedical applications of bioconjugation. The purpose of Bioconjugation Protocols: Methods and Str- egies is therefore to provide instruction and inspiration for all those scientists confronting the challenges of semisynthesizing functional biomolecular reagents for a wide variety of applications ranging from novel biomedical diagnostics, to therapeutics, to biomaterials. Part I contains seven protocols for the preparation of protein conjugates.

Handbook of In Vivo Chemistry in Mice

Author : Katsunori Tanaka
Publisher : John Wiley & Sons
ISBN 13 : 3527344322
Total Pages : 560 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Handbook of In Vivo Chemistry in Mice by : Katsunori Tanaka

Download or read book Handbook of In Vivo Chemistry in Mice written by Katsunori Tanaka and published by John Wiley & Sons. This book was released on 2020-04-27 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides timely, comprehensive coverage of in vivo chemical reactions within live animals This handbook summarizes the interdisciplinary expertise of both chemists and biologists performing in vivo chemical reactions within live animals. By comparing and contrasting currently available chemical and biological techniques, it serves not just as a collection of the pioneering work done in animal-based studies, but also as a technical guide to help readers decide which tools are suitable and best for their experimental needs. The Handbook of In Vivo Chemistry in Mice: From Lab to Living System introduces readers to general information about live animal experiments and detection methods commonly used for these animal models. It focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release. Topics include: currently available mouse models; biocompatible fluorophores; radionuclides for radiodiagnosis/radiotherapy; live animal imaging techniques such as positron emission tomography (PET) imaging; magnetic resonance imaging (MRI); ultrasound imaging; hybrid imaging; biocompatible chemical reactions; ligand-directed nucleophilic substitution chemistry; biorthogonal prodrug release strategies; and various selective targeting strategies for live animals. -Completely covers current techniques of in vivo chemistry performed in live animals -Describes general information about commonly used live animal experiments and detection methods -Focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release -Places emphasis on material properties required for the development of appropriate compounds to be used for imaging and therapeutic purposes in preclinical applications Handbook of In Vivo Chemistry in Mice: From Lab to Living System will be of great interest to pharmaceutical chemists, life scientists, and organic chemists. It will also appeal to those working in the pharmaceutical and biotechnology industries.

Review of Organic Functional Groups

Author : Thomas L. Lemke
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9781608310166
Total Pages : 198 pages
Book Rating : 4.3/5 (11 download)

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Book Synopsis Review of Organic Functional Groups by : Thomas L. Lemke

Download or read book Review of Organic Functional Groups written by Thomas L. Lemke and published by Lippincott Williams & Wilkins. This book was released on 2012 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its Student Workbook CD-ROM and new case studies, the Fifth Edition of this acclaimed self-paced review enables students to master the principles and applications of organic functional groups. Moreover, it prepares students for the required pharmacy courses in medicinal chemistry by thoroughly covering nomenclature, physical properties, chemical properties, and metabolism. As students progress through the text, they will develop such important skills as drawing chemical structures and predicting the solubility, instabilities, and metabolism of each organic functional group.

Antibody-Drug Conjugates

Author : Kenneth J. Olivier, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111906080X
Total Pages : 560 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Antibody-Drug Conjugates by : Kenneth J. Olivier, Jr.

Download or read book Antibody-Drug Conjugates written by Kenneth J. Olivier, Jr. and published by John Wiley & Sons. This book was released on 2016-11-14 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development

Immobilized Affinity Ligand Techniques

Author : Greg T. Hermanson
Publisher : Academic Press
ISBN 13 :
Total Pages : 494 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Immobilized Affinity Ligand Techniques by : Greg T. Hermanson

Download or read book Immobilized Affinity Ligand Techniques written by Greg T. Hermanson and published by Academic Press. This book was released on 1992-08-27 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a practical guide to the preparation and use of immobilized affinity ligands for purification, catalysis, and analysis. Special emphasis is given to immunochemical techniques including antibody isolation, preparation of antibody fragments using immobilized enzymes, and immunoaffinity chromatography. The book provides easy-to-follow, well-tested protocols to allow the uninitiated to use these techniques to the maximum advantage with minimum hassle. In addition, it shows researchers how to save money by making their own optimized affinity supports. Matrix activation: Ligand immobilization, Binding and elution of target molecules, Enzyme catalysis on solid supports, Analytical affinity chromatography, Isolation/purification of antibodies, Preparation of antibody fragments, Immunoaffinity chromatography, Immobilization of nucleic acids, Use of immobilized ligands for removal of trace contaminants Practical advice on choosing: Matrices, Spacers, Methods of activation and coupling Background information and insights on: Affinity interactions, The ease and power of affinity chromatography, Attaching molecules to insoluble supports, Matrices currently in use, Over 20 methods of activation, Spacers, Extensive References

Nanochemistry

Author : Geoffrey A Ozin
Publisher : Royal Society of Chemistry
ISBN 13 : 1782626263
Total Pages : pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Nanochemistry by : Geoffrey A Ozin

Download or read book Nanochemistry written by Geoffrey A Ozin and published by Royal Society of Chemistry. This book was released on 2015-10-09 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: International interest in nanoscience research has flourished in recent years, as it becomes an integral part in the development of future technologies. The diverse, interdisciplinary nature of nanoscience means effective communication between disciplines is pivotal in the successful utilization of the science. Nanochemistry: A Chemical Approach to Nanomaterials is the first textbook for teaching nanochemistry and adopts an interdisciplinary and comprehensive approach to the subject. It presents a basic chemical strategy for making nanomaterials and describes some of the principles of materials self-assembly over 'all' scales. It demonstrates how nanometre and micrometre scale building blocks (with a wide range of shapes, compositions and surface functionalities) can be coerced through chemistry to organize spontaneously into unprecedented structures, which can serve as tailored functional materials. Suggestions of new ways to tackle research problems and speculations on how to think about assembling the future of nanotechnology are given. Primarily designed for teaching, this book will appeal to graduate and advanced undergraduate students. It is well illustrated with graphical representations of the structure and form of nanomaterials and contains problem sets as well as other pedagogical features such as further reading, case studies and a comprehensive bibliography.

Enzyme-Mediated Ligation Methods

Author : Timo Nuijens
Publisher : Springer Nature
ISBN 13 : 1493995464
Total Pages : 369 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Enzyme-Mediated Ligation Methods by : Timo Nuijens

Download or read book Enzyme-Mediated Ligation Methods written by Timo Nuijens and published by Springer Nature. This book was released on 2019-06-03 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses different enzyme-catalyzed ligation methodologies for a variety of different chemical transformations. This book wants readers to view enzymes as a powerful tool in both academic and industrial research. Chapters in this book cover topics such as sortase A-mediated generation of site-specifically conjugated antibody-drug conjugates; omniligase-catalyzed inter- and intramolecular ligation; ligation catalyzed by microbial transglutaminase; peptide cyclization mediated by cyanobactin macrocyclases, butelase 1 and sortase A; using BioID as a tool for protein proximity labeling in living cells; and inducible, selective labeling of proteins via enzymatic oxidation of tyrosine. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Enzyme-Mediated Ligation Methods is a valuable resource for students and scientists from different disciplines who are interested in using enzymatic strategies to answer their research questions.

Fluorescent Analogs of Biomolecular Building Blocks

Author : Marcus Wilhelmsson
Publisher : John Wiley & Sons
ISBN 13 : 1118175867
Total Pages : 474 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Fluorescent Analogs of Biomolecular Building Blocks by : Marcus Wilhelmsson

Download or read book Fluorescent Analogs of Biomolecular Building Blocks written by Marcus Wilhelmsson and published by John Wiley & Sons. This book was released on 2016-04-04 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescent Analogs of Biomolecular Building Blocks focuses on the design of fluorescent probes for the four major families of macromolecular building blocks. Compiling the expertise of multiple authors, this book moves from introductory chapters to an exploration of the design, synthesis, and implementation of new fluorescent analogues of biomolecular building blocks, including examples of small-molecule fluorophores and sensors that are part of biomolecular assemblies.

Chemical and Biological Synthesis

Author : Nick J Westwood
Publisher : Royal Society of Chemistry
ISBN 13 : 178801507X
Total Pages : 339 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Chemical and Biological Synthesis by : Nick J Westwood

Download or read book Chemical and Biological Synthesis written by Nick J Westwood and published by Royal Society of Chemistry. This book was released on 2018-08-16 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology. Covering the synthetic approaches that can be applied across the whole field of chemical biology, this book provides synthetic chemists with the broader context to which their work contributes and the biological questions that can be addressed through it. An ideal guide for postgraduate students and researchers in synthetic organic chemistry and chemical biology, Chemical and Biological Synthesis introduces synthetic techniques and methods to those who wish to incorporate synthesis for the first time in their biology-focused research programmes.