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Life An Introduction To Complex Systems Biology
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Book Synopsis Life: An Introduction to Complex Systems Biology by : Kunihiko Kaneko
Download or read book Life: An Introduction to Complex Systems Biology written by Kunihiko Kaneko and published by Springer. This book was released on 2006-09-14 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines life not from the reductionist point of view, but rather asks the questions: what are the universal properties of living systems, and how can one construct from there a phenomenological theory of life that leads naturally to complex processes such as reproductive cellular systems, evolution and differentiation? The presentation is relatively non-technical to appeal to a broad spectrum of students and researchers.
Book Synopsis An Introduction to Systems Biology by : Uri Alon
Download or read book An Introduction to Systems Biology written by Uri Alon and published by CRC Press. This book was released on 2006-07-07 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.
Book Synopsis Mathematical Modeling in Systems Biology by : Brian P. Ingalls
Download or read book Mathematical Modeling in Systems Biology written by Brian P. Ingalls and published by MIT Press. This book was released on 2022-06-07 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology. Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels. The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3–8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.
Book Synopsis Complex Systems Science in Biomedicine by : Thomas Deisboeck
Download or read book Complex Systems Science in Biomedicine written by Thomas Deisboeck and published by Springer Science & Business Media. This book was released on 2007-06-13 with total page 857 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.
Download or read book Systematic written by James R. Valcourt and published by Bloomsbury Publishing USA. This book was released on 2017-02-07 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: A brilliant young scientist introduces us to the fascinating field that is changing our understanding of how the body works and the way we can approach healing. SYSTEMATIC is the first book to introduce general readers to systems biology, which is improving medical treatments and our understanding of living things. In traditional bottom-up biology, a biologist might spend years studying how a single protein works, but systems biology studies how networks of those proteins work together--how they promote health and how to remedy the situation when the system isn't functioning properly. Breakthroughs in systems biology became possible only when powerful computer technology enabled researchers to process massive amounts of data to study complete systems, and has led to progress in the study of gene regulation and inheritance, cancer drugs personalized to an individual's genetically unique tumor, insights into how the brain works, and the discovery that the bacteria and other microbes that live in the gut may drive malnutrition and obesity. Systems biology is allowing us to understand more complex phenomena than ever before. In accessible prose, SYSTEMATIC sheds light not only on how systems within the body work, but also on how research is yielding new kinds of remedies that enhance and harness the body's own defenses.
Download or read book Modeling Life written by Alan Garfinkel and published by Springer. This book was released on 2017-09-06 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book develops the mathematical tools essential for students in the life sciences to describe interacting systems and predict their behavior. From predator-prey populations in an ecosystem, to hormone regulation within the body, the natural world abounds in dynamical systems that affect us profoundly. Complex feedback relations and counter-intuitive responses are common in nature; this book develops the quantitative skills needed to explore these interactions. Differential equations are the natural mathematical tool for quantifying change, and are the driving force throughout this book. The use of Euler’s method makes nonlinear examples tractable and accessible to a broad spectrum of early-stage undergraduates, thus providing a practical alternative to the procedural approach of a traditional Calculus curriculum. Tools are developed within numerous, relevant examples, with an emphasis on the construction, evaluation, and interpretation of mathematical models throughout. Encountering these concepts in context, students learn not only quantitative techniques, but how to bridge between biological and mathematical ways of thinking. Examples range broadly, exploring the dynamics of neurons and the immune system, through to population dynamics and the Google PageRank algorithm. Each scenario relies only on an interest in the natural world; no biological expertise is assumed of student or instructor. Building on a single prerequisite of Precalculus, the book suits a two-quarter sequence for first or second year undergraduates, and meets the mathematical requirements of medical school entry. The later material provides opportunities for more advanced students in both mathematics and life sciences to revisit theoretical knowledge in a rich, real-world framework. In all cases, the focus is clear: how does the math help us understand the science?
Download or read book Modularity written by Werner Callebaut and published by MIT Press. This book was released on 2005 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modularity—the attempt to understand systems as integrations of partially independent and interacting units—is today a dominant theme in the life sciences, cognitive science, and computer science. The concept goes back at least implicitly to the Scientific (or Copernican) Revolution, and can be found behind later theories of phrenology, physiology, and genetics; moreover, art, engineering, and mathematics rely on modular design principles. This collection broadens the scientific discussion of modularity by bringing together experts from a variety of disciplines, including artificial life, cognitive science, economics, evolutionary computation, developmental and evolutionary biology, linguistics, mathematics, morphology, paleontology, physics, theoretical chemistry, philosophy, and the arts. The contributors debate and compare the uses of modularity, discussing the different disciplinary contexts of "modular thinking" in general (including hierarchical organization, near-decomposability, quasi-independence, and recursion) or of more specialized concepts (including character complex, gene family, encapsulation, and mosaic evolution); what modules are, why and how they develop and evolve, and the implication for the research agenda in the disciplines involved; and how to bring about useful cross-disciplinary knowledge transfer on the topic. The book includes a foreword by the late Herbert A. Simon addressing the role of near-decomposability in understanding complex systems. Contributors: Lee Altenberg, Lauren W. Ancel-Meyers, Carl Anderson, Robert B. Brandon, Angela D. Buscalioni, Raffaele Calabretta, Werner Callebaut, Anne De Joan, Rafael Delgado-Buscalioni, Gunther J. Eble, Walter Fontana, Fernand Gobet, Alicia de la Iglesia, Slavik V. Jablan, Luigi Marengo, Daniel W. McShea, Jason Mezey, D. Kimbrough Oller, Domenico Parisi, Corrado Pasquali, Diego Rasskin-Gutman, Gerhard Schlosser, Herbert A. Simon, Roger D. K. Thomas, Marco Valente, Boris M. Velichkovsky, Gunter P. Wagner, Rasmus G. Winter Vienna Series in Theoretical Biology
Book Synopsis Complex Adaptive Systems by : John H. Miller
Download or read book Complex Adaptive Systems written by John H. Miller and published by Princeton University Press. This book was released on 2009-11-28 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first clear, comprehensive, and accessible account of complex adaptive social systems, by two of the field's leading authorities. Such systems--whether political parties, stock markets, or ant colonies--present some of the most intriguing theoretical and practical challenges confronting the social sciences. Engagingly written, and balancing technical detail with intuitive explanations, Complex Adaptive Systems focuses on the key tools and ideas that have emerged in the field since the mid-1990s, as well as the techniques needed to investigate such systems. It provides a detailed introduction to concepts such as emergence, self-organized criticality, automata, networks, diversity, adaptation, and feedback. It also demonstrates how complex adaptive systems can be explored using methods ranging from mathematics to computational models of adaptive agents. John Miller and Scott Page show how to combine ideas from economics, political science, biology, physics, and computer science to illuminate topics in organization, adaptation, decentralization, and robustness. They also demonstrate how the usual extremes used in modeling can be fruitfully transcended.
Book Synopsis Encyclopedia of Complexity and Systems Science by :
Download or read book Encyclopedia of Complexity and Systems Science written by and published by Springer. This book was released on 2009-06-26 with total page 10398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This encyclopedia provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. It links fundamental concepts of mathematics and computational sciences to applications in the physical sciences, engineering, biomedicine, economics and the social sciences.
Download or read book Philosophy of Complex Systems written by and published by Elsevier. This book was released on 2011-05-23 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: The domain of nonlinear dynamical systems and its mathematical underpinnings has been developing exponentially for a century, the last 35 years seeing an outpouring of new ideas and applications and a concomitant confluence with ideas of complex systems and their applications from irreversible thermodynamics. A few examples are in meteorology, ecological dynamics, and social and economic dynamics. These new ideas have profound implications for our understanding and practice in domains involving complexity, predictability and determinism, equilibrium, control, planning, individuality, responsibility and so on. Our intention is to draw together in this volume, we believe for the first time, a comprehensive picture of the manifold philosophically interesting impacts of recent developments in understanding nonlinear systems and the unique aspects of their complexity. The book will focus specifically on the philosophical concepts, principles, judgments and problems distinctly raised by work in the domain of complex nonlinear dynamical systems, especially in recent years. -Comprehensive coverage of all main theories in the philosophy of Complex Systems -Clearly written expositions of fundamental ideas and concepts -Definitive discussions by leading researchers in the field -Summaries of leading-edge research in related fields are also included
Book Synopsis Network Medicine by : Joseph Loscalzo
Download or read book Network Medicine written by Joseph Loscalzo and published by Harvard University Press. This book was released on 2017-02-01 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. With contributions from leading experts, Network Medicine introduces this rapidly evolving field of research, which promises to revolutionize the diagnosis and treatment of human diseases.
Book Synopsis Systems Biology by : Bernhard Palsson
Download or read book Systems Biology written by Bernhard Palsson and published by Cambridge University Press. This book was released on 2015-01-26 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive single-authored textbook on genome-scale models and the bottom-up approach to systems biology.
Download or read book Signs Of Life written by Ricard V. Solé and published by . This book was released on 2000-12-26 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Signs of Life" applies complexity to the whole of biology-from molecules to Gaia-and sets a revolutionary new agenda for complexity theory, evolution, and development
Author :Alexander S. Mikhailov Publisher :Springer Science & Business Media ISBN 13 :9783540421641 Total Pages :316 pages Book Rating :4.4/5 (216 download)
Book Synopsis From Cells to Societies by : Alexander S. Mikhailov
Download or read book From Cells to Societies written by Alexander S. Mikhailov and published by Springer Science & Business Media. This book was released on 2002 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using simple models this book shows how we can gain insights into the behavior of complex systems. It is devoted to the discussion of functional self-organization in large populations of interacting active elements. The authors have chosen a series of models from physics, biochemistry, biology, sociology and economics, and systematically discuss their general properties. The book addresses researchers and graduate students in a variety of disciplines.
Book Synopsis Introduction to Molecular Biology, Genomics and Proteomics for Biomedical Engineers by : Robert B. Northrop
Download or read book Introduction to Molecular Biology, Genomics and Proteomics for Biomedical Engineers written by Robert B. Northrop and published by CRC Press. This book was released on 2008-10-28 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illustrates the Complex Biochemical Relations that Permit Life to Exist It can be argued that the dawn of the 21st century has emerged as the age focused on molecular biology, which includes all the regulatory mechanisms that make cellular biochemical reaction pathways stable and life possible. For biomedical engineers, this concept is essential to their chosen profession. Introduction to Molecular Biology, Genomics, and Proteomics for Biomedical Engineers hones in on the specialized organic molecules in living organisms and how they interact and react. The book’s sound approach to this intricately complex field makes it an exceptional resource for further exploration into the biochemistry, molecular biology, and genomics fields. It is also beneficial for electrical, chemical, and civil engineers as well as biophysicists with an interest in modeling living systems. This seminal reference includes many helpful tools for self study, including— 143 illustrations, 32 in color, to bolster understanding of complex biochemical relations 20 tables for quick access to precise data 100 key equations Challenging self-study problems within each chapter Conveys Human Progress in the Manipulation of Genomes at the Molecular Level In response to growing global interest in biotechnology, this valuable text sheds light on the evolutionary theories and future trends in genetic medicine and stem cell research. It provides a broader knowledge base on life-permitting complexities, illustrates how to model them quantitatively, and demonstrates how to manipulate them in genomic-based medicine and genetic engineering. Consequently, this book allows for a greater appreciation among of the incredible complexity of the biochemical systems required to sustain life in its many forms. A solutions manual is available for instructors wishing to convert this reference to classroom use.
Book Synopsis The Computational Beauty of Nature by : Gary William Flake
Download or read book The Computational Beauty of Nature written by Gary William Flake and published by MIT Press. This book was released on 2000-01-27 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gary William Flake develops in depth the simple idea that recurrent rules can produce rich and complicated behaviors. In this book Gary William Flake develops in depth the simple idea that recurrent rules can produce rich and complicated behaviors. Distinguishing "agents" (e.g., molecules, cells, animals, and species) from their interactions (e.g., chemical reactions, immune system responses, sexual reproduction, and evolution), Flake argues that it is the computational properties of interactions that account for much of what we think of as "beautiful" and "interesting." From this basic thesis, Flake explores what he considers to be today's four most interesting computational topics: fractals, chaos, complex systems, and adaptation. Each of the book's parts can be read independently, enabling even the casual reader to understand and work with the basic equations and programs. Yet the parts are bound together by the theme of the computer as a laboratory and a metaphor for understanding the universe. The inspired reader will experiment further with the ideas presented to create fractal landscapes, chaotic systems, artificial life forms, genetic algorithms, and artificial neural networks.
Book Synopsis Introduction to Urban Science by : Luis M. A. Bettencourt
Download or read book Introduction to Urban Science written by Luis M. A. Bettencourt and published by MIT Press. This book was released on 2021-08-17 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: A novel, integrative approach to cities as complex adaptive systems, applicable to issues ranging from innovation to economic prosperity to settlement patterns. Human beings around the world increasingly live in urban environments. In Introduction to Urban Science, Luis Bettencourt takes a novel, integrative approach to understanding cities as complex adaptive systems, claiming that they require us to frame the field of urban science in a way that goes beyond existing theory in such traditional disciplines as sociology, geography, and economics. He explores the processes facilitated by and, in many cases, unleashed for the first time by urban life through the lenses of social heterogeneity, complex networks, scaling, circular causality, and information. Though the idea that cities are complex adaptive systems has become mainstream, until now those who study cities have lacked a comprehensive theoretical framework for understanding cities and urbanization, for generating useful and falsifiable predictions, and for constructing a solid body of empirical evidence so that the discipline of urban science can continue to develop. Bettencourt applies his framework to such issues as innovation and development across scales, human reasoning and strategic decision-making, patterns of settlement and mobility and their influence on socioeconomic life and resource use, inequality and inequity, biodiversity, and the challenges of sustainable development in both high- and low-income nations. It is crucial, says Bettencourt, to realize that cities are not "zero-sum games" and that knowledge, human cooperation, and collective action can build a better future.
