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Author : William Wallace Cleland
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.:/5 (89 download)
Download or read book Isotope Effects on Enzyme-catalyzed Reactions written by William Wallace Cleland and published by . This book was released on 1977 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul F. Cook
Publisher : CRC Press
ISBN 13 : 9780849353123
Total Pages : 656 pages
Book Rating : 4.3/5 (531 download)
Download or read book Enzyme Mechanism from Isotope Effects written by Paul F. Cook and published by CRC Press. This book was released on 1991-09-20 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isotope effects have become one of the most powerful tools available to the enzymologist for probing enzymic mechanisms. Enzyme Mechanism from Isotope Effects presents the basic theory underlying isotope effects, including the latest findings on proton tunneling and coupled atomic notions. Specific theoretical applications are emphasized in regard to the types of information that can be obtained using isotope effects. The book also examines recent theoretical treatments of the product dependence of deuterium isotope effects, multiple isotope effects and isotope effects on intermediate partitioning. Other topics include a complete discussion of methods for measuring isotope effects, including a detailed description of the use of the isotope ratio mass spectrometer to obtain isotope effects, and a review of the literature regarding mechanistic information obtained from isotope effects for individual classes of enzyme-catalyzed reactions. Enzyme Mechanism from Isotope Effects is an excellent reference source for investigators using isotope effects in their research. The book is also valuable for reference libraries and instructors teaching courses in enzyme mechanism.
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)
Download or read book Isotope Effects on Enzyme-catalyzed Reactions written by and published by . This book was released on 1977 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : W. Wallace Cleland
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (473 download)
Download or read book Isotope Effects on Enzyme-catalyzed Reactions written by W. Wallace Cleland and published by . This book was released on 1977 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Max Wolfsberg
Publisher : Springer Science & Business Media
ISBN 13 : 9048122651
Total Pages : 477 pages
Book Rating : 4.0/5 (481 download)
Download or read book Isotope Effects written by Max Wolfsberg and published by Springer Science & Business Media. This book was released on 2009-12-15 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the title suggests, Isotope Effects in the Chemical, Geological and Bio Sciences deals with differences in the properties of isotopically substituted molecules, such as differences in the chemical and physical properties of water and the heavy waters. Since the various fields in which isotope effects are applied do not only share fundamental principles but also experimental techniques, this book includes a discussion of experimental apparatus and experimental techniques. Isotope Effects in the Chemical, Geological and Bio Sciences is an educational monograph addressed to graduate students and others undertaking isotope effect research. The fundamental principles needed to understand isotope effects are presented in appropriate detail. While it is true that these principles are more familiar to students of physical chemistry and some background in physical chemistry is recommended, the text provides enough detail to make the book an asset to students in organic and biochemistry, and geochemistry.
Author : John Sears Blanchard
Publisher :
ISBN 13 :
Total Pages : 662 pages
Book Rating : 4.:/5 (89 download)
Download or read book Determination of Isotope Effects to Elucidate Enzyme Mechanisms written by John Sears Blanchard and published by . This book was released on 1979 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 0128122749
Total Pages : 634 pages
Book Rating : 4.1/5 (281 download)
Download or read book Measurement and Analysis of Kinetic Isotope Effects written by and published by Academic Press. This book was released on 2017-09-12 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental Analysis of Enzyme Mechanism Using Isotope Effects, Volume 596, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this comprehensive update include Measurement of enzyme binding isotope effects, Chemical ligation and isotope labeling to locate dynamic effects, Measurement of heavy enzyme isotope effects, Extracting kinetic isotope effects from a global analysis of reaction progress curves, KIE of metabolic flux and enzymes, Solvent and Primary KIE on Flavin Enzymes, and The Rapid Determination of Primary Deuterium Isotope Effects on Enzyme-Catalyzed Proton Transfer at Carbon in 50/50 HOH/DOD. Readers who are interested in applying or understanding this research will find useful methods currently used for measuring isotope effects on solution and enzyme reactions. Written by pioneers of modern isotope effect research Is the only collection of modern kinetic isotope effect methods currently available
Author : Paul Martin Karl Weiss
Publisher :
ISBN 13 :
Total Pages : 342 pages
Book Rating : 4.:/5 (89 download)
Download or read book The Use of Isotope Effects as a Probe of Enzyme Reaction Mechanisms written by Paul Martin Karl Weiss and published by . This book was released on 1987 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Steven Rosenberg
Publisher :
ISBN 13 :
Total Pages : 692 pages
Book Rating : 4.:/5 (27 download)
Download or read book The Elucidation of Mechanism and Transition State Structure for Enzyme and Non-enzyme Catalyzed Reactions with the Aid of Novel Methods for the Measurement of Oxygen-18 Isotope Effects written by Steven Rosenberg and published by . This book was released on 1978 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Amnon Kohen
Publisher : CRC Press
ISBN 13 : 1420028022
Total Pages : 1092 pages
Book Rating : 4.4/5 (2 download)
Download or read book Isotope Effects In Chemistry and Biology written by Amnon Kohen and published by CRC Press. This book was released on 2005-11-01 with total page 1092 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of isotope effects has expanded exponentially in the last decade, and researchers are finding isotopes increasingly useful in their studies. Bringing literature on the subject up to date, Isotope Effects in Chemistry and Biology covers current principles, methods, and a broad range of applications of isotope effects in the physical, biolo
Author : Joseph BenJamin Rucker
Publisher :
ISBN 13 :
Total Pages : 566 pages
Book Rating : 4.:/5 (33 download)
Download or read book Probes of Hydrogen Tunneling in Enzyme-catalyzed Reactions written by Joseph BenJamin Rucker and published by . This book was released on 1995 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mark Walter Ruszczycky
Publisher :
ISBN 13 :
Total Pages : 530 pages
Book Rating : 4.:/5 (173 download)
Download or read book V/K Isotope Effects on Enzyme Catalyzed Nucleophilic Displacement written by Mark Walter Ruszczycky and published by . This book was released on 2006 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rudolf K. Allemann
Publisher : Royal Society of Chemistry
ISBN 13 : 0854041222
Total Pages : 412 pages
Book Rating : 4.8/5 (54 download)
Download or read book Quantum Tunnelling in Enzyme-catalysed Reactions written by Rudolf K. Allemann and published by Royal Society of Chemistry. This book was released on 2009 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, there has been an explosion in knowledge and research associated with the field of enzyme catalysis and H-tunneling. Rich in its breath and depth, this introduction to modern theories and methods of study is suitable for experienced researchers those new to the subject. Edited by two leading experts, and bringing together the foremost practitioners in the field, this up-to-date account of a rapidly developing field sits at the interface between biology, chemistry and physics. It covers computational, kinetic and structural analysis of tunnelling and the synergy in combining these methods (with a major focus on H-tunneling reactions in enzyme systems). The book starts with a brief overview of proton and electron transfer history by Nobel Laureate, Rudolph A. Marcus. The reader is then guided through chapters covering almost every aspect of reactions in enzyme catalysis ranging from descriptions of the relevant quantum theory and quantum/classical theoretical methodology to the description of experimental results. The theoretical interpretation of these large systems includes both quantum mechanical and statistical mechanical computations, as well as simple more approximate models. Most of the chapters focus on enzymatic catalysis of hydride, proton and H" transfer, an example of the latter being proton coupled electron transfer. There is also a chapter on electron transfer in proteins. This is timely since the theoretical framework developed fifty years ago for treating electron transfers has now been adapted to H-transfers and electron transfers in proteins. Accessible in style, this book is suitable for a wide audience but will be particularly useful to advanced level undergraduates, postgraduates and early postdoctoral workers.
Author : Gertz I. Likhtenshtein
Publisher : Springer Science & Business Media
ISBN 13 : 0306481103
Total Pages : 239 pages
Book Rating : 4.3/5 (64 download)
Download or read book New Trends in Enzyme Catalysis and Biomimetic Chemical Reactions written by Gertz I. Likhtenshtein and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book is a view of enzyme catalysis by a physico-chemist with long-term experience in the investigation of structure and action mechanism of biological catalysts. This book is not intended to provide an exhaustive survey of each topic but rather a discussion of their theoretical and experimental background, and recent developments. The literature of enzyme catalysis is so vast and many scientists have made important contribution in the area, that it is impossible in the space allowed for this book to give a representative set of references. The author has tried to use reviews, and general principles of articles. He apologizes to those he has not been able to include. . ... The monograph is intended for scientists working on enzyme catalysis and adjacent areas such as chemical modeling of biological processes, homogeneous catalysis, biomedical research and biotechnology. The book can be use as a subsidiary manual for instructors, graduate and undergraduate students of university biochemistry and chemistry departments."--Pages ix-x.
Author : Jeffrey D. Hermes
Publisher :
ISBN 13 :
Total Pages : 506 pages
Book Rating : 4.:/5 (89 download)
Download or read book Novel Uses of Isotope Effects to Elucidate Enzyme Reaction Mechanisms written by Jeffrey D. Hermes and published by . This book was released on 1983 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Judith Klinman
Publisher : Springer
ISBN 13 : 3642389627
Total Pages : 217 pages
Book Rating : 4.6/5 (423 download)
Download or read book Dynamics in Enzyme Catalysis written by Judith Klinman and published by Springer. This book was released on 2013-09-14 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Christopher M. Cheatum and Amnon Kohen, Relationship of Femtosecond–Picosecond Dynamics to Enzyme-Catalyzed H-Transfer. Cindy Schulenburg and Donald Hilvert, Protein Conformational Disorder and Enzyme Catalysis. A. Joshua Wand, Veronica R. Moorman and Kyle W. Harpole, A Surprising Role for Conformational Entropy in Protein Function. Travis P. Schrank, James O. Wrabl and Vincent J. Hilser, Conformational Heterogeneity Within the LID Domain Mediates Substrate Binding to Escherichia coli Adenylate Kinase: Function Follows Fluctuations. Buyong Ma and Ruth Nussinov, Structured Crowding and Its Effects on Enzyme Catalysis. Michael D. Daily, Haibo Yu, George N. Phillips Jr and Qiang Cui, Allosteric Activation Transitions in Enzymes and Biomolecular Motors: Insights from Atomistic and Coarse-Grained Simulations. Karunesh Arora and Charles L. Brooks III, Multiple Intermediates, Diverse Conformations, and Cooperative Conformational Changes Underlie the Catalytic Hydride Transfer Reaction of Dihydrofolate Reductase. Steven D. Schwartz, Protein Dynamics and the Enzymatic Reaction Coordinate.
Author : Kenneth B. Taylor
Publisher : Springer Science & Business Media
ISBN 13 : 0306480255
Total Pages : 237 pages
Book Rating : 4.3/5 (64 download)
Download or read book Enzyme Kinetics and Mechanisms written by Kenneth B. Taylor and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzyme Kinetics and Mechanisms takes the reader through the experimental techniques and the logic by which the mechanisms of enzyme-catalyzed reactions can be elucidated by the results of steady-state kinetics and related experiments. It is meant to make these investigations both satisfying and effective. In distinction to other available descriptions, the descriptions in enzyme Kinetics and Mechanisms are limited to more commonly utilized and useful models and techniques. The logic relating the chemical models to the mathematical models and the logic of relating the mathematical models to data is presented in rather concise text, figures and equations. The development of mathematical models from chemical models is done by a unique algorithm that is both simple and quick, and the same concept are utilized to develop models for the effects of a variety of reaction conditions on the initial velocity. In addition, the various relationships of data, mathematical models and the chemical models is illustrated with examples from the scientific literature.
