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Interleukin 2 And Killer Cells In Cancer
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Book Synopsis Interleukin-2 and Killer Cells in Cancer by : Eva Lotzova
Download or read book Interleukin-2 and Killer Cells in Cancer written by Eva Lotzova and published by CRC Press. This book was released on 2018-02-01 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first-and only-publication available which provides the most recent information in this particular field of biomedicine. Interleukin-2 (IL-2) and IL-2 activated killer cells have been shown to have a potential in the treatment of a variety of human malignant diseases. This work comprehensively summarizes basic aspects of IL-2 as well as its clinical application, therefore making all these aspects easily accessible to the readers. Because of the clinical significance of this molecule in the treatment of cancer, the basic and clinical investigations in the IL-2 field are rapidly expanding, together with the interest of the scientific and medical community. This book is an excellent educational and teaching tool for scientists, clinicians, and students. Those who already have expertise in research in the IL-2 area will find this reference indispensible.
Book Synopsis The role of interleukin-2 in the treatment of cancer patients by : J. Wagstaff
Download or read book The role of interleukin-2 in the treatment of cancer patients written by J. Wagstaff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recombinant human interleukin-2 became available for clinical use in the mid 1980s. Recent years have seen an enormous amount of clinical research with this cytokine and interleukin-2 has now been registered for use in a number of European countries for the treatment of metastatic renal cell carcinoma. This book is designed to provide the clinical oncologist wishing to use interleukin-2 with a basic background concerning the biology of the agent, a discussion concerning practical aspects, of its clinical use including management of toxicity and an overview of the clinical results together with a description of how this internesting cytokine might be developed in the future.
Book Synopsis Interleukin-2 and Killer Cells in Cancer by : Eva Lotzova
Download or read book Interleukin-2 and Killer Cells in Cancer written by Eva Lotzova and published by CRC Press. This book was released on 1989-12-21 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first-and only-publication available which provides the most recent information in this particular field of biomedicine. Interleukin-2 (IL-2) and IL-2 activated killer cells have been shown to have a potential in the treatment of a variety of human malignant diseases. This work comprehensively summarizes basic aspects of IL-2 as well as its clinical application, therefore making all these aspects easily accessible to the readers. Because of the clinical significance of this molecule in the treatment of cancer, the basic and clinical investigations in the IL-2 field are rapidly expanding, together with the interest of the scientific and medical community. This book is an excellent educational and teaching tool for scientists, clinicians, and students. Those who already have expertise in research in the IL-2 area will find this reference indispensible.
Book Synopsis Lymphocytes in Immunotherapy of Cancer by : Paul Koldovsky
Download or read book Lymphocytes in Immunotherapy of Cancer written by Paul Koldovsky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past, research in cancer immunology has produced informa tion important for other medical disciplines. It helped, for example, in formulating the laws of immunogenetics and in achieving a better understanding of the mechanism governing the fate of allotrans planted tissue. Cancer has often been considered a foreign body, and therefore many attempts have been made to cure it on the basis of the immunological principles applicable to parasitic, bacterial, or viral diseases. Vaccination has been investigated clinically for its po tential to prevent cancer [1], and clinical research into the cure of cancer has included active immunization [2], nonspecific stimulation of defense mechanisms [3], and transfer of passive immunity by cells [4] or by antibodies [5]. These experiments have been of limited value and in some cases have even had an adverse effect. The reputation of cancer immunology has suffered, and the concept has often been severely criticized. However, the basic postulate that cancer must originate from the body's own cells, and that the immune system belongs to the principal regulatory mechanisms, remains valid. In recent years new research into clinical cancer immunotherapy has included critical appraisal of all its potential benefits, and also of the risks and limitations. It is dangerous to make unrealistic promises or to speak or think in terms of "miracle weapons" or a "magic bul let.
Book Synopsis The Biology and Clinical Applications of Interleukin-2 by : Robert C. Rees
Download or read book The Biology and Clinical Applications of Interleukin-2 written by Robert C. Rees and published by IRL Press. This book was released on 1990 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular structure of interleukin-2 (IL-2) and that of its receptor subunits provide a basis for understanding lymphocyte activation by IL-2 and the generation of effector cells capable of mediating cytotoxicity towards tumors. This book provides an up-to-date account of IL-2, its effect on lymphocyte function, and clinical applications. Internationally know experts review the molecular aspects of cell signalling, giving insight on the in vivo pathways of activation likely to be important in determining clinical responses. They also examine the use of cytokines, particularly IL-2, in the treatment of cancer, and describe the results of recent clinical trials using IL-2, as well as of adoptive cell therapy. Providing a clear account of recent progress, the book also reviews the problems involved in attempting to improve the therapeutic benefit of IL-2, along with the importance of mechanisms which subverse IL-2 responses. This is the most up-to-date account of molecular research and clinical trials in this area, and will be of great benefit to students and researchers in immunology, pharmacology, biochemistry, and oncology who are interested in this vitally important topic.
Book Synopsis Interleukin 2 in the in Vitro Generation and in Vivo Effectiveness of Tumor Specific T Lymphocytes [microform] by : Gordon B. Mills
Download or read book Interleukin 2 in the in Vitro Generation and in Vivo Effectiveness of Tumor Specific T Lymphocytes [microform] written by Gordon B. Mills and published by National Library of Canada. This book was released on 1984 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to respond to a foreign challenge, cells of the immune system must recognize the pathogen as foreign and must also receive a "second signal'. Both signals are required to induce the proliferation and differentiation of effector cells. Malignant disease in the otherwise immunocompetent host could escape immune control through failure to recognize tumor cells as foreign or through lack of the required "second signal". Previous work suggested that Interleukin 2 may be one of the second signals stimulating immune cells. Failure of Interleukin 2 production or action may allow malignant cells to escape the immune system. Therefore, an attractive method of immunotherapy would be to increase the positive immunoregulatory action of IL2 in vivo. Unfortunately, methods for modulating Interleukin action in vivo are not available. Therefore, removing lymphocytes from tumor-bearing mice, culturing them with exogenous Interleukin 2 and, subsequently, reinfusing the programed cells into tumor-bearing mice was explored as a model of a possible immunotherapeutic technique. Spleen cells from tumor-bearing mice contain populations of precursor cells reactive to autologous tumor. Culture of these cells with exogenous Interleukin 2 generated a population of helper lymphocytes able to recruit host anti-tumor activity. Culture with IL2 also generated two populations of lymphocytes directly cytotoxic to tumor cells. One of the populations of cytotoxic lymphocytes, generated by culture with Interleukin 2 and autologous tumor, was relatively specific to the sensitizing tumor. These are probably "classical" cytotoxic T lymphocytes. The second population of cytotoxic cells, generated by culture with Interleukin 2 alone, demonstrated a broader spectrum of anti-tumor reactivity. Identifying the origin of the cell responsible for this non-specific activity has proven to be difficult. The broad spectrum of activity, the lack of requirement for antigen sensitization, and the lack of H2 restriction are appropriate for "natural killer" cells; whereas, the time course of activation and the surface marker phenotype are appropriate for "classical" cytotoxic lymphocytes. The precursors of both cytolytic cell populations, described above, are significantly increased in tumor-bearing animals. This suggests that tumor recognition occurs in tumor-bearing animals but that the "second signal" required for proliferation and differentiation is not present or not received. Interleukin 2 can provide this signal at least in vitro. Culture of peripheral blood cells from ovarian cancer patients with either human IL2 or murine IL2 generated cytotoxic lymphocytes which were active against autologous tumor. In the immunotherapy of murine tumors, the cytotoxic lymphocyte containing populations were most effective if given shortly after injection of the tumor. The response was dose related. Repeated injections were more effective than single injections. The cultured cells homed poorly to the tumor, therefore injection directly into the tumor site was more effective than intravenous administration. Therapy with cytotoxic lymphocytes was synergistic with surgical therapy of CaD2 tumors. Therapy with cytotoxic lymphocyte containing populations consistently improved the survival of mice with intraperitoneal P815 tumors. Despite the improved survival of mice following therapy, there were few long term survivors. Therapy with cytotoxic lymphocyte containing populations cured some mice with subcutaneous P815 tumors. The mice that died of the tumor did not demonstrate an improvement in survival times compared to untreated mice. Mice cured of the P8 15 tumor by treatment with cytotoxic lymphocyte containing preparations remain tumor-immune. There were no significant detrimental side effects of therapy with cytotoxic lymphocytes.
Book Synopsis Between Bench and Bedside by : Ilana Löwy
Download or read book Between Bench and Bedside written by Ilana Löwy and published by Harvard University Press. This book was released on 1996 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between Bench and Bedside is a compelling account of the clinical trials of interleukin-2 at a major French cancer hospital. Löwy's book offers a remarkable insider's view of the culture of clinical experimentation in oncology.
Book Synopsis Studies of the Immunological Effects of Interleukin-2 in Patients with Bladder Cancer and Renal Cell Carcinoma by : Gregers Gautier Hermann
Download or read book Studies of the Immunological Effects of Interleukin-2 in Patients with Bladder Cancer and Renal Cell Carcinoma written by Gregers Gautier Hermann and published by . This book was released on 1993 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Ronald B. Herberman Publisher :Springer Science & Business Media ISBN 13 :9780898387575 Total Pages :250 pages Book Rating :4.3/5 (875 download)
Book Synopsis Cancer Immunology: Innovative Approaches to Therapy by : Ronald B. Herberman
Download or read book Cancer Immunology: Innovative Approaches to Therapy written by Ronald B. Herberman and published by Springer Science & Business Media. This book was released on 1986-02-28 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the second in the 'Cancer Treatment and Research' series focussing on basic and clinical tumor immunology. It has a rather different focus or emphasis from that of the first volume, published two years ago. That work (Basic and Clinical Tumor Immunology, R.B. Herberman, ed., Martinus Nijhoff Publishers, 1983) devoted considerable attention to up dated summaries in various areas of classical tumor immunology: specific antitumor immunity, the immunologic competence of cancer patietns, char acterization of human tumor-associated antigens, the ability to propagate specifically immune T cells in culture in the presence of interleukin 2, and the use of such cells for adoptive immunotherapy of established tumors. of evidence concerning the immune However, it also reviewed the status surveillance hypothesis and pointed out the need to consider non-T cell mediated mechanisms of host resistance. In particular, one chapter sum marized information on the role of macrophages in host resistance against tumors. The present volume continues to emphasize one of the major themes of the first volume, innovative approaches to the therapy of cancer. It involves contributions from leading investigators on several primary types of therapeutic interventions related to monoclonal antibodies, the col laboration of monoclonal antibodies with macro phages to mediate antibody dependent cellular cytotoxicity, lymphokines, tumor vaccines, and natural killer cells. It also has an up-to-date summary of the immunologic aspects of the exciting and promising work being performed on human T cell leukemia virus in the laboratory of Dr. Robert Gallo.
Book Synopsis Lymphohaematopoietic Growth Factors in Cancer Therapy by : Roland Mertelsmann
Download or read book Lymphohaematopoietic Growth Factors in Cancer Therapy written by Roland Mertelsmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent experimental and clinical progress in the evaluation of cytokines in treatment concepts for cancer patients is the central theme of this book in the ESO Monographs series. The discussion revolves on the experimental basis as well as current clinical experience with the use of human recombinant cytokines. It gives the state of the art and, as such, puts into perspective potential areas of growth and future research.
Book Synopsis Lymphohaematopoietic Growth Factors in Cancer Therapy II by : Roland Mertelsmann
Download or read book Lymphohaematopoietic Growth Factors in Cancer Therapy II written by Roland Mertelsmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contents: Introduction and Overview Lymphopoietic Growth Factors: Pathophysiology of T-Cell Mediated Shock Induced by Bacterial Superantigens - Natural Killer Cells and Interleukin-2-Activated Killer Cells - TumourImmunogenicity Induced by Exogenous Interleukins - Cytokine Gene Therapy of Cancer - Analysis of T-Cell Receptor Variability in Tumour Infiltrating Lymphocytes - Clinical Studies with Interleukin-2: An Overview - Clinical Trials with Local Administration of Lymphopoietic Growth Factors - Clinical Trials with Interlaukin-2. The Rome Experience. Haematopoietic Growth Factors: Lymphohaematopoietic Growth Factor Use in Lung Cancer Patients - Clinical Trials with Haematopoietic Growth Factors and Peripheral Blood Stem Cells.
Book Synopsis Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation by : Gerard Socie
Download or read book Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation written by Gerard Socie and published by Academic Press. This book was released on 2018-11-22 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. - Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside - Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios - Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications
Book Synopsis Studies on Interleukin-2-activated Rat Natural Killer Cells by : Petrus Johannes Karel Kuppen
Download or read book Studies on Interleukin-2-activated Rat Natural Killer Cells written by Petrus Johannes Karel Kuppen and published by . This book was released on 1993 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology by : Witold Lasek
Download or read book Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology written by Witold Lasek and published by Springer. This book was released on 2016-09-23 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).
Book Synopsis Surgical Research by : Wiley W. Souba
Download or read book Surgical Research written by Wiley W. Souba and published by Academic Press. This book was released on 2001-01-25 with total page 1526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contributors. -- Foreword. -- Preface. -- Getting Started. -- Assessing Available Information. -- Organizing and Preliminary Planning for Surgical Research -- Writing a Protocol: Animals, Humans, and Use of Biologic, Chemical, and Radiologic Agents. -- Grantsmanship. -- Informed Consent and the Protection of Human Research Subjects: Historical Perspectives and Guide to Current United States Regulations. -- Animal Care and Maintenance. -- Funding Strategies and Agencies: Academic-Industrial Relationships; Intellectual Property. -- Statistical Considerations. -- Use of Nonexperimental Studies to Evaluate Surgical Procedures and Other Interventions: The Challenge of Risk Adjustment. -- Measuring Surgical Outcomes. -- Design of Clinical Trials. -- Using Administrative Data for Clinical Research. -- Research in the Intensive Care Unit: Ethical and Methodological Issues. -- Research in the Operating Room. -- Effects of Age and Gender. -- Strategies, Principles, and Techniques Using Transgeni ...
Book Synopsis Therapeutic Applications of Interleukin-2 by : Michael Atkins
Download or read book Therapeutic Applications of Interleukin-2 written by Michael Atkins and published by CRC Press. This book was released on 1993-03-08 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering everything from basic science to disease-specific clinical trials, current applications and future directions, this book discusses the novel biological response modifier interleukin-2. This immunoactive therapy is designed for use in the treatment of metastatic renal cancer and, possibly, melanoma and other malignancies. Examining the value and toxic manifestations of different treatment regimens, this text: describes the biochemistry of the IL-2 receptor, the activation of natural killer cells and the lymphokine-activated killer (LAK) cell phenomenon; explicates tumour-infiltrating lymphocytes and the effect of IL-2 on in vitro assays of immune function; emphasizes high-dose IL-2 therapy in renal cell carcinoma and malignant melanoma; reviews in detail IL-2 treatment of other solid tumours and haematologic malignancies; illustrates the use of lower dose regimens, regional administration and combinations of IL-2 with other therapies; elucidates toxicities associated with IL-2, their pathogenesis and clinical management; and highlights future developments, including gene therapy and the co-administration of cytokine antagonists to reduce toxicity.
Book Synopsis Tumor Immunology and Cancer Therapy by : R. H. Goldfarb
Download or read book Tumor Immunology and Cancer Therapy written by R. H. Goldfarb and published by CRC Press. This book was released on 2020-07-24 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a Tumor Immunology Symposium held in Pittsburgh, this work provides comprehensive coverage of the most important aspects of tumor immunology. It reveals novel approaches to the immunotherapy of cancer and presents complex issues in an accessible manner.
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