Infectious Microecology

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Infectious Microecology

Author : Lanjuan Li
Publisher : Springer
ISBN 13 : 3662438836
Total Pages : 667 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Infectious Microecology by : Lanjuan Li

Download or read book Infectious Microecology written by Lanjuan Li and published by Springer. This book was released on 2015-11-16 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Infectious Microecology: Theory and Applications" firstly introduces microecology in the study of infection and proposes new anti-infection methods and strategies and then provides a comprehensive and up-to-date overview of research on infectious microecology. It concludes with a new theory for studying infectious diseases. This book presents the basic theories and fundamentals of infectious microecology, covering all the microecological systems relevant to clinical work. It also describes a new strategy and method to combat infectious diseases and provides detailed descriptions of studies and techniques in infectious microecology. The book discusses utilizing 10 years’ worth of research and clinical practice, referring to recent literature on the relationship between infection and microecology and combined with the latest research findings on liver microecology. In addition, it outlines the latest advances in the theory and techniques in the field of infectious microecology. It is intended for doctors, researchers and graduate students in the fields of infectious disease and microecology. Dr. Lanjuan Li is member of the Chinese Academy of Engineering, she is also a Professor and Chief Physician at Zhejiang University, China.

Advances in Microbiology, Infectious Diseases and Public Health

Author : Gianfranco Donelli
Publisher : Springer
ISBN 13 : 3319432079
Total Pages : 125 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Advances in Microbiology, Infectious Diseases and Public Health by : Gianfranco Donelli

Download or read book Advances in Microbiology, Infectious Diseases and Public Health written by Gianfranco Donelli and published by Springer. This book was released on 2016-09-21 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advances in Microbiology, Infectious Diseases and Public Health Series will provide microbiologists, hygienists, epidemiologists and infectious diseases specialists with well-chosen contributed volumes containing updated information in the areas of basic and applied microbiology involving relevant issues for public health, including bacterial, fungal and parasitic infections, zoonoses and anthropozoonoses, environmental and food microbiology. The increasing threat of the multidrug-resistant microorganisms and the related host immune response, the new strategies for the treatment of biofilm-based, acute and chronic microbial infections, as well as the development of new vaccines and more efficacious antimicrobial drugs to prevent and treat human and animal infections will be also reviewed in this series in the light of the most recent achievements in these fields. Special attention will be devoted to the fast diffusion worldwide of the new findings of the most advanced translational researches carried out in the different fields of microbiological sciences, with the aim to promote a prompt validation and transfer at clinical level of the most promising experimental results.

Atlas of Oral Microbiology: From Healthy Microflora to Disease

Author : Xuedong Zhou
Publisher : Springer Nature
ISBN 13 : 9811578990
Total Pages : 368 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Atlas of Oral Microbiology: From Healthy Microflora to Disease by : Xuedong Zhou

Download or read book Atlas of Oral Microbiology: From Healthy Microflora to Disease written by Xuedong Zhou and published by Springer Nature. This book was released on 2021-01-06 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the second edition of Atlas of Oral Microbiology: From Healthy Microflora to Disease (ISBN 978-0-12-802234-4), with two new features: we add about 60 pictures of 14 newly isolated microbes from human dental plaque, at the same time, we re-organize the content of this book and provide more research progress about the oral microbiome bank of China, the invasion of oral microbiota into the gut, and the relationships between Oral Microflora and Human Diseases. This book is keeping up with the advanced edge of the international research field of oral microbiology. It innovatively gives us a complete description of the oral microbial systems according to different oral ecosystems. It collects a large number of oral microbial pictures, including cultural pictures, colonies photos, and electron microscopy photos. It is by far the most abundant oral microbiology atlas consists of the largest number of pictures. In the meantime, it also described in detail a variety of experimental techniques, including microbiological isolation, culture, and identification. It is an atlas with strong practical function. The editors and writers of this book have long been engaged in teaching and research work in oral microbiology and oral microecology. This book deserves a broad audience, and it will meet the needs of researchers, clinicians, teachers, and students major in biology, dental medicine, basic medicine, or clinical medicine. It can also be used to facilitate teaching and international academic exchanges.

Oxford Handbook of Infectious Diseases and Microbiology

Author : Estee Torok
Publisher : OUP Oxford
ISBN 13 : 0191039624
Total Pages : 944 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Oxford Handbook of Infectious Diseases and Microbiology by : Estee Torok

Download or read book Oxford Handbook of Infectious Diseases and Microbiology written by Estee Torok and published by OUP Oxford. This book was released on 2009-03-26 with total page 944 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the current approach to joint postgraduate training programmes in infectious diseases (ID) and microbiology, the Oxford Handbook of Infectious Diseases and Microbiology takes an integrated approach to both subjects. It covers the basic principles of bacteriology and virology, along with specific guidance on individual diseases and conditions, all in the accessible Oxford Medical Handbook style. Practical and comprehensive, this handbook includes coverage of national and international guidelines, together with information on topical issues such as bioterrorism and preventative medicine. Fully reviewed by specialist senior readers, and with useful links to up-to-date clinical information and online resources, this is an important addition to the Oxford Medical Handbook Series.

Oxford Handbook of Infectious Diseases and Microbiology

Author : Estée Török
Publisher : Oxford University Press
ISBN 13 : 019967132X
Total Pages : 914 pages
Book Rating : 4.1/5 (996 download)

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Book Synopsis Oxford Handbook of Infectious Diseases and Microbiology by : Estée Török

Download or read book Oxford Handbook of Infectious Diseases and Microbiology written by Estée Török and published by Oxford University Press. This book was released on 2017 with total page 914 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook takes an integrated approach to both infectious disease and microbiology. Referenced to national frameworks and current legislation, it covers basic principles of bacteriology and virology, specific information on diseases and conditions, and material on 'hot topics' such as bioterrorism and preventative medicine.

Cases in Medical Microbiology and Infectious Diseases

Author : Peter H. Gilligan
Publisher : John Wiley & Sons
ISBN 13 : 1555818676
Total Pages : 605 pages
Book Rating : 4.5/5 (558 download)

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Book Synopsis Cases in Medical Microbiology and Infectious Diseases by : Peter H. Gilligan

Download or read book Cases in Medical Microbiology and Infectious Diseases written by Peter H. Gilligan and published by John Wiley & Sons. This book was released on 2020-08-06 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cases in Medical Microbiology and Infectious Diseases challenges students to develop a working knowledge of the variety of microorganisms that cause infections in humans. This valuable, interactive text will help them better understand the clinical importance of the basic science concepts presented in medical microbiology or infectious disease courses. The cases are presented as "unknowns" and represent actual case presentations of patients the authors have encountered. Each case is accompanied by several questions to test knowledge in four broad areas including the organism's characteristics and laboratory diagnosis; pathogenesis and clinical characteristics of the infection; epidemiology; and prevention and, in some cases, drug resistance and treatment. This new fourth edition includes: an entirely new section, "Advanced Cases," which includes newly recognized disease agents as well as highly complex cases where the interaction of the immune system and human pathogens can be more closely examined a revised "Primer on the Laboratory Diagnosis of Infectious Diseases" section that reflects the increasing importance of molecular-based assays Forty-two new cases that explore the myriad advances in the study of infectious disease in the past decade Thirty-two updated cases that reflect the current state of the art as it relates to the organism causing the infection This textbook also include specific tools to assist students in solving the cases, including a table of normal values, glossary of medical terms, and figures illustrating microscopic organism morphology, laboratory tests, and clinical symptoms. Cases in Medical Microbiology and Infectious Diseases is a proven resource for preparing for Part I of the National Board of Medical Examiners Exam and an excellent reference for infectious disease rotations.

Hagan and Bruner's Microbiology and Infectious Diseases of Domestic Animals

Author : William Arthur Hagan
Publisher : Cornell University Press
ISBN 13 : 9780801418969
Total Pages : 976 pages
Book Rating : 4.4/5 (189 download)

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Book Synopsis Hagan and Bruner's Microbiology and Infectious Diseases of Domestic Animals by : William Arthur Hagan

Download or read book Hagan and Bruner's Microbiology and Infectious Diseases of Domestic Animals written by William Arthur Hagan and published by Cornell University Press. This book was released on 1988 with total page 976 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Infectious Diseases in the Female Patient

Author : Rudolph P. Galask
Publisher : Springer Science & Business Media
ISBN 13 : 1461248523
Total Pages : 276 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Infectious Diseases in the Female Patient by : Rudolph P. Galask

Download or read book Infectious Diseases in the Female Patient written by Rudolph P. Galask and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: In obstetrics and gynecology, as in other medical disciplines, great satisfaction comes from doing, but a greater satisfaction comes from knowing. The desire to know raises clinical practice to its highest level. This principle guided us in determining the objectives for this volume. Several standard textbooks of obstetrics and gynecology include information about infectious problems. Infectious Diseases in the Female Patient is unique in that it emphasizes primarily the basic science as pects of infections in obstetrics and gynecology. Although providing a practitioner's handbook was not our goal, the reader nevertheless will find discussions of the management of infections in the female pa tient. The continued growth of knowledge about infectious disease en countered in obstetrics and gynecology has come from many sources: bacteriology, virology, genetics, immunology, biochemistry, physiol ogy, and pharmacology. Insights from all these disciplines contribute to the conceptual framework of this volume. Many of the authors who contributed to this text are leaders in their respective areas of research and bring to the book a diversity of ex pertise and experience. Controversial issues are developed in a bal anced fashion, and, in most cases, opposing views are discussed. Since medical texts usually are read piece-meal rather than cover to cover, we have allowed some overlap between chapters. The slight degree of redundancy allows each chapter to stand on its own, so that the reader may obtain the necessary information from a single chapter.

Microbiology of Urinary Tract Infections

Author : Payam Behzadi
Publisher : BoD – Books on Demand
ISBN 13 : 1789849551
Total Pages : 112 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Microbiology of Urinary Tract Infections by : Payam Behzadi

Download or read book Microbiology of Urinary Tract Infections written by Payam Behzadi and published by BoD – Books on Demand. This book was released on 2019-02-13 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Generally, in accordance with anatomical characteristics, urinary tract infections (UTIs) and in particular recurrent UTIs occur in women; in contrast, UTIs normally occur in men with different predisposing factors. There are several types of UTIs, including asymptomatic and symptomatic, complicated and uncomplicated, acute and chronic with a diversity of microbial pathogens. In pathogens, virulence factors and genes determine the type and severity of the UTIs. Obviously, UTIs are a huge problem in global public healthcare systems with a wide range of predisposing factors, including gender, microbial agent, the host's immune deficiencies, genetic diseases, catheterization, etc. The recent items determine the microbiology of UTIs. Accurate diagnosis and definitive treatment are the key to UTI reduction.

HPV infection and cervical, vagina, and vulvar cancers

Author : Chengquan Zhao
Publisher : Frontiers Media SA
ISBN 13 : 2832553044
Total Pages : 152 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis HPV infection and cervical, vagina, and vulvar cancers by : Chengquan Zhao

Download or read book HPV infection and cervical, vagina, and vulvar cancers written by Chengquan Zhao and published by Frontiers Media SA. This book was released on 2024-08-09 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Persistent infection with oncogenic types of human papillomavirus (HPV) is commonly detected in the pre-cancerous lesions and invasive cancers of female lower genital organs. Currently, over 200 HPV genotypes have been identified. With the knowledge of HPV in female genital tracts infection and carcinogenesis advanced, HPV testing has recently been recommended as one of the primary screening methods for cervical cancer prevention. However, understanding HPV at a systematic level is lacking and disconnected. For example, the development and evaluation of new HPV vaccines face challenges related to efficacy, safety, and scalability. Viral persistence mechanisms and immune interaction among HPV subtypes require in-depth molecular and cellular studies. Addressing the long-term effectiveness of vaccination is another challenge. How bridge the gap between research and health policy for translating scientific findings into actionable guidelines is also difficult. This Research Topic aims to offer a forum for discussing new discoveries on HPV carcinogenesis, viral interaction, immune interaction, immune balance and escape among HPV viral subtypes and with other viruses, immune intervention for HPV infections; as well as updated information on cervical cancer screening/prevention guideline, and clinical management. On the global scale, it is of particular interest under-addressed and different levels of HPV research that face key challenges including basic science research, translational research, epidemiological research, and implementation sciences. We welcome manuscripts focused on the most recent advances in HPV or HPV-related women's lower genital malignancies, in regard to cancer prevention, diagnosis, and treatment. The subtopics include, but are not limited to the following: 1. HPV carcinogenesis, viral interaction, viral persistence, populational features of HPV infection (Review, Original Research, and Clinical Research). 2. Cervical and anal cancer screening/prevention by HPV testing, HPV self-testing, and HPV testing performance (Original Research). 3. Discoveries of HPV carcinogenesis, HPV genotyping, immune balance and escape among HPV viral subtypes and with other viruses, immune intervention for HPV infection in women (Original Research). 4. Advances and current status of HPV vaccine and performance of HPV vaccine worldwide (Review and Original Research). 5. Advances and updates in clinical management and guidelines in HPV-positive women (Review and Original Research). 6. Socioeconomic, cultural, and demographic features linked to HPV infections, female lower genital cancer development and prevention (Original Research). Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.

The Microbiology of Skin, Soft Tissue, Bone and Joint Infections

Author : Kateryna Kon
Publisher : Academic Press
ISBN 13 : 0128110937
Total Pages : 340 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Microbiology of Skin, Soft Tissue, Bone and Joint Infections by : Kateryna Kon

Download or read book The Microbiology of Skin, Soft Tissue, Bone and Joint Infections written by Kateryna Kon and published by Academic Press. This book was released on 2017-04-25 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Microbiology of Skin, Soft Tissue, Bone and Joint Infections: Volume 2 discusses modern approaches in diagnosis, treatment, and prophylaxis of skin, soft tissue, bone, and joint infections. The volume has been divided into three sections. The first section includes chapters on diagnosis, treatment, and prophylaxis of skin and soft tissue infections. It discusses antimicrobial and surgical treatment of wounds, diabetic foot, and different soft tissue infections. Ten chapters are devoted to cutaneous and musculoskeletal infections in special groups of patients, which have their own specificity, i.e. in pediatric and HIV-infected patients. Together with chapters on commonly present diseases, there are chapters which discuss interesting but not well studied pathologies (natal cleft pilonidal sinus) and pathogens (Malassezia and Shewanella spp.). The second section reviews etiology, pathogenesis, diagnosis and treatment of bone and joint infections, mainly osteomyelitis and prosthetic joint infections. Also, one chapter in this section discusses a newly emerging bacterial pathogen that causes skeletal infections, Kingella kingae. The third section incorporates alternative and new approaches—such as nanotechnology, ultrasound, novel delivery approaches and phyto-derived medicines—to the treatment and prophylaxis of skin, soft tissue, bone, and joint infections. - Encompasses a broad range of skin, soft tissue, bone, and joint infections, including questions of etiology, pathogenesis, diagnosis, prognosis, treatment, and prophylaxis - Written by highly professional and eminent surgeons, microbiologists, and infectious disease specialists - Discusses topics using modern insight, providing all necessary scientific information on each aspect - Includes scientific understanding and practical guidelines, which make it interesting for both research scientists and practitioners working with skin, soft tissue, bone, and joint infections

Systems Immunology and Infection Microbiology

Author : Bor-Sen Chen
Publisher : Academic Press
ISBN 13 : 0128173351
Total Pages : 673 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Systems Immunology and Infection Microbiology by : Bor-Sen Chen

Download or read book Systems Immunology and Infection Microbiology written by Bor-Sen Chen and published by Academic Press. This book was released on 2021-03-16 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Immunology and Infection Microbiology provides a large amount of biological system models, diagrams and flowcharts to illustrate development procedures and help users understand the results of systems immunology and infection microbiology. Chapters discuss systems immunology, systems infection microbiology, systematic inflammation and immune responses in restoration and regeneration process, systems' innate and adaptive immunity in infection process, systematic genetic and epigenetic pathogenic/defensive mechanism during bacterial infection on human cells is introduced, and the systematic genetic and epigenetic pathogenic/defensive mechanisms during viral infection on human cells. This book provides new big data-driven and systems-driven systems immunology and infection microbiology to researchers applying systems biology and bioinformatics in their work. It is also invaluable to several members of biomedical field who are interested in learning more about those approaches. - Encompasses one applicable example in every chapter to illustrate the solution procedure from big data mining, network modeling, host/pathogen cross-talk detection, drug target identification and systems drug design - Presents flowcharts to represent the development procedure of systematic immunology and infection in a very clear format - Contains 100 color diagrams to help readers understand the related biological networks, their corresponding mechanisms, and significant network biomarkers for therapeutic drug design

Bugs as Drugs

Author : Robert A. Britton
Publisher : John Wiley & Sons
ISBN 13 : 1683673026
Total Pages : 725 pages
Book Rating : 4.6/5 (836 download)

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Book Synopsis Bugs as Drugs by : Robert A. Britton

Download or read book Bugs as Drugs written by Robert A. Britton and published by John Wiley & Sons. This book was released on 2018-02-01 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examining the enormous potential of microbiome manipulation to improve health Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease. In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include: How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response. The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage. The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis. Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes. Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.

Veterinary Microbiology and Microbial Disease

Author : P. J. Quinn
Publisher : John Wiley & Sons
ISBN 13 : 1118251164
Total Pages : 932 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Veterinary Microbiology and Microbial Disease by : P. J. Quinn

Download or read book Veterinary Microbiology and Microbial Disease written by P. J. Quinn and published by John Wiley & Sons. This book was released on 2011-10-07 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbiology is one of the core subjects for veterinary students, and since its first publication in 2002, Veterinary Microbiology and Microbial Disease has become an essential text for students of veterinary medicine. Fully revised and expanded, this new edition updates the subject for pre-clinical and clinical veterinary students in a comprehensive manner. Individual sections deal with bacteriology, mycology and virology. Written by an academic team with many years of teaching experience, the book provides concise descriptions of groups of microorganisms and the diseases which they cause. Microbial pathogens are discussed in separate chapters which provide information on the more important features of each microorganism and its role in the pathogenesis of diseases of animals. The international and public health significance of these pathogens are reviewed comprehensively. The final section is concerned with the host and is organized according to the body system affected. Tables, boxes and flow diagrams provide information in an easily assimilated format. This edition contains new chapters on molecular diagnostics and on infectious conditions of the skin, cardiovascular system, urinary tract and musculoskeletal system. Many new colour diagrams are incorporated into this edition and each chapter has been updated. Key features of this edition: Twelve new chapters included Numerous new illustrations Each chapter has been updated Completely re-designed in full colour Fulfils the needs of veterinary students and academics in veterinary microbiology Companion website with figures from the book as Powerpoints for viewing or downloading by chapter: www.wiley.com/go/quinn/veterinarymicrobiology Veterinary Microbiology and Microbial Disease remains indispensable for all those studying and teaching this essential component of the veterinary curriculum.

Desk Encyclopedia of Microbiology

Author : Moselio Schaechter
Publisher : Elsevier
ISBN 13 : 008047246X
Total Pages : 1176 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Desk Encyclopedia of Microbiology by : Moselio Schaechter

Download or read book Desk Encyclopedia of Microbiology written by Moselio Schaechter and published by Elsevier. This book was released on 2003-12-11 with total page 1176 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Desk Encyclopedia of Microbiology aims to provide an affordable and ready access to a large variety of microbiological topics within one set of covers. This handy desk-top reference brings together an outstanding collection of work by the top scientists in the field. Covering topics ranging from the basic science of microbiology to the current "hot" topics in the field.* Provides a broad, easily accessible perspective on a wide range of microbiological topics* A synthesis of the broadest topics from the comprehensive and multi-volumed Encyclopedia of Microbiology, Second Edition * Helpful resource in preparing for lectures, writing reports, or drafting grant applications

The role of viable but non-infectious developmental forms in chlamydial biology

Author : Robert V Schoborg
Publisher : Frontiers E-books
ISBN 13 : 2889193217
Total Pages : 120 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis The role of viable but non-infectious developmental forms in chlamydial biology by : Robert V Schoborg

Download or read book The role of viable but non-infectious developmental forms in chlamydial biology written by Robert V Schoborg and published by Frontiers E-books. This book was released on 2014-11-04 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chlamydiae are Gram-negative, obligate intracellular bacteria with a complex developmental cycle comprising a metabolically less-active, infectious stage, the elementary body (EB), and a metabolically more active stage, the reticulate body (RB). They are responsible for many acute and chronic diseases in humans and animals. In order to play a causative role in chronic diseases, chlamydiae would need to persist and to re-activate within infected cells/tissues for extended periods of time. Persistence in vitro is defined as viable but non-cultivable chlamydiae involving morphologically enlarged, aberrant, and nondividing RBs, termed aberrant bodies (AB). In vitro, alterations of the normal developmental cycle of chlamydiae can be induced by the addition of Interferon-? (IFN-?), tumor necrosis factor-a (TNF-a) and penicillin G exposure as well as amino acid or iron deprivation, monocyte infection and co-infection with viruses. In vivo, key questions include whether or not ABs occur in infected patients and animals and whether such ABs can contribute to prolonged, chronic inflammation, fibrosis, and scarring through continuing stimulation of the host immune system known from diseases such as trachoma, pelvic inflammatory disease, reactive arthritis and atherosclerosis. To date, the direct causal role in the pathogenesis of chlamydial infection and persistence in vivo has been questioned since there was no tractable animal model of chlamydial persistence so far. A very recent study was able to establish an experimental animal model of in vivo persistence, when C. muridarum vaginally-infected mice were gavaged with amoxicillin. Amoxicillin treatment induced C. muridarum to enter the persistent state in vivo. Recent in vivo data from patients indicate that viable but non-infectious developmental stages are present in the genital tract of chronically-infected women and that the gastrointestinal tract might be a reservoir for persistent chlamydial infections at other sites.

Vaginal microecological disorder and gynecological diseases

Author : Zhangran Chen
Publisher : Frontiers Media SA
ISBN 13 : 2832538371
Total Pages : 188 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Vaginal microecological disorder and gynecological diseases by : Zhangran Chen

Download or read book Vaginal microecological disorder and gynecological diseases written by Zhangran Chen and published by Frontiers Media SA. This book was released on 2023-11-06 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: