Systems Immunology And Infection Microbiology

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Systems Immunology and Infection Microbiology

Author : Bor-Sen Chen
Publisher : Academic Press
ISBN 13 : 0128173351
Total Pages : 673 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Systems Immunology and Infection Microbiology by : Bor-Sen Chen

Download or read book Systems Immunology and Infection Microbiology written by Bor-Sen Chen and published by Academic Press. This book was released on 2021-03-16 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Immunology and Infection Microbiology provides a large amount of biological system models, diagrams and flowcharts to illustrate development procedures and help users understand the results of systems immunology and infection microbiology. Chapters discuss systems immunology, systems infection microbiology, systematic inflammation and immune responses in restoration and regeneration process, systems' innate and adaptive immunity in infection process, systematic genetic and epigenetic pathogenic/defensive mechanism during bacterial infection on human cells is introduced, and the systematic genetic and epigenetic pathogenic/defensive mechanisms during viral infection on human cells. This book provides new big data-driven and systems-driven systems immunology and infection microbiology to researchers applying systems biology and bioinformatics in their work. It is also invaluable to several members of biomedical field who are interested in learning more about those approaches. Encompasses one applicable example in every chapter to illustrate the solution procedure from big data mining, network modeling, host/pathogen cross-talk detection, drug target identification and systems drug design Presents flowcharts to represent the development procedure of systematic immunology and infection in a very clear format Contains 100 color diagrams to help readers understand the related biological networks, their corresponding mechanisms, and significant network biomarkers for therapeutic drug design

Systems Biology of Microbial Infection

Author : Reinhard Guthke
Publisher : Frontiers E-books
ISBN 13 : 2889190609
Total Pages : 139 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Systems Biology of Microbial Infection by : Reinhard Guthke

Download or read book Systems Biology of Microbial Infection written by Reinhard Guthke and published by Frontiers E-books. This book was released on with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: The systems biology of microbial infections aims at describing and analysing the confrontation of the host with bacterial and fungal pathogens. It intends to understand and to model the interaction of the host, in particular the immune system of humans or animals, with components of pathogens. This comprises experimental studies that provide spatio-temporal data from monitoring the response of host and pathogenic cells to perturbations or when interacting with each other, as well as the integrative analysis of genome-wide data from both the host and the pathogen. In perspective, the host-pathogen interaction should be described by a combination of spatio-temporal models with interacting molecular networks of the host and the pathogen. The aim is to unravel the main mechanisms of pathogenicity, to identify diagnostic biomarkers and potential drug targets, and to explore novel strategies for personalized therapy by computer simulations. Some microorganisms are part of the normal microbial flora, existing either in a mutualistic or commensal relationship with the host. Microorganisms become pathogenic if they posses certain physiological characteristics and virulence determinants as well as capabilities for immune evasion. Despite the different pathogenesis of infections, there are several common traits: (1) Before infection, pathogens must be able to overcome (epithelial) barriers. The infection starts by adhesion and colonization and is followed by entering of the pathogen into the host through the mucosa or (injured) skin. (2) Next, infection arises if the pathogen multiplies and overgrows the normal microbial flora, either at the place of entrance or in deeper tissue layers or organs. (3) After the growth phase, the pathogen damages the host’s cells, tissues and organs by producing toxins or destructive enzymes. Thus, systems biology of microbial infection comprises all levels of the pathogen and the host’s immune system. The investigation may start with the pathogen, its adhesion and colonization at the host, its interaction with host cell types e.g. epithelia cells, dendritic cells, macrophages, neutrophils, natural killer cells, etc. Because infection diseases are mainly found in patients with a weakened immune system, e.g. reduced activities of immune effector cells or defects in the epithelial barriers, systems biology of infection can also start with modelling of the immune defence including innate and adaptive immunity. Systems biological studies comprise both experimental and theoretical approaches. The experimental studies may be dedicated to reveal the relevance of certain genes or proteins in the above mentioned processes on the side of the pathogen and/or the host by applying functional and biochemical analyses based on knock-out mutants and knock- down experiments. At the theoretical, i.e. mathematical and computational, side systems biology of microbial infection comprises: (1) modelling of molecular mechanisms of bacterial or fungal infections, (2) modelling of non-protective and protective immune defences against microbial pathogens to generate information for possible immune therapy approaches, (3) modelling of infection dynamics and identification of biomarkers for diagnosis and for individualized therapy, (4) identifying essential virulence determinants and thereby predicting potential drug targets.

Infection & Immunity

Author : John Playfair
Publisher : Oxford University Press
ISBN 13 : 0199609500
Total Pages : 398 pages
Book Rating : 4.1/5 (996 download)

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Book Synopsis Infection & Immunity by : John Playfair

Download or read book Infection & Immunity written by John Playfair and published by Oxford University Press. This book was released on 2013-01-24 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors describe the main causes of infection that our bodies have to battle against - from bacteria to viruses - and explain the intricate and fascinating way that our bodies respond to infection - from detection of these potentially dangerous organisms, to their ultimate elimination

Janeway's Immunobiology

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Systems Immunology

Author : Jayajit Das
Publisher : CRC Press
ISBN 13 : 1351646141
Total Pages : 405 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Systems Immunology by : Jayajit Das

Download or read book Systems Immunology written by Jayajit Das and published by CRC Press. This book was released on 2018-09-03 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Taken together, the body of information contained in this book provides readers with a bird’s-eye view of different aspects of exciting work at the convergence of disciplines that will ultimately lead to a future where we understand how immunity is regulated, and how we can harness this knowledge toward practical ends that reduce human suffering. I commend the editors for putting this volume together." –Arup K. Chakraborty, Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined. Readers from immunology, quantitative biology, and applied physics will benefit from the following: Fundamental principles of computational immunology and modern quantitative methods for studying immune response at the single molecule, cellular, organism, and population levels. An overview of basic concepts in modeling and data analysis. Coverage of topics where mechanistic modeling has contributed substantially to current understanding. Discussion of genetic diversity of the immune system, cell signaling in the immune system, immune response at the cell population scale, and ecology of host-pathogen interactions.

Infection and Immunity

Author : D H Davies
Publisher : CRC Press
ISBN 13 : 020348438X
Total Pages : 250 pages
Book Rating : 4.2/5 (34 download)

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Book Synopsis Infection and Immunity by : D H Davies

Download or read book Infection and Immunity written by D H Davies and published by CRC Press. This book was released on 2002-09-11 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise text explores the interactions between pathogens and the immune system. Taking a disease-based approach, it explains how micro-organisms adapted to growth in human hosts can evade the immune system and cause disease. The opening chapter overviews the innate and adaptive immune responses to microbes. Subsequent chapters are specific to particular pathogens, beginning with their biology and leading on to illustrate mechanisms of adaptation and ensuing consequences. Each of these chapters ends with a summary, review questions and further reading lists. Summaries, review questions and further reading make this book suitable for self-directed study. Infection and Immunity is ideal for any undergraduates taking a course that explores the interaction between pathogens and the human immune system.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Treating Infectious Diseases in a Microbial World

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309180686
Total Pages : 102 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Treating Infectious Diseases in a Microbial World by : National Research Council

Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Systems Biology

Author : Michael G. Katze
Publisher : Springer Science & Business Media
ISBN 13 : 3642330991
Total Pages : 278 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Systems Biology by : Michael G. Katze

Download or read book Systems Biology written by Michael G. Katze and published by Springer Science & Business Media. This book was released on 2013-01-04 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies—oligonucleotide microarrays, mass spectrometry, and next-generation sequencing—and the analysis of this data through sophisticated mathematical algorithms. It is perhaps the use of mathematics, to integrate abundant and diverse types of data and to generate models of interconnected molecular networks, that best characterizes systems biology.

Immunology, Infection, and Immunity

Author : Gerald Bryan Pier
Publisher :
ISBN 13 :
Total Pages : 752 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Immunology, Infection, and Immunity by : Gerald Bryan Pier

Download or read book Immunology, Infection, and Immunity written by Gerald Bryan Pier and published by . This book was released on 2004 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying Digital Learning Guide CD-ROM is an interactive, automated program that organizes key information from the textbook, paces you through learning the material, and then allows you to quiz yourself and assess your progress.

Integrative Computational Systems Biology Approaches in Immunology and Medicine

Author : Lars Kaderali
Publisher : Frontiers Media SA
ISBN 13 : 2889458016
Total Pages : 290 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Integrative Computational Systems Biology Approaches in Immunology and Medicine by : Lars Kaderali

Download or read book Integrative Computational Systems Biology Approaches in Immunology and Medicine written by Lars Kaderali and published by Frontiers Media SA. This book was released on 2019-04-09 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immunology and Evolution of Infectious Disease

Author : Steven A. Frank
Publisher : Princeton University Press
ISBN 13 : 9780691095950
Total Pages : 364 pages
Book Rating : 4.0/5 (959 download)

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Book Synopsis Immunology and Evolution of Infectious Disease by : Steven A. Frank

Download or read book Immunology and Evolution of Infectious Disease written by Steven A. Frank and published by Princeton University Press. This book was released on 2002-07-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description

The Microbiology of Central Nervous System Infections

Author :
Publisher : Academic Press
ISBN 13 : 0128138076
Total Pages : 344 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Microbiology of Central Nervous System Infections by :

Download or read book The Microbiology of Central Nervous System Infections written by and published by Academic Press. This book was released on 2018-02-17 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Microbiology of Central Nervous System Infections, Volume 3, discusses modern approaches to the diagnosis, treatment and prophylaxis of central nervous system (CNS) infections. This new release is divided into five sections that cover treatment strategies, imaging, molecular diagnosis, management of CNS infections with metal nanoparticles, and prophylaxis of CNS infections, including bacterial, viral and fungal infections. The last section contains a chapter on transmissible spongiform encephalopathies and modern trends in its diagnosis and treatment. University teachers, medical practitioners, graduate and postgraduate students, researchers in microbiology, and those in the pharmaceutical and laboratory diagnostic industries will find the book very important. Encompasses a broad range of central nervous system infections, including questions of etiology, pathogenesis, diagnosis, prognosis, treatment and prophylaxis Written by highly professional and eminent surgeons, microbiologists and infectious disease specialists Includes scientific understanding and practical guidelines, making it interesting for both research scientists and practitioners

Immunology of Infection

Author : Stefan H.E. Kaufmann
Publisher : Gulf Professional Publishing
ISBN 13 : 9780125215329
Total Pages : 844 pages
Book Rating : 4.2/5 (153 download)

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Book Synopsis Immunology of Infection by : Stefan H.E. Kaufmann

Download or read book Immunology of Infection written by Stefan H.E. Kaufmann and published by Gulf Professional Publishing. This book was released on 2002-12-19 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology of Infection, 2nd Edition, edited by two leading experts in the field, presents the most appropriate up-to-date experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the Microbiologist interested in analysing host-pathogen relationships, this volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology and parasitology. This new edition of Immunology of Infection provides ready-to-use "recipes", and the latest emerging techniques as well as novel approaches to the tried and tested, established methods included in the successful first edition. Methods in Microbiologyis the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting edge protocols to directly benefit your research. Includes techniques for genome-wide expression profiling of both the pathogen and host and of the host response to infection Cytometric analysis of cytokine secretion by immune cells Describes tetramer technology for the quantitative analysis of antigen specific T cell responses Analysis of host cells and pathogens involved in the host-microbe interplay Covers techniques useful for the analysis of human and murine systems Includes techniques for the prediction and determination of MHC ligands and T cell epitopes Covers the fundamentals and practice of DNA vaccines Describes methods for the isolation and propagation of human dendritic cells

Idiotypes in Medicine: Autoimmunity, Infection and Cancer

Author : R.C. Kennedy
Publisher : Elsevier
ISBN 13 : 9780080534435
Total Pages : 540 pages
Book Rating : 4.5/5 (344 download)

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Book Synopsis Idiotypes in Medicine: Autoimmunity, Infection and Cancer by : R.C. Kennedy

Download or read book Idiotypes in Medicine: Autoimmunity, Infection and Cancer written by R.C. Kennedy and published by Elsevier. This book was released on 1997-11-19 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

A History of Medical Bacteriology and Immunology

Author : W. D. Foster
Publisher : Butterworth-Heinemann
ISBN 13 : 1483162451
Total Pages : 244 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis A History of Medical Bacteriology and Immunology by : W. D. Foster

Download or read book A History of Medical Bacteriology and Immunology written by W. D. Foster and published by Butterworth-Heinemann. This book was released on 2014-05-20 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: A History of Medical Bacteriology and Immunology provides the account of the history of bacteriology from the year 1900 to 1938. This book presents details about the discovery of the important pathogenic bacteria of man, of how they were shown to be causally related to disease, and of the use of these discoveries in the diagnosis, treatment, and prevention of disease. Other topics discussed include the development of the germ theory of infectious diseases; contribution of Louis Pasteur and Robert Koch to medical bacteriology; and discovery of the more important human pathogenic bacteria. This text also discusses the scientific basis and practical application of immunology to medicine; main developments in bacteriology during the early 20th century; and chemotherapy of bacterial disease. This medically oriented text is beneficial for students and individuals conducting study on medical bacteriology and immunology.

Encyclopedia of Infection and Immunity

Author :
Publisher : Elsevier
ISBN 13 : 9780128187319
Total Pages : 2112 pages
Book Rating : 4.1/5 (873 download)

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Book Synopsis Encyclopedia of Infection and Immunity by :

Download or read book Encyclopedia of Infection and Immunity written by and published by Elsevier. This book was released on 2022-04-22 with total page 2112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Infection and Immunity provides new insights into the interactions between bacteria, fungi, parasites and their hosts. Specific areas of interest include host cellular and immune response to microbes, molecular mechanisms of action of beneficial microbes or host-associated microbial communities, microbial pathogenesis, virulence factors, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. Comprised of over 200 chapters written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases. More than 100 years after Robert Koch and Louis Pasteur established the microbial etiology of communicable diseases, the field of microbiology is experiencing a second period of rapid growth and expansion, driven by the realization that changes in host-associated microbial communities might be at the root of a broad spectrum of noncommunicable human diseases. These advances follow on the heels of recent progress in high-throughput sequencing technology, which has provided a wealth of information on the human microbiome and its physiological potential. Offers a contemporary review of current infection and immunity research, and insights into the future direction of the field Meticulously researched and cross-referenced to allow students, researchers and professionals to find relevant information quickly and easily Includes chapters written by academics and practitioners from various fields and regions, ensuring that the knowledge within is easily understood by, and applicable to, a large audience