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Author : Tim Durfee
Publisher :
ISBN 13 :
Total Pages : 298 pages
Book Rating : 4.:/5 (318 download)
Download or read book Identification of Complexes Involving the Retinoblastoma Tumor Suppressor Protein written by Tim Durfee and published by . This book was released on 1993 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pedro G. Santiago-Cardona
Publisher : Humana Press
ISBN 13 : 9781493975648
Total Pages : 200 pages
Book Rating : 4.9/5 (756 download)
Download or read book The Retinoblastoma Protein written by Pedro G. Santiago-Cardona and published by Humana Press. This book was released on 2018-02-22 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the mechanisms of pRb inactivation detailing repressive mechanisms commonly associated to cancer, and representative of the experimentally relevant tests used in the establishment of cancer diagnosis and prognosis. Chapters contain protocols and in-depth discussions for commonly used experimental approaches to assess the status and function of components of the pRb pathway, including pRb itself, in cell lines and biological samples.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, The Retinoblastoma Protein aims to serve as a guide to assist molecular cancer biologists in their search for understanding of the molecular functions of this preeminent tumor suppressor.
Author : Govindasamy Kumaramanickavel
Publisher : BoD – Books on Demand
ISBN 13 : 9535104357
Total Pages : 184 pages
Book Rating : 4.5/5 (351 download)
Download or read book Retinoblastoma written by Govindasamy Kumaramanickavel and published by BoD – Books on Demand. This book was released on 2012-03-28 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retinoblastoma is the first tumor suppressor gene discovered ever. The discovery opened a new avenue in the field of oncology leading to the identification of 35 tumor suppressor genes, till date in our genome. This book is an excellent compilation of both clinical and basic science information that meets the needs of a young clinician and a researcher at the same time. It also has abundant information on recent advances and cutting-edge knowledge in intracellular molecular cross-talking of retinoblastoma protein with various cellular viral-like proteins.
Author : Blossom Damania
Publisher : Springer Science & Business Media
ISBN 13 : 0387689451
Total Pages : 805 pages
Book Rating : 4.3/5 (876 download)
Download or read book DNA Tumor Viruses written by Blossom Damania and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book focuses on the DNA viruses in the human population that are associated with cancers. It covers most of the viruses that are thought to contribute to human malignancy. This book represents a comprehensive review of the field of DNA tumor virology. Right now, while there are books out there that cover individual viruses that are also covered in this book, there is no single book that covers this topic comprehensively. This book is the first current, comprehensive review of its kind in the market.
Download or read book Biochemical and Structural Investigations of the Retinoblastoma Protein, Its Binding Partners, and the BRG1 Protein - a Subunit of Human SWI/SNF Remodeling Complexes written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Two projects were undertaken in this thesis. The first project involved functional investigations on the retinoblastoma protein (pRb) and its interaction with binding partners. The second project involved the characterization of functional domains of the human BRG1 protein including the 3D structure determination of BRG1 bromodomain. The retinoblastoma tumor suppressor protein (pRb) is a key negative regulator of cell proliferation that is frequently deregulated in human cancer. More than 130 proteins have been reported to bind to pRb directly. Many of these interactions were reported with the pRb small pocket, which is the major focus of tumorigenic mutations in pRb, and comprises the A and B cyclin - like domains (amino acids 379-578 and 641-791, respectively). However, results found in the literature are ambiguous and contradictory. We have investigated some of these interactions using purified proteins and in-vitro biophysical and biochemical methods, which included, nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, isothermal titration calorimetry (ITC), the affinity chromatography pull-down assays, and gel filtration chromatography. The interactions of pRb with the following proteins were checked using this approach: MyoD, Id-2, E2F1, HDAC1, PAI2, HPV E7, SV40 large T antigen, BRG1, and gankyrin. Myogenic differentiation promoting, MyoD and inhibiting, Id-2, factors were reported to interact with the pRb pocket domain to coordinate the cell growth and differentiation during the process of myogenesis. There have been contradictory reports in the literature regarding the direct interaction between pRb and MyoD, pRb and Id-2 proteins. We probed these interactions using our multimethod in-vitro approach. Using this approach and we were able to document interactions between pRb and HPV-E7, pRb and SV40 large T antigen, MyoD and DNA, and MyoD and Id-2. However using the same approach, we could unambiguously show that there is no direct protein-protei.
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Erik Stephen Knudsen
Publisher :
ISBN 13 :
Total Pages : 318 pages
Book Rating : 4.:/5 (318 download)
Download or read book The Retinoblastoma Tumor Suppressor Protein written by Erik Stephen Knudsen and published by . This book was released on 1996 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mellone Noelene Marchong
Publisher :
ISBN 13 : 9780494395493
Total Pages : 244 pages
Book Rating : 4.3/5 (954 download)
Download or read book Identification of CDH11 as a Candidate Tumor Suppressor in Retinoblastoma and Characterization of Its Role in Retina and Retinoblastoma written by Mellone Noelene Marchong and published by . This book was released on 2007 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since Kundson's two hit hypothesis of the retinoblastoma tumor susceptibility gene in 1971 and the subsequent cloning of RB1 in 1986 and 1987, pRB has been the highlight of cancer research. It represents the prototypical model for inherited cancers and has since lead to better understanding of cancer genetics. The disease is unique in that its initiating mutational events are known, loss of both alleles of RB1, mutational events 1 and 2 (M1 and M2). Investigation of mutational events, M3-Mn, that lead to its progression will be useful for better understanding of retinoblastoma tumorigenesis, which can ultimately translate to the development of new and better therapeutics that can be used to halt retinoblastoma progression at a very early stage. Loss of chromosomal region 16q22 is a significant genomic change recognized not only in retinoblastoma but in numerous other cancers. Using loss of heterozygosity (LOB) and quantitative multiplex PCR (QM-PCR) techniques on a total of 76 retinoblastoma tumors we were able to narrow down the genomic region of loss on chromosome 16q22. We identified a gene, CDH11, to be a candidate tumor suppressor in retinoblastoma, as it was found to display copy number loss in 58% of 71 tumors and protein expression loss in tumors of both human and murine retinoblastoma. To study the role of cadherin-11 in retinogenesis, I compared developing retinae of Cdh11+/+, Cdh11+/- and Cdh11-/- mouse littermates, and report that Cdh11 plays a subtle role during murine retinogenesis, whereby it supports the development of the retinoblastoma susceptibility cells in the transgenic SV40 large T-antigen mouse model of retinoblastoma (TAg-RB). I also report that retinoblastoma tumors in mice with mutant alleles of Cdh11 grow faster than tumors in mice with normal Cdh11 alleles. These results herein, concur with characteristics identifying tumor suppressor genes. Thus, I provide compelling evidence to support a tumor suppressor role for Cdh11 in retinoblastoma progression.
Author : Manfred Schwab
Publisher : Springer Science & Business Media
ISBN 13 : 3540665277
Total Pages : 1017 pages
Book Rating : 4.5/5 (46 download)
Download or read book Encyclopedic Reference of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2001-10-15 with total page 1017 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid and focused information about topics of cancer research for the clinical and basic scientist, students and informed laymen. It will be readily accessible, both electronically and in print, such that it will be of value to both the scientific community and the public.
Download or read book Biochemical and Biophysical Characterization of the Retinoblastoma Protein and Its Interacting Partners written by and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The retinoblastoma tumor suppressor protein, pRb, is a nuclear phosphoprotein that acts as a negative regulator of cellular proliferation and apoptosis, and a promoter of cell differentiation. All of its physiological functions were ascribed based on its ability to interact with a plethora of cellular and viral oncoproteins. However, detailed structural and functional analysis of pRb has been hampered by a lack of pure protein. In the presented thesis, we report the construction, expression and three-step purification of the A/B pocket region of pRb in a bacterial expression system. Our protocol allows the production of 5-6 mg of pure unlabelled pRb and 3-4 mg of isotopic labelled pRb per liter of E. coli culture. The molecular mass of the purified protein was estimated to be ~39 kDa by SDS-PAGE and gel filtration. N-terminal amino acid analysis and Western blot studies were used to characterize the E. coli purified human pRb. The secondary and tertiary structural integrity of the protein was investigated by CD and NMR spectroscopy. The preparation of pRb reported here provides sufficient amounts of this protein for a detailed functional and structural characterization of the retinoblastoma protein. The isotopic labelled protein can be used to validate proposed pRb protein-protein interactions as well as for structure determination and drug design. The unlabelled protein can be used to make complexes of pRb and its partner proteins, and solving crystal structures of these complexes may explain the mechanism of action of pRb in various cellular processes. As an application of this work, we have probed interactions between pRb and MyoD. MyoD belongs to a group of muscle specific basic helix-loop-helix (bHLH) transcription factors that are essential for muscle cell differentiation in vertebrates. Preceding studies showed interaction of MyoD with the small pocket domain of pRb. Through pull-down assays and NMR titrations, here we demonstrate that the small pocket domain.
Author : David E. Fisher
Publisher : Springer Science & Business Media
ISBN 13 : 1592592309
Total Pages : 441 pages
Book Rating : 4.5/5 (925 download)
Download or read book Tumor Suppressor Genes in Human Cancer written by David E. Fisher and published by Springer Science & Business Media. This book was released on 2000-10-26 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.
Author : Manfred Schwab
Publisher : Springer Science & Business Media
ISBN 13 : 3540368477
Total Pages : 3307 pages
Book Rating : 4.5/5 (43 download)
Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Author : Karol Sikora
Publisher : Wiley
ISBN 13 : 9780471925835
Total Pages : 364 pages
Book Rating : 4.9/5 (258 download)
Download or read book Genes and Cancer written by Karol Sikora and published by Wiley. This book was released on 1990-10-26 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work serves as an introduction to the applications of molecular biology in the field of oncology. It provides a basic understanding of the genetic events involved in fully developed human cancer, including research into inherited and acquired gene defects initiating new neoplasms and the subsequent genetic alterations involved in tumor progression. Some of the specific topics explored include gene control, molecular therapy and antibodies, drug resistance, growth factors and receptors, and tumor biology. While intended primarily as an advanced text for oncologists, postgraduate molecular geneticists and molecular biologists, the book will certainly be of interest to other researchers who frequently encounter cancer in their practice.
Author : Olivier Binda
Publisher : Academic Press
ISBN 13 : 012802609X
Total Pages : 468 pages
Book Rating : 4.1/5 (28 download)
Download or read book Chromatin Signaling and Diseases written by Olivier Binda and published by Academic Press. This book was released on 2016-08-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling. Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored. Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with aging Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling Helps researchers learn about the quickly expanding field of chromatin signaling
Author : Renato Paro
Publisher : Springer Nature
ISBN 13 : 3030686701
Total Pages : 215 pages
Book Rating : 4.0/5 (36 download)
Download or read book Introduction to Epigenetics written by Renato Paro and published by Springer Nature. This book was released on 2021-03-23 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Author : Kelly K. Hunt
Publisher : Springer Science & Business Media
ISBN 13 : 159745222X
Total Pages : 469 pages
Book Rating : 4.5/5 (974 download)
Download or read book Gene Therapy for Cancer written by Kelly K. Hunt and published by Springer Science & Business Media. This book was released on 2007-10-26 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.
Author : Peggy J Farnham
Publisher :
ISBN 13 : 9783642799112
Total Pages : 160 pages
Book Rating : 4.7/5 (991 download)
Download or read book Transcriptional Control of Cell Growth written by Peggy J Farnham and published by . This book was released on 1995-12-12 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
