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Host Pathogen Interactions In Streptococcal Diseases
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Book Synopsis Host-Pathogen Interactions in Streptococcal Diseases by : G Singh Chhatwal
Download or read book Host-Pathogen Interactions in Streptococcal Diseases written by G Singh Chhatwal and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases.
Book Synopsis Streptococcus Pneumoniae by : Jeremy Brown
Download or read book Streptococcus Pneumoniae written by Jeremy Brown and published by Academic Press. This book was released on 2015-05-08 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Streptococcus Pneumoniae: Molecular Mechanisms of Host-Pathogen Interactions provides a comprehensive overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology. It presents a state-of-the-art overview of the implications of existing data, along with the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections and how to combat these infections. Users will find a timely update on the topic, as the dramatic increase in antibiotic resistance pneumoniae cases and limitations of the currently available pneumoniae vaccines are creating new concerns on these gram-positive bacteria that are endowed with a high virulence potential, and are the most common etiologic agent of respiratory and life-threatening invasive diseases. Provides an updated overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology Helps strengthen interdisciplinary networking and the focus of scientific resources by targeting epidemiology, vaccines, genetics, antibiotic resistance, clonal dissemination, Streptococcus pneumoniae biology, functional genomics, inflammasome, biomarkers, and more Multi-authored by leaders in the field who present a state-of-the-art overview of what the implications are of existing data, and the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections Supports combinatory networking in order to find new solutions in clinical therapies Reflects the most topical pneumococcal research trends
Book Synopsis Streptococci and the Host by : Thea Horaud
Download or read book Streptococci and the Host written by Thea Horaud and published by Springer Science & Business Media. This book was released on 2013-11-08 with total page 939 pages. Available in PDF, EPUB and Kindle. Book excerpt: Streptococci and enterococci are the etiologic agents of infectious diseases that rank among the most severe in human pathology. The diagnosis, antibiotherapy, and prevention of the streptococcal diseases have improved considerably. However, the reemergence of severe streptococcal and enterococcal diseases constitutes a growing public health con cern, which remains open to scientific and medical debate. The XIII'h Lancefield International Symposium on Streptococci and Streptococcal Diseases, held at Institut Pasteur, Paris, France, September 16---2el, 1996, attracted 505 par ticipants from 43 countries. Twenty-two percent of the participants were students, a clear sign of the intense interest in this field. Of the 390 presentations made at the symposium, 260 were submitted as manuscripts for the Proceedings; we have included 249 of these in this volume. This symposium provided a forum for the presentation of the most recent findings and approaches to understanding several important fields, such as new aspects of infec tion, bacteria~host interactions, epidemiology, and molecular genetics of streptococci and enterococci. Over the last three years, the study of these subjects has expanded as increas ingly sophisticated methods of molecular analysis have been applied to investigate the bi ology of pathogenic streptococci and enterococci. Virulence, vaccine strategies, genetics, antibiotic resistance, epidemiology, and immunology are now being examined through the lens of molecular biology. The application of recently developed techniques to this field will continue to yield insight into the mechanism by which these organisms cause disease.
Book Synopsis Cell Signaling in Host–Pathogen Interactions: The Host Point of View by : Diana Bahia
Download or read book Cell Signaling in Host–Pathogen Interactions: The Host Point of View written by Diana Bahia and published by Frontiers Media SA. This book was released on 2018-03-23 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of pathogens, such as parasites, bacteria, fungi and viruses to invade, persist and adapt in both invertebrate and vertebrate hosts is multifactorial and depends on both pathogen and host fitness. Communication between a pathogen and its host relies on a wide and dynamic array of molecular interactions. Through this constant communication most pathogens evolved to be relatively benign, whereas killing of its host by a pathogen represents a failure to adapt. Pathogens are lethal to their host when their interaction has not been long enough for adaptation. Evolution has selected conserved immune receptors that recognize signature patterns of pathogens as non-self elements and initiate host innate responses aimed at eradicating infection. Conversely, pathogens evolved mechanisms to evade immune recognition and subvert cytokine secretion in order to survive, replicate and cause disease. The cell signaling machinery is a critical component of the immune system that relays information from the receptors to the nucleus where transcription of key immune genes is activated. Host cells have developed signal transduction systems to maintain homeostasis with pathogens. Most cellular processes and cell signaling pathways are tightly regulated by protein phosphorylation in which protein kinases are key protagonists. Pathogens have developed multiple mechanisms to subvert important signal transduction pathways such as the mitogen activated protein kinase (MAPK) and the nuclear factor kB (NF-kB) pathways. Pathogens also secrete effectors that manipulate actin cytoskeleton and its regulators, hijack cell cycle machinery and alter vesicular trafficking. This research topic focuses on the cellular signaling mechanisms that are essential for host immunity and their subversion by pathogens.
Book Synopsis Bacterial Invasion of Host Cells by : Richard J. Lamont
Download or read book Bacterial Invasion of Host Cells written by Richard J. Lamont and published by Cambridge University Press. This book was released on 2004-03-29 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concerns the intimate association between bacteria and host cells. Many bacterial pathogens are able to invade and survive within cells at mucosal membranes. Remarkably, the bacteria themselves orchestrate this process through the exploitation of host cellular signal transduction pathways. Intracellular invasion can lead to disruption of host tissue integrity and perturbation of the immune system. An understanding of the molecular basis of bacterial invasion and of host cell adaptation to intracellular bacteria will provide fundamental insights into the pathophysiology of bacteria and the cell biology of the host. The book details specific examples of bacteria that are masters of manipulation of eukaryotic cell signaling and relates these events to the broader context of host-pathogen interaction. Written by experts in the field, this book will be of interest to researchers and graduate students in microbiology, immunology, biochemistry, as well as molecular medicine and dentistry.
Book Synopsis Bacterial Pathogenesis by : Frank R. DeLeo
Download or read book Bacterial Pathogenesis written by Frank R. DeLeo and published by Humana Press. This book was released on 2010-12-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial infections affect world health today as a leading cause of morbidity and mortality. This book presents in-depth methods and state-of-the-art protocols for investigating specific mechanisms of pathogenesis for a wide range of bacteria. Written by experts in the field, this invaluable collection includes protocols to study host-pathogen interactions, animal models of infection, and novel approaches to identifying therapeutic targets designed to control infections.
Author :Society for General Microbiology. Symposium Publisher :Cambridge University Press ISBN 13 :9780521592154 Total Pages :378 pages Book Rating :4.5/5 (921 download)
Book Synopsis Molecular Aspects of Host-Pathogen Interactions by : Society for General Microbiology. Symposium
Download or read book Molecular Aspects of Host-Pathogen Interactions written by Society for General Microbiology. Symposium and published by Cambridge University Press. This book was released on 1997-05-13 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reports the latest advances in defining the molecular basis of infection in both bacterial and viral systems.
Book Synopsis Infectious Diseases, Microbiology and Virology by : Luke S. P. Moore
Download or read book Infectious Diseases, Microbiology and Virology written by Luke S. P. Moore and published by Cambridge University Press. This book was released on 2019-12-05 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: A key resource for FRCPath and MRCP trainees, mapped to the current curriculum, using over 300 exam-style Q&A.
Download or read book Bacterial Pathogenesis written by and published by Academic Press. This book was released on 1998-07-01 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow Covers safety aspects, detection, identification and speciation Includes techniques for the study of host interactions and reactions in animals and plants Describes biochemical and molecular genetic approaches Essential methods for gene expression and analysis Covers strategies and problems for disease control
Book Synopsis Tuberculosis Host-pathogen Interactions by : Jeffrey David Cirillo
Download or read book Tuberculosis Host-pathogen Interactions written by Jeffrey David Cirillo and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Historically, tuberculosis was one of the first organisms associated with disease. Yet, despite progress, tuberculosis remains the most frequent cause of death in humans due to a single infectious agent. This text describes some of the recent, state-of-the-art advances related to our understanding of how this organism causes disease in humans, its mechanisms involved in parasitizing the host, as well as how the host resists or becomes susceptible to infection. We cover several of the molecular, biochemical and structural aspects of the bacterium responsible, Mycobacterium tuberculosis, and describe individual components of the host response and how these impact the course of disease. Although we cover only a very small portion of the field in this overview, we believe that there is a great deal of novel information present that will be valuable to any researcher or student of the field. We are at a stage where there are often more questions than answers, but use of the foundation that is now developing through the effort of tuberculosis researchers provides us with opportunities previously out of reach. This text provides overviews of the field in a number of different areas that will engage researchers interested in tuberculosis, and provide suggestions for ways to move forward. All of the authors hope that readers enjoy this taste of each area, and that their contributions will help others to make additional progress. Dr. Jeffrey D. Cirillo is a Regents Professor at Texas A & M University College of Medicine and the Director of the Center for Airborne Pathogens Research and Imaging with over 30 years of research in tuberculosis. Dr. Ying Kong is an Assistant Professor at the University of Tennessee Health Science Center with over 16 years of research in tuberculosis.
Book Synopsis Addressing Emerging Infectious Disease Threats by :
Download or read book Addressing Emerging Infectious Disease Threats written by and published by . This book was released on 1994 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: This plan addresses the need to improve our ability to identify infectious disease threats and respond to them effectively by improving the public health infrastructure at the local, state and federal levels. The goals of the plan are surveillance (detect, promptly investigate, and monitor emerging pathogens, the diseases they cause, and the factors influencing their emergence); applied research (integrate laboratory science and epidemiology to optimize public health practice); prevention and control (enhance communication of public health information about emerging diseases and ensure prompt implementation of prevention strategies); and infrastructure (strengthen local, state, and federal public health infrastructures to support surveillance and implement prevention and control programs).
Book Synopsis Polymicrobial Diseases by : Kim A. Brogden
Download or read book Polymicrobial Diseases written by Kim A. Brogden and published by . This book was released on 2002 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymicrobial diseases, those involving more than one etiologic agent, are more common than is generally realized and include respiratory diseases, gastroenteritis, conjunctivitis, keratitis, hepatitis, periodontal diseases, multiple sclerosis, genital infections, intra -- abdominal infections, and pertussis.
Book Synopsis Gram-positive Pathogens by : Vincent A. Fischetti
Download or read book Gram-positive Pathogens written by Vincent A. Fischetti and published by Amer Society for Microbiology. This book was released on 2006 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides comprehensive coverage of all gram-positive pathogens, including genome data. Appeals to clinicians, infectious disease specialists, and instructors and students seeking a single reference source on gram-positive bacteria.
Book Synopsis Necrotizing Soft Tissue Infections by : Anna Norrby-Teglund
Download or read book Necrotizing Soft Tissue Infections written by Anna Norrby-Teglund and published by Springer Nature. This book was released on 2020-10-20 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume aims to enhance the current understanding of clinical features, treatment and pathogenic aspects in necrotizing soft tissue infections. Various representative case studies are discussed to enhance the readers’ understanding of these complex diseases. Necrotizing soft tissue infections are rapidly spreading infections that may cause extensive soft tissue or limb loss, multiorgan failure and are associated with a considerable fatality rate. It is undisputed that rapid diagnosis and prompt intervention is directly related to survival. The initial presentation may be limited to unspecific symptoms such as tenderness, swelling, erythema and pain. Thus, diagnosis and management are challenging due to heterogeneity in clinical presentation, in co-morbidities, in microbiological aetiology, as well as in the pathogenic mechanisms. An international and multidisciplinary consortium, INFECT, has for the last 6 years been pursuing research aimed to advance the understanding of the clinical and pathogenic aspects of these infections. A central part has been to create a comprehensive clinical registry and associated biobank which have also formed the basis for the experimental studies. Using the INFECT patient cohort, as well as an integrated systems biology approach in patients and clinically relevant experimental models, an advanced insight of diagnostic features, causative microbial agents, treatment strategies, and pathogenic mechanisms (host and bacterial disease traits and their underlying interaction network) has been obtained.
Download or read book Vaccinology written by Gregg N. Milligan and published by John Wiley & Sons. This book was released on 2015-02-16 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes. Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.
Book Synopsis Staphylococcus and Streptococcus by : Sahra Kırmusaoğlu
Download or read book Staphylococcus and Streptococcus written by Sahra Kırmusaoğlu and published by BoD – Books on Demand. This book was released on 2020-03-11 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Staphylococcus spp. and Streptococcus spp. have not only got pathogenic isolates, but also non-pathogenic isolates. Staphylococcus spp. and Streptococcus spp. that are Gram positive cocci are the main pathogens in several infections. Virulence factors such as usual and unusual surface proteins encoded by resistance genes are the main causes of pathogenesis. Multidrug-resistant pathogens that are the main causes of morbidity and mortality worldwide have the ability to synthesize a number of destructive enzymes encoded by resistance genes such as ?-lactamases. Resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pneumoniae, Group A, and Group B Streptococcus have emerged throughout the world. To eliminate these resistant pathogens that cause untreatable, acute, and chronic infections, different new antimicrobials must be developed and used. The goal of this book is to provide the latest information about the above topics.
Book Synopsis Ending the War Metaphor by : Institute of Medicine
Download or read book Ending the War Metaphor written by Institute of Medicine and published by National Academies Press. This book was released on 2006-07-09 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases have existed longer than us, as long as us, or are relatively newer than us. It may be the case that a disease has existed for many, many years but has only recently begun affecting humans. At the turn of the century the number of deaths caused by infections in the United States had been falling steadily but since the '80s has seen an increase. In the past 30 years alone 37 new pathogens have been identified as human disease threats and 12% of known human pathogens have been classified as either emerging or remerging. Whatever the story, there is currently a "war" on infectious diseases. This war is simply the systematic search for the microbial "cause" of each disease, followed by the development of antimicrobial therapies. The "war" on infectious diseases, however, must be revisited in order to develop a more realistic and detailed picture of the dynamic interactions among and between host organisms and their diverse populations of microbes. Only a fraction of these microbes are pathogens. Thus, in order to explore the crafting of a new metaphor for host-microbe relationships, and to consider how such a new perspective might inform and prioritize biomedical research, the Forum on Microbial Threats of the Institute of Medicine (IOM) convened the workshop, Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship on March 16-17, 2005. Workshop participants examined knowledge and approaches to learning about the bacterial inhabitants of the human gut, the best known host-microbe system, as well as findings from studies of microbial communities associated with other mammals, fish, plants, soil, and insects. The perspective adopted by this workshop is one that recognizes the breadth and diversity of host-microbe relationships beyond those relative few that result in overt disease. Included in this summary are the reports and papers of individuals participating in the Forum as well as the views of the editors.
