Tuberculosis Host Pathogen Interactions

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Tuberculosis Host-Pathogen Interactions

Author : Jeffrey D. Cirillo
Publisher : Springer Nature
ISBN 13 : 3030253813
Total Pages : 255 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Tuberculosis Host-Pathogen Interactions by : Jeffrey D. Cirillo

Download or read book Tuberculosis Host-Pathogen Interactions written by Jeffrey D. Cirillo and published by Springer Nature. This book was released on 2019-09-10 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the progress in studies of tuberculosis host-pathogen interactions from several perspectives: molecular microbiology, immunology, animal models, clinical studies, epidemiology, and drug discovery. Tuberculosis (TB) remains a severe global public health problem. Complex interactions between environmental, microbial and host factors lead to clinically relevant infections. Studies on bacterial virulence, host-genetic, and immunological factors contributing to the susceptibility to TB provide an ever-growing foundation of knowledge that is critical to finding new interventions. Studies of immune mechanisms against M. tuberculosis infection have identified immunological markers associated with specific phenotypes in the host, providing insight into how they may be used to augment current treatment strategies. Recent advances in diagnosis, therapeutics and vaccines, as well as basic-research oriented studies have shed light on the development of new directions for prevention, treatment and control of TB. Improved understanding of the interplay between the bacterium and host is a key component of reducing incidence worldwide.

Persister Cells and Infectious Disease

Author : Kim Lewis
Publisher : Springer Nature
ISBN 13 : 3030252418
Total Pages : 295 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Persister Cells and Infectious Disease by : Kim Lewis

Download or read book Persister Cells and Infectious Disease written by Kim Lewis and published by Springer Nature. This book was released on 2019-11-13 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level.

Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism

Author : Jean Pieters
Publisher : Springer
ISBN 13 : 9783662521427
Total Pages : 0 pages
Book Rating : 4.5/5 (214 download)

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Book Synopsis Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism by : Jean Pieters

Download or read book Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism written by Jean Pieters and published by Springer. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.

Tuberculosis

Author : Larry S. Schlesinger
Publisher : Taylor & Francis
ISBN 13 : 042952420X
Total Pages : 175 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Tuberculosis by : Larry S. Schlesinger

Download or read book Tuberculosis written by Larry S. Schlesinger and published by Taylor & Francis. This book was released on 2022-03-10 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: M. tuberculosis remains one of the most successful human pathogens known. The causative agent of tuberculosis, it also has a unique ability to persist for years in the infected, apparently healthy host. This dormant organism can be reactivated years, even decades later to cause tuberculosis. This book reviews the most important state-of-the-art approaches currently used to study microbe-host interactions and highlights emerging methodologies.

Disease Control Priorities, Third Edition (Volume 6)

Author : King K. Holmes
Publisher : World Bank Publications
ISBN 13 : 1464805253
Total Pages : 506 pages
Book Rating : 4.4/5 (648 download)

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Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes

Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Systems Biology of Tuberculosis

Author : Johnjoe McFadden
Publisher : Springer Science & Business Media
ISBN 13 : 1461449669
Total Pages : 238 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Systems Biology of Tuberculosis by : Johnjoe McFadden

Download or read book Systems Biology of Tuberculosis written by Johnjoe McFadden and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book starts with a general introduction into the relevance of systems biology for understanding tuberculosis. This will be followed by several chapters which describe the application of systems biology to various aspects of the study of the pathogen, Mycobacterium tuberculosis, and its interaction with the host. The book provides the reader with an account of how the new science of systems biology is providing novel insights into the ancient scourge of tuberculosis. It will also describe how systems biology can be applied to the control of tuberculosis, including the development of new treatments, vaccines and diagnostics.

Tuberculosis and the Tubercle Bacillus

Author : William R. Jacobs, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 1555819567
Total Pages : 741 pages
Book Rating : 4.5/5 (558 download)

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Book Synopsis Tuberculosis and the Tubercle Bacillus by : William R. Jacobs, Jr.

Download or read book Tuberculosis and the Tubercle Bacillus written by William R. Jacobs, Jr. and published by John Wiley & Sons. This book was released on 2020-07-15 with total page 741 pages. Available in PDF, EPUB and Kindle. Book excerpt: Can today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035. This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs. Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB. Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against "persisters" and those that act on the electron transport complex and ATP synthase of M. tuberculosis. Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF. Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated. The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.

Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions

Author : Seyed Ehtesham Hasnain
Publisher : Springer Nature
ISBN 13 : 9813294132
Total Pages : 524 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions by : Seyed Ehtesham Hasnain

Download or read book Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions written by Seyed Ehtesham Hasnain and published by Springer Nature. This book was released on 2019-11-30 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews recent advances in the molecular and infection biology, pathology, and molecular epidemiology of Mycobacterium tuberculosis, as well as the identification and validation of novel molecular drug targets for the treatment of this mycobacterial disease. Despite being completely curable, tuberculosis is still one of the leading global causes of death. M. tuberculosis, the causative organism – one of the smartest pathogens known – adopts highly intelligent strategies for survival and pathogenesis. Presenting a wealth of information on the molecular infection biology of M. tuberculosis, as well as nontuberculous mycobacteria (NTM), the book provides an overview of the functional role of the PE/PPE group of proteins, which is exclusive to the genus Mycobacteria, of host-pathogen interactions, and virulence. It also explores the pathogenesis of the infection, pathology, epidemiology, and diagnosis of NTM. Finally it discusses current and novel approaches in vaccine development against tuberculosis, including the role of nanotechnology. With state-of-the-art contributions from experts in the respective domains, this book is an informative resource for practitioners as well as medical postgraduate students and researchers.

Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism

Author : Jean Pieters
Publisher : Springer
ISBN 13 : 9783642402333
Total Pages : 245 pages
Book Rating : 4.4/5 (23 download)

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Book Synopsis Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism by : Jean Pieters

Download or read book Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism written by Jean Pieters and published by Springer. This book was released on 2013-12-12 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.

Tuberculosis in Adults and Children

Author : Dorothee Heemskerk
Publisher : Springer
ISBN 13 : 3319191322
Total Pages : 66 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Tuberculosis in Adults and Children by : Dorothee Heemskerk

Download or read book Tuberculosis in Adults and Children written by Dorothee Heemskerk and published by Springer. This book was released on 2015-07-17 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

ESX-1: A Novel Alternative Secretion System in Mycobacterium Tuberculosis that Mediates the Host-pathogen Interaction

Author : Sarah A. Stanley
Publisher :
ISBN 13 :
Total Pages : 318 pages
Book Rating : 4.:/5 (85 download)

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Book Synopsis ESX-1: A Novel Alternative Secretion System in Mycobacterium Tuberculosis that Mediates the Host-pathogen Interaction by : Sarah A. Stanley

Download or read book ESX-1: A Novel Alternative Secretion System in Mycobacterium Tuberculosis that Mediates the Host-pathogen Interaction written by Sarah A. Stanley and published by . This book was released on 2006 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycobacterium tuberculosis is one of the world's most successful pathogens, infecting approximately one-third of humanity. This remarkable bacterium has infected human beings for millennia, and has evolved mechanisms for the manipulation of host biology to create an optimal environment for bacterial survival and growth. Here we describe the identification and characterization of ESX-1, the first alternative secretion system identified in M. tuberculosis, and show its fundamental importance for virulence. We have identified three genes, Rv3870, Rv3871, and Rv3877, that encode components of the ESX-1 secretion system, which functions to secrete ESAT-6 and CFP-10, proteins with dual functions as immunodominant antigens and virulence factors. Components and substrates of ESX-1 are required for full virulence of M. tuberculosis in both mice and macrophages. The ESX-1 secretion system functions to subvert host cell biology, and is required for the suppression of Interleukin-12 (IL-12) and Tumor Necrosis Factor-alpha (TNF-alpha). ESX-1 is also required for the induction, both in vivo and in vitro, of type I Interferons (IFNs), cytokines usually associated with an anti-viral immune response. We show that the induction of type I IFNs may be a pathogenic strategy that enhances virulence of M. tuberculosis. We also examine the role of the ESAT-6 and CFP-10 in the protective immune response in M. tuberculosis. We find that restoration of a functional ESX-1 system to the live attenuated vaccine strain mycobacterium Bacille Calmette-Guerin results in an increase in immunogenicity of this strain, which may lead to the development of more a more effective vaccine. These studies identify ESX-1 mediated secretion of ESAT-6 and CFP-10 to one of the most important pathways identified in M. tuberculosis, both for virulence of the organism and for induction of the protective immune response to infection, and begin to describe the mechanisms by which ESX-1 secretion regulates host biology and the outcome of infection.

Understanding Tuberculosis

Author : Pere-Joan Cardona
Publisher : BoD – Books on Demand
ISBN 13 : 953307938X
Total Pages : 566 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Understanding Tuberculosis by : Pere-Joan Cardona

Download or read book Understanding Tuberculosis written by Pere-Joan Cardona and published by BoD – Books on Demand. This book was released on 2012-02-15 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycobacterium tuberculosis is a disease that is transmitted through aerosol. This is the reason why it is estimated that a third of humankind is already infected by Mycobacterium tuberculosis. The vast majority of the infected do not know about their status. Mycobacterium tuberculosis is a silent pathogen, causing no symptomatology at all during the infection. In addition, infected people cannot cause further infections. Unfortunately, an estimated 10 per cent of the infected population has the probability to develop the disease, making it very difficult to eradicate. Once in this stage, the bacilli can be transmitted to other persons and the development of clinical symptoms is very progressive. Therefore the diagnosis, especially the discrimination between infection and disease, is a real challenge. In this book, we present the experience of worldwide specialists on the diagnosis, along with its lights and shadows.

Bacteria and Intracellularity

Author : Pascale Cossart
Publisher : John Wiley & Sons
ISBN 13 : 1683673549
Total Pages : 702 pages
Book Rating : 4.6/5 (836 download)

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Book Synopsis Bacteria and Intracellularity by : Pascale Cossart

Download or read book Bacteria and Intracellularity written by Pascale Cossart and published by John Wiley & Sons. This book was released on 2019-12-20 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacteria and Intracellularity clearly demonstrates that cellular microbiology as a field has reached maturity, extending beyond the strictly cellular level to infections of various organs and tissues. Decades of intense investigation into host-bacterial pathogen interactions have highlighted common concepts in intracellularity but also very diverse mechanisms underlying the various infections produced by bacteria. This book offers a wide-ranging look at the latest studies, including: foodborne pathogens, including how, when, and where bacteria interact with the gut and its microbiota infections of the urogenital tract, endothelial barriers, and the nervous system major advances in work with Mycobacterium tuberculosis and M. leprae subcellular microbiology, including metabolism of infected cells, nuclear biology, and microRNAs endosymbionts, in particular the latest work with Wolbachia and its effect on insect transmission of viral pathogens research into cell autonomous defense pathways that has led to major insights into immunology and innate immunity the latest developments in technology, for the next steps in the study of intracellularity All facets of cellular physiology, within the entire scope of cells and host tissues, can be targeted by pathogens. This book offers to researchers, students, and laboratorians a valuable overview of the state of current research into the cellular microbiology of host-pathogen interactions.

Mycobacterium Tuberculosis Pathogenesis, Infection Prevention and Treatment

Author : Davide Maria Ferraris
Publisher :
ISBN 13 : 9783039366590
Total Pages : 128 pages
Book Rating : 4.3/5 (665 download)

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Book Synopsis Mycobacterium Tuberculosis Pathogenesis, Infection Prevention and Treatment by : Davide Maria Ferraris

Download or read book Mycobacterium Tuberculosis Pathogenesis, Infection Prevention and Treatment written by Davide Maria Ferraris and published by . This book was released on 2020 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB) and it represents a persistent public health threat for a number of complex biological and sociological reasons. According to the most recent Global Tuberculosis Report (2019) edited by the World Health Organization (WHO), TB is considered the ninth cause of death worldwide and the leading cause of mortality by a single infectious agent, with the highest rate of infections and death toll rate mostly concentrated in developing and low-income countries. We present here the editorial section to the Special Issue entitled “Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment” that includes 7 research articles and a review. The scientific contributions included in the Special Issue mainly focus on the characterization of MTB strains emerging in TB endemic countries as well as on multiple mechanisms adopted by the bacteria to resist and to adapt to antitubercular therapies.

Advanced Concepts in Human Immunology: Prospects for Disease Control

Author : Pooja Jain
Publisher : Springer Nature
ISBN 13 : 3030339467
Total Pages : 413 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Advanced Concepts in Human Immunology: Prospects for Disease Control by : Pooja Jain

Download or read book Advanced Concepts in Human Immunology: Prospects for Disease Control written by Pooja Jain and published by Springer Nature. This book was released on 2020-08-11 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights information derived primarily from clinical samples, with particular reference to theoretical and scientific aspects of the human immune system. This text will focus on topics that range from host-pathogen interactions in infectious disease to host immune response in cancer, allergic diseases, neuroinflammatory diseases, and autoimmune disorders. The reader will also have a well-rounded understanding of the behavior of the immune system with particular emphasis on the role of immunoproteomics in immunotherapy, neuroprotective immunity for neurodegenerative and neuroinfectious disease, leukemia-associated dendritic cell induction of adaptive immunity dysregulation, and the role of immune checkpoint inhibitors in cancer, infection, as well as neuroinflammation. Taken together, the contents of this book are intended for both clinicians and researchers in academia and industry.

Nanotechnology Based Approaches for Tuberculosis Treatment

Author : Prashant Kesharwani
Publisher : Academic Press
ISBN 13 : 0128226110
Total Pages : 284 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Nanotechnology Based Approaches for Tuberculosis Treatment by : Prashant Kesharwani

Download or read book Nanotechnology Based Approaches for Tuberculosis Treatment written by Prashant Kesharwani and published by Academic Press. This book was released on 2020-06-10 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology Based Approaches for Tuberculosis Treatment discusses multiple nanotechnology-based approaches that may help overcome persisting limitations of conventional and traditional treatments. The book summarizes the types of nano drugs, their synthesis, formulation, characterization and applications, along with the most important administration routes. It also explores recent advances and achievements regarding therapeutic efficacy and provides possible future applications in this field. It will be a useful resource for investigators, pharmaceutical researchers, innovators and scientists working on technology advancements in the areas of targeted therapies, nano scale imaging systems, and diagnostic modalities in tuberculosis. Addresses the gap between nanomedicine late discovery and early development of tuberculosis therapeutics Explores tuberculosis nanomedicine standardization and characterization with newly developed treatment, diagnostic and treatment monitoring modalities Covers the field thoroughly, from the pathogenesis of tuberculosis and multi-drug resistant mycobacterium tuberculosis, to treatment approaches using nanotechnology and different nanocarriers

Handbook of Tuberculosis

Author : Stefan H. E. Kaufmann
Publisher : Wiley-Blackwell
ISBN 13 : 9783527316830
Total Pages : 1350 pages
Book Rating : 4.3/5 (168 download)

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Book Synopsis Handbook of Tuberculosis by : Stefan H. E. Kaufmann

Download or read book Handbook of Tuberculosis written by Stefan H. E. Kaufmann and published by Wiley-Blackwell. This book was released on 2008-03-17 with total page 1350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coinciding with the first TB therapies to enter clinical trials in 60 years, this is the most comprehensive account of the latest developments in clinical, therapeutic and basic research into the disease, presented by the most prolific of all researchers in the field. Divided into three clearly structured volumes, the first deals with molecular biology and biochemistry of the pathogen, including genetics and genomics, as well as drug design. The second volume covers cell biology, immunology and vaccine development, while the third is devoted to epidemiology and clinical approaches, including drug resistance, veterinary aspects and clinical field trials. With one new infection worldwide every second, this is an essential reference for bacteriologists, immunologists, pathologists and pathophysiologists, molecular and cell biologists, as well as those working in the pharmaceutical industry.