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Vaccinology
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Download or read book Vaccinology written by Gregg N. Milligan and published by John Wiley & Sons. This book was released on 2015-02-16 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes. Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.
Download or read book Vaccinology written by W. John W. Morrow and published by John Wiley & Sons. This book was released on 2012-09-04 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.
Book Synopsis Bioinformatics for Vaccinology by : Darren R. Flower
Download or read book Bioinformatics for Vaccinology written by Darren R. Flower and published by John Wiley & Sons. This book was released on 2008-10-13 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: “... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once...” Human Vaccines, 2010 "... This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..." –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.
Book Synopsis Vaccinology and Methods in Vaccine Research by : Rebecca Ashfield
Download or read book Vaccinology and Methods in Vaccine Research written by Rebecca Ashfield and published by Elsevier. This book was released on 2022-03-16 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccinology and Methods in Vaccine Research is a combination of cutting-edge methodologies, experimental approaches and literature reviews. The book covers all aspects of vaccine development, including basic immunology (focusing on the stimulation of adaptive immunity, which is required for vaccine efficacy), approaches to vaccine design and target validation, vaccine biomanufacturer and clinical development. Existing vaccinology resources are theoretical reference books, whereas this book provides a practical handbook for use in the research lab and classroom by those working in vaccinology and training others in the field. It is authored and edited by scientists actively engaged in vaccine research and development for day-to-day teaching/methodological advice. Addresses how to design a vaccine for an emerging disease, from a practical point-of -view, with chapters written by scientists who are grappling with these questions Provides new approaches to vaccine development. including vaccine targeting and virus-like-particle vaccines Gives up-to-date information and methodologies in use for vaccine adjuvants
Book Synopsis Introduction to Molecular Vaccinology by : Matthias Giese
Download or read book Introduction to Molecular Vaccinology written by Matthias Giese and published by Springer. This book was released on 2016-03-11 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an easy-to-understand introduction to the complex topic of vaccine research and development. It gives a comprehensive though clearly arranged insight to the most important aspects of molecular vaccinology, leading from the basics in immunology, to design of vaccines and mode of action of vaccines to the actual formulation, manufacturing and registration of vaccines. The volume is therefore a valuable text about modern vaccinology for graduate students and a basic introduction for newcomers in vaccine design and development.
Book Synopsis System Vaccinology by : Vijay Kumar Prajapati
Download or read book System Vaccinology written by Vijay Kumar Prajapati and published by Academic Press. This book was released on 2022-08-20 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emergence of new and deadly infectious diseases is significantly deteriorating the human health. Development of vaccine by the scientist has become an important weapon to control the spread of infectious diseases as well as to improve the life expectancy at global level in 20th-21st Century. This book will provide the in-depth knowledge of vaccine history, and development of new strategies to design efficacious and safe vaccine molecule. This book will cover the development of system vaccinology and their applications revolutionize the vaccine discovery. This will provide a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials. My purpose to write this book to educate the students and researchers with modern development in the field of vaccinology and empowering the researcher with new tools and methodology for developing potential and immunogenic vaccines. This book will be helpful to solve the curiosity of science and medical background students related with vaccinology and will be helpful to devise a new vaccine molecule to control the spread of new and emerging pathogens. Systems biology is a rapidly expanding research discipline aiming to integrate multifaceted datasets generated using state-of-the-art high- throughput technologies such as arrays and next-generation sequencing. Combined with sophisticated computational analysis we are able to interrogate host responses to infections and vaccination on a systems level, thus generating important new hypotheses and discovering unknown associations between immunological parameters. Provides in-depth knowledge of vaccine history Covers the development of system vaccinology and their applications revolutionize the vaccine discovery Gives insights to the development of new strategies to design efficacious and safe vaccine molecule Provides a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials Highlights the importance of differential miRNA expression, microbiome after vaccination for human health Serves the need of students and researcher for applying computational tools and quick designing of potential molecule which may be proposed for vaccine trial Take the decisions to perform the kind of experiments for assessment of vaccine immunogenicity Aims to understand disease pathogenesis and host responses to infection and vaccination Offers a seamless continuum of scientific discovery and vaccine invention
Book Synopsis Vaccines for Veterinarians E-Book by : Ian R Tizard
Download or read book Vaccines for Veterinarians E-Book written by Ian R Tizard and published by Elsevier Health Sciences. This book was released on 2019-11-19 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both a theoretical text and a practical handbook, Vaccines for Veterinarians is the first of its kind to bring the basic science of animal vaccination and the practical details of vaccine use together in one single volume. From the first chapter on the history of vaccination and the triumph of rinderpest eradication to the last chapter on the rapidly emerging field of cancer vaccines, this book offers a truly comprehensive grounding in established and emerging vaccines for both major and minor species. Specific topics include viral vectored vaccines, DNA-plasmid vaccines, RNA vaccines, reverse vaccinology, the complexities of adjuvant use, vaccine failures and adverse events, vaccine production and regulation, robotic vaccination machines, contraceptive and production-enhancing vaccines, and so much more. At a time when resistance to human vaccination is receiving much publicity, this evidence-based book is the ideal counter to ill-informed speculation — serving as a timely reminder that vaccination is essential for the control of infectious diseases in animals. Well-respected and experienced veterinary author, Ian Tizard, provides expert guidance on the topic of vaccinations and immunology in veterinary medicine. Expert Consult site offers an online version of the book, making it easy to search the entire book electronically. The latest information on viral vectored vaccines keeps you up-to-date on the topic as well as the properties and relative advantages of currently used vectors in animal vaccines. Survey of vaccine responses covers the different mechanisms by which the immune system responds to different types of vaccines. Inclusion of the latest vaccine technologies discusses the advantages and disadvantages of DNA-plasmid vaccines, RNA vaccines, and more. Coverage of adverse events and hypersensitivities includes the best ways to treat them and report them. Coverage of passive immunization discusses the growing use of therapeutic monoclonal antibodies in veterinary medicine. Coverage of immunotherapy includes recent improvements and new products in both active and passive immunotherapy against animal cancers.
Book Synopsis The Vaccine Book by : Barry R. Bloom
Download or read book The Vaccine Book written by Barry R. Bloom and published by Academic Press. This book was released on 2016-06-23 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment. This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child’s risk. Provides insights into diseases that could be prevented, along with the challenges facing research scientists in the world of vaccines Gives new ideas about future vaccines and concepts Introduces new vaccines and concepts Gives ideas about challenges facing public and private industrial investors in the vaccine area Discusses the problem of declining immunization rates and vaccine hesitancy
Download or read book Veterinary Vaccines written by R. Pandey and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines have historically been considered to be the most cost-effective method for preventing communicable diseases. It was a vaccine that enabled global eradication of the dreaded disease smallpox. Mass immunization of children forms the anchor of the strategy of the World Health Organization (WHO) to attain "health for all" status by the year 2000. Vaccinology is undergoing a dimensional change with the advances that have taken place in immunology and genetic engineering. Vaccines that confer short or inadequate immunity or that have side effects are being replaced by better vaccines. New vaccines are being developed for a variety of maladies. Monoclonal antibodies and T cell clones have been employed to delineate the immunodeterminants on microbes, an approach elegantly complemented by computer graphics and molecular imaging techniques. Possibilities have opened for obtaining hitherto scarce antigens of parasites by the DNA recombinant route. Better appreciation of the idiotypic network has aroused research on anti idiotypic vaccines. Solid-phase synthesis of peptides is leading to an array of synthetic vaccines, an approach that is expected to attain its full potential once the sequences activating suppressor cells are discovered and the rules for presentation of antigens to T and B cells are better worked out. A new breed of vaccines is on the horizon that seeks to control fertility. Originally conceived to intercept a step in the reproductive process, they are conceptual models for developing approaches to regulate the body's internal processes.
Book Synopsis The Science and Applications of Synthetic and Systems Biology by : Institute of Medicine
Download or read book The Science and Applications of Synthetic and Systems Biology written by Institute of Medicine and published by National Academies Press. This book was released on 2011-12-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Download or read book Vaccines written by Joseph Domachowske and published by Springer Nature. This book was released on 2020-11-01 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to provide easy-to-read and basic information about vaccines for those undertaking a vaccine course or for medical providers seeking to improve their skills. Written by expert medical educators in the areas of infectious diseases, medical microbiology, and pediatrics, this book begins by establishing the fundamentals of vaccines such as what constitutes a vaccine, how they are manufactured and composed, how they are tested for safety and efficacy, and how vaccine recommendations are developed and conveyed to health care providers and their patients. The book then explains the composition, safety profile, effectiveness, and current recommendations for use of every available vaccine, alphabetized by infection. The concluding section illuminates practical concerns every vaccinating clinician experiences, including vaccine confidence and hesitancy, misconceptions, and patient communication. Vaccines: A Clinical Overview and Practical Guide is an excellent learning tool for all students and providers administering vaccines to patients, including infectious disease specialists and other internal medicine subspecialists, pediatricians, geriatricians, as well as all other primary care physicians, nurse practitioners, physician’s assistants, and nurses.
Book Synopsis Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines by : Darren R. Flower
Download or read book Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines written by Darren R. Flower and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.
Book Synopsis Vaccines for Biodefense and Emerging and Neglected Diseases by : Alan D.T. Barrett
Download or read book Vaccines for Biodefense and Emerging and Neglected Diseases written by Alan D.T. Barrett and published by Academic Press. This book was released on 2009-03-05 with total page 1488 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last 20 years has seen a rapid increase in infectious diseases, particularly those that are termed "emerging diseases" such as SARS, "neglected diseases" such as malaria and those that are deemed biothreats such as anthrax. It is well-recognized that the most effective modality for preventing infectious diseases is vaccination. This book provides researchers with a better understanding of what is currently known about these diseases, including whether there is a vaccine available or under development. It also informs readers of the key issues in development of a vaccine for each disease. * Provides a comprehensive treatise of the agents that are responsible for emerging and neglected diseases and those that can be used as biothreats * Includes the processes such as the vaccine development pathway, vaccine manufacturing and regulatory issues that are critical to the generation of these vaccines to the marketplace * Each chapter will include a map of the world showing where that particular disease is naturally found
Download or read book Vaccines written by Stanley A. Plotkin and published by Elsevier Health Sciences. This book was released on 2008-02-11 with total page 1748 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, this respected reference offers comprehensive and current coverage of every aspect of vaccination-from development to use in reducing disease. It provides authoritative information on vaccine production, available preparations, efficacy, and safety...recommendations for vaccine use, with rationales...data on the impact of vaccination programs on morbidity and mortality...and more. And now, as an Expert Consult title, it includes a companion web site offering this unparalleled guidance where and when you need it most! Provides a complete understanding of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well an epidemiology and public health issues. Offers comprehensive coverage of both existing vaccines and vaccines currently in the research and development stage. Examines vaccine stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease control strategies. Analyses the cost-benefit and cost-effectiveness of vaccines. Discusses the proper use of immune globulins and antitoxins. Illustrates concepts and objective data with approximately 600 tables and figures. Includes access to a companion web site offering the complete contents of the book - fully searchable - for rapid consultation from anyplace with an Internet connection.
Book Synopsis Biological DNA Sensor by : Ken Ishii
Download or read book Biological DNA Sensor written by Ken Ishii and published by Academic Press. This book was released on 2013-10-30 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class experts Ideal source of information for those wanting to learn about DNA sensing Provides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them
Book Synopsis The Vaccine Handbook by : Gary S. Marshall
Download or read book The Vaccine Handbook written by Gary S. Marshall and published by Lippincott Williams & Wilkins. This book was released on 2004 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Vaccine Handbook has a simple purpose- to draw together authoritative information about vaccines into a simple and concise resource that can be used in the office, clinic, and hospital. Not an encyclopedia or scientific textbook, The Vaccine Handbook gives practical advice and provides enough background for the practitioner to understand the recommendations and explain them to his or her patients. For each vaccine, the authors discuss the disease and its epidemiology, the vaccine’s efficacy and safety, and the practical questions most frequently asked about the vaccine’s use. The authors also discuss problems such as allergies, breastfeeding, dosing intervals and missed vaccines, and immunocompromised individuals. This handbook is also available electronically for handheld computers. See Media listing for details.
Book Synopsis Vaccination Programmes by : Susan Hahné
Download or read book Vaccination Programmes written by Susan Hahné and published by Routledge. This book was released on 2021-09-13 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccination programmes are of vital importance to public health and are present in virtually every country in the world. By promoting an understanding of the diverse effects of vaccination programmes, this textbook discusses how epidemiologic methods can be used to study, in real life, their impacts, benefits and risks. Written by expert practitioners in an accessible and concise style, this book is interspersed with practical examples which allow readers to acquire understanding through real-life data and problems. Part I provides an overview of basic concepts in vaccinology, immunology, vaccination programmes, infectious disease transmission dynamics, the various impacts of vaccination programmes and their societal context. Part II covers the main field tools used for the epidemiological evaluation of vaccination programmes: monitoring coverage and attitudes towards vaccination, surveillance of vaccine-preventable diseases and pathogens, seroepidemiological studies, methods to assess impact and outbreak investigation. Part III is dedicated to vaccine effectiveness and its assessment. Part IV includes an overview of the potential risks of vaccination and how to study these. Lastly, Part V deals with methods for an integrated assessment of benefits and risks of vaccination programmes. Suitable for professionals working in public health, epidemiology, biology and those working in health economics and vaccine development, Vaccination Programmes also serves as a textbook for postgraduate students in public health, epidemiology and infectious diseases. The book is aimed at all those involved in the many aspects of vaccination programmes, including public health professionals and epidemiologists. Its primary target audiences are master and doctoral students in infectious disease epidemiology and public health, post-doctoral participants of field epidemiology training programmes and public health professionals working in the post-implementation epidemiological evaluation of vaccines and vaccination programmes. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license
