Host Defense Dysfunctions In Trauma Shock And Sepsis

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Host Defense Dysfunction in Trauma, Shock and Sepsis

Author : Eugen Faist
Publisher : Springer Science & Business Media
ISBN 13 : 3642774059
Total Pages : 1219 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Host Defense Dysfunction in Trauma, Shock and Sepsis by : Eugen Faist

Download or read book Host Defense Dysfunction in Trauma, Shock and Sepsis written by Eugen Faist and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a unique overview of all aspects of host defense alterations under stressful conditions. It is based on the most important contributions given at the "2nd International Congress on the Immune Consequences of Trauma, Shock, and Sepsis-Mechanisms and Therapeutic Approaches," which was held in Munich under the auspices of the most distinguished scientific societies involved in this field (Society of Critical Care Medicine, European Society of Intensive Care Medicine, Societe Internationale de Chirurgie, Surgical Infection Society, Surgical Infection Society Europe, European Society for Surgical Research, International Society for Burn Injury, American Association for the Surgery of Trauma, and National Institutes of Health). Since the first conference of this kind in 1988, new information from basic studies and clinical trials has provided exciting and novel insights into the immune dysfunctions accom panying trauma, shock, and sepsis. The volume is divided into 18 parts presenting the structural background of trauma-induced alterations of immune and imflammatory mechanisms as well as the currently discussed therapeutic interventions designed to restore or maintain normal host defenses following major injury. Introducing the general theme of the book is a summary of the essential keystones of trauma and sepsis-related immune deficits. Discussions of the progress in trauma care brought through better understanding of the cell biology of injury and of the major clinical factors that influence host defense integrity in operative medicine provide a setting for understanding the wide array of detailed information that is presented thereafter.

Host Defense Dysfunctions in Trauma, Shock, and Sepsis

Author : Eugen Faist
Publisher : Berlin : Springer-Verlag
ISBN 13 :
Total Pages : 1330 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Host Defense Dysfunctions in Trauma, Shock, and Sepsis by : Eugen Faist

Download or read book Host Defense Dysfunctions in Trauma, Shock, and Sepsis written by Eugen Faist and published by Berlin : Springer-Verlag. This book was released on 1993 with total page 1330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a unique overview of all aspects of host defense alterations under stressful conditions. It is based on the most important contributions given at the "2nd International Congress on the Immune Consequences of Trauma, Shock, and Sepsis-Mechanisms and Therapeutic Approaches," which was held in Munich under the auspices of the most distinguished scientific societies involved in this field (Society of Critical Care Medicine, European Society of Intensive Care Medicine, Societe Internationale de Chirurgie, Surgical Infection Society, Surgical Infection Society Europe, European Society for Surgical Research, International Society for Burn Injury, American Association for the Surgery of Trauma, and National Institutes of Health). Since the first conference of this kind in 1988, new information from basic studies and clinical trials has provided exciting and novel insights into the immune dysfunctions accom panying trauma, shock, and sepsis. The volume is divided into 18 parts presenting the structural background of trauma-induced alterations of immune and imflammatory mechanisms as well as the currently discussed therapeutic interventions designed to restore or maintain normal host defenses following major injury. Introducing the general theme of the book is a summary of the essential keystones of trauma and sepsis-related immune deficits. Discussions of the progress in trauma care brought through better understanding of the cell biology of injury and of the major clinical factors that influence host defense integrity in operative medicine provide a setting for understanding the wide array of detailed information that is presented thereafter.

Host Defense Dysfunction in Trauma, Shock, and Sepsis

Author : Eugen Faist
Publisher : Berlin : Springer-Verlag
ISBN 13 : 9783540553298
Total Pages : 1296 pages
Book Rating : 4.5/5 (532 download)

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Book Synopsis Host Defense Dysfunction in Trauma, Shock, and Sepsis by : Eugen Faist

Download or read book Host Defense Dysfunction in Trauma, Shock, and Sepsis written by Eugen Faist and published by Berlin : Springer-Verlag. This book was released on 1993 with total page 1296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a unique overview of the sequence of steps of host defense impairment that result from injury and lead to multiple organ dysfunction syndrome. The crucial alterations of immune and inflammatory mechanisms as they are seen during ischemia, during inter- mediate inflammatory phases, and in states of bacterial sepsis are described in detail. The role of endotoxin, its mechanisms of action, and potential counterregulatory strategies to neutralize endotoxin in order to protect from shock are discussed, as there are major etiologic factors leading to organ failure such as hepatic cellular injury and bacterial translocation. Cytokines, as the central mediators in acute phase states and the modulation of cytokine action are then evaluated carefully. In the discussion of the clinical aspects of multiple organ failure, the antibiotic interactions with host defenses, the augmentation of immunoreactivity with special nutrients and the newest insights into the regulation of wound repair are elucidated. The final sections of this book deal with therapeutic immunomodulatory approaches for the prevention ofinfections and with interventional strategies in the therapy of septic shock.

Immune Consequences of Trauma, Shock, and Sepsis

Author : Eugen Faist
Publisher : Springer Science & Business Media
ISBN 13 : 3642734685
Total Pages : 587 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Immune Consequences of Trauma, Shock, and Sepsis by : Eugen Faist

Download or read book Immune Consequences of Trauma, Shock, and Sepsis written by Eugen Faist and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sepsis and infection are the major enemies of the intensive care patient in whom immunological defenses are severely impaired. This major problem is thefocus of attention in this book, based on the presentation of the First International Congress on the Immune Consequences of Trauma, Shock, and Sepsis, which is one of the first attempts to exchange ideas on the state-of-the-art in this area of immunology. Both basic and clinical research, including new centres of attention, are described. The growing role of immunology in medicine opens new avenues to the under- standing of trauma and sepsis and will allow the design of novel therapeutic approaches.

Evolving Concepts in Sepsis and Septic Shock

Author : Peter Q Eichacker
Publisher :
ISBN 13 : 9781461515821
Total Pages : 208 pages
Book Rating : 4.5/5 (158 download)

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Book Synopsis Evolving Concepts in Sepsis and Septic Shock by : Peter Q Eichacker

Download or read book Evolving Concepts in Sepsis and Septic Shock written by Peter Q Eichacker and published by . This book was released on 2000-12-31 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Brain and Host Defense

Author :
Publisher : Elsevier
ISBN 13 : 0444535454
Total Pages : 362 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis The Brain and Host Defense by :

Download or read book The Brain and Host Defense written by and published by Elsevier. This book was released on 2009-12-24 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems.Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. - Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases - Includes analysis of the role of the brain in the adaptive responses to disease - Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases

Immunology and Its Impact on Infections in Surgery

Author : Rainer Engemann
Publisher : Springer Science & Business Media
ISBN 13 : 3642790798
Total Pages : 266 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Immunology and Its Impact on Infections in Surgery by : Rainer Engemann

Download or read book Immunology and Its Impact on Infections in Surgery written by Rainer Engemann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, the recent developments in immunology and the impact on the treatment of infections in critical care and in surgery are presented, also describing how cellular immunology influences clinical treatment. This information helps in understanding the pathogenesis of infections in surgery and critical care. The impact of a standard treatment such as antibiotic therapy is evaluated and possible future therapy modalities outlined. This book will be of interest to clinicians and immunologists as scientists of both specialties have contributed to the book.

Pathology of Septic Shock

Author : Ernst T. Rietschel
Publisher : Springer Science & Business Media
ISBN 13 : 3642801862
Total Pages : 325 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Pathology of Septic Shock by : Ernst T. Rietschel

Download or read book Pathology of Septic Shock written by Ernst T. Rietschel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe sepsis and septic shock are the most serious compli cations of bacterial infections. Both gram-positive and gram negative bacteria can trigger these extreme inflammatory re sponses and, by so doing, cause substantial morbidity and mortality. In the United States alone, over 400 000 patients suffer from septicaemia each year, and approximately 100 000 of these patients die despite optimal intensive care and modern antimicrobial therapy. These dramatic figures have prompted intensive research to define the bacterial and host factors involved in the septic response. Scientists from many disciplines, including chem istry, physics, biology, medical microbiology, immunology, and pharmacology, have worked closely with clinicians to achieve rapid and profound progress. To translate this newly acquired knowledge into clinical practice, clinical trials have also been performed to evaluate numerous new therapeutic drugs. The disappointing results from these trials have underscored a major lesson, namely, that sepsis constitutes an extremely complex syndrome and that basic and clinical research must be greatly intensified in order to illuminate its molecular mechan isms. At this stage, the editors of the present volume of Current Topics in Microbiology and Immunology considered it would be rewarding to compile a volume summarizing our present basic and clinical knowledge on sepsis. Our particular gratitude extends to those international experts who have followed our invitation and elaborated on particular areas of the basic and clinical aspects of this field.

Multiple Organ Failure

Author : Arthur E. Baue
Publisher : Springer Science & Business Media
ISBN 13 : 1461212227
Total Pages : 750 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Multiple Organ Failure by : Arthur E. Baue

Download or read book Multiple Organ Failure written by Arthur E. Baue and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 750 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation in itself is not to be considered as a disease . . . and in disease, where it can alter the diseased mode of action, it likewise leads to a cure; but where it cannot accomplish that solitary purpose . . . it does mischief - John Hunter, A Treatise on the Blood, ITfIlammation, and Gunshot Woundr (London, 1794)1 As we reached the millennium, we recognized the gap between our scientific knowledge of biologic processes and our more limited clinical capabilities in the care of patients. Our science is strong. Molecular biology is powerful, but our therapy to help patients is weaker and more limited. For this reason, this book focuses on the problems of multiple organ failure (MOF), multiple organ dysfunction syndrome (MODS), and systemic inflammatory response syndrome is, patients who have severe injuries; require major, (SIRS) in high-risk patients, that overwhelming operations; or have serious illnesses requiring intensive care; patients who have diseases elsewhere, in other organs or systems, that limit their capabilities to survive a new insult; and patients who are elderly or at high risk for sepsis or other complications. These are the patients who need our help. They need the advances in science, in molecular biology, immunology, pathophysiology, biochemistry, genetics, high technology, and other areas of maximum support at the bedside. These advances could potentially have the greatest impact on improving patient care.

The Sepsis Text

Author : Jean-Louis Vincent
Publisher : Springer Science & Business Media
ISBN 13 : 0306476649
Total Pages : 848 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis The Sepsis Text by : Jean-Louis Vincent

Download or read book The Sepsis Text written by Jean-Louis Vincent and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is written at the dawn of a new era in the management of sepsis. Recent achievements in the clinical management of septic shock are the culmination of decades of basic and applied research by innovative researchers and clinical investigators worldwide. The contributing authors to this book have spearheaded much of this research and the Editors have endeavored to create a textbook that is comprehensive in nature while maintaining a specific focus upon the multitude of work that constitutes the spectrum of sepsis research including: pathophysiology; monitoring systems; general support; microbial aspects; complications; and anti-sepsis therapies.

Yearbook of Intensive Care and Emergency Medicine 2000

Author : Prof. Jean-Louis Vincent
Publisher : Springer Science & Business Media
ISBN 13 : 3662134551
Total Pages : 859 pages
Book Rating : 4.6/5 (621 download)

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Book Synopsis Yearbook of Intensive Care and Emergency Medicine 2000 by : Prof. Jean-Louis Vincent

Download or read book Yearbook of Intensive Care and Emergency Medicine 2000 written by Prof. Jean-Louis Vincent and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 859 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Yearbook compiles the most recent, widespread developments of experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in their field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine. (With approximately 90 contributions.)

Blood Substitutes

Author : Robert M. Winslow
Publisher : Springer Science & Business Media
ISBN 13 : 1461241146
Total Pages : 219 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Blood Substitutes by : Robert M. Winslow

Download or read book Blood Substitutes written by Robert M. Winslow and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is not a "proceedings" volume. Rather the chapters are essays by experts in the field of blood substitutes, invited by the editors to con tribute to the 1996 "Current Issues in Blood Substitutes Research and Development" course given in San Diego, March 18-21. The contributors were selected because of their expertise in areas deemed by the editors to be critical to the advancement of the field. The course, as in past years, is heavily influenced by feedback from par ticipants, and by research in this and related fields. In addition to the didactic lectures (for which these chapters are the foundation), the course also offers the opportunity for presentation of research reports, progress reports from the various companies currently commercializing products, and round table discussions of selected subjects. Thus, we are grateful to past participants for their helpful comments. Production of a book, especially on a short timeline, is not an easy feat.

Growth Factors and Wound Healing

Author : Thomas R. Ziegler
Publisher : Springer Science & Business Media
ISBN 13 : 1461218764
Total Pages : 374 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Growth Factors and Wound Healing by : Thomas R. Ziegler

Download or read book Growth Factors and Wound Healing written by Thomas R. Ziegler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this symposium was to provide basic and clinical investigators with the latest information on the biology of wound healing and tissue repair. Written and edited by eminent experts in the field, the papers cover the general concepts of wound healing; the role of nutrients; endogenous growth factors; clinical applications of growth hormone and IGF-1 therapy; and clinical applications of peptide growth factors.

Red Blood Cell Substitutes

Author : Alan Rudolph
Publisher : CRC Press
ISBN 13 : 9780824700584
Total Pages : 512 pages
Book Rating : 4.7/5 (5 download)

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Book Synopsis Red Blood Cell Substitutes by : Alan Rudolph

Download or read book Red Blood Cell Substitutes written by Alan Rudolph and published by CRC Press. This book was released on 1997-09-05 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents an up-to-date treatment of research strategies, clinical and commercial developments, and regulatory and economic issues pertaining to the formulation of effective and safe red blood cell substitutes. The text examines regulatory and socioeconomic aspects of blood substitute products, and global tranfusion practices from the perspective of blood banks and the US Food and Drug Administrations. It also includes the mechanisms of action and consequences of blood substitute administration.

Life-Threatening Coagulation Disorders in Critical Care Medicine

Author : Viola Hach-Wunderle
Publisher : Springer Science & Business Media
ISBN 13 : 3642604900
Total Pages : 139 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Life-Threatening Coagulation Disorders in Critical Care Medicine by : Viola Hach-Wunderle

Download or read book Life-Threatening Coagulation Disorders in Critical Care Medicine written by Viola Hach-Wunderle and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypercoagulability and bleeding are problems physicians frequently encounter when treating intensive care patients. The coagulation mechanism is a tightly controlled system. Its balance is disturbed in conditions such as septicemia, trauma, shock, and others. The dis turbances may be local or disseminated and the therapeutic options available are limited and nonspecific: limited since in most cir cumstances they may not affect the underlying disease and are si milarly independent of the pathogenic mechanism; nonspecific since they cannot be specifically targeted to the problem of local or sys temic disturbance of coagulation. Furthermore, increased and de creased coagulability may be present at the same time. Activation of coagulation may lead to fibrin deposition and decreased hemostatic capacity, as seen in disseminated intravascular coagulation. New diagnostic approaches for acquired disorders of coagulation have been developed and form a new basis for therapeutic strategies. Despite this progress, many physicians are aware of the problem that, especially for intensive care patients, a treatment very often has to be selected before diagnostic procedures can be completed. We also know that for many diseases rare occurrence or the hetero genity of the patient population make it quite difficult to conduct clinical studies which prove that a therapeutic regimen is efficacious. Thus, much discussion about coagulation disorders in critically ill patients is still necessary. Even so, it is important to provide guidelines for handling these problems.

National Library of Medicine Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1536 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1993 with total page 1536 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Vascular Responses to Pathogens

Author : Felicity N.E. Gavins
Publisher : Academic Press
ISBN 13 : 0128013257
Total Pages : 254 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Vascular Responses to Pathogens by : Felicity N.E. Gavins

Download or read book Vascular Responses to Pathogens written by Felicity N.E. Gavins and published by Academic Press. This book was released on 2015-10-31 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular Responses to Pathogens focuses on the growing research from leaders in the field for both the short and long-term impact of pathogens on the vasculature. It discusses various organisms, including bacteria, parasites, and viruses, and their role in key events leading to vascular disease. Formatted to discuss the topic of the interaction of pathogens with the vascular rather than individual diseases described separately, this reference demonstrates that common mechanisms are at play in many different diseases because they have a similar context, their vasculature. This all-inclusive reference book is a must-have tool for researchers and practicing clinicians in the areas of vascular biology, microvasculature, cardiology, and infectious disease. - Covers a wide spectrum of organisms and provides analysis of pathogens and current therapeutic strategies in the context of their vasculature - Provides detailed perspectives on key components contributing to vascular pathogens from leaders in the field - Interfaces between both vascular biology and microbiology by encompassing information on how pathogens affect both macro and microvasculature - Includes coverage of the clinical aspects of sepsis and current therapeutic strategies and anti-sepsis drugs