Handbook Of Animal Models And Its Uses In Cancer Research

Download Handbook Of Animal Models And Its Uses In Cancer Research full books in PDF, epub, and Kindle. Read online Handbook Of Animal Models And Its Uses In Cancer Research ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Handbook of Animal Models and its Uses in Cancer Research

Author : Surajit Pathak
Publisher : Springer Nature
ISBN 13 : 9811938245
Total Pages : 1158 pages
Book Rating : 4.8/5 (119 download)

DOWNLOAD NOW!

Book Synopsis Handbook of Animal Models and its Uses in Cancer Research by : Surajit Pathak

Download or read book Handbook of Animal Models and its Uses in Cancer Research written by Surajit Pathak and published by Springer Nature. This book was released on 2023-01-31 with total page 1158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.

Animal Models in Cancer Drug Discovery

Author : Asfar Azmi
Publisher : Academic Press
ISBN 13 : 0128147059
Total Pages : 470 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!

Book Synopsis Animal Models in Cancer Drug Discovery by : Asfar Azmi

Download or read book Animal Models in Cancer Drug Discovery written by Asfar Azmi and published by Academic Press. This book was released on 2019-04-16 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Handbook of Laboratory Animal Science

Author : Jann Hau
Publisher : CRC Press
ISBN 13 : 9780849343902
Total Pages : 228 pages
Book Rating : 4.3/5 (439 download)

DOWNLOAD NOW!

Book Synopsis Handbook of Laboratory Animal Science by : Jann Hau

Download or read book Handbook of Laboratory Animal Science written by Jann Hau and published by CRC Press. This book was released on 1994-06-02 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set presents a comprehensive description of laboratory animal genetics, diseases, health monitoring, nutrition, and the environmental impact on animal testing. It considers the ethics of animal experimentation through a complete review of European and North American legislation on the topic. It discusses alternatives to animal experiments, including the use of isolated organs, cell cultures, and computer simulations. The book also examines general methods, including experimental design and statistical evaluation, non-surgical and surgical techniques, anesthesia, and post-mortem examinations. Reviews of animal models for studying diseases of different organ systems, infectious diseases, cancer, and toxicology are featured as well.

Animal Models in Research

Author : Harikrishnan Vijayakumar Sreelatha
Publisher : Springer Nature
ISBN 13 : 9819700485
Total Pages : 645 pages
Book Rating : 4.8/5 (197 download)

DOWNLOAD NOW!

Book Synopsis Animal Models in Research by : Harikrishnan Vijayakumar Sreelatha

Download or read book Animal Models in Research written by Harikrishnan Vijayakumar Sreelatha and published by Springer Nature. This book was released on with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mouse Models of Cancer

Author : Cory Abate-Shen
Publisher :
ISBN 13 : 9781621820048
Total Pages : 0 pages
Book Rating : 4.8/5 (2 download)

DOWNLOAD NOW!

Book Synopsis Mouse Models of Cancer by : Cory Abate-Shen

Download or read book Mouse Models of Cancer written by Cory Abate-Shen and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The laboratory mouse is an important model for addressing questions in cancer biology. In recent years, the questions have become more refined, and mouse models are increasingly being used to develop and test cancer therapeutics. Thus, the need for more sophisticated and clinically relevant mouse models has grown, as has the need for innovative tools to analyze and validate them. This laboratory manual provides cutting-edge methods for generating and characterizing mouse models that accurately recapitulate many features of human cancer. The contributors describe strategies for producing genetic models, including transgenic germline models, gene knockouts and knock-ins, and conditional and inducible systems, as well as models derived using transposon-based insertional mutagenesis, RNA interference, viral-mediated gene delivery, and chemical carcinogens. Tissue recombination, organ reconstitution, and transplantation methods to develop chimeric, allograft, and xenograft models are covered. Approaches to characterize tumor development, progression, and metastasis in these models using state-of-the-art imaging and histopathological, surgical, and other techniques are also included. Other chapters cover the use of mouse models to test and optimize drugs in pre-, co-, and postclinical trials. An appendix specifically addresses the use of mouse cancer models in translational studies and the integration of mouse and human clinical investigations. This manual is therefore an indispensable laboratory resource for all researchers, from the graduate level upward, who study cancer and its treatment.

Tumor Models in Cancer Research

Author : Beverly A. Teicher
Publisher : Humana Press
ISBN 13 : 9781475768824
Total Pages : 690 pages
Book Rating : 4.7/5 (688 download)

DOWNLOAD NOW!

Book Synopsis Tumor Models in Cancer Research by : Beverly A. Teicher

Download or read book Tumor Models in Cancer Research written by Beverly A. Teicher and published by Humana Press. This book was released on 2013-04-03 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Tumor Models in Cancer Research

Author : Beverly A. Teicher
Publisher : Humana Press
ISBN 13 : 9780896038875
Total Pages : 690 pages
Book Rating : 4.0/5 (388 download)

DOWNLOAD NOW!

Book Synopsis Tumor Models in Cancer Research by : Beverly A. Teicher

Download or read book Tumor Models in Cancer Research written by Beverly A. Teicher and published by Humana Press. This book was released on 2001-11-07 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Animal Modeling in Cancer

Author : Vladimir Korinek
Publisher : Mdpi AG
ISBN 13 : 9783036512761
Total Pages : 274 pages
Book Rating : 4.5/5 (127 download)

DOWNLOAD NOW!

Book Synopsis Animal Modeling in Cancer by : Vladimir Korinek

Download or read book Animal Modeling in Cancer written by Vladimir Korinek and published by Mdpi AG. This book was released on 2021-08-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection Editor.

Handbook of Animal Models Rheumatic Disease

Author : Robert A. Greenwald
Publisher : CRC-Press
ISBN 13 : 9780849329883
Total Pages : 256 pages
Book Rating : 4.3/5 (298 download)

DOWNLOAD NOW!

Book Synopsis Handbook of Animal Models Rheumatic Disease by : Robert A. Greenwald

Download or read book Handbook of Animal Models Rheumatic Disease written by Robert A. Greenwald and published by CRC-Press. This book was released on 1988-09-30 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detailed methods of the most widely used and best established animal models and related approaches to the study of rheumatic diseases and their treatment are presented in this major reference book. The detailed description of each model allows the reader to select the model most appropriate for his research and to reproduce the model without resorting to additional references. In addition, other methods for induction of the model, sources for procurement of suitable animals and validation of the model are highlighted. Methods for eliciting non-spontaneous phenomena, follow-up examinations and data collection are also described. Specific techniques such as joint-injection, obtaining synovial tissue, methods of assessment and similar non-specific information are emphasized. This easy-to-read resource text is essential for scientists, graduate students, research assistants, physicians and other invbestigators who use animal models for the study of rheumatic diseases.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030916785X
Total Pages : 223 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by : National Research Council

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Guide for the Care and Use of Laboratory Animals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309154006
Total Pages : 246 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Guide for the Care and Use of Laboratory Animals by : National Research Council

Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Cancer Stem Cells and Signaling Pathways

Author : Surajit Pathak
Publisher : Elsevier
ISBN 13 : 0443132119
Total Pages : 703 pages
Book Rating : 4.4/5 (431 download)

DOWNLOAD NOW!

Book Synopsis Cancer Stem Cells and Signaling Pathways by : Surajit Pathak

Download or read book Cancer Stem Cells and Signaling Pathways written by Surajit Pathak and published by Elsevier. This book was released on 2023-11-14 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression. Presents cancer stem characteristics and their signaling pathways Highlights the use of animal models for cancer research, the use of genetically modified stem cells to deliver antitumor agents, and the significance of stem cell signaling in drug discovery Covers basic and translational research appropriate for scientists and clinicians exploring alternative treatments for various cancers

Microbial Omics in Environment and Health

Author : Minu Kesheri
Publisher : Springer Nature
ISBN 13 : 9819717698
Total Pages : 427 pages
Book Rating : 4.8/5 (197 download)

DOWNLOAD NOW!

Book Synopsis Microbial Omics in Environment and Health by : Minu Kesheri

Download or read book Microbial Omics in Environment and Health written by Minu Kesheri and published by Springer Nature. This book was released on with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neuroprotective Effects of Phytochemicals in Brain Ageing

Author : Surajit Pathak
Publisher : Springer Nature
ISBN 13 : 9819972698
Total Pages : 387 pages
Book Rating : 4.8/5 (199 download)

DOWNLOAD NOW!

Book Synopsis Neuroprotective Effects of Phytochemicals in Brain Ageing by : Surajit Pathak

Download or read book Neuroprotective Effects of Phytochemicals in Brain Ageing written by Surajit Pathak and published by Springer Nature. This book was released on with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Gut Microbiome and Brain Ageing

Author : Surajit Pathak
Publisher : Springer Nature
ISBN 13 : 9819988039
Total Pages : 355 pages
Book Rating : 4.8/5 (199 download)

DOWNLOAD NOW!

Book Synopsis Gut Microbiome and Brain Ageing by : Surajit Pathak

Download or read book Gut Microbiome and Brain Ageing written by Surajit Pathak and published by Springer Nature. This book was released on with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Reducing Environmental Cancer Risk

Author : Suzanne H. Reuben
Publisher : DIANE Publishing
ISBN 13 : 1437934218
Total Pages : 240 pages
Book Rating : 4.4/5 (379 download)

DOWNLOAD NOW!

Book Synopsis Reducing Environmental Cancer Risk by : Suzanne H. Reuben

Download or read book Reducing Environmental Cancer Risk written by Suzanne H. Reuben and published by DIANE Publishing. This book was released on 2010-10 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though overall cancer incidence and mortality have continued to decline in recent years, cancer continues to devastate the lives of far too many Americans. In 2009 alone, 1.5 million American men, women, and children were diagnosed with cancer, and 562,000 died from the disease. There is a growing body of evidence linking environmental exposures to cancer. The Pres. Cancer Panel dedicated its 2008¿2009 activities to examining the impact of environmental factors on cancer risk. The Panel considered industrial, occupational, and agricultural exposures as well as exposures related to medical practice, military activities, modern lifestyles, and natural sources. This report presents the Panel¿s recommend. to mitigate or eliminate these barriers. Illus.

Handbook of Animal Models of Infection

Author : Merle A. Sande
Publisher : Academic Press
ISBN 13 : 9780080533551
Total Pages : 1136 pages
Book Rating : 4.5/5 (335 download)

DOWNLOAD NOW!

Book Synopsis Handbook of Animal Models of Infection by : Merle A. Sande

Download or read book Handbook of Animal Models of Infection written by Merle A. Sande and published by Academic Press. This book was released on 1999-05-28 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for in vivo efficacy and to position the therapy for specific infections where it may have therapeutic promise. The book is divided into five sections; the first covering the general methodologies, followed by sections describing experimental bacterial, mycotic, parasitic, and viral infections. Discusses ethical and safety aspects in an introductory background section Covers principles of animal care and current techniques appropriate for the use of animal models of infection Details a wide range of animals including rodents, rabbits, cats, and primates Provides hands-on descriptions of how to set up the model Discusses the major advantages and limitations of each model Ensures full coverage of bacterial, fungal, viral, and parasitic infections