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Author : Christopher L. VanDeusen
Publisher :
ISBN 13 :
Total Pages : 802 pages
Book Rating : 4.F/5 ( download)
Download or read book Guanidine Based Molecular Transporters for Drug Delivery written by Christopher L. VanDeusen and published by . This book was released on 2003 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Theodore C. Jessop
Publisher :
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.F/5 ( download)
Download or read book Molecular Transporters for Drug Delivery written by Theodore C. Jessop and published by . This book was released on 2005 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kanaka Pattabiraman
Publisher :
ISBN 13 :
Total Pages : 492 pages
Book Rating : 4.F/5 ( download)
Download or read book The Design, Synthesis and Evaluation of Guanidine-based Molecular Transporters written by Kanaka Pattabiraman and published by . This book was released on 2004 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Elena A. Goun
Publisher :
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.F/5 ( download)
Download or read book Molecular Transporters for Drug Delivery written by Elena A. Goun and published by . This book was released on 2007 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christina Barnes Cooley
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (748 download)
Download or read book Design, Synthesis, and Evaluation of Molecular Transporters for Probe, Drug, and SiRNA Delivery written by Christina Barnes Cooley and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: My graduate studies have focused on the design, synthesis, and biological evaluation of novel probe and drug delivery technologies. This research has explored the development of new molecular transporter scaffolds with a focus on step economy and translational costs as well as evaluation of their uptake and delivery properties in cells and animals. Chapter 1 provides a historical context and overview of guanidinium-rich molecular transporter technology. Chapter 2 describes the development of a new family of guanidinium-rich oligocarbonate molecular transporter which are flexibly and efficiently assembled by a one-step oligomerization strategy. These novel oligocarbonate transporters were shown to exhibit excellent uptake properties both in cells and animal models. Chapter 3 is directed at the utility of an oligomerization approach to generate molecular transporters by the design, synthesis, and evaluation of new aphipathic co-oligomers for the delivery of siRNA, an oligonucleotide cargo of intense therapeutic interest. Amphipathic carbonate co-oligomers were prepared by an oligomerization strategy and demonstrated to effectively package, deliver, and release functional siRNA in cells. Chapter 4 describes the effects of a branched guanidinium array on the transport and delivery efficiency of releasable dendrimeric guanidinium-rich transporters. These transporters were synthesized and demonstrated to deliver and release a small molecule for turnover by its intracellular target enzyme by bioluminescence assays in cells and transgenic animal models. Chapter 5 describes the design, synthesis, and preliminary biological evaluation of lipidated molecular transporter derivatives of the immunosuppressant drug rapamycin for topical delivery.
Author : Lisa Renee Jones
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.F/5 ( download)
Download or read book I. Guanidinium Rich Molecular Transporters written by Lisa Renee Jones and published by . This book was released on 2008 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : José A. Pomposo
Publisher : John Wiley & Sons
ISBN 13 : 3527806393
Total Pages : 504 pages
Book Rating : 4.5/5 (278 download)
Download or read book Single-Chain Polymer Nanoparticles written by José A. Pomposo and published by John Wiley & Sons. This book was released on 2017-08-18 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first book on this important and emerging topic presents an overview of the very latest results obtained in single-chain polymer nanoparticles obtained by folding synthetic single polymer chains, painting a complete picture from synthesis via characterization to everyday applications. The initial chapters describe the synthetics methods as well as the molecular simulation of these nanoparticles, while subsequent chapters discuss the analytical techniques that are applied to characterize them, including size and structural characterization as well as scattering techniques. The final chapters are then devoted to the practical applications in nanomedicine, sensing, catalysis and several other uses, concluding with a look at the future for such nanoparticles. Essential reading for polymer and materials scientists, materials engineers, biochemists as well as environmental chemists.
Author : Lee Robert Wright
Publisher :
ISBN 13 :
Total Pages : 510 pages
Book Rating : 4.F/5 ( download)
Download or read book The Oligoguanidine Transport System a Novel Approach to Drug Delivery written by Lee Robert Wright and published by . This book was released on 2003 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Martin F. Fromm
Publisher : Springer Science & Business Media
ISBN 13 : 3642145418
Total Pages : 457 pages
Book Rating : 4.6/5 (421 download)
Download or read book Drug Transporters written by Martin F. Fromm and published by Springer Science & Business Media. This book was released on 2010-11-19 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.
Author : Aleš Prokop
Publisher : Springer Science & Business Media
ISBN 13 : 9400712480
Total Pages : 871 pages
Book Rating : 4.4/5 (7 download)
Download or read book Intracellular Delivery written by Aleš Prokop and published by Springer Science & Business Media. This book was released on 2011-05-26 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices. This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included. Intracellular delivery / therapy is a highly topical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.
Author : Ulo Langel
Publisher : CRC Press
ISBN 13 : 1420040774
Total Pages : 427 pages
Book Rating : 4.4/5 (2 download)
Download or read book Cell-Penetrating Peptides written by Ulo Langel and published by CRC Press. This book was released on 2002-05-29 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major problems with drug delivery is the inability of large hydrophilic compounds to pass through the lipid membrane of the cell, thus making drugs such as polypeptides and oligonucleotides of limited therapeutic value. Until recently, the transport of such molecules into the cytoplasmic and nuclear compartments of living cells seemed a
Author : Ziwei Huang
Publisher : John Wiley & Sons
ISBN 13 : 0470131853
Total Pages : 560 pages
Book Rating : 4.4/5 (71 download)
Download or read book Drug Discovery Research written by Ziwei Huang and published by John Wiley & Sons. This book was released on 2007-06-11 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post Genomics Drug Discovery and Research explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences. It provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical discovery in the post-genomics era. Integrates several developing and cutting-edge technologies and methods like bioinformatics, experimental therapeutics, and molecular recognition Includes discussion on topics such as: computer-aided ligand design; peptide and protein chemistry and synthesis; synthesis of active natural products; and the use of emerging technologies like proteomics, nanotechnology, or bioengineering.
Author : Yitzhak Rosen
Publisher : CRC Press
ISBN 13 : 1351643851
Total Pages : 941 pages
Book Rating : 4.3/5 (516 download)
Download or read book Drug Delivery written by Yitzhak Rosen and published by CRC Press. This book was released on 2017-09-19 with total page 941 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrating the clinical and engineering aspects of drug delivery, this book offers a much needed comprehensive overview and patient-oriented approach for enhanced drug delivery optimization and advancement. Starting with an introduction to the subject and pharmacokinetics, it explores advances for such topics as oral, gastroretentive, intravitreal, and intrathecal drug delivery, as well as insulin delivery, gene delivery, and biomaterials-based delivery systems. It also describes drug delivery in cancer, cardiac, infectious diseases, airway diseases, and obstetrics and gynecology applications. Examining special clinical states requiring innovative drug delivery modifications, such as hypercoagulability often seen in pregnancy, cancer, and autoimmune diseases, the book also discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, simulations, and other venues. It also describes the latest drug delivery advances involving nanomaterials, NEMS and MEMS devices, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasound. The book is rounded out by a chapter on the FDA regulatory and bioethical challenges involved in advancing drug delivery.
Author : Jaroslav Sebestik
Publisher : Springer Science & Business Media
ISBN 13 : 3709112060
Total Pages : 244 pages
Book Rating : 4.7/5 (91 download)
Download or read book Biomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures written by Jaroslav Sebestik and published by Springer Science & Business Media. This book was released on 2012-12-13 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendrimers are repeatedly branched and roughly spherical large molecules. They can be used in various medical applications, such as anticancer polymeric nanomedicines and nanocarriers, gene carriers and vectors in gene delivery, contrast agents for molecular imaging and vaccines against infectious diseases and cancer. The highly branched, multivalent nature and molecular architecture of dendrimers make them ideal tools for a variety of tissue engineering applications. This book describes different categories of dendrimers, their biomedical and physico-chemical applications as well as convergent and divergent syntheses, click chemistry and ligation strategies. It is a rich source of information for researchers in biochemistry and pharmacology working on drug development as well as for organic chemists who are engaged in synthesis of dendrimers.
Author : American Chemical Society
Publisher :
ISBN 13 :
Total Pages : 962 pages
Book Rating : 4.:/5 (334 download)
Download or read book Journal written by American Chemical Society and published by . This book was released on 2003 with total page 962 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 868 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Beverley Isherwood
Publisher : Royal Society of Chemistry
ISBN 13 : 1839160799
Total Pages : 273 pages
Book Rating : 4.8/5 (391 download)
Download or read book Phenotypic Drug Discovery written by Beverley Isherwood and published by Royal Society of Chemistry. This book was released on 2020-12-09 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.
