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Author : Peng George Wang
Publisher :
ISBN 13 : 9780841298989
Total Pages : pages
Book Rating : 4.2/5 (989 download)
Download or read book Glycan-Based Cellular Communication written by Peng George Wang and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ajit Varki
Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.6/5 (968 download)
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309260868
Total Pages : 171 pages
Book Rating : 4.3/5 (92 download)
Download or read book Transforming Glycoscience written by National Research Council and published by National Academies Press. This book was released on 2012-10-23 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.
Author : Thomas Lütteke
Publisher : Humana
ISBN 13 : 9781493941957
Total Pages : 0 pages
Book Rating : 4.9/5 (419 download)
Download or read book Glycoinformatics written by Thomas Lütteke and published by Humana. This book was released on 2016-10-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides current glycoinformatics methods and protocols used to support the determination of carbohydrate structures in biological samples as well as carbohydrate structure databases, the interaction of carbohydrates with proteins, and theoretical and experimental methods to study their three-dimensional structure and dynamics. Glycoinformatics explores this recently emerged field, which has come into being in order to address the needs of encoding, storing, and analyzing carbohydrate ‘sequences’ and their taxonomy using computers. Written in the highly successful Methods in Molecular Biology series format, chapters contain the kind of detailed description and key implementation advice to ensure successful results. Authoritative and timely, Glycoinformatics demonstrates the progress that has been achieved in glycoinformatics, which indicates that it is no longer a niche subject covered by only a few scientists but is truly coming of age.
Author : Adeel Malik
Publisher : CRC Press
ISBN 13 : 1000344320
Total Pages : 305 pages
Book Rating : 4.0/5 (3 download)
Download or read book The Glycome written by Adeel Malik and published by CRC Press. This book was released on 2021-07-07 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive understanding of the enigmatic identity of the glycome, a complex but important area of research that has been largely ignored due to its complexity. The authors thoroughly deal with almost all aspects of the glycome, i.e., elucidation of the glycan identity enigma and its role in regulation of the cellular process, and in disease etiology. The book bridges the knowledge gap in understanding the glycome, from being a cell signature to its applications in disease etiology. In addition, it details many of the major insights regarding the possible role of the glycome in various diseases as a therapeutic marker. The book systematically covers the major aspects of the glycome, including the significance of substituting the diverse monosaccharide units to glycoproteins, the role of glycans in disease pathologies, and the challenges and advances in glycobiology. The authors stress the significance and huge encoding power of carbohydrates as well as provide helpful insights in framing the bigger picture. The Glycome: Understanding the Diversity and Complexity of Glycobiology details state-of-the-art developments and emerging challenges of glycome biology, which are going to be key areas of future research, not only in the glycobiology field but also in pharmaceutics.
Author : Dipak K. Banerjee
Publisher : Nova Science Publishers
ISBN 13 : 9781536194371
Total Pages : 434 pages
Book Rating : 4.1/5 (943 download)
Download or read book Glycome written by Dipak K. Banerjee and published by Nova Science Publishers. This book was released on 2021 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycome: The Hidden Code in BiologyDescription: "Glycome: The Hidden Code in Biology" addresses one of the most fundamental questions in biology today. The book targets readers with little expertise as well as the experts in Glycoscience. Sugars are electroneutral. However, linking sugars to sugars, or attaching sugars to proteins or lipids changes the structural and functional identities of the glycoconjugate, and enables to form cellular networks of 4Gs [i.e., glycoproteins (N-linked or O-linked), glycosphingolipids, proteoglycans and glycosaminoglycans (GAGs)]. These glycans (i) support growth, proliferation and differentiation of cells and tissues; (ii) protect cells from foreign invasions including bacteria, viruses, parasites as well as from changes in the extracellular environment; (iii) act as biomarkers and participate in transmembrane signaling. The glycans are not ubiquitous but they are tissue/species specific.Structurally, the glycans are diverse, and form linear to highly branched structures. This diversity is present not only across the species but also within cells of the same species, i.e., the glycoforms. Nuclear magnetic resonance (NMR) and mass spectrometric (MS) studies (i.e., Glycomics) have evaluated and contributed significantly in delineating the structural diversity of glycans. Glycomics, in fact, has helped in overcoming many earlier technological barriers which were otherwise very laborious and time consuming. Plant lectins being carbohydrate binding proteins with a high degree of sugar specificity have been useful tools to characterize the carbohydrate structures they recognize. The glycan structures complement their biosynthetic processes. Because of the highly compartmentalized nature of the process, the glycans move between compartments during their assembly. This is believed to be mediated by vesicular structures but the participation of exosomes cannot be ruled out. A large number of genetic disorders [gangliosidosis, mucopolysaccharidoses, congenital disorders of glycosylation (CDG)] are due to abnormal glycan synthesis or degradation. Disproportionate expression of glycans is also found in diseases like cancer, neurological disorders, diabetes, metabolic syndromes, and infection. This raises questions about the regulatory principle(s) in glycan biosynthesis. There is no template for glycan chain synthesis, elongation, processing or termination. The cells/tissues follow a highly conserved mechanism. The assumption is glycosylation uses donor and acceptor interactions as the driving force. Increased or decreased synthesis of glycans in response to the environmental change influence cell function, i.e., growth, survival or death favor of a "push-pull" hypothesis. In the absence of a genetic code for sugars, the assembly as well as the processing of glycan chains are controlled by the Glycome. Unlike the genome, the Glycome is hidden for the normal eye but its communication skills with the cellular microenvironment and genome for glycan synthesis and degradation are enormous. Seventeen chapters in the book are dedicated to walk the readers through the diversities of the Glycome. The authors have used mammalian, microbial and plant systems to achieve the desired goal.
Author : Benjamin P. Kellman
Publisher :
ISBN 13 :
Total Pages : 346 pages
Book Rating : 4.:/5 (119 download)
Download or read book Essentiality, Biosynthesis, and Prediction of Glycosylation written by Benjamin P. Kellman and published by . This book was released on 2020 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycans, polysaccharides generalizable to a colored graph with colored edges, decorate proteins and cell membranes at the cell-environment interface, and modulate intercellular communication, from development to pathogenesis. Providing further challenges, glycan biosynthesis and cellular behavior are co-regulating systems. We begin with a discussion of how glycosylation contributes to extracellular responses and signaling. We further organize approaches for disentangling the roles of glycans in multicellular interactions using newly available datasets and tools, including glycan biosynthesis models, omics datasets, and systems-level analyses. Thus, emerging tools in big data analytics and systems biology are facilitating novel insights on glycans and their relationship with multicellular behavior. With mechanistic and abstract models of glycan biosynthesis, glycosylation remains unpredictable. While DNA, RNA, and proteins undergo templated synthesis, wherein request (i.e., base-pairing or codon) is made and fulfillment (i.e., nucleotide or amino acid addition), glycan biosynthesis is principally non-templated; metabolically constrained. The premise of the final chapter is that glycoconjugates and glycan-biosynthetic enzymes exist in physical space, have physical and chemical attributes, and therefore interact, attract, and repel each other. Because the glycoconjugate is the point of reference for a glycan and it displays the most variation in the system of glycan biosynthesis, we hypothesize that the glycoconjugate surface is the template-request of the glycan biosynthesis while metabolite availability is the context-dependent, and therefore confounding, fulfillment of that request. Towards expanding our understanding of glycan biosynthesis, we explore site-specific glycosylation databases, amino-acid substitution matrixes, pathogenic mutations and empirical observations of sequence-dependent glycosylation to support the separation of templated biosynthesis into two parts: the request (e.g., codon, or nucleotide) and the request fulfillment (e.g., addition of the corresponding amino acid or paired nucleotide). Here we explore multiple modes of glycomic analysis including glycan-level, flux-level, and substructure-level analysis. Each resolution provides varying degrees of accuracy and insight but none provided clear and global generalizability. In the final chapter, we establish a genetic encoding for glycosylation providing support for genetic and metabolic encoding. A templated encoding for glycan biosynthesis will make glycans predictable and broadly accessible beyond direct empirical observation.
Author : Hans-Joachim Gabius
Publisher : John Wiley & Sons
ISBN 13 : 3527644946
Total Pages : 560 pages
Book Rating : 4.5/5 (276 download)
Download or read book The Sugar Code written by Hans-Joachim Gabius and published by John Wiley & Sons. This book was released on 2011-09-19 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE
Author : Nia S. Beckley
Publisher :
ISBN 13 :
Total Pages : 149 pages
Book Rating : 4.:/5 (71 download)
Download or read book Development and Application of Tools for Glycan Characterization written by Nia S. Beckley and published by . This book was released on 2009 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycans are essential components of all living things because they function as key elements of cellular membranes and extracellular spaces by mediating cell-cell communication, transduction pathways, and cellular development, function, and survival. Because glycans are secondary gene products that depend on the availability of sub-cellular enzymes for synthesis, research on their structure, synthesis, and biological significance has lagged behind that of DNA and proteins due to both a lack of appreciation of their importance and the slow pace at which tools are being developed to study them. In this thesis, three projects focus on the development, application, and exploration of tools for glycan characterization. The first project resulted in the successful optimization of an analytical method to isolate and characterize O-linked glycans, on which relatively few research projects focus because of the limited availability of tools to isolate them and the need for specific analytical equipment to properly characterize them. Using this optimized method, the O-linked glycans of bovine mucin and fetuin were successfully profiled, and the analysis of the former provided the motivation for a second project focused on the significance of goblet cells and mucins in influenza infection. This project explored the potential benefits of a glycoprotein direct binding assay as a way to obtain quantitative information about lectin and influenza hemagglutinin specificities. Using mucins adsorbed to a polystyrene plate, it was possible to obtain quantitative binding constants for two commonly used lectins. The last project focused on the isolation and characterization of the cell surface N-linked glycans from chicken erythrocytes, turkey erythrocytes, and human tracheal epithelial (HTE) cells. Analysis of these cell types is warranted due to their importance as model systems to study influenza infection. The results of this project provide a context for future questions about the relevance of the erythrocyte model system for studying influenza binding specificities. All of these projects reiterate the importance of the study of glycobiology by showing how both the development and application of tools to study glycans can provide in new and interesting information about pathological processes related to human health and disease.
Author : Kiyoko F. Aoki-Kinoshita
Publisher : CRC Press
ISBN 13 : 1000687538
Total Pages : 264 pages
Book Rating : 4.0/5 (6 download)
Download or read book Glycome Informatics written by Kiyoko F. Aoki-Kinoshita and published by CRC Press. This book was released on 2009-11-19 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Focused, State-of-the-Art Overview of This Evolving FieldPresents Various Techniques for GlycoinformaticsThe development and use of informatics tools and databases for glycobiology and glycomics research have increased considerably in recent years. In addition to accumulating well-structured glyco-related data, researchers have now developed semi
Author : Hans-Joachim Gabius
Publisher : John Wiley & Sons
ISBN 13 : 3527614729
Total Pages : 663 pages
Book Rating : 4.5/5 (276 download)
Download or read book Glycosciences written by Hans-Joachim Gabius and published by John Wiley & Sons. This book was released on 2008-09-26 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey of the topic, ranging from basic molecular research to clinical applications. Critical reviews by leading experts in each field summarize the state of knowledge and discuss the anticipated benefits of novel approaches and strategies. These include the impact of modern analysis techniques on glycobiology, the use of synthetic neoglycoproteins, or the clinical consequences of new insights into the physiological role of lectins and glycoconjugates in pathology, oncology, immunity, neuroscience and reproduction medicine. Throughout, the aim is to separate realistic applications from mere hopes.
Author :
Publisher : Academic Press
ISBN 13 : 0128016140
Total Pages : 418 pages
Book Rating : 4.1/5 (28 download)
Download or read book Glycosylation and Cancer written by and published by Academic Press. This book was released on 2015-02-26 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. Provides information on cancer research Outstanding and original reviews Suitable for researchers and students
Author : Els J. M. Van Damme
Publisher : Frontiers Media SA
ISBN 13 : 2889194213
Total Pages : 137 pages
Book Rating : 4.8/5 (891 download)
Download or read book Plant Glycobiology – a sweet world of lectins, glycoproteins, glycolipids and glycans written by Els J. M. Van Damme and published by Frontiers Media SA. This book was released on 2015-02-12 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants synthesize a wide variety of unique glycan structures which play essential roles during the life cycle of the plant. Being omnipresent throughout the plant kingdom, ranging from simple green algae to modern flowering plants, glycans contribute to many diverse processes. Glycans can function as structural components in the plant cell wall, assist in the folding of nascent proteins, act as signaling molecules in plant defense responses or (ER) stress pathways, or serve within the energy metabolism of a plant. In most cases, glycans are attached to other macromolecules to form so-called glycoconjugates (e.g. glycoproteins, proteoglycans and glycolipids), but they can also be present as free entities residing in the plant cell. Next to the broad, complex set of glycans, plants also evolved an elaborate collection of lectins or proteins with a lectin-like domain, which can recognize and bind to endogenous (plants-own) or exogenous (foreign) glycans. Though still poorly understood in plants, the dynamic interactions between lectins and carbohydrate structures are suggested to be involved in gene transcription, protein folding, protein transport, cell adhesion, signaling as well as defense responses. As such, a complex and largely undetermined glycan-interactome is established inside plant cells, between cells and their surrounding matrix, inside the extracellular matrix, and even between organisms. Studying the biological roles of plant glycans will enable to better understand plant development and physiology in order to fully exploit plants for food, feed and production of pharmaceutical proteins. In this Research Topic, we want to provide a platform for articles describing the latest research, perspectives and methodologies related to the fascinating world of plant glycobiology, with a focus on following subjects: 1. Identification and characterization of plant glycans, their biosynthetic and degradation enzymes 2. Characterization of plant lectins and glycoproteins 3. Plant glycans in the plant’s energy metabolism 4. Role of plant glycans in plant defense signaling 5. Use of plant lectins in pest control 6. Plant lectins as new tools in human medicine 7. Glyco-engineering in plants
Author : Marija Pezer
Publisher : Springer Nature
ISBN 13 : 3030769127
Total Pages : 588 pages
Book Rating : 4.0/5 (37 download)
Download or read book Antibody Glycosylation written by Marija Pezer and published by Springer Nature. This book was released on 2021-10-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author : Azita Alavi
Publisher : Springer Science & Business Media
ISBN 13 : 1461518857
Total Pages : 291 pages
Book Rating : 4.4/5 (615 download)
Download or read book Glycoimmunology written by Azita Alavi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Third Jenner International Glycoimmunology meeting held in Il Ciocco, Tuscany, Italy, October 11-14, 1994
Author : Bernd Lepenies
Publisher : Frontiers Media SA
ISBN 13 : 2889632555
Total Pages : 239 pages
Book Rating : 4.8/5 (896 download)
Download or read book Lectins and Their Ligands in Shaping Immune Responses written by Bernd Lepenies and published by Frontiers Media SA. This book was released on 2019-12-23 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joëlle Roche
Publisher : MDPI
ISBN 13 : 3038427934
Total Pages : 261 pages
Book Rating : 4.0/5 (384 download)
Download or read book The Epithelial-to-Mesenchymal Transition (EMT) in Cancer written by Joëlle Roche and published by MDPI. This book was released on 2018-04-09 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "The Epithelial-to-Mesenchymal Transition (EMT) in Cancer" that was published in Cancers
