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Genome Mining And Synthetic Biology In Marine Natural Products Discovery
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Book Synopsis Genome Mining and Synthetic Biology in Marine Natural Products Discovery by : Maria Costantini
Download or read book Genome Mining and Synthetic Biology in Marine Natural Products Discovery written by Maria Costantini and published by MDPI. This book was released on 2021-09-03 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, marine genomics has become a rapidly growing field, helped by the large amount of information that is becoming available to the international scientific community. Taking into account the current excitement in the field of marine biotechnology, this Special Issue entitled “Genome Mining and Synthetic Biology in Marine Natural Product Discovery” aims to to assess the impact of these molecular approaches on the discovery of bioactive compounds from marine organisms. The term “genome mining” is used to identify all bioinformatic investigations aimed at detecting the biosynthetic pathways of bioactive natural products and their possible functional and chemical interactions. Several studies are now reporting on marine organisms. Oceans cover nearly 70% of the Earth’s surface and host a huge ecological, chemical, and biological diversity. The natural conditions of the sea favor, in marine organisms, the production of a large variety of novel molecules with great pharmaceutical potential. Marine organisms are unique in their structural and functional features compared to terrestrial ones. Innovation in this field is very rapid, as revealed by the funding of several Seventh Framework Programme (FP7) and Horizon 2020 projects under the topic “Blue Growth”, with the urgent goal of discovering new drugs.
Book Synopsis Genome Mining and Synthetic Biology in Marine Natural Products Discovery by : Maria Costantini
Download or read book Genome Mining and Synthetic Biology in Marine Natural Products Discovery written by Maria Costantini and published by . This book was released on 2021 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, marine genomics has become a growning rapidly field, helped by the large amount of information that is becoming available to the international scientific community. Taking into account the current excitement in the field of marine biotechnology, this Special Issue entitled “Genome Mining and Synthetic Biology in Marine Natural Product Discovery” aims to to assess the impact of these molecular approaches on the discovery of bioactive compounds from marine organisms. The term “genome mining” is used to identify all bioinformatic investigations aimed at detecting the biosynthetic pathways of bioactive natural products and their possible functional and chemical interactions. Several studies are now reporting on marine organisms. Oceans cover nearly 70% of the Earth's surface and host a huge ecological, chemical, and biological diversity. The natural conditions of the sea favor, in marine organisms, the production of a large variety of novel molecules with great pharmaceutical potential. Marine organisms are unique in their structural and functional features compared to terrestrial ones. Innovation in this field is very rapid, as revealed by the funding of several Seventh Framework Programme (FP7) and Horizon 2020 projects under the topic “Blue Growth”, with the urgent goal of discovering new drugs.
Book Synopsis Genome Mining and Marine Microbial Natural Products by : Kui Hong
Download or read book Genome Mining and Marine Microbial Natural Products written by Kui Hong and published by MDPI. This book was released on 2020-01-07 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources.
Book Synopsis From Molecules to Genes and Back Again by : Michelle Antoinette Schorn
Download or read book From Molecules to Genes and Back Again written by Michelle Antoinette Schorn and published by . This book was released on 2018 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nature has created elegant and efficient ways of assembling a wide variety of diverse chemical scaffolds. Microbes are prolific producers of these secondary metabolites, which can have profound bioactivities and be harnessed for use in medicine. Within their genomes, microbes possess the blueprints for making natural products, and recent advances in high-throughput DNA sequencing have revealed a much larger repertoire of specialized chemistry than what can be observed in the lab. This bacterial 'dark matter' has the potential to contain the instructions for making countless new chemical scaffolds and represents an untapped source for drug discovery. Connecting secondary metabolite compounds with their biosynthetic gene clusters can inform novel biosynthetic transformations, provide a renewable source of promising bioactive compounds, and inspire synthetic biology approaches to assembling new molecules. Chapter 2 of this dissertation connects two pharmaceutically relevant natural products with their corresponding biosynthetic gene clusters. The epoxyketone proteasome inhibitors epoxomicin and eponemycin are naturally produced by actinomycete bacteria, and whole genome sequencing revealed their genetic underpinnings and native resistance mechanism. This work represents the first elucidation of biosynthetic gene clusters for epoxyketone proteasome inhibitors. Chapter 3 takes a wider lens to examine an understudied group of bacteria: the rare marine actinomycetes. Whole genome sequencing of a group of rare marine actinomycetes revealed an incredible wealth of biosynthetic potential and diversity not yet represented in current sequencing databases. This study establishes rare marine actinomycetes as a group worthy of further exploration for genome mining and drug discovery. Chapter 4 investigates a more complex system with a focus on uncultivatable cyanobacterial sponge symbionts. Previous work showed that the genomes of these symbionts contained the genes necessary to produce environmentally relevant poly-brominated diphenyl ethers (PBDEs). In assembling high quality draft genomes of two symbionts of distinct sponges, their full secondary metabolite potential was revealed. Additionally, genome mining led to the identification of two novel dysinosin molecules, representing the first example of mining for gene clusters in a metagenome assembled genome leading to new chemistry.
Book Synopsis Drug Discovery from Natural Products by : Olga Genilloud
Download or read book Drug Discovery from Natural Products written by Olga Genilloud and published by Royal Society of Chemistry. This book was released on 2012-08-21 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers an integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology as a starting point in novel drug development. The authors focus on different trends that are and will continue to be impacting multiples stages of modern drug discovery from NPs that have not been included in other works. This is complemented with a series of case studies from leading experts from industry and academia on key molecules and derivatives that have been chosen for their novelty in chemistry, biology and clinical applications. The book intends to reflect the current confluence of different disciplines in chemical biology and synthetic chemistry supported by a more profound knowledge of systems biology that ensures the concurrency and synergisms of expertise from different research fields that impact in the discovery of novel molecules. In the first section the chapters reflect recent approaches to exploit the biosynthetic potential of microbial resources (including genome mining, metagenomic and epigenetic approaches), as well as biosynthetic chemistry tools to respond to product supply and novel screening alternatives that have lead to the discovery of novel chemistry. The second part reviews, in the form of case studies, some examples of bioactive molecules in the important therapeutic areas of antiinfectives, oncology and antiparasitics.
Book Synopsis Marine Biotechnology in the Twenty-First Century by : National Research Council
Download or read book Marine Biotechnology in the Twenty-First Century written by National Research Council and published by National Academies Press. This book was released on 2002-05-29 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dramatic developments in understanding the fundamental underpinnings of life have provided exciting opportunities to make marine bioproducts an important part of the U.S. economy. Several marine based pharmaceuticals are under active commercial development, ecosystem health is high on the public's list of concerns, and aquaculture is providing an ever greater proportion of the seafood on our tables. Nevertheless, marine biotechnology has not yet caught the public's, or investor's, attention. Two workshops, held in October 1999 and November 2001 at the National Academies, were successful in highlighting new developments and opportunities in environmental and biomedical applications of marine biotechnology, and also in identifying factors that are impeding commercial exploitation of these products. This report includes a synthesis of the 2001 sessions addressing drug discovery and development, applications of genomics and proteomics to marine biotechnology, biomaterials and bioengineering, and public policy and essays contributed by the workshop speakers.
Book Synopsis Genome Mining and Marine Microbial Natural Products by : Alan Dobson
Download or read book Genome Mining and Marine Microbial Natural Products written by Alan Dobson and published by . This book was released on 2020 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources.
Book Synopsis Natural Product Genomics and Metabolomics of Marine Bacteria by :
Download or read book Natural Product Genomics and Metabolomics of Marine Bacteria written by and published by . This book was released on 2022-02-24 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Functional Metagenomics: Tools and Applications by : Trevor C. Charles
Download or read book Functional Metagenomics: Tools and Applications written by Trevor C. Charles and published by Springer. This book was released on 2017-10-09 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, the latest tools available for functional metagenomics research are described.This research enables scientists to directly access the genomes from diverse microbial genomes at one time and study these “metagenomes”. Using the modern tools of genome sequencing and cloning, researchers have now been able to harness this astounding metagenomic diversity to understand and exploit the diverse functions of microorganisms. Leading scientists from around the world demonstrate how these approaches have been applied in many different settings, including aquatic and terrestrial habitats, microbiomes, and many more environments. This is a highly informative and carefully presented book, providing microbiologists with a summary of the latest functional metagenomics literature on all specific habitats.
Book Synopsis Genome Mining and Metabolomics Approach Towards the Discovery of Marine Natural Products by : Kevin Jace Miranda
Download or read book Genome Mining and Metabolomics Approach Towards the Discovery of Marine Natural Products written by Kevin Jace Miranda and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Natural Products from Actinomycetes by : Ravishankar V. Rai
Download or read book Natural Products from Actinomycetes written by Ravishankar V. Rai and published by Springer Nature. This book was released on 2022-04-15 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides in-depth information about the ecology, diversity and applications of Actinomycetes. The book is divided into two major parts. The first part discusses the diversity, chemical biology and ecology of Actinomycetes. It also covers the discovery of natural products from soil, endophytic and marine-derived Actinomycetes. It includes natural product discovery, chemical biology, new methods for discovering secondary metabolites, structure elucidation and biosynthetic research of natural products. The chapters in this part focus on the effects of biological and chemical elicitation at molecular level on secondary metabolism in Actinomycetes. The second part of the book discusses genomic and synthetic biology approaches in Actinomycetes drug discovery. This part includes chapters focused on the application of metabolic engineering to optimize natural product synthesis and the use of omics data in engineering of regulatory genes. It covers the advanced tools of synthetic biology and metabolic engineering including cluster assembly, CRISPR/Cas9 technologies, and chassis strain development for natural product overproduction in Actinomycetes. It describes the use of bioinformatics tools for reprogramming of biosynthetic pathways through polyketide synthase and non-ribosomal peptide synthetase engineering. These advanced genomic and molecular tools are expected to accelerate the discovery and development of new natural products from Actinomycetes with medicinal and other industrial applications. The book is useful to researchers and students in the field of microbiology, pharmaceutical sciences and drug discovery.
Book Synopsis The discovery of bioactive natural products: The isolation and structural elucidation, genome mining, OSMAC strategy, and biotransformation by : Ling Liu
Download or read book The discovery of bioactive natural products: The isolation and structural elucidation, genome mining, OSMAC strategy, and biotransformation written by Ling Liu and published by Frontiers Media SA. This book was released on 2023-08-30 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Global Virology III: Virology in the 21st Century by : Paul Shapshak
Download or read book Global Virology III: Virology in the 21st Century written by Paul Shapshak and published by Springer Nature. This book was released on 2019-11-22 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global Virology, Volume III: Virology in the 21st Century examines work that has been undertaken, or is planned, in several fields of virology, in an effort to promote current and future work, research, and health. Fields and methods addressed include virology, immunology, space research, astrovirology/astrobiology, plasmids, swarm intelligence, bioinformatics, data-mining, machine learning, neural networks, critical equations, and advances in biohazard biocontainment. Novel and forward-looking methods, techniques, and approaches in research and development are presented by experts in the field.
Book Synopsis Chemical Biology of Natural Products by : David J. Newman
Download or read book Chemical Biology of Natural Products written by David J. Newman and published by CRC Press. This book was released on 2017-09-22 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.
Book Synopsis Synthetic Genomics by : Miguel Fernández-Niño
Download or read book Synthetic Genomics written by Miguel Fernández-Niño and published by BoD – Books on Demand. This book was released on 2022-02-02 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current advances in sequencing, data mining, DNA synthesis, cloning, in silico modeling, and genome editing have opened a new field of research known as Synthetic Genomics. The main goal of this emerging area is to engineer entire synthetic genomes from scratch using pre-designed building blocks obtained by chemical synthesis and rational design. This has opened the possibility to further improve our understanding of genome fundamentals by considering the effect of the whole biological system on biological function. Moreover, the construction of non-natural biological systems has allowed us to explore novel biological functions so far not discovered in nature. This book summarizes the current state of Synthetic Genomics, providing relevant examples in this emerging field.
Book Synopsis Synthetic DNA and RNA Programming by : Patrick O’Donoghue
Download or read book Synthetic DNA and RNA Programming written by Patrick O’Donoghue and published by MDPI. This book was released on 2019-11-19 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dear Colleagues, Synthetic biology is a broad and emerging discipline that capitalizes on recent advances in molecular biology, genetics, protein and RNA engineering and omics technologies. These technologies have transformed our ability to reveal the biology of the cell and the molecular basis of disease. This Special Issue on “Synthetic RNA and DNA Programming” features original research articles and reviews, highlighting novel aspects of basic molecular biology and the molecular mechanisms of disease that were uncovered by the application and development of novel synthetic biology-driven approaches.
Book Synopsis The Science and Applications of Synthetic and Systems Biology by : Institute of Medicine
Download or read book The Science and Applications of Synthetic and Systems Biology written by Institute of Medicine and published by National Academies Press. This book was released on 2011-12-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
