Genetic Mosaicism

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Genetic Mosaicism

Author : János Szabad
Publisher : Cambridge Scholars Publishing
ISBN 13 : 1527571165
Total Pages : 160 pages
Book Rating : 4.5/5 (275 download)

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Book Synopsis Genetic Mosaicism by : János Szabad

Download or read book Genetic Mosaicism written by János Szabad and published by Cambridge Scholars Publishing. This book was released on 2021-06-17 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The presence of green and yellow ornamental plants around us, dark spots on our skin, people with brown and blue mosaic irises, and white-spotted dogs and horses are all well-known phenomena of life, and are recognisable genetic mosaics. Although such genetics mosaics live with us (and, in fact, we are all a genetic mosaics), little is known about the genetic bases of their origin. This book provides a general overview of the mechanisms that lead to the formation of different types of mosaics, listing an ample collection of examples to illustrate the impact of the genetic mosaics on our life. The book will appeal to the reader interested in understanding the relationship between genetic events and mosaicism, especially undergraduate and graduate students and medical doctors, as well as experts engaged in horticulture and animal breeding.

Medical Genetics: What is MOSAICISM?

Author : Dr.H.K.Saboowala.
Publisher : Dr.Hakim Saboowala
ISBN 13 :
Total Pages : 46 pages
Book Rating : 4./5 ( download)

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Book Synopsis Medical Genetics: What is MOSAICISM? by : Dr.H.K.Saboowala.

Download or read book Medical Genetics: What is MOSAICISM? written by Dr.H.K.Saboowala. and published by Dr.Hakim Saboowala. This book was released on 2022-08-07 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Genetics: What is MOSAICISM? When the fertilized egg begins to divide, it replicates its genetic material in cellular offspring. This cell replication builds and builds, creating tissues and organs in the body. In theory, each replicated cell should contain the exact same genetic information as the fertilized egg. However, this is not always the case. In rare instances, new genetic changes can occur in these replicated cells. These changes occur on the chromosomes, which are carry all of a person’s genetic information, located in each cell’s nucleus. Until recently, scientists thought the condition was straightforward—either a person had mosaicism or not. As genetic sequencing technology becomes more sophisticated, a picture is emerging in the field of genetics showing that we all have some amount of mosaicism. The more frequently mosaicism is found in the body, the greater likelihood a person can develop a health condition because of it. Thus, it is endeavoured in this E-Booklet to precisely discuss the followings: · How does Mosaicism occur? · Types of Mosaicism · Types of Disorders caused by Mosaicism along with ILLUSTRATIONS. · How is Mosaicism Diagnosed? · Use in Experimental Biology · Prognosis · Can Mosaicism be Prevented? …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Genetic Mosaics, and Other Essays

Author : Curt Stern
Publisher : Cambridge : Harvard University Press
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Genetic Mosaics, and Other Essays by : Curt Stern

Download or read book Genetic Mosaics, and Other Essays written by Curt Stern and published by Cambridge : Harvard University Press. This book was released on 1968 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mosaicism in Human Skin

Author : Rudolf Happle
Publisher : Springer Nature
ISBN 13 : 3030899373
Total Pages : 252 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Mosaicism in Human Skin by : Rudolf Happle

Download or read book Mosaicism in Human Skin written by Rudolf Happle and published by Springer Nature. This book was released on 2022-11-24 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition offers a fully revised and updated work on a rapidly growing field of knowledge, and was prepared by two experts whose goal was to explain the molecular basis of mosaic skin disorders in a language that is accessible for practicing physicians and medical students alike. It presents a timely and comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders in a straightforward, reader-friendly way that will help physicians to further improve genetic counseling and treatment outcomes. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, and include an explanation of genomic and epigenetic mosaicism and a description of the archetypical segmental patterns including the lines of Blaschko and the flag-like, phylloid and lateralization pattern, the non-segmental pattern of large congenital melanocytic nevi, and the sash-like arrangement as noted in a particular type of cutis tricolor. The concept of lethal mutations surviving as mosaics has now been confirmed by molecular analysis in many sporadically occurring phenotypes. The difference between monoallelic and biallelic traits has deepened our understanding of hereditary mosaics, especially of multiple benign skin tumors. Moreover, recognition of the fundamental difference between the simple segmental and the superimposed types of mosaicism is important for the purpose of genetic counseling. In the third part, the various mosaic skin disorders are examined in depth, including nevi, didymotic disorders, other binary genodermatoses, mosaic manifestations of autosomal skin disorders, and nevoid skin disorders such as phenotypes reflecting functional X-chromosome mosaicism or a superimposed mosaic manifestation of common skin diseases with a polygenic background. Reader-friendly and clearly structured, Mosaicism in Human Skin will appeal to both experienced dermatologists and residents in training, as well as to medical geneticists and pediatricians.

Genetic Mosaics and Cell Differentiation

Author : W. J. Gehring
Publisher : Springer Science & Business Media
ISBN 13 : 354035803X
Total Pages : 323 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Genetic Mosaics and Cell Differentiation by : W. J. Gehring

Download or read book Genetic Mosaics and Cell Differentiation written by W. J. Gehring and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The relationship of cell lineage and differentiation is one of the most intriguing problems in developmental biology. In most higher organisms, the analysis of the cell lineage has to rely on indirect methods. Only in the most suitable systems, like the nematodes, can the pattern of cell division be determined by direct observation under the microscope. In cases where this is not possible, the fate of the cells has to be examined by using cell markers. Most suitable for this purpose are genetic markers, provided that they do not interfere with the developmental pathway to be studied. However, suitable genetic markers and techniques for generating genetic mosaics are available in a few organisms only. Therefore, this volume is largely concerned with Drosophila and the mouse, which have been studied most extensively. In 1929 STURTEVANT introduced the analysis of gynandromorphs into devel opmental genetics. However, this important contribution remained largely unnoticed until the late sixties, when the potential of this technique for deter mining embryonic fate maps and the number of primordial cells was exploited, and the methodology extended to the mapping of mutational foci. Mitotic recombination was demostrated by STER:-

Genetic and Functional Mosaicism in the Mouse

Author :
Publisher :
ISBN 13 :
Total Pages : 43 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Genetic and Functional Mosaicism in the Mouse by :

Download or read book Genetic and Functional Mosaicism in the Mouse written by and published by . This book was released on 1964 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetic Mosaics and Chimeras in Mammals

Author : L. B. Russell
Publisher : Springer Science & Business Media
ISBN 13 : 1468433903
Total Pages : 480 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Genetic Mosaics and Chimeras in Mammals by : L. B. Russell

Download or read book Genetic Mosaics and Chimeras in Mammals written by L. B. Russell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cytogenomics

Author : Thomas Liehr
Publisher : Academic Press
ISBN 13 : 0128235802
Total Pages : 430 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Cytogenomics by : Thomas Liehr

Download or read book Cytogenomics written by Thomas Liehr and published by Academic Press. This book was released on 2021-05-25 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The book’s second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists. Offers applied approaches empowering a new generation of cytogenomic research using a balanced combination of classical and advanced technologies Provides a framework for interpreting chromosome structure and how this affects the functioning of the genome in health and disease Features chapter contributions from international leaders in the field

Females Are Mosaics

Author : Barbara Migeon
Publisher : Oxford University Press
ISBN 13 : 0190208473
Total Pages : 296 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis Females Are Mosaics by : Barbara Migeon

Download or read book Females Are Mosaics written by Barbara Migeon and published by Oxford University Press. This book was released on 2007-03-15 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Women can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome (inherited from their mother), females have two X chromosomes in every cell (one from each parent). The fathers copy works in some cells, while the mothers copy works in others. These two X chromosomes often function differently, especially if one carries a defective gene. Much has been written about the Y chromosome and its role in inducing maleness. This will be the first book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. Barbara Migeon, from the renowned McKusick-Nathan Institute at Johns Hopkins, is a major figure in clinical genetics and is eminently qualified to write this book, and she writes clearly and effectively. She describes both the underlying molecular mechanisms and the remarkable genetic consequences of X inactivation and its role in determining the biological concepts characteristic of women. Females are Mosaics will be valuable to geneticists, biologists, and all health professionals interested in women's health.

Encyclopedia of Basic Epilepsy Research

Author :
Publisher : Academic Press
ISBN 13 : 0123739616
Total Pages : 1853 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Encyclopedia of Basic Epilepsy Research by :

Download or read book Encyclopedia of Basic Epilepsy Research written by and published by Academic Press. This book was released on 2009-05-27 with total page 1853 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy. The only comprehensive reference for basic research and current activities in epilepsy Electronic format provides fast and easy access to updates and additions, with limited print version available as well Contains over 85 articles, all written by experts in epilepsy research

Heritable Human Genome Editing

Author : The Royal Society
Publisher : National Academies Press
ISBN 13 : 0309671132
Total Pages : 239 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Heritable Human Genome Editing by : The Royal Society

Download or read book Heritable Human Genome Editing written by The Royal Society and published by National Academies Press. This book was released on 2021-01-16 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry

Author : Thomas Lehner
Publisher : Academic Press
ISBN 13 : 0128005300
Total Pages : 798 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genomics, Circuits, and Pathways in Clinical Neuropsychiatry by : Thomas Lehner

Download or read book Genomics, Circuits, and Pathways in Clinical Neuropsychiatry written by Thomas Lehner and published by Academic Press. This book was released on 2016-06-07 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Genomic Mosaicism in Neurons and Other Cell Types

Author : José María Frade
Publisher : Humana
ISBN 13 : 9781493984404
Total Pages : 0 pages
Book Rating : 4.9/5 (844 download)

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Book Synopsis Genomic Mosaicism in Neurons and Other Cell Types by : José María Frade

Download or read book Genomic Mosaicism in Neurons and Other Cell Types written by José María Frade and published by Humana. This book was released on 2018-08-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents methods for the analysis of genomic variability in vertebrate neurons and broadens our knowledge in the ways we understand the brain and its neurons. The chapters in this book are divided into 5 parts, and cover the following topics: principles and approaches for discovery of somatic mosaicism in the brain, aneuploidy and ploidy variation, DNA copy number variation, LINE-1 retrotransposition, and genetic and genomic mosaicism in aging and disease. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Genomic Mosaicism in Neurons and Other Cell Types is a valuable resource for learning about the latest techniques for the analysis of genome and genetic mosaicism in vertebrate neurons.

The Geographic Mosaic of Coevolution

Author : John N. Thompson
Publisher : University of Chicago Press
ISBN 13 : 0226797627
Total Pages : 456 pages
Book Rating : 4.2/5 (267 download)

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Book Synopsis The Geographic Mosaic of Coevolution by : John N. Thompson

Download or read book The Geographic Mosaic of Coevolution written by John N. Thompson and published by University of Chicago Press. This book was released on 2005-06-15 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coevolution—reciprocal evolutionary change in interacting species driven by natural selection—is one of the most important ecological and genetic processes organizing the earth's biodiversity: most plants and animals require coevolved interactions with other species to survive and reproduce. The Geographic Mosaic of Coevolution analyzes how the biology of species provides the raw material for long-term coevolution, evaluates how local coadaptation forms the basic module of coevolutionary change, and explores how the coevolutionary process reshapes locally coevolving interactions across the earth's constantly changing landscapes. Picking up where his influential The Coevolutionary Process left off, John N. Thompsonsynthesizes the state of a rapidly developing science that integrates approaches from evolutionary ecology, population genetics, phylogeography, systematics, evolutionary biochemistry and physiology, and molecular biology. Using models, data, and hypotheses to develop a complete conceptual framework, Thompson also draws on examples from a wide range of taxa and environments, illustrating the expanding breadth and depth of research in coevolutionary biology.

CRISPR-Cas Systems

Author : Rodolphe Barrangou
Publisher : Springer Science & Business Media
ISBN 13 : 364234657X
Total Pages : 300 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis CRISPR-Cas Systems by : Rodolphe Barrangou

Download or read book CRISPR-Cas Systems written by Rodolphe Barrangou and published by Springer Science & Business Media. This book was released on 2012-12-13 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Handbook of Models for Human Aging

Author : P. Michael Conn
Publisher : Elsevier
ISBN 13 : 0080460062
Total Pages : 1103 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Handbook of Models for Human Aging by : P. Michael Conn

Download or read book Handbook of Models for Human Aging written by P. Michael Conn and published by Elsevier. This book was released on 2011-04-28 with total page 1103 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

Preimplantation Genetic Testing

Author : Darren K. Griffin
Publisher : CRC Press
ISBN 13 : 0429820305
Total Pages : 208 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis Preimplantation Genetic Testing by : Darren K. Griffin

Download or read book Preimplantation Genetic Testing written by Darren K. Griffin and published by CRC Press. This book was released on 2020-06-01 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preimplantation genetic testing (PGT) is now well established as a valuable treatment option for patients wishing to start or continue a family, for a range of indications from advanced maternal age to high risk of transmitting inherited disease. This text brings together contemporary thinking from international opinion leaders and will be an invaluable guide for practitioners in Reproductive Medicine wishing to keep pace with the latest developments and clinical data.