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Author : Zhaoyu Zheng (Chemist)
Publisher :
ISBN 13 :
Total Pages : 228 pages
Book Rating : 4.5/5 (346 download)
Download or read book Gas-phase Ion Chemistry Investigations by Ion Mobility and Mass Spectrometry written by Zhaoyu Zheng (Chemist) and published by . This book was released on 2021 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kris E. Sahlstrom
Publisher :
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.:/5 (42 download)
Download or read book Investigations of Gas Phase Ion-molecule Reactions at Elevated Pressures Using Ion Mobility-mass Spectrometry written by Kris E. Sahlstrom and published by . This book was released on 1997 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Peter B. Armentrout
Publisher : Springer Science & Business Media
ISBN 13 : 3540000984
Total Pages : 318 pages
Book Rating : 4.5/5 (4 download)
Download or read book Modern Mass Spectrometry written by Peter B. Armentrout and published by Springer Science & Business Media. This book was released on 2003-06-23 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: I Reactivity: E. Uggerud: Physical Organic Chemistry of the Gas Phase. Reactivity Trends for Organic Cations.- S. Petrie, D.K. Bohme: Mass Spectrometric Approaches to Interstellar Chemistry.- F. Turecek: Transient Intermediates of Chemical Reactions by Neutralization-Reionization Mass Spectrometry.- II Metalorganic Chemistry: D. Schröder, H. Schwarz: Diastereoselective Effects in Gas-Phase Ion Chemistry.- D.A. Plattner: Metalorganic Chemistry in the Gas Phase: Insight into Catalysis.- III Mass Spectrometric Methodology: T. Wyttenbach, M.T. Bowers: Gas-Phase Conformations: The Ion Mobility/Ion Chromatography Method.- P.B. Armentrout: Threshold Collision-Induced Dissociations for the Determination of Accurate Gas-Phase Binding Energies and Reaction Barriers.- IV Medicinal Chemistry: S.A. Trauger, T. Junker, G. Siuzdak: Investigating Viral Proteins and Intact Viruses with Mass Spectrometry M. Brönstrup: High-Throughput Mass Spectrometry for Compound Characterization in Drug Discovery.
Author : Michael T. Bowers
Publisher : Academic Press
ISBN 13 : 1483216497
Total Pages : 363 pages
Book Rating : 4.4/5 (832 download)
Download or read book Gas Phase Ion Chemistry written by Michael T. Bowers and published by Academic Press. This book was released on 2013-10-22 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gas Phase Ion Chemistry, Volume 2 covers the advances in gas phase ion chemistry. The book discusses the stabilities of positive ions from equilibrium gas-phase basicity measurements; the experimental methods used to determine molecular electron affinities, specifically photoelectron spectroscopy, photodetachment spectroscopy, charge transfer, and collisional ionization; and the gas-phase acidity scale. The text also describes the basis of the technique of chemical ionization mass spectrometry; the energetics and mechanisms of unimolecular reactions of positive ions; and the photodissociation of gas-phase ions. The applications of molecular beam techniques to the study of ion-molecule collisions; as well as the variational treatment of charge transfer reactions are also encompassed. Chemists and biochemists will find the book invaluable.
Author : G.A. Eiceman
Publisher : CRC Press
ISBN 13 : 1420038974
Total Pages : 367 pages
Book Rating : 4.4/5 (2 download)
Download or read book Ion Mobility Spectrometry written by G.A. Eiceman and published by CRC Press. This book was released on 2005-06-23 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key Developments for Faster, More Precise Detection Capabilities Driven by the demand for the rapid and advanced detection of explosives, chemical and biological warfare agents, and narcotics, ion mobility spectrometry (IMS) undergone significant refinements in technology, computational capabilities, and understanding of the principles of gas phase
Author : L.M. Babcock
Publisher : Elsevier
ISBN 13 : 008049322X
Total Pages : 331 pages
Book Rating : 4.0/5 (84 download)
Download or read book Advances in Gas Phase Ion Chemistry written by L.M. Babcock and published by Elsevier. This book was released on 2001-12-21 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gas phase ion chemistry is a broad field that has many applications and which encompasses various branches of chemistry and physics. Advances in Gas Phase Ion Chemistry, Volume 4, describes innovative ways of studying reactions as well as the application of unique apparatuses to problems in this field. This volume contains a series of chapters, in the general area of gas phase chemistry and physics, which are at the cutting edge of research. The chapters are not meant to be general reviews, but focus on the author's own work. They focus on both experimental and theoretical work, which gives a balance to the volume. Applications are included to appeal to a wider audience and to broaden the knowledge of the more fundamentally inclined. An application to environmental pollution monitoring and medical monitoring of breath is included. With successive volumes, the coverage broadens to include more current research in the title area. The book is aimed at graduate researchers, university faculty and graduates in industry. The editors have made a specific effort to include contributions from those relatively new to the field, which brings in new ideas and perspectives, as well as those more established workers, who bring a wealth of experience.
Author : K.R. Jennings
Publisher : Springer Science & Business Media
ISBN 13 : 9401135185
Total Pages : 439 pages
Book Rating : 4.4/5 (11 download)
Download or read book Fundamentals of Gas Phase Ion Chemistry written by K.R. Jennings and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the proceedings of the 1990 Advanced Study Institute entitled "Fundamentals of Gas Phase Ion Chemistry" held at Mont Ste. Odile , Alsace, France, 25th June -6th July, 1990. The Institute brought together over 100 physicists, physical and organic chemists working on a wide variety of topics with gas-phase ion chemistry as the common theme. Many different viewpoints, making use of very different experimental and theoretical approaches, were brought to bear on the subject and provided a stimulating and up-to-date account of the subject. Although the Institute was built around the invited lectures, many specific points were addressed in workshops which consisted of informal discussion groups which were organised by participants during the Institute. This volume therefore contains not only chapters based on the lectures but summaries of many of the workshops which adds considerably to the diversity of information presented. This Advanced Study Institute was the fifth in a series of NATO-sponsored institutes devoted to various aspects of the physics and chemistry of gas phase ions. These meetings have been held every four years since the first, held in Biarritz in 1974, considered "Interactions between Ions and Molecules". The five volumes which comprise the proceedings of these meetings illustrate very clearly the many advances in theory and experiment which have taken place over the last 20 years.
Author : Frank Sobott
Publisher : Royal Society of Chemistry
ISBN 13 : 1839161663
Total Pages : 547 pages
Book Rating : 4.8/5 (391 download)
Download or read book Ion Mobility-Mass Spectrometry written by Frank Sobott and published by Royal Society of Chemistry. This book was released on 2021-11-26 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a comprehensive guide to the technique, each chapter is written by an internationally recognised expert and will help the end users understand the practicalities of using different instruments for different ion mobility purposes.
Author : Brian Herbert Clowers
Publisher :
ISBN 13 :
Total Pages : 348 pages
Book Rating : 4.:/5 (647 download)
Download or read book Separation of Gas Phase Isomers Using Ion Mobiliby and Mass Spectrometry written by Brian Herbert Clowers and published by . This book was released on 2005 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jeffrey P. Kiplinger
Publisher :
ISBN 13 :
Total Pages : 476 pages
Book Rating : 4.3/5 (9 download)
Download or read book Investigations of Ion-molecule Reactions in the Gas Phase by Ion Cyclotron Resonance Mass Spectrometry written by Jeffrey P. Kiplinger and published by . This book was released on 1984 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Elsevier
ISBN 13 : 0080550886
Total Pages : 281 pages
Book Rating : 4.0/5 (85 download)
Download or read book Advances in Gas Phase Ion Chemistry written by and published by Elsevier. This book was released on 1996-05-14 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Gas Phase Ion Chemistry
Author : Christoph A. Schalley
Publisher : John Wiley & Sons
ISBN 13 : 0470131152
Total Pages : 593 pages
Book Rating : 4.4/5 (71 download)
Download or read book Mass Spectrometry of Non-Covalent Complexes written by Christoph A. Schalley and published by John Wiley & Sons. This book was released on 2009-09-08 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Details the many benefits of applying mass spectrometry to supramolecular chemistry Except as a method for the most basic measurements, mass spectrometry (MS) has long been considered incompatible with supramolecular chemistry. Yet, with today's methods, the disconnect between these two fields is not warranted. Mass Spectrometry and Gas-Phase Chemistry of Non-Covalent Complexes provides a convincing look at how modern MS techniques offer supramolecular chemists a powerful investigatory toolset. Bringing the two fields together in an interdisciplinary manner, this reference details the many different topics associated with the study of non-covalent complexes in the gas phase. The text begins with brief introductions to supramolecular chemistry and such relevant mass spectrometric methods as ionization techniques, analyzers, and tandem MS experiments. The coverage continues with: How the analyte's transition into the gas phase changes covalent bonding How limitations and pitfalls in analytical methods may produce data misinterpretations Artificial supramolecular aggregates and their examination Biomolecules, their complexes, and their examination After the general remarks making up the first section of the book, the following sections describe specific experimental procedures and are illustrated with numerous examples and short tutorials. Detailed citations end each chapter. Mass spectrometrists, supramolecular chemists, students in these fields, and interested readers from other disciplines involving the study of non-covalent bonds will all value Mass Spectrometry and Gas-Phase Chemistry of Non-Covalent Complexes as an innovative and practical resource.
Author : Michael T. Bowers
Publisher : Academic Press
ISBN 13 : 1483216489
Total Pages : 369 pages
Book Rating : 4.4/5 (832 download)
Download or read book Gas Phase Ion Chemistry written by Michael T. Bowers and published by Academic Press. This book was released on 2013-10-22 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gas Phase Ion Chemistry, Volume 1 covers papers on the advances of gas phase ion chemistry. The book discusses the advances in flow tubes and the measurement of ion-molecule rate coefficients and product distributions; the ion chemistry of the earth's atmosphere; and the classical ion-molecule collision theory. The text also describes statistical methods in reaction dynamics; the state selection by photoion-photoelectron coincidence; and the effects of temperature and pressure in the kinetics of ion-molecule reactions. The energy distribution in the unimolecular decomposition of ions, as well as the rapidity of ion-molecule reactions are also encompassed. Chemists, physicists, and people working in aeronomy laboratory and involved in space research will find the book invaluable.
Author : Hongwen Chen
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (872 download)
Download or read book Investigations of Ionic and Neutral Species in the Gas Phase by Tandem Mass Spectrometry written by Hongwen Chen and published by . This book was released on 1992 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A major application of tandem mass spectrometry is the study of gas-phase ion chemistry. Gas-phase ion chemistry involving ion thermochemistry and ion dissociation characteristics, is one of the foundations of analytical chemistry.
Author : Samuel J. Allen
Publisher :
ISBN 13 :
Total Pages : 193 pages
Book Rating : 4.:/5 (988 download)
Download or read book Development of Ion Mobility Mass Spectrometry Instrumentation to Investigate the Gas-phase Structures of Protein and Protein Complex Ions written by Samuel J. Allen and published by . This book was released on 2017 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation reports the development of new ion mobility mass spectrometry (IM-MS) instrumentation to analyze protein and protein complex ions. IM-MS is a gas-phase analytical technique that separate ions based on their collision cross section (a description of ion shape) and mass-to-charge ratio. Electrospray ionization of samples from buffered solutions at biologically relevant pH generates “native-like” protein ions, which retain noncovalent interactions and compact conformations. IM-MS analysis enables the determination of the shape and assembly of native-like ions, which can be used to infer information about the solution conformations of biomolecules. New IM devices were developed to improve the informational content obtained from IM-MS experiments. First, an RF-confining drift cell was developed and implemented in a commercial mass spectrometer. Experimental results and ion trajectories implemented using SIMION were used to describe the separation principles of ions in RF-confining drift cells. Those results show that RF-confining drift cells separate ions similarly to traditional IM devices and that applied RF potentials have minimal effects on the effective temperatures of gas-phase ions. The RF-confining drift cells was used to report collision cross sections for 349 ions, 155 of which are for ions that have not been characterized previously using IM. The effects of ionization conditions and analyte solutions on the charge states and collision cross sections of ions was also investigated. An additional IM device based on Structures for Lossless Ion Manipulations (SLIM) was developed. SLIM is an emerging IM technology that can be implemented as modular platforms to perform ion separations, filtering, and trapping. The first collision cross sections determined using SLIM are reported. IM analysis of native-like protein ions shows that those ions exhibit significant structural heterogeneity in the gas-phase. To evaluate the stability and dynamics of native-like protein ions, IM-IM-MS functionality was implemented into the SLIM device. Dynamic gas-phase conformations were observed for native-like protein ions, which has significant implications for the broader community’s interpretation of IM-MS results. The stability of structural subpopulations of native-like ions was investigated as a function of gas-phase ion lifetime at near-ambient temperatures. The conformations of subpopulations evolve continuously in the gas-phase, but even after 4 seconds, the subpopulations exhibit different distributions of collision cross sections. This suggests that native-like ions in IM-MS experiments can retain some memory of their initial gas-phase structures for up to seconds at near-ambient temperature.
Author : Matthew Cooke Bernier
Publisher :
ISBN 13 :
Total Pages : 212 pages
Book Rating : 4.:/5 (93 download)
Download or read book Ionization, Dissociation, and the Investigation of Structure in Small Molecular Models to Develop a Broader Understanding of Gas Phase Ion Chemistry written by Matthew Cooke Bernier and published by . This book was released on 2014 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation focuses on molecular systems in the low-mass range to determine how chemical and structural changes can affect subsequent fragmentation chemistry and protonation site. Each system was investigated using MS analysis and gas-phase ion structural techniques selected from tandem MS (MSMS), hydrogen-deuterium exchange (HDX), ion-mobility (IM), and action infra-red multi-photon dissociation (IRMPD). In Chapter 3, the non-standard amino acid gamma-aminobutyric acid (GABA) was placed into a peptide system to test a mechanism which explained the lack of a3 ions in standard peptide fragmentations. GABA extends the peptide backbone by two methylene units and its insertion into the second position of larger peptides increases the intensity of a3 ion. Using MSMS, it was found that this was a result of blocking common favorable fragmentation pathways. The results demonstrated the use of modified peptides for revealing reasons for how peptides fragment. Chapter 4 focused on a unique set of non-canonical amino acids and their ability to affect the trans/cis nature of adjacent amide bonds in peptide sequences. In solution, 4-R-Flouroproline (R-Flp) is found to favor the trans peptide bond and 4-S-fluoroproline (S-flp) favors the cis bond. IRMPD and IM-MS were employed to investigate the fragment ions containing these two prolyl-ring substitutions as the structures of the b2 ions might indicate the prevalence of cis vs. trans peptide bond in the gas-phase. In experiments, the residues favoring trans vs. cis bonds, respectively, formed greater proportions of the trans/cis fragment ions, showing a correlation between solution and gas-phase structural trends of peptides.
Author : Lei Tao
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (747 download)
Download or read book Investigation on Gas-phase Structures of Biomolecules Using Ion Mobility-mass Spectrometry written by Lei Tao and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: IM-MS is a 2-D technique which provides separations based on ion shape (ionneutralcollision cross-section, [omega]) and mass (m/z ratio). Ion structures can be deducedfrom the measured collision cross-section ([omega]meas) by calculating the collision crosssections([omega]calc) of candidates generated by molecular dynamics (MD) and compared withthe experiment results. A database of [omega]s for singly-charged peptide ions is presented. Standard proteins are digested using different enzymes (trypsin, chymotrypsin and pepsin), resulting in peptides that differ in amino acid composition. The majority (63%) of the peptide ion correlates well with the globular structures, but some exhibit [omega]s that are significantly larger or smaller than the average correlation. Of the peptide ions having larger [omega]s, approximately 71% are derived from trypsin digestion, and most of the peptide ions that have smaller [omega]s are derived from pepsin digestion, and most of the peptide ions that have smaller [omega]s are deroved from pepson digestion (90%). We use computational simulations and clustering methods to assign backbone conformations for singly-protonated ions of the model peptide (NH2-Met-Ile-Phe-Ala- Gly-Ile-Lys-COOH) formed by both MALDI and ESI and compare the structures of MIFAGIK derivatives to test the 'sensitivity' of the cluster analysis method. Cluster analysis suggests that [MIFAGIK + H] ions formed by MALDI have a predominantly turn structure even though the low energy ions prefer partial helical conformers. Although the ions formed by ESI have [omega]s that are different from those formed by MALDI, the results of cluster analysis indicate that the ions backbone structures are similar. Chemical modifications (N-acetyl, methylester, as well as addition of Boc or Fmoc groups) of MIFAGIK, alter the distribution of various conformers. The most dramatic changes are observed for the [M + Na] ion, which show a strong preference for random coil conformers, owing to the strong solvation by the backbone amide groups. [Omega]meas of oligodeoxynucleotides in different length have been measured in both positive and negative modes. For a given molecular weight and charge state, [omega]meas of the oligodeoxynucleotide, ions are smaller than those of the peptides, indicating their different packing efficiency. A novel generalized non-Boltzman sampling MD has been utilized to investigate the gas-phase ion conformations of dGGATC based on the free energy values. Theory predicts only one low-energy conformer for the zwitterionic form of dGGATC− while dGGATC+ ions have several stable conformers in both canonical and zwitterionic form in the gas phase, in good agreement with the experiment.
