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Formulation And Characterization Of Biodegradable Polylactide Co Glycolide Microspheres Containing A Protein Immunogen And Polylactic Acid Microspheres Containing Hexamethylmelamine
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Book Synopsis Formulation and Characterization of Biodegradable Poly(lactide-co-glycolide) Microspheres Containing a Protein Immunogen and Poly(lactic Acid) Microspheres Containing Hexamethylmelamine by : Madhusudan Hariharan
Download or read book Formulation and Characterization of Biodegradable Poly(lactide-co-glycolide) Microspheres Containing a Protein Immunogen and Poly(lactic Acid) Microspheres Containing Hexamethylmelamine written by Madhusudan Hariharan and published by . This book was released on 1997 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fabrication and Characterization of Controlled Release of Proteins and Peptides from Poly Glu Lactide-co-glycolide (PLGA) Microspheres by : Md Rezaul Haque Ansary
Download or read book Fabrication and Characterization of Controlled Release of Proteins and Peptides from Poly Glu Lactide-co-glycolide (PLGA) Microspheres written by Md Rezaul Haque Ansary and published by . This book was released on 2016 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biodegradable poly(lactide-co-glycolide) (PLGA)-based microspheres and nanoparticles have received much attention over the last twenty-five years for controlled parenteral delivery of therapeutic protein and peptide drugs. In general, PLGA-based injectable delivery systems of macromolecular protein and peptide drugs still suffer from two major technical problems associated with their inherent stability problem. Initial burst release followed by very slow and incomplete release is one of the most serious problems in the formulation of PLGA-based protein drugs delivery system. In this study, two model proteins, bovine serum albumin (BSA) and lysozyme, and a therapeutic peptide drug, insulin loaded double-walled microspheres have been fabricated using a fast degrading glucose core, hydroxyl-terminated poly(lactide-co-glycolide) (Glu-PLGA) and a moderate degrading carboxyl-terminated PLGA polymers to reduce the high initial burst release and to eliminate the lag phase from the release profile of PLGA microspheres. Double-walled microspheres were prepared using a modified water-in-oil-in-oil-in-water (w1/o/o/w2) method. In addition, single-polymer microspheres were prepared by a conventional water-in-oil-in-water (w1/o/w2) emulsion solvent evaporation method for comparison. The microspheres size, morphology, encapsulation efficiency, thermal properties, in vitro drug release, and structural integrity of BSA, lysozyme and insulin were evaluated in this study. The bioactivity of released lysozyme was determined using Micrococcus lysodeikticus as substrate. Moreover, in vivo release and bioactivity of insulin was evaluated upon subcutaneous injection of insulin loaded microspheres in STZ induced diabetic rats. BSA, lysozyme and insulin loaded double-walled microspheres prepared with Glu-PLGA and PLGA polymers in a mass ratio of 1:1 showed reduced particle size (
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1997 with total page 830 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Smart Drug Delivery System by : Ali Demir Sezer
Download or read book Smart Drug Delivery System written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2016-02-10 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Book Synopsis Functional Chitosan by : Sougata Jana
Download or read book Functional Chitosan written by Sougata Jana and published by Springer Nature. This book was released on 2020-03-05 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thanks to their unique properties, chitosan and chitosan-based materials have numerous applications in the field of biomedicine, especially in drug delivery. This book examines biomedical applications of functional chitosan, exploring the various functions and applications in the development of chitosan-based biomaterials. It also describes the chemical structure of chitosan and discusses the relationship between their structure and functions, providing a theoretical basis for the design of biomaterials. Lastly, it reviews chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and gene delivery.
Book Synopsis Pediatric Gender Assignment by : Stephen A. Zderic
Download or read book Pediatric Gender Assignment written by Stephen A. Zderic and published by Springer Science & Business Media. This book was released on 2003-01-31 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the proceedings from a conference that took place in Dallas in the spring of 1999 which was entitled "Pediatric Gender Assignment - A Critical Reappraisal". Some participants rightfully argued that the conference really focused on the issue of pediatric gender assignment, and that reassignment was not applied in most cases. Their comments were reflected in the title of this monograph. This multidisciplinary meeting was sponsored by a conference grant from the National Institutes of Health, and a broad inquiry into this complex topic took place from many points of view. Basic scientists offered insight into mechanisms of sexual differentiation of the gonads, physical phenotype and imprinting of the central nervous system. Endocrinologists reviewed their experience in diagnosis and management, surgeons described traditional as well as innovative approaches, and there was strong representation from the ethical and behavioral sciences. In putting together such a panel, it was essential that we identify a cast of speakers who could address their viewpoints with strong convictions, and yet not let their passions render the meeting counter productive. We were not disappointed. While many differing points of view were firmly expressed by the panelists and audience, all viewpoints were accorded the respect they deserved. The concept behind the meeting and this book really originated in 1997 shortly after Diamond and Sigmundson published their long term follow up study of the John/Joan case.
Book Synopsis Drug Delivery Systems by : Vasant V. Ranade
Download or read book Drug Delivery Systems written by Vasant V. Ranade and published by CRC Press. This book was released on 2003-08-26 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug delivery technologies represent a vast and vital area of Research and Development. The demand for innovative drug delivery systems continues to grow, and this growth continues to drive new developments. Building on the foundation provided by the first edition, Drug Delivery Systems, Second Edition covers the latest developments in both
Book Synopsis Handbook of Anticancer Pharmacokinetics and Pharmacodynamics by : William Figg
Download or read book Handbook of Anticancer Pharmacokinetics and Pharmacodynamics written by William Figg and published by Humana Press. This book was released on 2004-03-26 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.
Book Synopsis Design and Development of New Nanocarriers by : Alexandru Mihai Grumezescu
Download or read book Design and Development of New Nanocarriers written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2017-11-30 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. - Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products - Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years - Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry
Book Synopsis Injectable Dispersed Systems by : Diane J. Burgess
Download or read book Injectable Dispersed Systems written by Diane J. Burgess and published by CRC Press. This book was released on 2019-08-30 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative guide will serve as the most current source on the design and manufacturing of parenteral dispersed systems-showcasing the utility of dispersed systems in drug delivery, drug targeting, and pharmaceutical engineering.
Book Synopsis Apoptosis and Cancer Chemotherapy by : John A. Hickman
Download or read book Apoptosis and Cancer Chemotherapy written by John A. Hickman and published by Springer Science & Business Media. This book was released on 1999-04-08 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past few years have witnessed an astonishing international effort that established the role of some 20 new molecules in apoptosis and added activation or suppression of apoptosis to the accepted biological functions of a great many others already familiar in cancer biology. Some of these molecules are receptors, transducing cytokine-mediated signals; others appear to intensify or diminish the risk that a compro mised cell will fire its apoptosis effector mechanism. All are of interest as potential targets for tumor therapy, and some may prove to be control points influenced in the pathogenesis of cancer and other diseases as diverse as viral infection, neurodegenerative disorders, and stroke. Sometimes, in the midst of these developments, a kind of euphoria ap pears to have gripped the research community, with the expectation that apoptosis will afford explanations to many unsolved questions in cellu lar regulation. This book, in a series of thoughtful and provocative ar ticles--some from established leaders in the field, and others from younger scientists--seeks to redress the balance.
Book Synopsis Drug Delivery Systems in Cancer Therapy by : Dennis M. Brown
Download or read book Drug Delivery Systems in Cancer Therapy written by Dennis M. Brown and published by Springer Science & Business Media. This book was released on 2003-09-08 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.
Download or read book Nanomedicines written by Martin Braddock and published by Royal Society of Chemistry. This book was released on 2016-04-28 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will provide an overview of the chemistry of nanocarrier design and the considerations that need to be made when developing a nanomedicine.
Book Synopsis Handbook of Cancer Vaccines by : Michael A. Morse
Download or read book Handbook of Cancer Vaccines written by Michael A. Morse and published by Springer Science & Business Media. This book was released on 2004-01-28 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.
Book Synopsis Alphaherpesviruses by : Sandra Knowles Weller
Download or read book Alphaherpesviruses written by Sandra Knowles Weller and published by Caister Academic Press Limited. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.
Book Synopsis Cell Cycle Inhibitors in Cancer Therapy by : Antonio Giordano
Download or read book Cell Cycle Inhibitors in Cancer Therapy written by Antonio Giordano and published by Springer Science & Business Media. This book was released on 2003 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.
Book Synopsis Signaling Networks and Cell Cycle Control by : J. Silvio Gutkind
Download or read book Signaling Networks and Cell Cycle Control written by J. Silvio Gutkind and published by Springer Science & Business Media. This book was released on 2000-04-14 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent dramatic expansion of our knowledge about how cell surface receptors transmit signals to the nucleus, together with the identification of key signaling and cell-cycle-regulating molecules, has provided a major opportunity to search for novel targets for therapeutic intervention in many diseases. In Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases, leading scientists summarize this knowledge and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Rich in cutting-edge insights and authoritative critical analysis, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.
