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Exposure Response Modeling
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Book Synopsis Exposure-Response Modeling by : Jixian Wang
Download or read book Exposure-Response Modeling written by Jixian Wang and published by CRC Press. This book was released on 2015-07-17 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover the Latest Statistical Approaches for Modeling Exposure-Response RelationshipsWritten by an applied statistician with extensive practical experience in drug development, Exposure-Response Modeling: Methods and Practical Implementation explores a wide range of topics in exposure-response modeling, from traditional pharmacokinetic-pharmacody
Book Synopsis The Prevention and Treatment of Missing Data in Clinical Trials by : National Research Council
Download or read book The Prevention and Treatment of Missing Data in Clinical Trials written by National Research Council and published by National Academies Press. This book was released on 2010-12-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Book Synopsis Assessment of Exposure-Response Functions for Rocket-Emission Toxicants by : National Research Council
Download or read book Assessment of Exposure-Response Functions for Rocket-Emission Toxicants written by National Research Council and published by National Academies Press. This book was released on 1998-07-24 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The U.S. Air Force is developing a model to assist commanders in determining when it is safe to launch rocket vehicles. The model estimates the possible number and types of adverse health effects for people who might be exposed to the ground cloud created by rocket exhaust during a normal launch or during an aborted launch that results in a rocket being destroyed near the ground. Assessment of Exposure-Response Functions for Rocket-Emmission Toxicants evaluates the model and the data used for three rocket emission toxicants: hydrogen chloride, nitrogen dioxide, and nitric acid.
Book Synopsis A Framework to Guide Selection of Chemical Alternatives by : National Research Council
Download or read book A Framework to Guide Selection of Chemical Alternatives written by National Research Council and published by National Academies Press. This book was released on 2014-10-29 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Historically, regulations governing chemical use have often focused on widely used chemicals and acute human health effects of exposure to them, as well as their potential to cause cancer and other adverse health effects. As scientific knowledge has expanded there has been an increased awareness of the mechanisms through which chemicals may exert harmful effects on human health, as well as their effects on other species and ecosystems. Identification of high-priority chemicals and other chemicals of concern has prompted a growing number of state and local governments, as well as major companies, to take steps beyond existing hazardous chemical federal legislation. Interest in approaches and policies that ensure that any new substances substituted for chemicals of concern are assessed as carefully and thoroughly as possible has also burgeoned. The overarching goal of these approaches is to avoid regrettable substitutions, which occur when a toxic chemical is replaced by another chemical that later proved unsuitable because of persistence, bioaccumulation, toxicity, or other concerns. Chemical alternative assessments are tools designed to facilitate consideration of these factors to assist stakeholders in identifying chemicals that may have the greatest likelihood of harm to human and ecological health, and to provide guidance on how the industry may develop and adopt safer alternatives. A Framework to Guide Selection of Chemical Alternatives develops and demonstrates a decision framework for evaluating potentially safer substitute chemicals as primarily determined by human health and ecological risks. This new framework is informed by previous efforts by regulatory agencies, academic institutions, and others to develop alternative assessment frameworks that could be operationalized. In addition to hazard assessments, the framework incorporates steps for life-cycle thinking - which considers possible impacts of a chemical at all stages including production, use, and disposal - as well as steps for performance and economic assessments. The report also highlights how modern information sources such as computational modeling can supplement traditional toxicology data in the assessment process. This new framework allows the evaluation of the full range of benefits and shortcomings of substitutes, and examination of tradeoffs between these risks and factors such as product functionality, product efficacy, process safety, and resource use. Through case studies, this report demonstrates how different users in contrasting decision contexts with diverse priorities can apply the framework. This report will be an essential resource to the chemical industry, environmentalists, ecologists, and state and local governments.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author :Agency for Health Care Research and Quality (U.S.) Publisher :Government Printing Office ISBN 13 :1587634236 Total Pages :204 pages Book Rating :4.5/5 (876 download)
Book Synopsis Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide by : Agency for Health Care Research and Quality (U.S.)
Download or read book Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Book Synopsis Handbook of Exposure Therapies by : David C.S. Richard
Download or read book Handbook of Exposure Therapies written by David C.S. Richard and published by Elsevier. This book was released on 2011-10-11 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exposure Therapy refers to any clinical intervention in which a client directly confronts a source of fear. Since high levels of anxiety can not be maintained indefinitely, repeated exposure leads to decreased anxiety. This type of treatment is effective with phobias, post traumatic stress disorder, obsessive compulsive disorders, panic, generalized anxiety, and several other disorders. It's also been found to be effective in helping to treat substance abuse. Although exposure-based treatments have been extensively researched and reported in the literature, there is no single comprehensive treatment of exposure therapies. Writings tend to be limited to larger pieces on treating specific disorders or types of patients. A comprehensive book on the use of these treatments across patient disorders will be of great use to practitioners. The book is divided into three sections: Foundation, Applications, and Issues. Foundation chapters considers theoretical and assessment issues. Applications chapters will discuss research literature on each disorder having been proven to be successfully treated with exposure therapy. Issue chapters will discuss liability issues, false memory syndrome, and the use of computers and virtual reality in exposure therapy. *Covers the broad range of exposure therapies in one comprehensive source *Provides an integrated look at exposure therapy across a variety of disorders *Each such chapter will include a case study *Blends literature review and practice guidelines
Book Synopsis Physiologically Based Pharmacokinetic (PBPK) Modeling by : Jeffrey W. Fisher
Download or read book Physiologically Based Pharmacokinetic (PBPK) Modeling written by Jeffrey W. Fisher and published by Academic Press. This book was released on 2020-05-20 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more. Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research Authored by expert editors and contributors who are among the best PBPK modelers in the world
Book Synopsis Mathematical Models for Estimating Occupational Exposure to Chemicals by : Wil F. Ten Berge
Download or read book Mathematical Models for Estimating Occupational Exposure to Chemicals written by Wil F. Ten Berge and published by AIHA. This book was released on 2000 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses mathematical exposure models which may assist industrial hygienists in determining acceptable exposure limits in the workplace.
Book Synopsis Estimating the Public Health Benefits of Proposed Air Pollution Regulations by : National Research Council
Download or read book Estimating the Public Health Benefits of Proposed Air Pollution Regulations written by National Research Council and published by National Academies Press. This book was released on 2002-10-30 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: EPA estimates that thousands of premature deaths and cases of illnesses may be avoided by reducing air pollution. At the request of Congress, this report reviews the scientific basis of EPA's methods used in estimating the public health benefits from its air pollution regulations.
Author :Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation Publisher :National Academies Press ISBN 13 :0309133343 Total Pages :422 pages Book Rating :4.3/5 (91 download)
Book Synopsis Health Risks from Exposure to Low Levels of Ionizing Radiation by : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation
Download or read book Health Risks from Exposure to Low Levels of Ionizing Radiation written by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation and published by National Academies Press. This book was released on 2006-03-23 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.
Book Synopsis Atkinson's Principles of Clinical Pharmacology by : Shiew-Mei Huang
Download or read book Atkinson's Principles of Clinical Pharmacology written by Shiew-Mei Huang and published by Academic Press. This book was released on 2021-10-16 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. Presents the essential knowledge for effective practice of clinical pharmacology Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology Offers an extensive regulatory section that addresses US and international issues and guidelines Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK
Book Synopsis Chemical Mixtures and Combined Chemical and Nonchemical Stressors by : Cynthia V. Rider
Download or read book Chemical Mixtures and Combined Chemical and Nonchemical Stressors written by Cynthia V. Rider and published by Springer. This book was released on 2018-02-16 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures. This book will provide an introduction to key issues and multiple options for evaluating both the toxicity of mixtures as well as the risk associated with exposure to mixtures. Additionally, promising tools adapted from other disciplines will be discussed in the context of mixtures toxicology and risk assessment. Finally, the discussion will move beyond chemical mixtures to address incorporating non-chemical stressors into toxicity studies and cumulative risk assessments. Although exposure to multiple chemical and non-chemical stressors is the rule, not the exception, consideration of mixtures in toxicology and risk assessment continues to be a significant challenge. This book will be an essential resource for researchers and professionals in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics.
Book Synopsis Crystalline Silica, Quartz by : F. Rice
Download or read book Crystalline Silica, Quartz written by F. Rice and published by . This book was released on 2000 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise assessment of the adverse effects on human health caused by exposure to quartz the most common form of crystalline silica. Quartz is a frequently occurring solid component of most natural mineral dusts. Human exposure occurs most often during occupational activities involving movement of earth disturbance of silica-containing products such as masonry and concrete or use or manufacture of silica-containing products. As respirable quartz dust particles can be inhaled and deposited in the lung the report gives particular attention to evidence of an increased risk of lung cancer in occupationally exposed workers. Most studies in laboratory animals have concentrated on adverse effects associated with long-term inhalation of particles. Effects observed include cellular proliferation nodule formation suppressed immune function and alveolar proteinosis. While exposure clearly induces pulmonary tumours in one species other species show less or no malignant tumour response. The evaluation of risks to human health draws on a large number of epidemiological studies of workers exposed to respirable quartz dust. Occupational exposure has been linked to an increased incidence of silicosis ung cancer and pulmonary tuberculosis. Studies have also documented statistically significant increases in cases of bronchitis emphysema chronic obstructive pulmonary disease autoimmune-related diseases including scleroderma rheumatoid arthritis and systemic lupus erythematosus and renal disease. In reviewing these findings the report underscores several uncertainties inherent to the study of respiratory diseases in occupational populations that complicate the assessment of risks associated with exposure to quartz dust. The need for improved methods of exposure assessment and data analysis is stressed.
Book Synopsis Health Effects of Exposure to Low Levels of Ionizing Radiations by : National Research Council
Download or read book Health Effects of Exposure to Low Levels of Ionizing Radiations written by National Research Council and published by National Academies Press. This book was released on 1998-09-04 with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt: The US Environmental Protection Agency Office of Radiation and Indoor Air asked the National Research Council to evaluate whether sufficient new data exist to warrant a reassessment of health risks reported in Health Effects of Exposure to Low Levels of Ionizing Radiations (BEIR V) in 1990. To respond to this request, the National Research Council assembled the Committee on Health Risks of Exposure to Low Levels of Ionizing Radiations. The work of the committee was conducted in what was called the BEIR VII phase-1 study. To assist the committee during its deliberations, various scientists were consulted for advice, and a workshop on the impact of biology on risk assessment was held in collaboration with the Department of Energy Office of Health and Environmental Research. The intent of the workshop was to address the implications of new understanding of the biologic basis of radiation injury and carcinogenesis for risk assessment.
Book Synopsis The Clinician's Guide to Exposure Therapies for Anxiety Spectrum Disorders by : Timothy A. Sisemore
Download or read book The Clinician's Guide to Exposure Therapies for Anxiety Spectrum Disorders written by Timothy A. Sisemore and published by New Harbinger Publications. This book was released on 2012-12-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a mental health professional, it can be difficult to help anxious clients face their fears and anxieties. Exposure therapy is widely appreciated as one of the most effective therapeutic treatments for anxiety spectrum disorders; however, it is often underutilized due to problems that present themselves during treatment, such as client unwillingness or hesitancy, or a lack of understanding on the professional’s part regarding targeted applications. The Clinician's Guide to Exposure Therapies for Anxiety Spectrum Disorders offers guidance in creating specific exposure exercises for clients’ individual fears and phobias, as well as tools to help you and your clients overcome common roadblocks that arise during exposure therapy. In addition, this clinician’s guide presents detailed solutions and specific exposure strategies for the most common fears and phobias clients experience. You will learn to implement exposure therapy and integrate it with other evidence-based practices, such as cognitive behavioral therapy (CBT), dialectical behavior therapy (DBT), and acceptance and commitment therapy (ACT). The book also includes reproducible worksheets you can use to help clients develop hierarchies of exposure and information about using prolonged exposure therapy for post-traumatic stress disorder. If you are looking for a powerful resource for treating anxiety disorders, this is it.
Book Synopsis Stress and Trauma by : Patricia A. Resick
Download or read book Stress and Trauma written by Patricia A. Resick and published by Psychology Press. This book was released on 2014-01-02 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress and Trauma provides a well-written, accessible overview of traumatic stress studies. It reviews the full range of clinical disorders that may result from extreme stress, with particular emphasis on the most common disorder - post-traumatic stress disorder (PTSD). The book reviews research on the prevalence of trauma and the prevalence of relevant disorders following trauma. It goes on to look at psychological theories of stress and trauma, the biology of stress and trauma reactions, and the factors prior to, during and after traumatic events that place people at particular risk for the development of psychological problems. The book goes on to look at treatment of trauma-related psychological problems, and covers the use of medication and a range of psychological treatments. Different types of therapy are described and research findings on these approaches are reviewed. Stress and Trauma will provide a valuable overview of the area for advanced undergraduates, early post-graduate training, and mental health professionals seeking an update of recent developments.
