Estudio de la evolución clínica de la hipertensión y desarrollo de albuminuria mediante estrategias ómicas

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (12 download)

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Book Synopsis Estudio de la evolución clínica de la hipertensión y desarrollo de albuminuria mediante estrategias ómicas by : Laura González Calero

Download or read book Estudio de la evolución clínica de la hipertensión y desarrollo de albuminuria mediante estrategias ómicas written by Laura González Calero and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: La hipertensión arterial (HTA) es causa fundamental de enfermedad (riesgo) cardiovascular (CV) y renal. El sistema renina-angiotensina (SRA), es un sistema vasoconstrictor esencial que en condiciones patológicas participa en la producción de daño orgánico, y en su inhibición se centra la terapia más comúnmente empleada en el tratamiento de los pacientes hipertensos. Sin embargo, se ha observado que tanto la enfermedad CV como la renal progresan en un número no despreciable de individuos, a pesar de estar bajo supresión crónica de SRA. En los pacientes con hipertensión esencial y función renal normal, el aumento de la excreción urinaria de albúmina (albuminuria) se considera marcador de progresión de la enfermedad cardiovascular y de empeoramiento de la función renal, independientemente de la coexistencia de diabetes. La albuminuria es, parcialmente, una consecuencia de la presión arterial (PA) alta. Además, otros factores tales como la inflamación sistémica y la disfunción endotelial también participan en su aparición, así como en la disminución progresiva de la tasa de filtración glomerular (del inglés, “estimated glomerular filtration rate” eGFR). Actualmente, no es posible predecir qué individuos con valores dentro del rango de normalidad (normoalbuminuria), progresarán negativamente desarrollando albuminuria. Igualmente, se desconocen los mecanismos que subyacen a ese desarrollo. En esta tesis hemos planteado un estudio de carácter traslacional empleando varios abordajes ómicos (2D-DIGE, iTRAQ, RMN y SRM-LC-MS/MS) en orina y exosomas de orina de pacientes hipertensos con supresión crónica de SRA con el primer objetivo de identificar perfiles moleculares (proteínas y metabolitos) asociados al desarrollo de albuminuria. En un estudio prospectivo, identificamos potenciales dianas (proteínas y metabolitos) predictoras, es decir, capaces de predecir qué pacientes normoalbuminúricos progresarán y cuáles no...

Nutrigenetics

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Publisher : MDPI
ISBN 13 : 3038429953
Total Pages : 231 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Nutrigenetics by : Dolores Corella

Download or read book Nutrigenetics written by Dolores Corella and published by MDPI. This book was released on 2018-07-10 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Nutrigenetics" that was published in Nutrients

Nutrition and Aging

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805573219
Total Pages : 266 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Nutrition and Aging by : Irwin H. Rosenberg

Download or read book Nutrition and Aging written by Irwin H. Rosenberg and published by Karger Medical and Scientific Publishers. This book was released on 2002 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humanity is aging. In the last century, life expectancy has increased by as much as 25 years, the greatest increase in 5'000 years of history. As a consequence the elderly constitute today the fastest growing segment of the world's population. This new situation creates many social problems and challenges to health care which both the developed as well as the developing countries will have to cope with. The present publication shows that scientific progress has reached a level where nutritional interventions may play a decisive part in the prevention of degenerative conditions of age, improvement of quality of life and impact on health care burden and resources. Topics deal with such different aspects as the influence of prenatal and early infant nutrition on the future aged individual and effects of energetic restriction on longevity. Further contributions include studies on mitochondrial alterations, digestive problems, specific metabolic deviations mediated by insulin, bone degradation, structural changes, neuromuscular dysfunctions, mental state of the elderly as well as the response of the immune system to nutrient intake. Finally the book offers a review of requirements appropriate to meet the age-related public health challenges of the 21st century.

Krause's Food & the Nutrition Care Process

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Publisher : Elsevier Health Sciences
ISBN 13 : 1437722334
Total Pages : 1255 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Krause's Food & the Nutrition Care Process by : L. Kathleen Mahan

Download or read book Krause's Food & the Nutrition Care Process written by L. Kathleen Mahan and published by Elsevier Health Sciences. This book was released on 2012-01-01 with total page 1255 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most respected nutrition text for more than 50 years, Krause's Food & the Nutrition Care Process delivers comprehensive and up-to-date information from respected educators and practitioners in the field. The latest recommendations of the Dietary Guidelines for Americans 2010, new and expanded chapters, and a large variety of tables, boxes, and pathophysiology algorithms provide need-to-know information with ease, making this text perfect for use in class or everyday practice. Clear, logical organization details each step of complete nutritional care from assessment to therapy. UNIQUE! Pathophysiology algorithms clarify the illness process and to ensure more effective care. New Directions boxes reflect the latest research in emerging areas in nutrition therapy. Focus On boxes provide additional detail on key chapter concepts. Clinical Insight boxes and Clinical Scenarios with detailed Sample Nutrition Diagnosis statements help ensure the most accurate and effective interventions in practice. Key terms listed at the beginning of each chapter and bolded within the text provide quick access to important nutrition terminology. More than 1,000 self-assessment questions on a companion Evolve website reinforce key textbook content. Reorganized table of contents reinforces the Nutrition Care Process structure endorsed by the American Dietetic Association (ADA). New recommendations reflect a comprehensive approach to diet and nutrition that incorporates the Dietary Guidelines for Americans 2010, the MyPyramid food guide, and the Eating Well with Canada's Food Guide recommendations. MNT for Thyroid Disorders chapter details important nutrition considerations for managing thyroid disorders. New calcium and vitamin D Dietary Recommended Intakes (DRIs) improve monitoring of nutrient intake. Expanded Nutrition in Aging chapter includes assessment and nutritional care guidelines for the growing elderly patient population. Growth grids for children detail proper patient nutrition during infancy and early childhood. Extensively revised MNT for Food Allergies chapter highlights the importance of food allergy management in clinical nutrition therapy. Updated appendices enhance assessment accuracy with the latest laboratory findings and normal values.

Proteomic Methods in Neuropsychiatric Research

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Publisher : Springer
ISBN 13 : 9783319524788
Total Pages : 0 pages
Book Rating : 4.5/5 (247 download)

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Book Synopsis Proteomic Methods in Neuropsychiatric Research by : Paul C. Guest

Download or read book Proteomic Methods in Neuropsychiatric Research written by Paul C. Guest and published by Springer. This book was released on 2017-04-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies. This book describes the step-by-step use of proteomic methods such as two-dimensional gel electrophoresis, multiplex immunoassay, liquid chromatography mass spectrometry (LC-MS) and selective reaction monitoring MS, to increase our understanding of these diseases, with the ultimate aim of improving patient care. The volume will be of high interest to clinical scientists, physicians and pharmaceutical company scientists as it gives insights into the latest technologies enabling the revolution of personalized medicine. It is of direct interest to both technical and bench biomarker scientists as it gives step by step instructions on how to carry out each of the protocols. It is also of interest to researchers as each technique will be presented in the context of a specific neurological disorder, including Alzheimer's disease, multiple sclerosis, autism spectrum disorders, schizophrenia, major depressive disorder and bipolar disorder. Finally, it will also highlight the future research efforts in this field, which are endeavoring to convert proteomic platforms to the form of hand held devices which can be used in a point of care setting and return diagnostic results within the timeframe of a visit to the general practitioner.

Nutrition and Mental Health

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Publisher : CRC Press
ISBN 13 : 1439863369
Total Pages : 313 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Nutrition and Mental Health by : Ruth Leyse-Wallace

Download or read book Nutrition and Mental Health written by Ruth Leyse-Wallace and published by CRC Press. This book was released on 2013-01-29 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although primary advanced vitamin and mineral deficiencies are rare in the developed world, many common health conditions deplete nutritional status, including sub-optimal dietary intake, frequent alcohol consumption, changes in appetite due to aging, food allergies or sensitivities, special diets, and eating disorders. Covering topics as diverse a

Encyclopedia of Signaling Molecules

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Publisher : Springer
ISBN 13 : 9781493968008
Total Pages : 6330 pages
Book Rating : 4.9/5 (68 download)

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Book Synopsis Encyclopedia of Signaling Molecules by : Sangdun Choi

Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.

Cellular Diagnostics

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805585551
Total Pages : 764 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Cellular Diagnostics by : Ulrich Sack

Download or read book Cellular Diagnostics written by Ulrich Sack and published by Karger Medical and Scientific Publishers. This book was released on 2009-01-01 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the updated English version of the 2006 German bestseller Zellulare Diagnostik, a comprehensive presentation of flow cytometry and its applications. While some techniques of immunophenotyping by flow cytometry already are routine procedures in the laboratory, new methods for the functional characterization of cells, the analysis of rare cells, and the diagnosis of complex materials have only begun to win wide recognition. New approaches such as slide-based cytometry will lead to an increase in the use of cytometric techniques. Multiparameter approaches will further improve analysis. The book provides a comprehensive and detailed compilation of all aspects of flow cytometry in research and the clinic. For newcomers it offers a thorough introduction, for advanced users, specific protocols and interpretation assistance.

Children with Special Health Care Needs

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Publisher : American Dietetic Associati
ISBN 13 : 0880913460
Total Pages : 185 pages
Book Rating : 4.8/5 (89 download)

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Book Synopsis Children with Special Health Care Needs by : Betty L. Lucas

Download or read book Children with Special Health Care Needs written by Betty L. Lucas and published by American Dietetic Associati. This book was released on 2004 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Legally Lean

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Publisher : Mag, Incorporated
ISBN 13 : 9780983583196
Total Pages : 252 pages
Book Rating : 4.5/5 (831 download)

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Book Synopsis Legally Lean by : Rd Lisa Dorfman MS

Download or read book Legally Lean written by Rd Lisa Dorfman MS and published by Mag, Incorporated. This book was released on 2014-12-01 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sports Nutrition Strategies for Optimal Health and Performance.

Cell Cycle Control

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Publisher : IRL Press
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cell Cycle Control by : Christopher Hutchison

Download or read book Cell Cycle Control written by Christopher Hutchison and published by IRL Press. This book was released on 1995 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of developing technologies has revealed the extraordinary degree to which cell cycle control mechanisms have been conserved through eukaryotic evolution. This monograph relates the current scientific understanding of cell cycle control.

Pediatric Nutrition

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Publisher :
ISBN 13 : 9781581108163
Total Pages : 0 pages
Book Rating : 4.1/5 (81 download)

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Book Synopsis Pediatric Nutrition by : American Academy of Pediatrics. Committee on Nutrition

Download or read book Pediatric Nutrition written by American Academy of Pediatrics. Committee on Nutrition and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proper childhood nutrition can be the bedrock of lifelong health. This AAP manual makes clear policies and procedures for the best nutrition for well children as well as those with metabolic abnormalities and serious illnesses.