Eicosanoids Apolipoproteins Lipoprotein Particles And Atherosclerosis

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Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis

Author : Claude L. Malmendier
Publisher : Springer Science & Business Media
ISBN 13 : 1461307333
Total Pages : 345 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis by : Claude L. Malmendier

Download or read book Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis written by Claude L. Malmendier and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasma lipoproteins constitute a unique macromolecular system of lipid-protein complexes responsible for the transport of lipids from their sites of origin to their sites of utilization either as metabolic fuel or as structural components of cell membranes. Although studies on the role of lipoproteins in the mechanism of lipid transport are meritorious in their own right, the ever-increasing interest in chemical and functional properties of this remarkable class of conjugated proteins stems from the impressive evidence of their direct involvement in the genesis and develop ment of atherosclerotic lesions. The initial emphasis on neutral lipids and phospholipids as the most characteristic constituents of operationally defined lipoprotein classes has shifted in recent years to their protein moieties or apolipoproteins. The discovery of a number of apolipoproteins and characterization of familial hypolipoproteinemias as apolipoprotein deficiency disorders indicated that apolipoproteins play an essential role in maintaining the structural stability and integrity of lipoprotein particles. In addition to their role in the formation of lipoproteins, apolipoproteins were shown to perform a variety of functions in metabolic conversion of lipoproteins and their interactions with cellular surfaces. Results from several laboratories have demonstrated that the chemical and metabolic heterogeneity of operationally-defined lipoprotein classes is due to the presence of several discrete lipoprotein particles with similar physical properties but different and characteristic apolipoprotein composition. Thus, the apolipoproteins have emerged not only as essential structural and functional constituents of lipoproteins but also as unique chemical markers for identifying and classifying lipoprotein particles.

Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis

Author : Claude L. Malmendier
Publisher : Springer
ISBN 13 : 9781461280552
Total Pages : 362 pages
Book Rating : 4.2/5 (85 download)

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Book Synopsis Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis by : Claude L. Malmendier

Download or read book Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis written by Claude L. Malmendier and published by Springer. This book was released on 2011-10-18 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasma lipoproteins constitute a unique macromolecular system of lipid-protein complexes responsible for the transport of lipids from their sites of origin to their sites of utilization either as metabolic fuel or as structural components of cell membranes. Although studies on the role of lipoproteins in the mechanism of lipid transport are meritorious in their own right, the ever-increasing interest in chemical and functional properties of this remarkable class of conjugated proteins stems from the impressive evidence of their direct involvement in the genesis and develop ment of atherosclerotic lesions. The initial emphasis on neutral lipids and phospholipids as the most characteristic constituents of operationally defined lipoprotein classes has shifted in recent years to their protein moieties or apolipoproteins. The discovery of a number of apolipoproteins and characterization of familial hypolipoproteinemias as apolipoprotein deficiency disorders indicated that apolipoproteins play an essential role in maintaining the structural stability and integrity of lipoprotein particles. In addition to their role in the formation of lipoproteins, apolipoproteins were shown to perform a variety of functions in metabolic conversion of lipoproteins and their interactions with cellular surfaces. Results from several laboratories have demonstrated that the chemical and metabolic heterogeneity of operationally-defined lipoprotein classes is due to the presence of several discrete lipoprotein particles with similar physical properties but different and characteristic apolipoprotein composition. Thus, the apolipoproteins have emerged not only as essential structural and functional constituents of lipoproteins but also as unique chemical markers for identifying and classifying lipoprotein particles.

Lipoproteins and Atherosclerosis

Author : Claude L. Malmendier
Publisher : Springer Science & Business Media
ISBN 13 : 146841268X
Total Pages : 248 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Lipoproteins and Atherosclerosis by : Claude L. Malmendier

Download or read book Lipoproteins and Atherosclerosis written by Claude L. Malmendier and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atherosclerosis which accounts in Western Europe for more than 40 % of deaths, is a generalized disease that develops slowly and is symptomless until lesions have become sufficiently severe to cause myocardial or cerebral infarction. Research on specific and precocious markers of atherosclerosis and the development of non invasive techniques for their early detection represent major challenges in biomedical field. We hope that this volume of edited papers, a consequence of the third international colloquium on atherosclerosis, conducted at the University of Brussels, Belgium through the support of the "Fondation de Recherche sur l' AtherosclE,rose" will contribute to this goal. Among the topics discussed the major ones were the mechanism of action of lipolytic enzymes, the deficiency or dysregulation of cellular receptors, the genetic deficiencies of apolipoproteins, and the panoply of external factors as diet, physical exercise, drugs, which mOdify the lipoprotein metabolism. Special interest was also devoted to potent techniques as kinetic analysis of metabolic tracers and use of monoclonal antibodies. Their contribution to the detection and treatment of atherosclerosis will be obviously essential in the future.

Lipoprotein (a)

Author : Angelo Scanu
Publisher : Elsevier
ISBN 13 : 0323159443
Total Pages : 240 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Lipoprotein (a) by : Angelo Scanu

Download or read book Lipoprotein (a) written by Angelo Scanu and published by Elsevier. This book was released on 2012-12-02 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipoprotein(a) presents the proceedings of the International Symposium, held in Chicago, Illinois, on December 2–3, 1988. It discusses the different aspects of the research on lipoprotein(a), commonly referred to as Lp(a). It covers a wide range of topics, including comparative biology, metabolism, structure, epidemiology, and treatment. Comprised of 15 chapters, the book starts with an overview of the role of Lp(a) in atherosclerotic cardiovascular disease (ASCVD), followed by a discussion on recent findings and developments. It then considers the relationship between elevated plasma Lp(a) and the inherited risk factor for the development of coronary heart disease. The reader is also introduced to the various components of Lp(a), which include neutral lipids, polar lipids, apoprotein(a), and apoprotein B. Other chapters discuss the specific functions of apolipoproteins in plasma lipid metabolism, which determine the fate of the various lipoprotein particles in plasma. This book will be of benefit to cardiologists and medical practitioners.

Lipoprotein Subfractions Omega-3 Fatty Acids

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Author : H.U. Klör
Publisher : Springer Science & Business Media
ISBN 13 : 3642834477
Total Pages : 211 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Lipoprotein Subfractions Omega-3 Fatty Acids by : H.U. Klör

Download or read book Lipoprotein Subfractions Omega-3 Fatty Acids written by H.U. Klör and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: On November 6 and 7, 1987, lipid and lipoprotein researchers from all over Europe convened in Munich on the occasion of the second European Workshop on Lipid Metabolism (EWLM). This informal gathering was devoted to two main topics, and recent research results were presented and discussed during a poster session. Recent developments in the physiology and pathophysiology of lipoprotein sub fractions were discussed on the first day of the meeting. In recent years, new analytical tools have been created for analyzing lipoprotein subfractions, particularly the apolipoprotein component. With the, introduction of immunological and elec trophoretic methods it has become clear that the heterogeneity of the plasma lipopro tein system is even greater than had been assumed only a decade or so ago. Despite this, it is apparent from the contributions to this volume that new methods for differentiating lipoprotein subfractions will increase our understanding of lipoprotein metabolism, especially of the triglyceride-rich lipoprotein particles and the high density lipoproteins. The complex functions of the various plasma apolipoproteins and their association with the lipoprotein lipid in single or complex lipoprotein particles give rise to a complex and dynamic metabolic system that changes constantly during the day. While it has for some time been possible to delineate fairly accurately the atherogenic potential of low-density lipoproteins, which are comparatively simple lipoprotein particles, the new methods of lipoprotein subfraction analysis will be needed to select and differentiate amongst the potentially atherogenic triglyceride rich particles, especially the chylomicron and very low density lipoprotein remnants.

Apolipoproteins in Lipid Disorders

Author : Maryvonne Rosseneu
Publisher : Springer Science & Business Media
ISBN 13 : 3709191483
Total Pages : 107 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Apolipoproteins in Lipid Disorders by : Maryvonne Rosseneu

Download or read book Apolipoproteins in Lipid Disorders written by Maryvonne Rosseneu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is increasing evidence for the clinicial value of the apo lipoprotein measurements. Besides cholesterol in plasma and li poprotein fractions, which is currently used as an indicator of cardiovascular risk, the measurement of the AI and B apolipopro teins can provide additional information about the patients' clinical status. Several studies show that apo B is higher and apo AI is lower in patients with angiographically documented coronary heart dis ease than in symptomatic patients without coronary heart disease. Moreover, discriminant analysis indicated that the concentration of Apo AI and B in plasma are better discriminators than lipo protein cholesterol for identifying patients with coronary heart disease. In some studies the apo Bjapo AI ratio appears to be a more powerful predictor than individual lipoproteins. In a recent study carried out in men, apolipoproteins AI and B were better correlated with the severity of cardiovascular disease than HDL and LDL cholesterol. The predictive power of apolipoproteins could however not be demonstrated in all studies and the value of apolipoprotein measurements in the field of clinical chemistry is still controversial. This is probably due to discrepancies between the results of various studies, arising from differences in the type of immunoassays, the lack of universal reference materials, differ ences between study protocols, variations in the selection of patients and in the grading and interpretation of coronary lesions.

Biochemistry of Lipids, Lipoproteins and Membranes

Author : Neale Ridgway
Publisher : Elsevier
ISBN 13 : 0444634495
Total Pages : 625 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Biochemistry of Lipids, Lipoproteins and Membranes by : Neale Ridgway

Download or read book Biochemistry of Lipids, Lipoproteins and Membranes written by Neale Ridgway and published by Elsevier. This book was released on 2015-07-24 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry References from current literature will be included in each chapter to facilitate more in-depth study Key concepts are supported by figures and models to improve reader understanding Chapters provide historical perspective and current analysis of each topic

Lipids and Cardiovascular Disease

Author :
Publisher :
ISBN 13 :
Total Pages : 226 pages
Book Rating : 4.:/5 (636 download)

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Book Synopsis Lipids and Cardiovascular Disease by :

Download or read book Lipids and Cardiovascular Disease written by and published by . This book was released on 1990 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Diet and Health

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309039940
Total Pages : 765 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Diet and Health by : National Research Council

Download or read book Diet and Health written by National Research Council and published by National Academies Press. This book was released on 1989-01-01 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

Triglyceride, High Density Lipoprotein, and Coronary Heart Disease

Author : Naomi Miller
Publisher :
ISBN 13 :
Total Pages : 96 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Triglyceride, High Density Lipoprotein, and Coronary Heart Disease by : Naomi Miller

Download or read book Triglyceride, High Density Lipoprotein, and Coronary Heart Disease written by Naomi Miller and published by . This book was released on 1992 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: This bibliography is organized into sections on background; relationship of high density lipoprotein, triglyceride, and coronary heart disease; genetics and genetic syndromes; secondary causes of high triglyceride and low high density lipoprotein; measurement of high density lipoprotein and triglyceride; evidence from clinical trials; approach to high triglyceride and low high density lipoprotein; and monographs.

Biochemistry of Lipids, Lipoproteins and Membranes

Author :
Publisher :
ISBN 13 : 9780444803030
Total Pages : 596 pages
Book Rating : 4.8/5 (3 download)

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Book Synopsis Biochemistry of Lipids, Lipoproteins and Membranes by :

Download or read book Biochemistry of Lipids, Lipoproteins and Membranes written by and published by . This book was released on 1991 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Current Bibliographies in Medicine

Author :
Publisher :
ISBN 13 :
Total Pages : 528 pages
Book Rating : 4.M/5 ( download)

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Book Synopsis Current Bibliographies in Medicine by :

Download or read book Current Bibliographies in Medicine written by and published by . This book was released on 1988 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1836 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt:

National Library of Medicine Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1178 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1989 with total page 1178 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics

Author : Claude L. Malmendier
Publisher : Springer Science & Business Media
ISBN 13 : 146845904X
Total Pages : 430 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics by : Claude L. Malmendier

Download or read book Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics written by Claude L. Malmendier and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past two decades have seen steady progress in our understanding of the pathogenesis of atherosclerosis. The role of low density lipoprotein (LOL) increase and of LOL receptor deficiency or malfunctions in familial hypercholesterolemia has been largely enlightened by the works of Brown and Goldstein. These authors postulated also that modification of LOL to a form recognized by the scavenger or acetyl-LOL receptor may be required for lipid loading of macrophage-derived foam cells in the lesions. A growing body of evidence suggests that oxidative modification of LOL could enhance its atherogenicity by its implication as a factor in the generation of foam cells. Thus, if the role of LOL in the pathogenesis of hypercholesterolemia was well established a great deal of information appears currently on new approaches such as the mechanisms leading to the accumulation of foam cells, the impact of LOL structural alterations, notably oxidation and the role of gene mutations of apolipoprotein Band/or LOL receptor The opening topic is devoted to these new avenues outlined in the field of hypercholesterolemia. The first part concerns the genetic aspects of atherosclerosis: mainly the genetics of apo 1 ipoprote ins , their transcriptional regulation, the amino acid mutations of the apo B gene and of the LOL receptor gene, the structural domains and the acylation sites of apoprotein B.

Current Catalog

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Catalog by :

Download or read book Current Catalog written by and published by . This book was released on 1991 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

Lipid Biochemistry

Author : Michael I. Gurr
Publisher : John Wiley & Sons
ISBN 13 : 1405172703
Total Pages : 339 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Lipid Biochemistry by : Michael I. Gurr

Download or read book Lipid Biochemistry written by Michael I. Gurr and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition of this successful and popular book in 1970, the subject of lipid biochemistry has evolved greatly and this fifth up-to-date and comprehensive edition includes much new and exciting information. Lipid Biochemistry, fifth edition has been largely re-written in a user-friendly way, with chapters containing special interest topic boxes, summary points and lists of suggested reading, further enhancing the accessibility and readability of this excellent text. Contents include abbreviations and definitions used in the study of lipids, routine analytical methods, fatty acid structure and metabolism, dietary lipids and lipids as energy stores, lipid transport, lipids in cellular structures and the metabolism of structural lipids. The book provides a most comprehensive treatment of the subject, making it essential reading for all those working with or studying lipids. Upper level students of biochemistry, biology, clinical subjects, nutrition and food science will find the contents of this book invaluable as a study aid, as will postgraduates specializing in the topics covered in the book. Professionals working in research in academia and industry, including personnel involved in food and nutrition research, new product formulation, special diet formulation (including nutraceuticals and functional foods) and other clinical aspects will find a vast wealth of information within the book's pages. Michael Gurr was a Visiting Professor in Human Nutrition at the University of Reading, UK and at Oxford Brookes University, UK. John Harwood is a Professor of Biochemistry at the School of Biosciences, Cardiff University, UK. Keith Frayn is a Professor of Human Metabolism at the Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK.