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Effect Of Vitamin D Supplementation On Glucose Control And Inflammatory Response In Type Ii Diabetic Patients
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Book Synopsis Effect of Vitamin D Supplementation on Glucose Control and Inflammatory Response in Type II Diabetic Patients by : Mohammed Eida Al-Sofiani
Download or read book Effect of Vitamin D Supplementation on Glucose Control and Inflammatory Response in Type II Diabetic Patients written by Mohammed Eida Al-Sofiani and published by . This book was released on 2013 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effect of Vitamin D Supplementation on Inflammation in Type 2 Diabetes: a Meta-analysis of Randomized Controlled Trials by : Mousa Aya
Download or read book Effect of Vitamin D Supplementation on Inflammation in Type 2 Diabetes: a Meta-analysis of Randomized Controlled Trials written by Mousa Aya and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: BACKGROUND: Chronic low-grade inflammation is common in obesity and related chronic conditions, including type 2 diabetes. Vitamin D has been proposed to have anti-inflammatory properties; however the effect of vitamin D supplementation on inflammation in type 2 diabetes has not been established. AIM: We conducted a systematic review and meta-analysis to examine the effect of vitamin D supplementation on inflammatory markers compared to placebo or usual care in patients with type 2 diabetes, and to identify relevant knowledge gaps. METHODS: Medline, CINAHL, EMBASE and All EBM were systematically searched (from inception to 25 January 2017) for randomized controlled trials (RCTs) investigating the effects of vitamin D supplementation on inflammatory markers in type 2 diabetes patients. Two independent reviewers screened all full text articles (no date or language limits) for RCTs of vitamin D supplementation (any form, route, duration, and co-supplementation) compared to placebo or usual care on all inflammatory marker outcomes in patients with type 2 diabetes (on any treatment regimen and with or without comorbidities). Meta-analyses and meta-regression were conducted using random-effects models to calculate standardized mean differences (SMD) and 95%CIs. Two independent reviewers extracted data and assessed risk of bias and quality using the grading of recommendations, assessment, development and evaluation (GRADE) approach.RESULTS: Twenty-nine RCTs (n=1,780) met the inclusion criteria, 20 of which had available data for pooling. In meta-analyses of 20 RCTs (n=1,270), vitamin D-supplemented groups had lower follow-up levels of C-reactive protein (SMD: -0.23 mg/L (-0.37,-0.09); p=0.002), tumor necrosis factor-alpha (SMD: -0.49 pg/ml (-0.84,-0.15); p=0.005), and erythrocyte sedimentation rate (SMD: -0.47 mm/hr (-0.89,-0.05); p=0.03), and higher levels of leptin (SMD: 0.42 u00b5g/L (0.04, 0.81); p=0.03), compared to placebo. No differences were observed for adiponectin, interleukin-6, or E-selectin (all p>0.05). In meta-regression and subgroup analyses, age, sex, BMI, diabetes duration, baseline vitamin D status, and supplementation dose and duration did not alter the results. There was no evidence of heterogeneity (p>0.1) or publication bias (p>0.1) and most studies were low to moderate risk of bias. CONCLUSIONS: Our meta-analysis provides level one evidence that vitamin D supplementation may improve chronic low-grade inflammation in patients with type 2 diabetes. Further studies are needed to establish whether improved inflammation following vitamin D supplementation would translate into improved health outcomes for patients with type 2 diabetes. PROSPERO registration number: CRD42016047755.
Book Synopsis Extraskeletal Effects of Vitamin D by : Emilia Pauline Liao
Download or read book Extraskeletal Effects of Vitamin D written by Emilia Pauline Liao and published by Humana Press. This book was released on 2018-04-23 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the skeletal effects of vitamin D are well-documented, the role and importance of vitamin D outside of bone health has not been well-established. Vitamin D receptors are located in nearly every tissue of the body, and low levels of vitamin D are associated with a range of various diseases. This book provides an in-depth examination of these extraskeletal effects of vitamin D and the associations between vitamin D deficiency and various disease states. Beginning with a review of the biochemistry and physiology of vitamin D, subsequent chapters investigate its relationship to autoimmune and infectious diseases, various forms of cancer, endocrine issues such as diabetes, obesity and reproductive function, cardiovascular disease and muscle weakness. Concluding chapters discuss the role of vitamin D in neurological disorders, including Alzheimer's Disease, and cognitive function. Focusing on extraskeletal effects only across a range of conditions, Extraskeletal Effects of Vitamin D will be an important resource for clinical endocrinologists and primary care physicians.
Book Synopsis Systematic Review of the Effectiveness of Vitamin D Supplement for Type 2 Diabetes Mellitus Patients by : Jing Xu
Download or read book Systematic Review of the Effectiveness of Vitamin D Supplement for Type 2 Diabetes Mellitus Patients written by Jing Xu and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Systematic Review of the Effectiveness of Vitamin D Supplement for Type 2 Diabetes Mellitus Patients" by Jing, Xu, 许静, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Background Worldwide, as of 2010, about 285 million people suffered diabetes mellitus (DM), with type 2 constituting about 90% of the cases. DM is more common, in particular, type 2 diabetes mellitus (T2DM) in developed countries. The greatest increase in prevalence appears in Asia and Africa. More important, it associated with complications including uremia, heart disease and diabetic retinopathy. Recent research has investigated whether there would have effect of vitamin D (VD) supplementation in addition to other treatment or/and relevant interventions that would improve health outcomes of patients diagnosed with T2DM. Furthermore, the costs of using VD supplements are relatively low. Methods A systematic review was conducted by searching for relevant studies published from the year of 2004 to 2014 (all the studies were randomized controlled trials) from database of PubMed with specified keywords. All studies were conducted in Asia and all subjects were T2DM patients. Studies were included when they were in relation to the association between VD supplementation and T2DM patients. After filtering, ten trials were identified to be relevant and adopted in this systematic review. The effects of calcium intake were also explored whenever applicable. Results Ten studies were included, with all of them conducted in Asia. In seven trials, VD supplementation indicated insignificantly differences of VD effects on T2DM through impact of metabolic parameters such as glycated hemoglobin (HbA1c), Fasting plasma glucose (FPG), insulin, insulin resistance (IR).etc. However, three trials revealed significant differences in HbA1c, FPG, insulin, IR and insulin sensitivity (IS) with VD supplementation. Conclusions There were insufficient evidences concerning the effectiveness of VD supplementary for T2DM patients in Asian populations, in terms of improving their health outcomes. It could be likely to be useful for our Hong Kong Chinese population. Because some included trials were subject to small sample sizes, incompletely follow up, and/or low methodological quality, these might influence the validity of the findings. Future studies on the effectiveness of VD for T2DM would be warranted for Chinese population. Subjects: Non-insulin-dependent diabetes Vitamin D - Therapeutic use
Book Synopsis Vitamin D Deficiency in Patients with Type 2 Diabetes in a Shanghai Hospital by : Xiaoming Zhuang
Download or read book Vitamin D Deficiency in Patients with Type 2 Diabetes in a Shanghai Hospital written by Xiaoming Zhuang and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Vitamin D Deficiency in Patients With Type 2 Diabetes in a Shanghai Hospital: the Impact on Glycemic Control" by Xiaoming, Zhuang, 庄小鸣, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Objective：Low vitamin D has been implicated in the development of type 2 diabetes. However, whether vitamin D continues to have a clinically significant effect in existing diabetes is unclear. The objective of this study was to examine the association of serum vitamin D with glycemic control in established type 2 diabetes. Methods: This was a retrospective analysis of medical records. Characteristics of 487 patients with type 2 diabetes were stratified by vitamin D status and serum glycosylated hemoglobin (HbA1c). Vitamin D deficiency among the subjects was studied. The relationship between vitamin D and glycemic control was explored by multiple linear regression, multivariate analysis of variance (MANOVA) and chi-square test. Patients were stratified into overweight and non-overweight group based on body mass index (BMI), and the association of serum vitamin D concentration with glycemic control was evaluated in each group. Insulin resistance and C-peptide as mediators between vitamin D and HbA1c was tested. The impact of vitamin D on cholesterol metabolism was also assessed. Results: (1) Vitamin D deficiency was highly prevalent, accounting for 88.3% of the study sample. (2) Serum vitamin D levels were significantly inversely associated with serum HbA1c. This correlation was stronger in overweight group than in non-overweight group. There was no significant relationship between serum vitamin D levels and fasting plasma glucose (FPG). HbA1c was significantly lower in vitamin D insufficiency group than in vitamin D severe deficiency group. (3) Insulin resistance partially mediated the association between vitamin D and HbA1c. (4) No significant association of Vitamin D with low density lipoprotein (LDL) or high density lipoprotein (HDL) was found in this study. Conclusions: There was an inverse association between serum vitamin D levels and HbA1c. The inverse correlation of serum vitamin D level and HbA1c was stronger in overweight group than in non-overweight group, which indicates patients with obesity might benefit more from vitamin D supplementation. DOI: 10.5353/th_b5099026 Subjects: Vitamin D deficiency Non-insulin-dependent diabetes
Book Synopsis Effects of Vitamin D Deficiency and Supplementation on Vascular Function in Patients with Type II Diabetes by : Yuen-Fung Yiu
Download or read book Effects of Vitamin D Deficiency and Supplementation on Vascular Function in Patients with Type II Diabetes written by Yuen-Fung Yiu and published by Open Dissertation Press. This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Effects of Vitamin D Deficiency and Supplementation on Vascular Function in Patients With Type II Diabetes" by Yuen-fung, Yiu, 饒元豐, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Despite the medical advances in recent decades, cardiovascular disease (CVD) remains one of the leading causes of mortality in most developing countries. Ongoing efforts have been focused on evaluating new strategies targeting on novel risk factors. Vitamin D deficiency, a previously neglected condition, has recently attracted much attention from the scientific community with its potential extra-skeletal effects. There is accumulating evidence from epidemiological studies that a suboptimal 25-hydroxyvitamin D [25(OH)D] level is associated with all-cause and cardiovascular mortality, increased risk of coronary heart disease, stroke and peripheral vascular disease, and various traditional CVD risk factors including hypertension, diabetes mellitus (DM) and metabolic syndrome. Several theories have been proposed to explain these relationships but none receive universal recognition. There is recent laboratory evidence that vitamin D may exert specific effects in patients with DM. However, relationships between vitamin D deficiency and supplementation on vascular function in this group of patients are unclear. In this dissertation, I sought to explore the effects of vitamin D deficiency on vascular function in patients with type II DM in a cross-sectional study. In the later part, the results of a randomized controlled trial investigating the effects of daily vitamin D supplementation in type II DM patients are presented and discussed. The cross-sectional study (Chapter 3) investigated the association of vitamin D status with endothelial function as measured by brachial flow-mediated dilation (FMD) and circulating endothelial progenitor cell (EPC) numbers in 280 patients with type II DM. The results showed that suboptimal vitamin D status was more common among patients with DM. Furthermore, patients with vitamin D deficiency had significantly lower brachial FMD (mean difference = -1.43%, 95% CI: -2.31 to -0.55, P = 0.001) and CD133/KDR+ EPC counts (mean difference = -0.12%, 95% CI: -0.21 to -0.02, P = 0.022) than those with sufficient vitamin D after adjustment for age, sex and cardiovascular risk factors, including HbA1c levels. Based on these positive results, the objectives of the randomized controlled trial (Chapter 4) were to study and confirm the effects of daily oral vitamin D supplementation on the vascular function in this group of patients. Over a 12-week period, 100 DM patients with suboptimal vitamin D status were randomized to receive 5,000 IU/day vitamin D or placebo. There were no reported adverse events including hypercalcemia, although a slight increase in serum ionized calcium (treatment effect 0.037 mmol/L, P = 0.018) was recorded in the vitamin D group. Despite a significant improvement in serum 25(OH)D in the treatment group, supplementation of vitamin D did not result in any significant improvement in vascular function as determined by FMD, circulating EPC count or arterial stiffness (all P > 0.05). Furthermore, the serum level of high-sensitivity C-reactive protein, oxidative stress markers, low- and high-density lipoprotein and glycated haemoglobin were also similar between two groups (all P > 0.05). The results of this study did not support a therapeutic role of supplementation with vitamin D for cardiovascular benefits. In conclusion, the results of these studies demonstrated that deficiency of vit
Book Synopsis Vitamin D Deficiency by : Julia Fedotova
Download or read book Vitamin D Deficiency written by Julia Fedotova and published by BoD – Books on Demand. This book was released on 2020-02-26 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D is the topic for many discussions in the scientific community. Nowadays, a different interpretation of this secosteroid hormone is needed. Today the term "vitamin" may be considered outdated. This compound may be correctly be called a vitamin only when it is administered to humans or animals that suffer from its deficiency. This book attempts to clarify the role of Vitamin D deficiency in many pathological processes in the whole organism. Chapters in this book cover such issues as the earliest clinical and preclinical investigations of the consequences of Vitamin D deficiency for cognitive, cardiovascular, metabolic, immune, and renal disorders.
Book Synopsis Vitamin D Status, Inflammation, and Oxidative Stress by : Yogita Kalyanrao Dhas
Download or read book Vitamin D Status, Inflammation, and Oxidative Stress written by Yogita Kalyanrao Dhas and published by . This book was released on 2023-03-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride by : Institute of Medicine
Download or read book Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride written by Institute of Medicine and published by National Academies Press. This book was released on 1999-10-17 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1941, Recommended Dietary Allowances (RDAs) has been recognized as the most authoritative source of information on nutrient levels for healthy people. Since publication of the 10th edition in 1989, there has been rising awareness of the impact of nutrition on chronic disease. In light of new research findings and a growing public focus on nutrition and health, the expert panel responsible for formulation RDAs reviewed and expanded its approachâ€"the result: Dietary Reference Intakes. This new series of references greatly extends the scope and application of previous nutrient guidelines. For each nutrient the book presents what is known about how the nutrient functions in the human body, what the best method is to determine its requirements, which factors (caffeine or exercise, for example) may affect how it works, and how the nutrient may be related to chronic disease. The first volume of Dietary Reference Intakes includes calcium, phosphorus, magnesium, vitamin D, and fluoride. The second book in the series presents information about thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Based on analysis of nutrient metabolism in humans and data on intakes in the U.S. population, the committee recommends intakes for each age groupâ€"from the first days of life through childhood, sexual maturity, midlife, and the later years. Recommendations for pregnancy and lactation also are made, and the book identifies when intake of a nutrient may be too much. Representing a new paradigm for the nutrition community, Dietary Reference Intakes encompasses: Estimated Average Requirements (EARs). These are used to set Recommended Dietary Allowances. Recommended Dietary Allowances (RDAs). Intakes that meet the RDA are likely to meet the nutrient requirement of nearly all individuals in a life-stage and gender group. Adequate Intakes (AIs). These are used instead of RDAs when an EAR cannot be calculated. Both the RDA and the AI may be used as goals for individual intake. Tolerable Upper Intake Levels (ULs). Intakes below the UL are unlikely to pose risks of adverse health effects in healthy people. This new framework encompasses both essential nutrients and other food components thought to pay a role in health, such as dietary fiber. It incorporates functional endpoints and examines the relationship between dose and response in determining adequacy and the hazards of excess intake for each nutrient.
Download or read book Podocytopathy written by Z.-H. Liui and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-16 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.
Book Synopsis Dietary Intake and Type 2 Diabetes by : Omorogieva Ojo
Download or read book Dietary Intake and Type 2 Diabetes written by Omorogieva Ojo and published by MDPI. This book was released on 2019-12-05 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prevalence of diabetes is on the increase in the UK and worldwide, partly due to changes in lifestyle which predispose individuals to overweight and obesity. It is estimated that about 90% of the currently diagnosed adults have type 2 diabetes, and based on the World Health Organisation (WHO) report, about 422 million adults were living with diabetes in 2014 compared with 108 million in 1980; this condition caused about 1.5 million deaths in 2012. In the United States of America, it is estimated that about 30.3 million adults are living with diabetes, with a further 1.5 million new diabetes cases diagnosed every year, representing an increasing prevalence of this condition. Diabetes represents a major public health challenge, despite advances in technology and the pharmaceutical industry. These problems may be in the form of acute or long-term complications. Therefore, in order to attenuate the problems of diabetes, management strategies usually include lifestyle changes such as increased physical activity and dietary interventions. Studies which evaluate the role of nutrition in the management of type 2 diabetes often involve human and animal models as these approaches enable us to have a broader and more in-depth understanding of the condition. In some cases, diabetes may co-exist with other conditions, such as stroke, and these may present unique challenges with regard to nutritional interventions. This Special Issue aims to evaluate the risk factors associated with type 2 diabetes and the role of the diet in the management of people with this condition. This evidence is drawn from both human and animal studies.
Book Synopsis Nutritional Management of Diabetes Mellitus by : Gary Frost
Download or read book Nutritional Management of Diabetes Mellitus written by Gary Frost and published by John Wiley & Sons. This book was released on 2003-11-04 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes mellitus is a common disorder where the body is no longer able to regulate blood glucose levels correctly owing to defects in insulin secretion or action. While some people require treatment with insulin, many are able to control their diabetes through management of diet, e.g. by decreasing the fat intake and increasing the amount of fibre. This book provides an up-to-date review of the dietary management of diabetes looking at general topics, such as the metabolic principles of nutrition, as well as more specific topics, such as nutritional management of diabetic children, pregnant women and the elderly. A specialist text on the nutritional management of diabetes A practical book, useful in clinical practice Written by well respected clinicians within the field
Book Synopsis Nutrition and HIV by : Saurabh Mehta
Download or read book Nutrition and HIV written by Saurabh Mehta and published by CRC Press. This book was released on 2018-05-15 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world continues to lose more than a million lives each year to the HIV epidemic, and nearly two million individuals were infected with HIV in 2017 alone. The new Sustainable Development Goals, adopted by countries of the United Nations in September 2015, include a commitment to end the AIDS epidemic by 2030. Considerable emphasis on prevention of new infections and treatment of those living with HIV will be needed to make this goal achievable. With nearly 37 million people now living with HIV, it is a communicable disease that behaves like a noncommunicable disease. Nutritional management is integral to comprehensive HIV care and treatment. Improved nutritional status and weight gain can increase recovery and strength of individuals living with HIV/AIDS, improve dietary diversity and caloric intake, and improve quality of life. This book highlights evidence-based research linking nutrition and HIV and identifies research gaps to inform the development of guidelines and policies for the United Nations’ Sustainable Development Goals. A comprehensive approach that includes nutritional interventions is likely to maximize the benefit of antiretroviral therapy in preventing HIV disease progression and other adverse outcomes in HIV-infected men and women. Modification of nutritional status has been shown to enhance the quality of life of those suffering HIV/AIDS, both physically in terms of improved body mass index and immunological markers, and psychologically, by improving symptoms of depression. While the primary focus for those infected should remain on antiretroviral treatment and increasing its availability and coverage, improvement of nutritional status plays a complementary role in the management of HIV infection.
Book Synopsis Immune-Modulatory Effects of Vitamin D by : Susu M. Zughaier
Download or read book Immune-Modulatory Effects of Vitamin D written by Susu M. Zughaier and published by Frontiers Media SA. This book was released on 2020-12-16 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis Feldman and Pike’s Vitamin D by : Martin Hewison
Download or read book Feldman and Pike’s Vitamin D written by Martin Hewison and published by Elsevier. This book was released on 2023-10-28 with total page 1382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike’s Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field. In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic insights into the mechanisms of disease. Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including sports medicine, opthalmology, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field. A comprehensive reference ranging from basic biochemistry, cell biology, and physiology principles to the clinical diagnostic and management implications of vitamin D Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of vitamin D, as opposed to searching through thousands of journal articles Chapters written by the most prominent and well-published names in the field
Download or read book Vitamin D written by Martin Hewison and published by Academic Press. This book was released on 2017-12-14 with total page 1268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D: Volume 2: Health, Disease and Therapeutics, Fourth Edition, authoritatively covers the evidence for new roles for vitamin D, ranging from cardiovascular disease, to cancer, diabetes, inflammatory bowel disease, multiple sclerosis and renal disease. This collection represents a who’s who of vitamin D research and the coverage is appropriately broad, drawing in internal medicine, orthopedics, oncology and immunology. Clinical researchers will gain a strong understanding of the molecular basis for a particular area of focus. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin D Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articles Chapter authors include the most prominent and well-published names in the field Targets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis and vitamin D deficiency Presents a clinical focus on disorders, analogs, cancer, immunity, inflammation, disease and therapeutic applications
Book Synopsis The Effects of High-dose Vitamin D Supplementation on Inflammation in Patients with Chronic Hepatitis C Infection by : Ryan Matson
Download or read book The Effects of High-dose Vitamin D Supplementation on Inflammation in Patients with Chronic Hepatitis C Infection written by Ryan Matson and published by . This book was released on 2012 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although vitamin D deficiency is classically associated with skeletal diseases such as rickets and osteomalacia, it is now clear that the physiologic effects of deficiency extend well beyond just calcium and bone homeostasis. It has been proposed that vitamin D may play an important role in the pathogenesis of cardiovascular disease, common cancers, response to infections, and autoimmune diseases as well. In addition, research continues to support an association with vitamin D status and immunomodulation and the inflammatory response to a number of infectious and noninfectious diseases. One such disease is hepatitis C infection. Although it has been shown that vitamin D deficiency confers an unfavorable clinical response to antiviral therapy in patients with recurrent hepatitis C, the mechanism for this observation remains unclear. Vitamin D's ability to modulate the immune system in response to infection could play a role in determining the inflammatory profile in chronically infected patients, but this hypothesis has yet to be tested. It is known that patients with chronic liver disease display a certain inflammatory profile, as indicated by the proportion of M1 as compared to M2 macrophages as discovered on liver biopsies, as well as the cytokine profile present in circulation. The aim of this independent study project is to test the hypothesis that vitamin D supplementation in patients with chronic hepatitis c infection will alter the systemic inflammatory profile characterized by their macrophage populations and cytokine profiles.
