Development And Applications Of A New Reverse Genetics Method For The Generation Of Single Stranded Positive Sense Rna Viruses

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Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics

Author : Yoshihiro Kawaoka
Publisher : Springer Science & Business Media
ISBN 13 : 366206099X
Total Pages : 354 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics by : Yoshihiro Kawaoka

Download or read book Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics written by Yoshihiro Kawaoka and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Negative-strand RNA viruses, so named because of the polarity of their genomic RNA to mRNA, include important human and non-human pathogens. This volume covers major advances in reverse genetics techniques over the past decade, state-of-the-art basic science and the clinical implications of experimental findings. This should rekindle interest in negative-strand RNA viruses among readers, including those in other disciplines, leading to further progress in understanding these important viruses and in developing effective measures of control.

Peste des Petits Ruminants Virus

Author : Muhammad Munir
Publisher : Springer
ISBN 13 : 9783662523087
Total Pages : 0 pages
Book Rating : 4.5/5 (23 download)

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Book Synopsis Peste des Petits Ruminants Virus by : Muhammad Munir

Download or read book Peste des Petits Ruminants Virus written by Muhammad Munir and published by Springer. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a timely and comprehensive review of essential research on Peste des Petits Ruminants Virus (PPRV), ranging from its historical distribution, molecular epidemiology, genome structure, viral proteins, immunity, viral pathogenesis, clinical and molecular diagnosis to advances in vaccine developments and future challenges. PPRV, a Rinderpest-like virus, is the causative agent of one of the most rapidly emerging viral diseases among domestic small ruminants, and the host spectrum has now been expanded to wild small ruminants and camels. With the global eradication of the first livestock disease, Rinderpest, attention is now turning to repeating the procedure for PPR. Each of the book’s 13 chapters is dedicated to a specific topic, providing up-to-date literature and discussions by renowned scientists who have made seminal contributions in their respective fields of expertise. Special emphasis has been placed on the analysis of different global efforts to eradicate PPR. This book offers a valuable reference source for virologists, field veterinarians, infection and molecular biologists, immunologists, scientists in related fields and veterinary school libraries.

Molecular Virology

Author : Susanne Modrow
Publisher : Springer
ISBN 13 : 9783642207174
Total Pages : 0 pages
Book Rating : 4.2/5 (71 download)

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Book Synopsis Molecular Virology by : Susanne Modrow

Download or read book Molecular Virology written by Susanne Modrow and published by Springer. This book was released on 2013-09-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book gives a comprehensive overview on the knowledge of virus infection relevant for humans and animals. For each virus family the molecular details of the virus particle and the viral replication cycle are described. In the case of virus types with relevance for human and/or animal health the data on molecular biology, genetics and virus-cell interaction are combined with those concerning, pathogenesis, epidemiology, clinics, prevention and therapy.

Reverse Genetics of RNA Viruses

Author : Anne Bridgen
Publisher : John Wiley & Sons
ISBN 13 : 111840534X
Total Pages : 482 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Reverse Genetics of RNA Viruses by : Anne Bridgen

Download or read book Reverse Genetics of RNA Viruses written by Anne Bridgen and published by John Wiley & Sons. This book was released on 2012-10-07 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reverse genetics, the genetic manipulation of RNA viruses to create a wild-type or modified virus, has led to important advances in our understanding of viral gene function and interaction with host cells. Since many severe viral human and animal pathogens are RNA viruses, including those responsible for polio, measles, rotaviral diarrhoea and influenza infections, it is also an extremely powerful technique with important potential application for the prevention and control of a range of human and animal viral diseases. Reverse Genetics of RNA Viruses provides a comprehensive account of the very latest developments in reverse genetics of RNA viruses through a wide range of applications within each of the core virus groups including; positive sense, negative sense and double stranded RNA viruses. Written by a team of international experts in the field, it provides a unique insight into how the field has developed, what problems are being addressed now and where applications may lead in the future. It will prove invaluable to bioscience, medical and veterinary students, those starting research in this area as well as other researchers and teachers needing to update their knowledge of this fast-moving field. An authoritative, comprehensive overview of reverse genetics in RNA Viruses. Includes numerous examples of cutting- edge applications of reverse genetics within each of the RNA viral groups. Written by a team of international experts, including some of the leading researchers in the field.

New Advances on Zika Virus Research

Author : Luis Martinez-Sobrido
Publisher : MDPI
ISBN 13 : 3038977640
Total Pages : 554 pages
Book Rating : 4.0/5 (389 download)

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Book Synopsis New Advances on Zika Virus Research by : Luis Martinez-Sobrido

Download or read book New Advances on Zika Virus Research written by Luis Martinez-Sobrido and published by MDPI. This book was released on 2019-04-02 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.

Automated DNA Sequencing and Analysis

Author : Mark D. Adams
Publisher : Elsevier
ISBN 13 : 0080926398
Total Pages : 389 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Automated DNA Sequencing and Analysis by : Mark D. Adams

Download or read book Automated DNA Sequencing and Analysis written by Mark D. Adams and published by Elsevier. This book was released on 2012-12-02 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely book for DNA researchers, Automated DNA Sequencing and Analysis reviews and assesses the state of the art of automated DNA sequence analysis-from the construction of clone libraries to the developmentof laboratory and community databases. It presents the methodologies and strategies of automated DNA sequence analysis in a way that allows them to be compared and contrasted. By taking a broad view of the process of automated sequence analysis, the present volume bridges the gap between the protocols supplied with instrument and reaction kits and the finalized data presented in the research literature. It will be an invaluable aid to both small laboratories that are interested in taking maximum advantageof automated sequence resources and to groups pursuing large-scale cDNA and genomic sequencing projects. - The field of automation in DAN sequencing and analysis is rapidly moving, this book fulfils those needs, reviews the history of the art and provides pointers to future development.

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Virology Methods Manual

Author : Hillar O. Kangro
Publisher : Elsevier
ISBN 13 : 0080543588
Total Pages : 385 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Virology Methods Manual by : Hillar O. Kangro

Download or read book Virology Methods Manual written by Hillar O. Kangro and published by Elsevier. This book was released on 1996-04-16 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Virology Methods Manual is a comprehensive source of methods for the study, manipulation, and detection of viruses. Edited by Brian Mahy and Hillar Kangro, this work describes the most up-to-date, definitive techniques, provided by experts in each area, and presented with easy-to-use, step-by-step protocols. This new manual will satisfy the needs of virologists and all those working with viruses who need a practical guide to methods that work! - Provides up-to-date techniques by experts worldwide - Presents common, step-by-step protocols in an attractive, easy-to-use fashion - Contains useful appendices including virus taxonomy, metabolic inhibitors, and Bio-safety in the virology laboratory

Learning from SARS

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309182158
Total Pages : 376 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Learning from SARS by : Institute of Medicine

Download or read book Learning from SARS written by Institute of Medicine and published by National Academies Press. This book was released on 2004-04-26 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The emergence of severe acute respiratory syndrome (SARS) in late 2002 and 2003 challenged the global public health community to confront a novel epidemic that spread rapidly from its origins in southern China until it had reached more than 25 other countries within a matter of months. In addition to the number of patients infected with the SARS virus, the disease had profound economic and political repercussions in many of the affected regions. Recent reports of isolated new SARS cases and a fear that the disease could reemerge and spread have put public health officials on high alert for any indications of possible new outbreaks. This report examines the response to SARS by public health systems in individual countries, the biology of the SARS coronavirus and related coronaviruses in animals, the economic and political fallout of the SARS epidemic, quarantine law and other public health measures that apply to combating infectious diseases, and the role of international organizations and scientific cooperation in halting the spread of SARS. The report provides an illuminating survey of findings from the epidemic, along with an assessment of what might be needed in order to contain any future outbreaks of SARS or other emerging infections.

Coronaviruses

Author : Helena J. Maier
Publisher : Humana
ISBN 13 : 9781071609026
Total Pages : 278 pages
Book Rating : 4.6/5 (9 download)

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Book Synopsis Coronaviruses by : Helena J. Maier

Download or read book Coronaviruses written by Helena J. Maier and published by Humana. This book was released on 2021-09-08 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed new edition provides a comprehensive collection of protocols applicable to all members of the Coronavirinae sub-family currently and that are also transferrable to other fields of virology. Beginning with a section on detection, discovery, and evolution, the volume continues with coverage of propagation and titration of coronaviruses, genome manipulation, study of virus-host interactions, as well as imaging coronavirus infections. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Coronaviruses: Methods and Protocols, Second Edition serves as a valuable guide to researchers working to identify and control viruses with increased potential to cross the species barrier and to develop the diagnostics, vaccines, and antiviral therapeutics that are required to manage future outbreaks in both humans and animals.

Bluetongue

Author : Peter Mertens
Publisher : Academic Press
ISBN 13 : 0080918972
Total Pages : 507 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Bluetongue by : Peter Mertens

Download or read book Bluetongue written by Peter Mertens and published by Academic Press. This book was released on 2008-10-29 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third volume in the Institute of Animal Health (IAH) Biology of Animal Infections Series, Bluetongue discusses one of the most economically important diseases of domesticated livestock. Affecting primarily sheep particularly the improved mutton and wool breeds, it is now endemic in Africa, India, the Middle and Far East, Australia and the Americas, and over the last six years has caused a series of outbreaks throughout the Mediterranean region and central Europe. Bluetongue represent a paradigm not only for the other orbiviruses (such as African horse sickness virus, which shares the same vector species) but also for other insect transmitted diseases, including those of humans. - The only single definitive work that provides both historical and up to date data on the disease - Describes the latest developments in epidemiological modelling, molecular epidemiology and vaccine development, as well as explaining the current global epidemiology of the disease - Outlines the importance and possible mechanisms of overwintering, and the impact of global warming on the vectors and virus distribution

Immunopharmacology

Author : Manzoor M. Khan
Publisher : Springer Science & Business Media
ISBN 13 : 0387779760
Total Pages : 275 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Immunopharmacology by : Manzoor M. Khan

Download or read book Immunopharmacology written by Manzoor M. Khan and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.

Clinical Immunology E-Book

Author : Robert R. Rich
Publisher : Elsevier Health Sciences
ISBN 13 : 0723437106
Total Pages : 1324 pages
Book Rating : 4.7/5 (234 download)

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Book Synopsis Clinical Immunology E-Book by : Robert R. Rich

Download or read book Clinical Immunology E-Book written by Robert R. Rich and published by Elsevier Health Sciences. This book was released on 2012-10-26 with total page 1324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offer your patients the best possible care with clear, reliable guidance from one of the most respected and trusted resources in immunology. Authoritative answers from internationally renowned leaders in the field equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems. Depend on authoritative information from leading experts in the field who equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems. Focus on the information that’s most relevant to your daily practice through a highly clinical focus and an extremely practical organization that expedites access to the answers you need. Stay at the forefront of your field with cutting-edge coverage of the human genome project, immune-modifier drugs, and many other vital.

Arenaviruses I

Author : M.B.A. Oldstone
Publisher : Springer Science & Business Media
ISBN 13 : 3642560296
Total Pages : 322 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Arenaviruses I by : M.B.A. Oldstone

Download or read book Arenaviruses I written by M.B.A. Oldstone and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the subject of arenaviruses was visited by Current Topics in Microbiology and Immunology 14 years ago, enormous advances have been made in this area. The receptor for several arenaviruses, alpha-dystroglycan, was identified, the replication strategy of these viruses was decoded, and application of a reverse genetics system for studying viral gene function and viral biology is well underway. In addition to reviewing these advances, Volume I includes discussion of arenaviral molecular phylogeny, reservoirs in rodents and clinical diseases caused by both new world and old world arenaviruses.

Essential Human Virology

Author : Jennifer Louten
Publisher : Academic Press
ISBN 13 : 0323914926
Total Pages : 412 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Essential Human Virology by : Jennifer Louten

Download or read book Essential Human Virology written by Jennifer Louten and published by Academic Press. This book was released on 2022-05-28 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Human Virology, Second Edition focuses on the structure and classification of viruses, virus transmission and virus replication strategies based upon type of viral nucleic acid. Several chapters focus on notable and recognizable viruses and the diseases caused by them, including influenza, HIV, hepatitis viruses, poliovirus, herpesviruses and emerging and dangerous viruses. Additionally, how viruses cause disease (pathogenesis) is highlighted, along with discussions on immune response to viruses, vaccines, anti-viral drugs, gene therapy, the beneficial uses of viruses, research laboratory assays and viral diagnosis assays. Fully revised and updated with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses, the book provides students with a solid foundation in virology. - Focuses on human diseases and the cellular pathology that viruses cause - Highlights current and cutting-edge technology and associated issues - Presents real case studies and current news highlights in each chapter - Features dynamic illustrations, chapter assessment questions, key terms, and a summary of concepts, as well as an instructor website with lecture slides, a test bank and recommended activities - Updated and revised, with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses

Virus-Induced Gene Silencing

Author : Annette Becker
Publisher : Humana Press
ISBN 13 : 9781627032773
Total Pages : 0 pages
Book Rating : 4.0/5 (327 download)

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Book Synopsis Virus-Induced Gene Silencing by : Annette Becker

Download or read book Virus-Induced Gene Silencing written by Annette Becker and published by Humana Press. This book was released on 2013-02-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants are amazing organisms to study, some are important sources for pharmaceuticals, and others can help to elucidate molecular mechanisms required for a plant’s development and its interactions with the biotic or abiotic environment. Functional genomics is vastly lagging behind the speed of genome sequencing as high-throughput gene function assays are difficult to design, specifically for non-model plants. Bioinformatics tools are useful for gene identification and annotation but are of limited value for predictions concerning gene functions as gene functions are uncovered best by experimental approaches. Virus-Induced-Gene-Silencing (VIGS) is an easy to use, fast, and reliable method to achieve down regulation of target gene expression. Virus-Induced Gene Silencing: Methods and Protocols provides detailed protocols for VIGS experiments in several plant species including model and non-model plants. Also included in this book are recently developed protocols for VIGS-derived microRNA production in the plant or protein over expression, as well as chapters devoted to summarizing the molecular mechanisms of VIGS action and the vector systems developed so far. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Virus-Induced Gene Silencing: Methods and Protocols serves as a valuable resource for researchers from diverse fields of plant biology interested in experimental approaches to analyzing gene functions.

Heritable Human Genome Editing

Author : The Royal Society
Publisher : National Academies Press
ISBN 13 : 0309671132
Total Pages : 239 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Heritable Human Genome Editing by : The Royal Society

Download or read book Heritable Human Genome Editing written by The Royal Society and published by National Academies Press. This book was released on 2021-01-16 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.