Author : Han Wang
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)
Book Synopsis Developing Novel Drug Delivery Systems For Platinum-based Anticancer Drugs Using Coordination-driven Self-assembly by : Han Wang
Download or read book Developing Novel Drug Delivery Systems For Platinum-based Anticancer Drugs Using Coordination-driven Self-assembly written by Han Wang and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platinum complexes are the most common anticancer agents used in the chemotherapeutic treatment regimens. (Wheate, Walker et al. 2010) Cisplatin, carboplatin, and oxaliplatin are the FDA-approved platinum-based chemotherapeutics used for clinical cancer therapy. (Wang 2005) However, patients treated with Pt-based drugs usually suffer from a variety of side effects including kidney damage, nerve damage, hearing loss, and suppression of bone marrow activity. To overcome these undesired side effects, it is necessary to develop a suitable drug delivery system for carrying anticancer agents to the target location. (Farokhzad and Langer 2009) The primary goal of this work is to combine the Pt (IV) prodrugs with nanodelivery to develop new drug delivery systems. In the second chapter, we present a novel design to use metal-organic cages (MOCs) to encapsulate Pt-based anticancer agents for delivery. A fluorescein conjugated Pt (IV) prodrug of cisplatin is developed for its encapsulation in a cationic MOC via host-guest interactions, which then forms drug-loaded nanoparticles with an anionic polymer. In Chapter 3, we design a Pt6L4 hydrophobic metallacage to encapsulate combat platinum resistance in ovarian cancer cells. The cage is further formulated into nanoparticles upon mixing with fluorescein and pegylated anionic polymer. The metal organic cage has a 20-fold increase in solubility and exhibits lower resistance factor on chemoresistance ovarian cancer cell lines. In Chapter 4, we develop a new strategy to conjugate Pt (IV) prodrugs covalently to self-assembled supramolecular hexagon. This new platinum drug delivery platform controls the drug loading precisely and displays a superior therapeutic index compared to cisplatin against a panel of human cancer cell lines. In Chapter 5, we demonstrate two kinds of self-assembled M12L24 metallosupramolecular spheres which can further form lipid-coated nanoparticles. Such novel nanoparticles exhibit superior therapeutic effects compared with that of cisplatin and trigger both DNA and mitochondria damage after entering cancer cells. References Farokhzad, O. C. and R. Langer (2009). "Impact of nanotechnology on drug delivery." ACS nano 3(1): 16-20.Wang, D. (2005). "Lippard sJ." Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov 4: 307-320.Wheate, N. J., et al. (2010). "The status of platinum anticancer drugs in the clinic and in clinical trials." Dalton transactions 39(35): 8113-8127.