Cystogenesis

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Cystogenesis

Author : Jong Hoon Park
Publisher : Springer
ISBN 13 : 9811020418
Total Pages : 126 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Cystogenesis by : Jong Hoon Park

Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

The Liver

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436842
Total Pages : 1144 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-01-20 with total page 1144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Fibrocystic Diseases of the Liver

Author : Karen F. Murray
Publisher : Springer Science & Business Media
ISBN 13 : 160327524X
Total Pages : 511 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Fibrocystic Diseases of the Liver by : Karen F. Murray

Download or read book Fibrocystic Diseases of the Liver written by Karen F. Murray and published by Springer Science & Business Media. This book was released on 2010-07-23 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there have been huge advances in the understanding of the genetic and molecular basis of the fibrocystic diseases. This volume provides a thorough review of fibrocyctic diseases that affect the liver. It contains in-depth discussions of the genetics, molecular biology, pathogenesis, histology, clinical presentations, complications of, treatment, and prognosis of the conditions affecting children and adults, and hence will be the gold-standard reference for these conditions. In addition, the histological features that distinguish these conditions from other potentially fibrosing hepatopathies are illustrated. Conditions with syndromic features involving the kidney or other organ systems are also reviewed. Thorough review of the clinical phenotypes, their presentations, treatment, potential complications of, and prognosis is discussed. Fibrocystic Diseases of the Liver will be an invaluable resource for hepatologists, gastroenterologists, nephrologists, and hepatic surgeons who care for children and adults with liver disease, as well as basic scientists in molecular genetics, hepatobiliary pathophysiology, hepatology and nephrology.

Liver Disease in Children

Author : Frederick J. Suchy
Publisher : Cambridge University Press
ISBN 13 : 1139464035
Total Pages : 995 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Liver Disease in Children by : Frederick J. Suchy

Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2007-05-07 with total page 995 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.

Nephrology, An Issue of Primary Care: Clinics in Office Practice, E-Book

Author : Parvathi Perumareddi
Publisher : Elsevier Health Sciences
ISBN 13 : 0323760961
Total Pages : 177 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Nephrology, An Issue of Primary Care: Clinics in Office Practice, E-Book by : Parvathi Perumareddi

Download or read book Nephrology, An Issue of Primary Care: Clinics in Office Practice, E-Book written by Parvathi Perumareddi and published by Elsevier Health Sciences. This book was released on 2020-11-07 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Primary Care: Clinics in Office Practice, guest edited by Dr. Parvathi Perumareddi, is devoted to Nephrology. Articles in this issue include: Electrolyte Abnormalities, Pre-renal Azotemia, and Fluid Balance, Acute Kidney Injury, Chronic Kidney Disease and Chronic Renal Failure, Nephrotic Syndrome, Nephritic Syndrome (not urological), Renovascular Hypertension, Diabetic Nephropathy, Nephrolithiasis, Polycystic Kidney Disease, Renal Repercussions of Medications, Care of the Renal Transplant Patient, and more.

Oxidoreductases—Advances in Research and Application: 2013 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481678701
Total Pages : 502 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Oxidoreductases—Advances in Research and Application: 2013 Edition by :

Download or read book Oxidoreductases—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidoreductases—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Ascorbate Oxidase. The editors have built Oxidoreductases—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Ascorbate Oxidase in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Oxidoreductases—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Polycystic Kidney Disease

Author : Benjamin D. Cowley, Jr.
Publisher : Springer
ISBN 13 : 1493977849
Total Pages : 273 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Polycystic Kidney Disease by : Benjamin D. Cowley, Jr.

Download or read book Polycystic Kidney Disease written by Benjamin D. Cowley, Jr. and published by Springer. This book was released on 2018-05-24 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease. The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms. This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients. The final section covers current clinical trials and emerging therapies in PKD. Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.

Molecular and Genetic Basis of Renal Disease

Author : David B. Mount
Publisher : Elsevier Health Sciences
ISBN 13 : 1416002529
Total Pages : 604 pages
Book Rating : 4.4/5 (16 download)

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Book Synopsis Molecular and Genetic Basis of Renal Disease by : David B. Mount

Download or read book Molecular and Genetic Basis of Renal Disease written by David B. Mount and published by Elsevier Health Sciences. This book was released on 2008-01-01 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: This companion to Brenner and Rector's The Kidney offers a state-of-the-art summary of the most recent advances in renal genetics. Molecular and Genetic Basis for Renal Disease provides the nephrologist with a comprehensive look at modern investigative tools in nephrology research today, and reviews the molecular pathophysiology of the nephron as well as the most common genetic and acquired renal diseases. A comprehensive clinical review of Medelian renal disease is also be included. Detailed review of the molecular anatomy and pathophysiology of the nephron that provides relevant basic science to consider when diagnosing and managing patients with these disorders.

TGF-beta Superfamily Proteins—Advances in Research and Application: 2013 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481692828
Total Pages : 252 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis TGF-beta Superfamily Proteins—Advances in Research and Application: 2013 Edition by :

Download or read book TGF-beta Superfamily Proteins—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: TGF-beta Superfamily Proteins—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Transforming Growth Factors. The editors have built TGF-beta Superfamily Proteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Transforming Growth Factors in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of TGF-beta Superfamily Proteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Intracellular Signaling Peptides and Proteins—Advances in Research and Application: 2012 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464999333
Total Pages : 185 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Intracellular Signaling Peptides and Proteins—Advances in Research and Application: 2012 Edition by :

Download or read book Intracellular Signaling Peptides and Proteins—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular Signaling Peptides and Proteins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Intracellular Signaling Peptides and Pr. The editors have built Intracellular Signaling Peptides and Proteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Intracellular Signaling Peptides and Pr in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Intracellular Signaling Peptides and Proteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Polycystic Kidney Disease

Author : Jinghua Hu
Publisher : CRC Press
ISBN 13 : 0429888945
Total Pages : 391 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis Polycystic Kidney Disease by : Jinghua Hu

Download or read book Polycystic Kidney Disease written by Jinghua Hu and published by CRC Press. This book was released on 2019-10-24 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies. Key Features Explores the role of cilia in polycystic kidney disease Focuses on myriad state-of-the-art methods and techniques Reviews specific mutations integral to this autosomal genetic disease Includes discussions of model systems

Inflammation Mediators—Advances in Research and Application: 2013 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481676717
Total Pages : 163 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Inflammation Mediators—Advances in Research and Application: 2013 Edition by :

Download or read book Inflammation Mediators—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation Mediators—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Inflammation Mediators—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Inflammation Mediators—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Kidney Development and Disease

Author : Rachel K. Miller
Publisher : Springer
ISBN 13 : 3319514369
Total Pages : 372 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Kidney Development and Disease by : Rachel K. Miller

Download or read book Kidney Development and Disease written by Rachel K. Miller and published by Springer. This book was released on 2017-04-13 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.

Liver Diseases: New Insights for the Healthcare Professional: 2012 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464971870
Total Pages : 124 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Liver Diseases: New Insights for the Healthcare Professional: 2012 Edition by :

Download or read book Liver Diseases: New Insights for the Healthcare Professional: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver Diseases: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Liver Diseases. The editors have built Liver Diseases: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Liver Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Liver Diseases: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Organoids as Model Systems for Human Development, Disease and Clinical Applications

Author : Eumorphia Remboutsika
Publisher : Frontiers Media SA
ISBN 13 : 2889716600
Total Pages : 216 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Organoids as Model Systems for Human Development, Disease and Clinical Applications by : Eumorphia Remboutsika

Download or read book Organoids as Model Systems for Human Development, Disease and Clinical Applications written by Eumorphia Remboutsika and published by Frontiers Media SA. This book was released on 2021-11-23 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Developmental Models 2.0

Author : Mo Li
Publisher : Frontiers Media SA
ISBN 13 : 283250597X
Total Pages : 210 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Developmental Models 2.0 by : Mo Li

Download or read book Developmental Models 2.0 written by Mo Li and published by Frontiers Media SA. This book was released on 2022-11-16 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Ying Gu is employed by BGI-Research, all other Topic Editors declare no conflicts of interest.

Zakim and Boyer's Hepatology

Author : Thomas D. Boyer
Publisher : Elsevier Health Sciences
ISBN 13 : 0323446574
Total Pages : 1380 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Zakim and Boyer's Hepatology by : Thomas D. Boyer

Download or read book Zakim and Boyer's Hepatology written by Thomas D. Boyer and published by Elsevier Health Sciences. This book was released on 2016-12-13 with total page 1380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get the authoritative, up-to-date information you need on liver disease from the 7th Edition of the most trusted reference worldwide. Covering both basic science and recent clinical developments, this revised edition by Drs. Arun J. Sanyal, Thomas D. Boyer, Norah A. Terrault, and Keith D. Lindor, provides an in-depth, comprehensive look at the pathophysiology, diagnostic, and treatment information related to the liver. More than 1,100 figures and tables, many new and in full color, highlight completely updated content throughout. Expert, international authorship and comprehensive, easy-to-access information makes this edition the gold standard in the field of hepatology. Includes new information on the rapid changes in treatment paradigms for acute liver failure, the latest treatments for primary biliary cholangitis, full coverage of the gut microbiome and its role in liver disease, the newest developments in drug-induced liver injury, and changes in hepatitis C virus treatment and hot-button concerns about access to care. New summary boxes at the end of each chapter and a newly streamlined table of contents make it easier to find and understand the information you’re looking for. Hundreds of brand-new illustrations clearly present key aspects of liver disease.