Cortical Development Neurogenesis And Neurological Disorders

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Cortical Development: Neurogenesis and Neurological Disorders

Author : Oliva Novak
Publisher : American Medical Publishers
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.8/5 (874 download)

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Book Synopsis Cortical Development: Neurogenesis and Neurological Disorders by : Oliva Novak

Download or read book Cortical Development: Neurogenesis and Neurological Disorders written by Oliva Novak and published by American Medical Publishers. This book was released on 2023-09-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cortical development is generally referred to as the process through which cerebral cortex is formed in mammals. The development of the cerebral cortex is crucial and necessitates complicated sequential processes which must be precisely orchestrated. The specific connectivity, identity and laminar positioning of each single cortical neuron are determined by the timing and localization of neuronal progenitor proliferation and neuronal migration. Variations in any of these organized series of events, whether caused by environmental factors or genetic mutations, leads to defined brain pathologies commonly referred as malformations of cortical development (MCDs). They are known as the major cause of intellectual disability and drug-resistant epilepsy. In these varied group of disorders, macroscopic variations in the brain structure can be identified and possibly subtend a general restructuring of neuronal circuits. This book is compiled in such a manner, that it will provide in-depth knowledge about the neurogenesis and neurological disorders with respect to cortical development. Researchers and students in this field will be assisted by it.

From Neurons to Neighborhoods

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309069882
Total Pages : 610 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis From Neurons to Neighborhoods by : National Research Council

Download or read book From Neurons to Neighborhoods written by National Research Council and published by National Academies Press. This book was released on 2000-11-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Discovering the Brain

Author : National Academy of Sciences
Publisher : National Academies Press
ISBN 13 : 0309045290
Total Pages : 195 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Discovering the Brain by : National Academy of Sciences

Download or read book Discovering the Brain written by National Academy of Sciences and published by National Academies Press. This book was released on 1992-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration

Download In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration PDF Online Free

Author : Takeshi Kawauchi
Publisher : Frontiers Media SA
ISBN 13 : 2889199622
Total Pages : 270 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration by : Takeshi Kawauchi

Download or read book In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights into Neurogenesis and Neuronal Migration written by Takeshi Kawauchi and published by Frontiers Media SA. This book was released on 2016-09-21 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain consists of a complex but precisely organized neural network, which provides the structural basis of higher order functions. Such a complex structure originates from a simple pseudostratified neuroepithelium. During the developing mammalian cerebral cortex, a cohort of neural progenitors, located near the ventricle, differentiates into neurons and exhibits multi-step modes of migration toward the pial surface. Tight regulation of neurogenesis and neuronal migration is essential for the determination of the neuron number in adult brains and the proper positioning of excitatory and inhibitory neurons in a specific layer, respectively. In addition, defects in neurogenesis and neuronal migration can cause several neurological disorders, such as microcephaly, periventricular heterotopia and lissencephaly. Recent advances in genetic approaches to study the developing cerebral cortex, as well as the use of a number of novel techniques, particularly in vivo electroporation and time-lapse analyses using explant slice cultures, have significantly increased our understanding of cortical development. These novel techniques have allowed for cell biological analyses of cerebral cortical development in vivo or ex vivo, showing that many cellular events, including endocytosis, cell adhesion, microtubule and actin cytoskeletal regulation, neurotransmitter release, stress response, the consequence of cellular crowding (physical force), dynamics of transcription factors, midbody release and polarity transition are required for neurogenesis and/or neuronal migration. The aim of this research topic is to highlight molecular and cellular mechanisms underlying cerebral cortical development and its related neurological disorders from the cell biological point of views, such as cell division, cell-cycle regulation, cytoskeletal organization, cell adhesion and membrane trafficking. The topic has been organized into three chapters: 1) neurogenesis and cell fate determination, 2) neuronal migration and 3) cortical development-related neurological disorders. We hope that the results and discussions contributed by all authors in this research topic will be broadly useful for further advances in basic research, as well as improvements in the etiology and care of patients suffering from neurological and psychiatric disorders.

Cortical Development

Author : Gregory R. Bock
Publisher : John Wiley & Sons
ISBN 13 : 0470994029
Total Pages : 302 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Cortical Development by : Gregory R. Bock

Download or read book Cortical Development written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime. This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system. Chapters in this book deal specifically with cell fate determination, cell migration and disorders of cell migration; current concepts and new ideas about cortical arealisation, and disorders which can arise from incorrect arealisation; genes implicated in the development of cortical connectivity and related pathologies such as schizophrenia and synaesthesia; and susceptibility genes for cognitive disorders such as schizophrenia, autism, dyslexia, and attention deficit disorder.

In Vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights Into Neurogenesis and Neuronal Migration

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis In Vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights Into Neurogenesis and Neuronal Migration by :

Download or read book In Vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders: Cellular Insights Into Neurogenesis and Neuronal Migration written by and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain consists of a complex but precisely organized neural network, which provides the structural basis of higher order functions. Such a complex structure originates from a simple pseudostratified neuroepithelium. During the developing mammalian cerebral cortex, a cohort of neural progenitors, located near the ventricle, differentiates into neurons and exhibits multi-step modes of migration toward the pial surface. Tight regulation of neurogenesis and neuronal migration is essential for the determination of the neuron number in adult brains and the proper positioning of excitatory and inhibitory neurons in a specific layer, respectively. In addition, defects in neurogenesis and neuronal migration can cause several neurological disorders, such as microcephaly, periventricular heterotopia and lissencephaly. Recent advances in genetic approaches to study the developing cerebral cortex, as well as the use of a number of novel techniques, particularly in vivo electroporation and time-lapse analyses using explant slice cultures, have significantly increased our understanding of cortical development. These novel techniques have allowed for cell biological analyses of cerebral cortical development in vivo or ex vivo, showing that many cellular events, including endocytosis, cell adhesion, microtubule and actin cytoskeletal regulation, neurotransmitter release, stress response, the consequence of cellular crowding (physical force), dynamics of transcription factors, midbody release and polarity transition are required for neurogenesis and/or neuronal migration. The aim of this research topic is to highlight molecular and cellular mechanisms underlying cerebral cortical development and its related neurological disorders from the cell biological point of views, such as cell division, cell-cycle regulation, cytoskeletal organization, cell adhesion and membrane trafficking. The topic has been organized into three chapters: 1) neurogenesis and cell fate determination, 2) neuronal migration and 3) cortical development-related neurological disorders. We hope that the results and discussions contributed by all authors in this research topic will be broadly useful for further advances in basic research, as well as improvements in the etiology and care of patients suffering from neurological and psychiatric disorders.

Cortical Development

Author : Ryoichiro Kageyama
Publisher : Springer Science & Business Media
ISBN 13 : 4431544968
Total Pages : 282 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Cortical Development by : Ryoichiro Kageyama

Download or read book Cortical Development written by Ryoichiro Kageyama and published by Springer Science & Business Media. This book was released on 2013-09-30 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews recent progress in cortical development research, focusing on the mechanisms of neural stem cell regulation, neuronal diversity and connectivity formation, and neocortical organization. Development of the cerebral cortex, the center for higher brain functions such as cognition, memory, and decision making, is one of the major targets of current research. The cerebral cortex is divided into many areas, including motor, sensory, and visual cortices, each of which consists of six layers containing a variety of neurons with different activities and connections. As this book explains, such diversity in neuronal types and connections is generated at various levels. First, neural stem cells change their competency over time, giving sequential rise to distinct types of neurons and glial cells: initially deep layer neurons, then superficial layer neurons, and lastly astrocytes. The activities and connections of neurons are further modulated via interactions with other brain regions, such as the thalamocortical circuit, and via input from the environment. This book on cortical development is essential reading for students, postdocs, and neurobiologists.

Mechanisms of Neuronal Migration during Corticogenesis

Author : Chiaki Ohtaka-Maruyama
Publisher : Frontiers Media SA
ISBN 13 : 2889198863
Total Pages : 185 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Mechanisms of Neuronal Migration during Corticogenesis by : Chiaki Ohtaka-Maruyama

Download or read book Mechanisms of Neuronal Migration during Corticogenesis written by Chiaki Ohtaka-Maruyama and published by Frontiers Media SA. This book was released on 2016-07-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cerebral cortex plays central roles in many higher-order functions such as cognition, language, consciousness, and the control of voluntary behavior. These processes are performed by the densely interconnected networks of excitatory pyramidal neurons and inhibitory interneurons, and the balanced development of these two types of neuron is quite important. During cortical development, pyramidal neurons and interneurons show quite different migratory behaviors: radial migration and tangential migration, respectively. Pyramidal neurons are generated in the ventricular zone of the dorsal telencephalon, and migrate radially along radial glial fibers toward the pial surface, forming a six-layered cortical structure in an “ inside-out” manner. On the other hand, cortical interneurons are generated in the medial and caudal ganglionic eminence in the ventral telencephalon, and follow long tangential migratory paths into the cortex. Defects in these migration processes result in abnormalities in the cortical layer structure and neuronal networks, which may cause various neurological and psychiatric conditions such as epilepsy and schizophrenia. Accordingly, besides basic scientific interest, elucidation of the mechanism of neuronal migration is essential for understanding the pathogenesis of these diseases. This Research Topic includes a series of articles ranging from the basic mechanism of neocortical development to the malformation and evolution of the neocortex. We do hope that the present ebook will further stimulate the interest in the fascinating investigations of neuronal migration and corticogenesis.

Development of the Cerebral Cortex

Author : Gregory R. Bock
Publisher : John Wiley & Sons
ISBN 13 : 0470514817
Total Pages : 246 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Development of the Cerebral Cortex by : Gregory R. Bock

Download or read book Development of the Cerebral Cortex written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details the rapidly advancing research on the development of the cerebral cortex. Topics covered include: new physiological data showing patterns in developing cortical organization; abnormalities of cortical development associated with psychiatric disorders; and research on cell identity and regionalization of the cortex.

Neurogenesis in the Adult Brain II

Author : Tatsunori Seki
Publisher : Springer Science & Business Media
ISBN 13 : 443153945X
Total Pages : 211 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Neurogenesis in the Adult Brain II by : Tatsunori Seki

Download or read book Neurogenesis in the Adult Brain II written by Tatsunori Seki and published by Springer Science & Business Media. This book was released on 2011-06-15 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.

Translational Research in Traumatic Brain Injury

Author : Daniel Laskowitz
Publisher : CRC Press
ISBN 13 : 1498766579
Total Pages : 412 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Translational Research in Traumatic Brain Injury by : Daniel Laskowitz

Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2015-12-01 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

From Development to Degeneration and Regeneration of the Nervous System

Author : Charles E. Ribak PhD
Publisher : Oxford University Press
ISBN 13 : 9780199709168
Total Pages : 408 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis From Development to Degeneration and Regeneration of the Nervous System by : Charles E. Ribak PhD

Download or read book From Development to Degeneration and Regeneration of the Nervous System written by Charles E. Ribak PhD and published by Oxford University Press. This book was released on 2008-12-16 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides current information about the three areas mentioned in the title: Neuronal Migration and Development, Degenerative Brain Diseases, and Neural Plasticity and Regeneration. The chapters about brain development examine the cellular and molecular mechanisms by which neurons are generated from the ventricular zone in the forebrain and migrate to their destinations in the cerebral cortext. This description of cortical development also includes a discussions of the Cajal-Retzius cell. Another chapter provides insight about the development of another forebrain region, the hypothalamus. The remaining chapters of this section examine the clinical relevance of brain development in certain disease states in humans: neural tube defects and the normal and abnormal development of human electroencephalographic recordings during the first year of age. The second section on degenerative disorders of the brain begins wtih details about the dopaminergic neurons in the substantia niger and their loss in Parkinson's disease. Two subsequent chapters describe changes in brain aging, including changes in the numbers of myelinated axons. Other chapters in this section describe important cellular and molecular changes found in Alzheimer's disease and human epilepsy. Together, these chapters summarize much of our current knowledge about the major molecular and cellular changes found in several degenerative diseases of the brain. The last section addresses the issues of brain plasticity and regeneration in the adult brain and begins with a chapter on how the brain's own stem cells provide newly generated neurons to the hippocampal dentate gyrus and how these neurons become integrated into neural circuitry. The following two chapters examine some of the neuroplastic changes that take place in motor and sensory cortices of awake behaving primates. The concluding two chapters address the issue of regeneration in the injured spinal cord and the factors that may contribute to its success.

Neural Stem Cells and Therapy

Author : Tao Sun
Publisher : BoD – Books on Demand
ISBN 13 : 9533079584
Total Pages : 456 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Neural Stem Cells and Therapy by : Tao Sun

Download or read book Neural Stem Cells and Therapy written by Tao Sun and published by BoD – Books on Demand. This book was released on 2012-02-15 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collective work of international experts in the neural stem cell field. The book incorporates the characterization of embryonic and adult neural stem cells in both invertebrates and vertebrates. It highlights the history and the most advanced discoveries in neural stem cells, and summarizes the mechanisms of neural stem cell development. In particular, this book provides strategies and discusses the challenges of utilizing neural stem cells for therapy of neurological disorders and brain and spinal cord injuries. It is suitable for general readers, students, doctors and researchers who are interested in understanding the principles of and new discoveries in neural stem cells and therapy.

The Cell Cycle in the Central Nervous System

Author : Damir Janigro
Publisher : Springer Science & Business Media
ISBN 13 : 1597450219
Total Pages : 555 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis The Cell Cycle in the Central Nervous System by : Damir Janigro

Download or read book The Cell Cycle in the Central Nervous System written by Damir Janigro and published by Springer Science & Business Media. This book was released on 2008-01-23 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.

The Changing Nervous System

Author : Sarah H. Broman
Publisher : Oxford University Press
ISBN 13 : 0198028458
Total Pages : 430 pages
Book Rating : 4.1/5 (98 download)

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Book Synopsis The Changing Nervous System by : Sarah H. Broman

Download or read book The Changing Nervous System written by Sarah H. Broman and published by Oxford University Press. This book was released on 1999-07-15 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an integrated review of current research on neural plasticity and reorganization after early cerebral insults. Addressing both animal studies and a variety of diverse clinical populations, including children with congenital brain malformations, focal lesions, autism, and pervasive developmental disorders, this book summarizes many of the major advances on neural plasticity made in these areas over the past several years. Characterized by a broad historical perspective including contributions from some of the earliest researchers on environmental factors and brain organization, the book advances the reader form the laboratory to application in several human populations. Many of the components of the book explicitly address relationships of animal and human models, showing that the laboratory and the clinic are overlapping settings, not isolated chambers as they are often perceived. The understanding of neural plasticity and both biological and environmental factors that influence brain reorganization after early cerebral insult has major implications for treatment. The book outlines many of the potential applications for treatment of early brain disorders. The contributors include basic neuroscientists, cognitive neuroscientists, and clinician-researchers who work together to bridge gaps among disciplines. The book should facilitate collaborative research and applications in the critical areas of neural plasticity and brain reorganization. Advancement of knowledge of factors that prevent and enhance brain reorganization after early cerebral insult is a key to unraveling the mysteries of the developmental disorders characteristic of children and which influence their development through adulthood.

Building Brains

Author : David J. Price
Publisher : John Wiley & Sons
ISBN 13 : 111929388X
Total Pages : 386 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Building Brains by : David J. Price

Download or read book Building Brains written by David J. Price and published by John Wiley & Sons. This book was released on 2017-11-29 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a highly visual, readily accessible introduction to the main events that occur during neural development and their mechanisms Building Brains: An Introduction to Neural Development, 2nd Edition describes how brains construct themselves, from simple beginnings in the early embryo to become the most complex living structures on the planet. It explains how cells first become neural, how their proliferation is controlled, what regulates the types of neural cells they become, how neurons connect to each other, how these connections are later refined under the influence of neural activity, and why some neurons normally die. This student-friendly guide stresses and justifies the generally-held belief that a greater knowledge of how nervous systems construct themselves will help us find new ways of treating diseases of the nervous system that are thought to originate from faulty development, such as autism spectrum disorders, epilepsy, and schizophrenia. A concise, illustrated guide focusing on core elements and emphasizing common principles of developmental mechanisms, supplemented by suggestions for further reading Text boxes provide detail on major advances, issues of particular uncertainty or controversy, and examples of human diseases that result from abnormal development Introduces the methods for studying neural development, allowing the reader to understand the main evidence underlying research advances Offers a balanced mammalian/non-mammalian perspective (and emphasizes mechanisms that are conserved across species), drawing on examples from model organisms like the fruit fly, nematode worm, frog, zebrafish, chick, mouse and human Associated Website includes all the figures from the textbook and explanatory movies Filled with full-colorartwork that reinforces important concepts; an extensive glossary and definitions that help readers from different backgrounds; and chapter summaries that stress important points and aid revision, Building Brains: An Introduction to Neural Development, 2nd Edition is perfect for undergraduate students and postgraduates who may not have a background in neuroscience and/or molecular genetics. “This elegant book ranges with ease and authority over the vast field of developmental neuroscience. This excellent textbook should be on the shelf of every neuroscientist, as well as on the reading list of every neuroscience student.” —Sir Colin Blakemore, Oxford University “With an extensive use of clear and colorful illustrations, this book makes accessible to undergraduates the beauty and complexity of neural development. The book fills a void in undergraduate neuroscience curricula.” —Professor Mark Bear, Picower Institute, MIT. Highly Commended, British Medical Association Medical Book Awards 2012 Published with the New York Academy of Sciences

Neurogenesis in the Adult Brain I

Author : Tatsunori Seki
Publisher : Springer Science & Business Media
ISBN 13 : 4431539336
Total Pages : 413 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Neurogenesis in the Adult Brain I by : Tatsunori Seki

Download or read book Neurogenesis in the Adult Brain I written by Tatsunori Seki and published by Springer Science & Business Media. This book was released on 2011-06-15 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.