Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Collagen Self Assembly Induced Alignment And Quantitative Image Analysis full books in PDF, epub, and Kindle. Read online Collagen Self Assembly Induced Alignment And Quantitative Image Analysis ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Julian Haffegee
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (399 download)
Download or read book Collagen Self-assembly, Induced Alignment and Quantitative Image Analysis written by Julian Haffegee and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mae-Wan Ho
Publisher : World Scientific
ISBN 13 : 9812832599
Total Pages : 409 pages
Book Rating : 4.8/5 (128 download)
Download or read book The Rainbow and the Worm written by Mae-Wan Ho and published by World Scientific. This book was released on 2008 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly unusual book began as a serious inquiry into Schrdinger's question, ?What is life??, and as a celebration of life itself. It takes the reader on a voyage of discovery through many areas of contemporary physics, from non-equilibrium thermodynamics and quantum optics to liquid crystals and fractals, all necessary for illuminating the problem of life. In the process, the reader is treated to a rare and exquisite view of the organism, gaining novel insights not only into the physics, but also into ?the poetry and meaning of being alive.?This much-enlarged third edition includes new findings on the central role of biological water in organizing living processes; it also completes the author's novel theory of the organism and its applications in ecology, physiology and brain science.
Author : Francesco S. Pavone
Publisher : Taylor & Francis
ISBN 13 : 1439849153
Total Pages : 465 pages
Book Rating : 4.4/5 (398 download)
Download or read book Second Harmonic Generation Imaging written by Francesco S. Pavone and published by Taylor & Francis. This book was released on 2016-04-19 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second-harmonic generation (SHG) microscopy has shown great promise for imaging live cells and tissues, with applications in basic science, medical research, and tissue engineering. Second Harmonic Generation Imaging offers a complete guide to this optical modality, from basic principles, instrumentation, methods, and image analysis to biomedical a
Author : Darren Anderson
Publisher :
ISBN 13 : 9780494157466
Total Pages : 698 pages
Book Rating : 4.1/5 (574 download)
Download or read book Collagen Self-assembly written by Darren Anderson and published by . This book was released on 2006 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collagen is the major structural protein in mammals, and forms the basis of a variety of tissues essential for animal life, including bone, skin, teeth, cornea, tendon, and others. It self-assembles---both in vivo and in vitro---into a variety of biologically important structures, and this self-assembly process is highly dependent on solution pH, ionic strength, and the concentration of the collagen monomer. Kinetic studies demonstrating these dependencies are presented for the formation of the most important aggregate, native type collagen. The cold dissociation of collagen that does not contain complete non-helical telopeptide regions is also demonstrated. Based on these studies, five different types of collagen intermediates are identified and a partially hierarchical fibrillogenesis mechanism is proposed, along with a detailed kinetic model. In order to further understand collagen fibrillogenesis at a molecular level, a previously predicted structure of the collagen monomer is completely relaxed using condensed phase molecular dynamics simulations. For validation purposes, several experimentally solved model collagen structures are simulated in the same way, and the simulation results agree with the crystal structures to within the experimental error. Therefore, a structure of the collagen monomer is proposed that comprises the most complete model currently developed. This model forms the basis for two sets of simulations aimed at explaining the formation of several of the polymorphisms of collagen. First, a three-dimensional analysis of the interactions between collagen monomers in fibrillar aggregates is presented, including hydrophobic-hydrophobic and electrostatic interactions. An examination of these interactions as a function of overlap between monomers demonstrates the origin of the topological regularity in native type collagen. Second, a detailed molecular model for formation of segmental long spacing crystallites of collagen is presented, involving bridging of in-register collagen monomers by nucleotide triphosphate moieties at colocalized acidic and basic residues. The proposed model is confirmed using molecular mechanics and dynamics simulations.
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (878 download)
Download or read book Collagen Alignment Imaging and Analysis for Breast Cancer Classification written by and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mortality in cancer patients is directly attributable to the ability of cancer cells to metastasize to distant sites from the primary tumor. This migration of tumor cells begins with a remodeling of the local tumor microenvironment including changes to the extracellular matrix. In breast cancer, it has been proposed that the alignment of extracellular collagen fibers surrounding tumor epithelial cells can serve as a quantitative image-based biomarker for survival of invasive ductal carcinoma patients. This dissertation reports on the design and validation of a set of optical and computational tools to enable large-scale investigations of the interaction between collagen and tumor cells. We have built a novel imaging system which captures large field of view images of collagen and cells within tissue sections on microscope slides. The system uses second harmonic generation (SHG) imaging to capture collagen information and bright field imaging to capture information about cellular structures. We have named the system the compact automated multiphoton microscope (CAMM). We have developed computational tools that semi-automatically score collagen interactions with tumor cells via a variety of metrics, a method we call Electronic Tumor Associated Collagen Signatures (eTACS). The eTACS system produced classifications that had statistically significant correlation with manual TACS classifications and significantly prognostic correlation with disease specific survival. The eTACS classifications accurately predicted breast cancer patient recurrence producing a disease free survival hazard ratio of 2.59. Feature rank analysis revealed that TACS positive fibers were more well aligned with each other, generally lower density, and terminated within or near groups of epithelial cells at steeper angles of interaction. In addition, we have investigated the limitations to 3D collagen imaging with SHG and have observed that forward SHG detection is required for accurate 3D imaging. We have also developed a prototype system using single photon fluorescence optical imaging combined with physical sectioning to capture three dimensional images of whole mount tissues. We call the system SETI (Sequential Erosive Tissue Imaging). SETI is being developed to study contrast agent localization, prostate cancer progression mechanisms, and breast cancer extracellular matrix properties.
Author : Ricardo A. Pires
Publisher : John Wiley & Sons
ISBN 13 : 3527825835
Total Pages : 388 pages
Book Rating : 4.5/5 (278 download)
Download or read book Multifunctional Hydrogels for Biomedical Applications written by Ricardo A. Pires and published by John Wiley & Sons. This book was released on 2022-05-12 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional Hydrogels for Biomedical Applications Comprehensive resource presenting a thorough overview of the biomedical applications of hydrogels This book provides an overview of the development and applications of the clinically relevant hydrogels that are used particularly in tissue engineering, regenerative medicine, and drug delivery. Taking a multidisciplinary approach, it goes through the material from chemistry, materials science, biology, medicine, nanotechnology, and bioengineering points of view. Sample topics covered by the three well-qualified editors include: The design, functions, and developments of hydrogels Proteins and polysaccharides that mimic extracellular matrix Generation and applications of supramolecular hydrogels Design and functions of cell encapsulation systems Multifunctional Hydrogels for Biomedical Applications is a useful all-in-one reference work for materials scientists, polymer chemists, and bioengineers which provides a comprehensive, contemporary understanding of hydrogels and their applications targeting a wide variety of pathologies.
Author : Yuping Li
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (665 download)
Download or read book The Mechanism of Collagen Self-assembly written by Yuping Li and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The acceleration of fibrillogenesis rate with increasing pH from 6.6 to 9.2 is consistent with a reduction of surface net charge since the isoelectric point of soluble collagen is approaching. The native D-periodicity of 62 nm was found except at pH 7.1 where collagen molecules form short banding of 50-60 nm in the early stage of fibrillogenesis which might be caused by unusual alignment of collagen molecules in fibrils. We also introduced different monovalent and divalent electrolytes into fibril formation instead of PBS buffer. It was found the fibril formation was facilitated by divalent ions. Divalent ions can shift the isoelectric point of collagen by adsorption. We proposed the adsorbed divalent ions form the salt bridges between collagen which facilitate fibril formation. The unusual periodicities along the collagen fibril were also found which might be come from altered alignment of molecules due to the change of surface charge. These studies provide new insight on understanding the basis for collagen fibril formation and help for designing new biomaterials.
Author : Peter Fratzl
Publisher : Springer Science & Business Media
ISBN 13 : 0387739068
Total Pages : 516 pages
Book Rating : 4.3/5 (877 download)
Download or read book Collagen written by Peter Fratzl and published by Springer Science & Business Media. This book was released on 2008-05-10 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.
Author : Naghmeh Rezaei
Publisher :
ISBN 13 :
Total Pages : 97 pages
Book Rating : 4.:/5 (112 download)
Download or read book Mechanical Studies of Single Collagen Molecules Using Imaging and Force Spectroscopy written by Naghmeh Rezaei and published by . This book was released on 2016 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collagen is a key component of the extracellular matrix and is the most abundant protein in vertebrates. Collagen is found in almost every connective tissue of the body including skin, bone, tendon, cartilage, arteries and cornea, where it plays a crucial role in providing structural support. Collagen molecules self-assemble to form hierarchical structures, from single molecules to fibrils to fibers and tissues. Structural and mechanical changes at the molecular level may affect self-assembly of the molecules and the resulting tissue. Despite its significance, the mechanics of collagen and its flexibility at the molecular level remain contentious, and collagen has been variously described as a flexible polymer to a semi-rigid rod. In this thesis, I present my work developing and utilizing experimental and analytical tools to study the mechanical proprieties of molecular collagen. I carefully designed and controlled a wide variety of experimental conditions, such as different collagen types and sources, solution pH and salt concentrations, and analysed the results in search of potential reasons for inconsistency in reported results of collagen flexibility at the basic molecular level. Atomic force microscopy (AFM) imaging is used to study effect of environmental factors such as ionic strength and pH on molecular conformations and flexibility of single collagen molecules. In addition, molecular conformations of different types of collagen from different sources are compared using AFM imaging. I measure persistence length of collagen molecules, a measure of flexibility, arising due to the conformational sampling of collagen. My results link the bending energy of collagen molecules to how tightly the helix is wound. In order to analyse AFM images of collagen, I developed an image and statistical analysis algorithm, SmarTrace, optimized for my images of collagen. The program was validated using images of DNA with known persistence length, then applied to collagen molecules. Analysis of different types of collagen in two different solutions and type I collagen in solutions of different ionic strength and pH show that collagen's flexibility depends strongly on ionic strength and pH. In addition, it shows that different types of collagen show similar average conformational characteristics in a given solution environment. In addition, mechanical properties and force-response of single collagen and procollagen molecules are studied using optical tweezers. I discuss the challenges of stretching single collagen proteins, whose length is much less than the size of the microspheres used as manipulation handles, and show how instrumental design and biochemistry can be used to overcome these challenges. The result of this work is an improved understanding of the sensitivity of molecular flexibility, stability and response of collagen to environmental factors. This can shed light on identifying underlying mechanisms of collagen-related diseases as well as designing and producing improved engineered biomaterials with tunable properties.
Author : Douglas J. Taatjes
Publisher : Springer Science & Business Media
ISBN 13 : 1592599931
Total Pages : 505 pages
Book Rating : 4.5/5 (925 download)
Download or read book Cell Imaging Techniques written by Douglas J. Taatjes and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: A diverse collection of state-of-the-art methods for the microscopic imaging of cells and molecules. The authors cover a wide spectrum of complimentary techniques, including such methods as fluorescence microscopy, electron microscopy, atomic force microscopy, and laser scanning cytometry. Additional readily reproducible protocols on confocal scanning laser microscopy, quantitative computer-assisted image analysis, laser-capture microdissection, microarray image scanning, near-field scanning optical microscopy, and reflection contrast microscopy round out this eclectic collection of cutting-edge imaging techniques now available. The authors also discuss preparative methods for particles and cells by transmission electron microscopy.
Author : M. Tzaphlidou
Publisher :
ISBN 13 :
Total Pages : 138 pages
Book Rating : 4.:/5 (248 download)
Download or read book Collagen: Image Processing and Quantitative Ultrastructural Studies written by M. Tzaphlidou and published by . This book was released on 2000 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hiroyuki Ohshima
Publisher : John Wiley & Sons
ISBN 13 : 1118542762
Total Pages : 1188 pages
Book Rating : 4.1/5 (185 download)
Download or read book Encyclopedia of Biocolloid and Biointerface Science, 2 Volume Set written by Hiroyuki Ohshima and published by John Wiley & Sons. This book was released on 2016-09-26 with total page 1188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diese Enzyklopädie konzentriert sich einzig und allein auf Biokolloide und Biogrenzflächen. Hauptthema sind nicht die wissenschaftlichen Aspekte rund um Kolloide und Grenzflächen. Mit Biokolloiden und Biogrenzflächen beschäftigen sich immer mehr Wissenschaftler, und in dieser Enzyklopädie werden zur Untersuchung von Phänomen in biologischen Systemen "weiche Partikel" und "weiche Grenzflächen" als Oberflächenmodelle herangezogen. - Beschreibt detailliert die grundlegenden Theorien und erläutert die physikalisch-chemischen und theoretischen Aspekte der Biokolloid- und Biogrenzflächenwissenschaft. - Beinhaltet auch eine ausführliche Beschreibung der weichen Grenzflächen und Oberflächen - Beschäftigt sich ebenfalls mit Anwendungen der Grundlagentheorien von Biokolloiden und Biogrenzflächen auf die Nano-, Bio- und Umweltwissenschaften. Ein nützliches Nachschlagewerk genau zur richtigen Zeit, für Forscher und Absolventen im Bereich der Biokolloid- und Biogrenzflächenwissenschaft sowie für Ingenieure der Fachrichtungen.
Author : Katsuhiko Ariga
Publisher : Elsevier
ISBN 13 : 0323994733
Total Pages : 648 pages
Book Rating : 4.3/5 (239 download)
Download or read book Materials Nanoarchitectonics written by Katsuhiko Ariga and published by Elsevier. This book was released on 2023-12-07 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials Nanoarchitectonics: From Integrated Molecular Systems to Advanced Devices provides the latest information on the design and molecular manipulation of self-organized hierarchically structured systems using tailor-made nanoscale materials as structural and functional units. The book is organized into three main sections that focus on molecular design of building blocks and hybrid materials, formation of nanostructures, and applications and devices. Bringing together emerging materials, synthetic aspects, nanostructure strategies, and applications, the book aims to support further progress, by offering different perspectives and a strong interdisciplinary approach to this rapidly growing area of innovation. This is an extremely valuable resource for researchers, advanced students, and scientists in industry, with an interest in nanoarchitectonics, nanostructures, and nanomaterials, or across the areas of nanotechnology, chemistry, surface science, polymer science, electrical engineering, physics, chemical engineering, and materials science. - Offers a nanoarchitectonic perspective on emerging fields, such as metal-organic frameworks, porous polymer materials, or biomimetic nanostructures - Discusses different approaches to utilizing "soft chemistry" as a source for hierarchically organized materials - Offers an interdisciplinary approach to the design and construction of integrated chemical nano systems - Discusses novel approaches towards the creation of complex multiscale architectures
Author :
Publisher :
ISBN 13 :
Total Pages : 712 pages
Book Rating : 4.3/5 (91 download)
Download or read book Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards written by and published by . This book was released on 2003 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030916463X
Total Pages : 222 pages
Book Rating : 4.3/5 (91 download)
Download or read book Visualizing Chemistry written by National Research Council and published by National Academies Press. This book was released on 2006-06-01 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists and engineers have long relied on the power of imaging techniques to help see objects invisible to the naked eye, and thus, to advance scientific knowledge. These experts are constantly pushing the limits of technology in pursuit of chemical imagingâ€"the ability to visualize molecular structures and chemical composition in time and space as actual events unfoldâ€"from the smallest dimension of a biological system to the widest expanse of a distant galaxy. Chemical imaging has a variety of applications for almost every facet of our daily lives, ranging from medical diagnosis and treatment to the study and design of material properties in new products. In addition to highlighting advances in chemical imaging that could have the greatest impact on critical problems in science and technology, Visualizing Chemistry reviews the current state of chemical imaging technology, identifies promising future developments and their applications, and suggests a research and educational agenda to enable breakthrough improvements.
Author : Bingyun Li
Publisher : Springer
ISBN 13 : 3319736647
Total Pages : 614 pages
Book Rating : 4.3/5 (197 download)
Download or read book Orthopedic Biomaterials written by Bingyun Li and published by Springer. This book was released on 2018-03-22 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest advances, applications, and challenges in orthopedic biomaterials. Topics covered include materials for orthopedic applications, including nanomaterials, biomimetic materials, calcium phosphates, polymers, biodegradable metals, bone grafts/implants, and biomaterial-mediated drug delivery. Absorbable orthopedic biomaterials and challenges related to orthopedic biomaterials are covered in detail. This is an ideal book for graduate and undergraduate students, researchers, and professionals working with orthopedic biomaterials and tissue engineering. This book also: Describes biodegradable metals for orthopedic applications, such as Zn-based medical implants Thoroughly covers various materials for orthopedic applications, including absorbable orthopedic biomaterials with a focus on polymers Details the state-of-the-art research on orthopedic nanomaterials and nanotechnology
Author : Bernard Querleux
Publisher : CRC Press
ISBN 13 : 981446385X
Total Pages : 550 pages
Book Rating : 4.8/5 (144 download)
Download or read book Computational Biophysics of the Skin written by Bernard Querleux and published by CRC Press. This book was released on 2016-04-19 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The accessibility of the skin in vivo has resulted in the development of non-invasive methods in the past 40 years that offer accurate measurements of skin properties and structures from microscopic to macroscopic levels. However, the mechanisms involved in these properties are still only partly understood. Similar to many other domains, including
