Choix Du Traitement Comparateur Dans Les Essais Controles Randomises

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Choix du traitement comparateur dans les essais contrôlés randomisés

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Author : Candice Poels-Estellat
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (117 download)

Book Synopsis Choix du traitement comparateur dans les essais contrôlés randomisés by : Candice Poels-Estellat

Download or read book Choix du traitement comparateur dans les essais contrôlés randomisés written by Candice Poels-Estellat and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Le choix du traitement comparateur dans un essai clinique (EC) influence son intérêt scientifique et son acceptabilité éthique liée aux risques auxquels sont exposés les patients du groupe contrôle. A partir de l'exemple de l'évaluation des biothérapies dans la polyarthrite rhumatoïde, l'analyse des comparateurs utilisés dans les EC lorsqu'il existe un traitement de référence a mis en évidence une nette prédominance des comparaisons versus placebo et un déficit d'essais face-face, respectivement 81 et 5 parmi les 102 comparaisons. Nous avons estimé que dans ces EC 9 879 patients recevaient en 2ème ligne de traitement un placebo et/ou leur précédent traitement considéré comme insuffisamment efficace, cela les exposant à des risques de dommages irréversibles. A partir d'une enquête internet randomisée réalisée sur des cas-papiers de patients fictifs, nous avons montré que pour 71% des 90 patients fictifs les médecins ne considéraient pas approprié de prescrire dans le cadre des soins le traitement correspondant au groupe contrôle de TEC dont le patient était issu. Au total 49% des patients fictifs auraient été inclus dans ces vrais EC alors qu'il était considéré inacceptable de leur prescrire dans le cadre des soins le traitement du groupe contrôle. Le principe d'équipoise n'est pas respecté et, contrairement aux recommandations éthiques internationale, les patients du groupe contrôle sont exposés à des risques de préjudices significatifs et/ou durables. Ces EC n'apporteront pas de données fiables sur l'efficacité et les bénéfices relatifs des différents traitements disponibles, leur pertinence scientifique est ainsi mise en cause

Essais cliniques comparatifs

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Author : Anne-Lise Méry-Brossel
Publisher :
ISBN 13 :
Total Pages : 128 pages
Book Rating : 4.:/5 (496 download)

Book Synopsis Essais cliniques comparatifs by : Anne-Lise Méry-Brossel

Download or read book Essais cliniques comparatifs written by Anne-Lise Méry-Brossel and published by . This book was released on 2004 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Le «traitement de référence» est un des groupes de témoin défini dans les textes réglementaires tels que ICH E10. Ce type de témoin commence à prendre une place prépondérante dans les essais cliniques pour de multiples raisons : l'utilisation de placebo est considérée comme non éthique face à l'augmentation des traitements disponibles ; il permet d'obtenir des données sur la place du nouveau médicament dans l'arsenal thérapeutique existant ; dans le contexte actuel de réduction des coûts de santé, les données de pharmaco-économie permettent d'évaluer le rapport bénéfice-coût pour fixer les prix. Seulement l'acceptabilité des essais cliniques avec un traitement de référence est différente selon les cultures et peut aller de l'obligation au Japon à la méfiance aux États-Unis. Une demande systématique d'essais avec comparateur actif soulève un certain nombre de problèmes pratiques tels que le choix du traitement de référence («Gold Standard»). Celui-ci est difficilement identifiable au sein d'un même pays, il n'existe quasiment pas à l'échelle européenne ou mondiale et devient un réel problème éthique dans les pays en voie de développement. Sur le plan statistique, un bon nombre de questions se posent quant à la sensibilité de l'essai, car montrer que deux traitement actifs sont équivalents ne veut pas forcément dire qu'ils sont efficaces. Malgré les résistances de certains, il semble inévitable que les essais cliniques avec un traitement de référence vont se généraliser car les données apportées par de tels essais bénéficient à l'Autorisation de Mise sur le Marché, à la fixation du prix et aux prescripteurs.

Opinion on the Ethical Aspects of Clinical Research in Developing Countries

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Author : European Group on Ethics in Science and New Technologies to the European Commission
Publisher :
ISBN 13 :
Total Pages : 220 pages
Book Rating : 4.:/5 (31 download)

Book Synopsis Opinion on the Ethical Aspects of Clinical Research in Developing Countries by : European Group on Ethics in Science and New Technologies to the European Commission

Download or read book Opinion on the Ethical Aspects of Clinical Research in Developing Countries written by European Group on Ethics in Science and New Technologies to the European Commission and published by . This book was released on 2003 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Treatise of the Scurvy in Three Parts

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Author : James Lind
Publisher :
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.+/5 (18 download)

Book Synopsis A Treatise of the Scurvy in Three Parts by : James Lind

Download or read book A Treatise of the Scurvy in Three Parts written by James Lind and published by . This book was released on 1753 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Androgen Deprivation Therapy

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Author : Richard J. Wassersug, PhD
Publisher : Springer Publishing Company
ISBN 13 : 0826183956
Total Pages : 247 pages
Book Rating : 4.8/5 (261 download)

Book Synopsis Androgen Deprivation Therapy by : Richard J. Wassersug, PhD

Download or read book Androgen Deprivation Therapy written by Richard J. Wassersug, PhD and published by Springer Publishing Company. This book was released on 2021-07-12 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for Androgen Deprivation Therapy: "To my knowledge [this] is the only book written in plain language (no medical jargon) explaining what’s happening during ADT, and detailing how to limit and often solve most associated side effects. It should be read by every man undergoing ADT, as well as family members and also healthcare providers. They will find all the details they need to get the most from this treatment..." Prof. N. Mottet, MD, PhD, Urologist, Medical Oncologist, Head of the Prostate Cancer Guidelines panel of the European Association of Urology Androgen Deprivation Therapy is the only guide written exclusively about the side effects of hormone therapy. The authors have collaborated with the European Association of Urology to produce this specially revised new edition to serve men affected by ADT across the globe. This comprehensive workbook for prostate cancer patients and their loved ones is filled with practical advice from experts in the field. The book covers a wealth of strategies to help men cope with ADT and maintain a good quality of life while on this treatment. It is not only an informational manual, but a guide for both patients and partners about ways to make changes in their lives that can keep them healthy and positive when the patient is on ADT. New to this Edition: Updates on the physical side effects of ADT and management strategies Expanded information on exercise and nutrition for men diagnosed with prostate cancer Updates on the primary drugs used to treat prostate cancer and extensive drug tables with common brand names worldwide Revisions throughout based on critical feedback from international medical experts in the field of prostate cancer and related disciplines Exercises, activities, worksheets, and other tools to promote discussion and inspire behavioural changes that can reduce the burden of ADT Officially endorsed by the European Association of Urology

Fundamentals of Complementary and Alternative Medicine - E-Book

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Author : Marc S. Micozzi
Publisher : Elsevier Health Sciences
ISBN 13 : 1437727050
Total Pages : 625 pages
Book Rating : 4.4/5 (377 download)

Book Synopsis Fundamentals of Complementary and Alternative Medicine - E-Book by : Marc S. Micozzi

Download or read book Fundamentals of Complementary and Alternative Medicine - E-Book written by Marc S. Micozzi and published by Elsevier Health Sciences. This book was released on 2010-04-01 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on emerging therapies and those best supported by clinical trials and scientific evidence, Fundamentals of Complementary and Alternative Medicine describes some of the most prevalent and the fastest-growing CAM therapies in use today. Prominent author Dr. Marc Micozzi provides a complete overview of CAM, creating a solid foundation and context for therapies in current practice. Coverage of systems and therapies includes mind, body, and spirit; traditional Western healing; and traditional ethnomedical systems from around the world. Discussions include homeopathy, massage and manual therapies, chiropractic, a revised chapter on osteopathy, herbal medicine, aromatherapy, naturopathic medicine, and nutrition and hydration. With its wide range of topics, this is the ideal CAM reference for both students and practitioners! An evidence-based approach focuses on treatments best supported by clinical trials and scientific evidence. Coverage of CAM therapies and systems includes those most commonly encountered or growing in popularity, so you carefully evaluate each treatment. Global coverage includes discussions of traditional healing arts from Europe, Asia, Africa, and the Americas. Longevity in the market makes this a classic, trusted text. Expert contributors include well-known writers such as Kevin Ergil, Patch Adams, Joseph Pizzorno, Victor Sierpina, and Marc Micozzi himself. Suggested readings and references in each chapter list the best resources for further research and study. New, expanded organization covers the foundations of CAM, traditional Western healing, and traditional ethnomedical systems from Asia, Africa, and the Americas, putting CAM in perspective and making it easier to understand CAM origins and contexts. NEW content includes legal and operational issues in integrative medicine, creative and expressive arts therapies, ecological pharmacology, hydration, mind-body thought and practice in America, osteopathy, reflexology, South American healing, traditional medicines of India, and Unani medicine. Revised and updated chapters include aromatherapy, classical acupuncture, energy medicine, biophysical devices (electricity, light, and magnetism), massage and touch therapies, traditional osteopathy, reflexology, vitalism, and yoga. New research studies explain how and why CAM therapies work, and also demonstrate that they do work, in areas such as acupuncture, energy healing, and mind-body therapies. Expanded content on basic sciences includes biophysics, ecology, ethnomedicine, neurobiology, and pschoneuroimmunology, providing the scientific background needed to learn and practice CAM and integrative medicine. Expanded coverage of nutrition and hydration includes practical information on Vitamin D and healthy hydration with fluid and electrolytes.

Clinical Therapeutic Applications of the Kinesio Taping Method - 3rd Edition

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Author : Kenzo Kase
Publisher :
ISBN 13 : 9780989032407
Total Pages : 249 pages
Book Rating : 4.0/5 (324 download)

Book Synopsis Clinical Therapeutic Applications of the Kinesio Taping Method - 3rd Edition by : Kenzo Kase

Download or read book Clinical Therapeutic Applications of the Kinesio Taping Method - 3rd Edition written by Kenzo Kase and published by . This book was released on 2013-02-14 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Assessing Quality of Life in Clinical Trials

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Author : Peter M. Fayers
Publisher :
ISBN 13 : 9780198527695
Total Pages : 490 pages
Book Rating : 4.5/5 (276 download)

Book Synopsis Assessing Quality of Life in Clinical Trials by : Peter M. Fayers

Download or read book Assessing Quality of Life in Clinical Trials written by Peter M. Fayers and published by . This book was released on 2005 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Researchers in all clinical fields are fully aware of the importance of Quality of Life measurements in judging the efficacy of a given treatment. Psychological criteria play an important role in this evaluation. Assessment of Quality of Life in Clinical Trials: methods and practice explores the current state of the art and illustrates the benefits and potential of health related quality of life assessment in clinical trials. It covers a wide range of analytical issues, emphasizing new and innovative approaches that are of practical and clinical importance.

Beyond the Relaxation Response

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Author : Herbert Benson MD
Publisher : Harmony
ISBN 13 : 059313771X
Total Pages : 192 pages
Book Rating : 4.5/5 (931 download)

Book Synopsis Beyond the Relaxation Response by : Herbert Benson MD

Download or read book Beyond the Relaxation Response written by Herbert Benson MD and published by Harmony. This book was released on 2019-07-02 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical stress-reduction program that uses meditation and spirituality to help you relieve headaches, lower blood pressure, fight insomnia, and decrease anxiety. "Workable and tested solutions for liberating the mind and body from tension, despair, and panic that predispose the human organism to disease." —Norman Cousins, author of Anatomy of an Illness In just minutes a day, you can easily master the techniques that have helped millions conquer or alleviate stress. Employing neither drugs nor doctors, Dr. Herbert Benson’s program is considered by many to be the most beneficial step forward in personal health and well-being in our time. Using what Dr. Benson calls the Faith Factor—a combination of meditation and religious or philosophical convictions—you can: • Reduce overall stress • Relieve headaches, backaches, and chest pains • Lower blood pressure and cholesterol levels • Fight insomnia • Decrease anxiety • Achieve greater inner peace and emotional balance

Of Bodies and Symptoms

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Author : Sylvie Fainzang
Publisher : PUBLICACIONS UNIVERSITAT ROVIRA i VIRGILI
ISBN 13 : 8469449915
Total Pages : 304 pages
Book Rating : 4.4/5 (694 download)

Book Synopsis Of Bodies and Symptoms by : Sylvie Fainzang

Download or read book Of Bodies and Symptoms written by Sylvie Fainzang and published by PUBLICACIONS UNIVERSITAT ROVIRA i VIRGILI. This book was released on 2011-06-20 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The question of the social treatment of the body and its transformations emerges in relation to issues of varying types (economic, therapeutic, ideological, cultural, aesthetic,commercial, technical). This book examines the various ways of managing bodily symptoms or transformations and the social stakes and systems of knowledge which relate to them, both on the medical and social level. The contributions provide analyses that concern a broad range of countries. Through the themes it tackles and the subjects it examines, this book reveals both the universal nature of the questions it asks, and the evolution of the objects and approaches of anthropology itself.

Tacit and Explicit Knowledge

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Author : Harry Collins
Publisher : University of Chicago Press
ISBN 13 : 0226113825
Total Pages : 201 pages
Book Rating : 4.2/5 (261 download)

Book Synopsis Tacit and Explicit Knowledge by : Harry Collins

Download or read book Tacit and Explicit Knowledge written by Harry Collins and published by University of Chicago Press. This book was released on 2010-06-15 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much of what humans know we cannot say. And much of what we do we cannot describe. For example, how do we know how to ride a bike when we can’t explain how we do it? Abilities like this were called “tacit knowledge” by physical chemist and philosopher Michael Polanyi, but here Harry Collins analyzes the term, and the behavior, in much greater detail, often departing from Polanyi’s treatment. In Tacit and Explicit Knowledge, Collins develops a common conceptual language to bridge the concept’s disparate domains by explaining explicit knowledge and classifying tacit knowledge. Collins then teases apart the three very different meanings, which, until now, all fell under the umbrella of Polanyi’s term: relational tacit knowledge (things we could describe in principle if someone put effort into describing them), somatic tacit knowledge (things our bodies can do but we cannot describe how, like balancing on a bike), and collective tacit knowledge (knowledge we draw that is the property of society, such as the rules for language). Thus, bicycle riding consists of some somatic tacit knowledge and some collective tacit knowledge, such as the knowledge that allows us to navigate in traffic. The intermixing of the three kinds of tacit knowledge has led to confusion in the past; Collins’s book will at last unravel the complexities of the idea. Tacit knowledge drives everything from language, science, education, and management to sport, bicycle riding, art, and our interaction with technology. In Collins’s able hands, it also functions at last as a framework for understanding human behavior in a range of disciplines.

World Health Statistics Quarterly

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Author : World Health Organization
Publisher :
ISBN 13 :
Total Pages : 468 pages
Book Rating : 4.:/5 (319 download)

Book Synopsis World Health Statistics Quarterly by : World Health Organization

Download or read book World Health Statistics Quarterly written by World Health Organization and published by . This book was released on 1978 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Adjuvant Therapy for Breast Cancer

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Author : Monica Castiglione
Publisher : Springer Science & Business Media
ISBN 13 : 0387751157
Total Pages : 483 pages
Book Rating : 4.3/5 (877 download)

Book Synopsis Adjuvant Therapy for Breast Cancer by : Monica Castiglione

Download or read book Adjuvant Therapy for Breast Cancer written by Monica Castiglione and published by Springer Science & Business Media. This book was released on 2009-07-11 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.

Breast Cancer

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Author : Emilio Bombardieri
Publisher : Springer Science & Business Media
ISBN 13 : 3540367810
Total Pages : 307 pages
Book Rating : 4.5/5 (43 download)

Book Synopsis Breast Cancer by : Emilio Bombardieri

Download or read book Breast Cancer written by Emilio Bombardieri and published by Springer Science & Business Media. This book was released on 2007-12-22 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: There can never be enough material in the public domain about cancers, and particularly breast cancer. This book adds much to the literature. It provides general information on breast cancer management and considers all new methods of diagnosis and therapy. It focuses on nuclear medicine modalities by comparing their results with other diagnostic and therapeutic approaches. The coverage provides readers with up-to-date knowledge on breast cancer as well as information on the advances in the field of diagnosis. It also details data on the development of some new modalities and provides a general overview of the available tools for breast cancer treatment.

Psoriatic Arthritis and Psoriasis

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Author : Adewale Adebajo
Publisher : Springer
ISBN 13 : 3319195301
Total Pages : 315 pages
Book Rating : 4.3/5 (191 download)

Book Synopsis Psoriatic Arthritis and Psoriasis by : Adewale Adebajo

Download or read book Psoriatic Arthritis and Psoriasis written by Adewale Adebajo and published by Springer. This book was released on 2016-01-11 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Educational advancement in the field of psoriatic arthritis which this book will provide is consistent with GRAPPA’s aims and objectives leading to a productive synergy. GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis), is recognized world wide as the leading international society for the study and promotion of awareness of psoriatic arthritis. GRAPPA is an association of leading rheumatologists, dermatologists, representatives of patient service leagues and other stakeholders focused on psoriasis and PsA.Psoriatic Arthritis (PsA) ranks with rheumatoid arthritis and axial spondyloarthritis as one of the most prevalent inflammatory arthropathies worldwide. There is now a significant global awareness among Rheumatologists, Dermatologists, Internal Medicine Specialists, Gastroenterologists, General Practitioners, Family Practitioners, Physiotherapists, Nurse Specialists, Immunogenetics and many other Health Care Professionals with regards to the importance of psoriatic arthritis.

The Back Book

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Author : Pack of 10
Publisher : Stationery Office Books (TSO)
ISBN 13 : 9780117029507
Total Pages : 21 pages
Book Rating : 4.0/5 (295 download)

Book Synopsis The Back Book by : Pack of 10

Download or read book The Back Book written by Pack of 10 and published by Stationery Office Books (TSO). This book was released on 2002-07-05 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Treatment of Tuberculosis

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Author : World Health Organization
Publisher :
ISBN 13 :
Total Pages : 60 pages
Book Rating : 4.:/5 (31 download)

Book Synopsis Treatment of Tuberculosis by : World Health Organization

Download or read book Treatment of Tuberculosis written by World Health Organization and published by . This book was released on 1993 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: