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Cerebral Blood Flow Regulation
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Book Synopsis The Cerebral Circulation by : Marilyn J. Cipolla
Download or read book The Cerebral Circulation written by Marilyn J. Cipolla and published by Biota Publishing. This book was released on 2016-07-28 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.
Book Synopsis Cerebral Blood Flow Regulation by : Nodar Prokof'evich Mitagvariia
Download or read book Cerebral Blood Flow Regulation written by Nodar Prokof'evich Mitagvariia and published by Nova Biomedical Books. This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of the mechanisms relating blood supply to the brain appeared to be, in some sense, at a deadlock. Despite extensive application of different methodical approaches, no qualitative progress has been observed in these studies at the present time. This is perhaps due to the traditional, but not understandable, separation of neurophysiological and "circulatory" studies. It may seem very paradoxical, but the study of cerebral blood circulation proceeds almost in complete isolation from the knowledge about brain functions and does not take into account the specificity of the working brain as a part of the whole body. This book comprehensively addresses the issues of blood flow regulation. It is well known that the brain belongs to the group of organs having a high level of oxygen consumption. Oxygen consumption by the brain is an average 4.6 ml per 100 g of tissue per minute. In humans, the level of oxygen consumption by the whole brain attains 46 ml/min. This makes up approximately 20% of the total oxygen volume consumed by the organism. Consequently, the cerebral tissue is characterised by highly energetic processes. There is evidence indicating that even in functionally resting conditions, 18% of the entire energy expenditure of the body is utilised by the brain Calculations made by Rushmer indicate that the intensity of energy consumption by the human brain appears to be on average 20 Watt.
Download or read book Cerebral Blood Flow written by and published by Elsevier. This book was released on 1972-01-01 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Brain Research is the most acclaimed and accomplished series in neuroscience. The serial is well-established as an extensive documentation of contemporary advances in the field. The volumes contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry and the behavioral sciences.
Book Synopsis Gupta and Gelb's Essentials of Neuroanesthesia and Neurointensive Care by : Arun Gupta
Download or read book Gupta and Gelb's Essentials of Neuroanesthesia and Neurointensive Care written by Arun Gupta and published by Cambridge University Press. This book was released on 2018-06-21 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition presents core clinical neuroanesthesia and neurointensive care knowledge in a practical, user-friendly format.
Book Synopsis Basic Physiology for Anaesthetists by : David Chambers
Download or read book Basic Physiology for Anaesthetists written by David Chambers and published by Cambridge University Press. This book was released on 2019-07-25 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Easily understood, up-to-date and clinically relevant, this book provides junior anaesthetists with an essential physiology resource.
Book Synopsis Vascular Mechanisms in CNS Trauma by : Eng H. Lo
Download or read book Vascular Mechanisms in CNS Trauma written by Eng H. Lo and published by Springer Science & Business Media. This book was released on 2013-11-04 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: While there are a number of books on the market that deal with neuronal mechanisms and targets, the proposed book will be the only one to cover the vascular aspects of CNS trauma. The contributing authors will present basic mechanisms, explain cutting-edge experimental models and techniques, and provide several clinical chapters that provide treating physicians with some insight on the cases that they see in the ICU. The table of contents is diverse and comprehensive with chapters on molecular mechanisms, physiology, pharmacology, stem cells, genomics and proteomics, in vivo MRI and PET, as well as the clinical management of vascular parameters.
Book Synopsis Monitoring of Cerebral Blood Flow and Metabolism in Intensive Care by : Andreas Unterberg
Download or read book Monitoring of Cerebral Blood Flow and Metabolism in Intensive Care written by Andreas Unterberg and published by Springer. This book was released on 2012-02-28 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until recently, monitoring of cerebral blood flow and metabolism was an unattained goal. Determination of cerebral blood flow was limited to intermittent measurements and particularly difficult to perform in critically ill patients. Meanwhile there are techniques available, however, to monitor cerebral blood flow and cerebral oxygenation, both globally and regionally. Therefore we thought it worthwhile to discuss these new continuous techniques and to compare them with well-known techniques which discontinuously measure CBF. For that purpose, an international workshop with some leading experts in the field was held in October 1992 in Berlin. The workshop consisted of about 20 lectures, either reviews on a special topic, or latest results. These contributions were given by invitation and were extensively discussed. Unfortunately it is impossible to reproduce the discussions. On the other hand, all speakers delivered a manuscript promptly after the meeting so that we were able to edit them within a short time. Since monitoring of cerebral blood flow in intensive care is a rapidly growing and changing topic, the written contributions should be quickly available. Authors, editors and publishers have tried to come close to this ideal. As editors we would like to thank the authors and the publishers who enabled us to come out with this volume of the proceedings as early as possible.
Book Synopsis Cardiovascular Pharmacology: Endothelial Control by :
Download or read book Cardiovascular Pharmacology: Endothelial Control written by and published by Academic Press. This book was released on 2010-12-16 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions. Contains up-to-date reviews of the most important emerging cardiovascular therapies written by world leaders in the field
Book Synopsis Regulation of Coronary Blood Flow by : Michitoshi Inoue
Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Book Synopsis Cerebral Blood Flow in Acute Head Injury by : Georg E. Cold
Download or read book Cerebral Blood Flow in Acute Head Injury written by Georg E. Cold and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last decade a multitude of studies concerning the dynamic changes in cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2), and intracranial pressure (ICP) in the acute phase after head injury have been published. These studies have been supplemented with studies of cerebral autoregulation, CO2 reactivity and barbiturate reactivity. Other investigations include studies of cerebrospinal fluid pH, bicarbonate, lactate and pyruvate. In this book experimental and clinical studies of the dynamic changes in CBF, CMRO2, CO2 reactivity and barbiturate reactivity are reviewed. The author's own clinical studies of the dynamic changes in CBF and cerebral metabolism are summarized and discussed, and the therapeutical implication as regards the use of artificial hyperventilation, sedation with barbiturate and mannitol treatment are discussed.
Book Synopsis Transcranial Doppler Sonography by : Rune Aaslid
Download or read book Transcranial Doppler Sonography written by Rune Aaslid and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every few years a dissertation comes to the area of clinical application of medical technology which carries us forward as on a magic carpet into new regions of understanding and patient care. This book is such a magic carpet. It brings together, in a clear and incisive fashion, important hemodynamic principles with a simple noninvasive method of application to a part of the cerebral vasculature which has been relatively inaccessible. To the lucky and perceptive person who reads this book, a feeling of excitement and hope for progress is engendered. The diligent application of the potentials of transcranial Doppler ultrasound brings new power to our efforts in understanding the cerebral circulation and the causes, treatment and prevention of cerebrovascular disorders. Merrill P. Spencer, M. D. Director Institute of Applied Physiology and Medicine Seattle, Wash. , July 1986 Acknowledgements I am greatly indebted to Prof. He1ge Nornes, Oslo, who introduced me to the fascinating study of cerebral hemodynamics in the early 1970's and since then continually encouraged my interest in this field. It was through his pioneering work on the cerebral circulation-using peroperative electromagnetic flowmetry and Doppler techniques-that the basis was laid for the noninvasive trans cranial approach to the circle of Willis described in this book. I also gratefully acknowledge the stimulating case discussions with Prof. Peter Huber, Berne, at the very early introduction of trans cranial Doppler, the inspiring exchange of ideas with Dr. Merrill P.
Book Synopsis Core Topics in Neuroanaesthesia and Neurointensive Care by : Basil F. Matta
Download or read book Core Topics in Neuroanaesthesia and Neurointensive Care written by Basil F. Matta and published by Cambridge University Press. This book was released on 2011-10-13 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Core Topics in Neuroanesthesia and Neurointensive Care is an authoritative and practical clinical text that offers clear diagnostic and management guidance for a wide range of neuroanesthesia and neurocritical care problems. With coverage of every aspect of the discipline by outstanding world experts, this should be the first book to which practitioners turn for easily accessible and definitive advice. Initial sections cover relevant anatomy, physiology and pharmacology, intraoperative and critical care monitoring and neuroimaging. These are followed by detailed sections covering all aspects of neuroanesthesia and neurointensive care in both adult and pediatric patients. The final chapter discusses ethical and legal issues. Each chapter delivers a state-of-the art review of clinical practice, including outcome data when available. Enhanced throughout with numerous clinical photographs and line drawings, this practical and accessible text is key reading for trainee and consultant anesthetists and critical care specialists.
Book Synopsis Regulation of Tissue Oxygenation, Second Edition by : Roland N. Pittman
Download or read book Regulation of Tissue Oxygenation, Second Edition written by Roland N. Pittman and published by Biota Publishing. This book was released on 2016-08-18 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Book Synopsis Cerebral Blood Flow and Metabolism by : Lars Edvinsson
Download or read book Cerebral Blood Flow and Metabolism written by Lars Edvinsson and published by . This book was released on 2002 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written and edited by the world's foremost authorities, the Second Edition of this landmark work is a current, comprehensive reference on cerebral blood flow and metabolism. The book covers the entire field in a systematic and coherent way and synthesizes the diverse body of basic science and clinical literature. The reader will gain a complete understanding of the anatomical, physiological, and pharmacological bases of the cerebral circulation, its regulation in health and disease, and the pathophysiological disturbances occurring in cerebrovascular disorders. Coverage includes stimulating discussions of future directions for research and therapeutic intervention.
Book Synopsis Brain Disorders in Critical Illness by : Robert D. Stevens
Download or read book Brain Disorders in Critical Illness written by Robert D. Stevens and published by Cambridge University Press. This book was released on 2013-09-19 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and post-discharge cognitive dysfunction are now recognized as major healthcare burdens. This comprehensive clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and preventative and therapeutic interventions, with a final section on clinical encephalopathy syndromes encountered in the ICU. Each chapter is rich in illustrations, with an executive summary and a helpful glossary of terms. Brain Disorders in Critical Illness is a seminal reference for all physicians and neuroscientists interested in the care and outcome of severely ill patients.
Book Synopsis Primer on Cerebrovascular Diseases by : K. Michael Welch
Download or read book Primer on Cerebrovascular Diseases written by K. Michael Welch and published by Academic Press. This book was released on 1997-04-24 with total page 855 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primer on Cerebrovascular Diseases is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, and presents the information in a comprehensive and easily accessible manner. The book also contains valuable information on practical applications of basic research. Presents topics in a comprehensive and accessible format Written by international authorities on cerebral vasculature Provides practical applications for researchers
Book Synopsis Oxford Textbook of Neurocritical Care by : Martin Smith
Download or read book Oxford Textbook of Neurocritical Care written by Martin Smith and published by Oxford University Press. This book was released on 2016 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oxford Textbook of Neurocritical Care provides an authoritative and up-to-date summary of the scientific basis, clinical techniques and management guidelines in this exciting clinical discipline. Authored by an international team of expert practitioners this textbook reflects world-wide practice.
